Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | HALLMARK_G2M_CHECKPOINT |
| Enrichment Score (ES) | -0.48918605 |
| Normalized Enrichment Score (NES) | -1.9558946 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.5509257E-4 |
| FWER p-Value | 0.002 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | MEIS2 | ENSG00000134138.20 | 99 | 3.701 | 0.0176 | No | ||
| 2 | HIST1H2BK | ENSG00000197903.7 | 154 | 3.468 | 0.0350 | No | ||
| 3 | SQLE | ENSG00000104549.12 | 823 | 2.241 | 0.0315 | No | ||
| 4 | HMGA1 | ENSG00000137309.19 | 1346 | 1.908 | 0.0296 | No | ||
| 5 | PML | ENSG00000140464.20 | 2373 | 1.513 | 0.0138 | No | ||
| 6 | STAG1 | ENSG00000118007.13 | 3483 | 1.228 | -0.0054 | No | ||
| 7 | MEIS1 | ENSG00000143995.20 | 3703 | 1.183 | -0.0042 | No | ||
| 8 | CDK4 | ENSG00000135446.17 | 4137 | 1.105 | -0.0083 | No | ||
| 9 | MARCKS | ENSG00000277443.3 | 4535 | 1.038 | -0.0120 | No | ||
| 10 | NUP50 | ENSG00000093000.19 | 4550 | 1.036 | -0.0068 | No | ||
| 11 | CCND1 | ENSG00000110092.3 | 4717 | 1.011 | -0.0052 | No | ||
| 12 | E2F4 | ENSG00000205250.9 | 5303 | 0.926 | -0.0138 | No | ||
| 13 | NUMA1 | ENSG00000137497.17 | 5978 | 0.843 | -0.0250 | No | ||
| 14 | CDKN1B | ENSG00000111276.11 | 6128 | 0.825 | -0.0240 | No | ||
| 15 | CHEK1 | ENSG00000149554.13 | 6143 | 0.823 | -0.0199 | No | ||
| 16 | FOXN3 | ENSG00000053254.15 | 6152 | 0.822 | -0.0157 | No | ||
| 17 | MAP3K20 | ENSG00000091436.17 | 6549 | 0.783 | -0.0207 | No | ||
| 18 | ABL1 | ENSG00000097007.19 | 6774 | 0.761 | -0.0219 | No | ||
| 19 | TFDP1 | ENSG00000198176.13 | 7858 | 0.659 | -0.0435 | No | ||
| 20 | HIRA | ENSG00000100084.14 | 7956 | 0.651 | -0.0423 | No | ||
| 21 | LBR | ENSG00000143815.15 | 8417 | 0.611 | -0.0497 | No | ||
| 22 | CKS1B | ENSG00000173207.13 | 8704 | 0.590 | -0.0532 | No | ||
| 23 | UPF1 | ENSG00000005007.12 | 10101 | 0.504 | -0.0830 | No | ||
| 24 | CDKN2C | ENSG00000123080.12 | 10414 | 0.484 | -0.0877 | No | ||
| 25 | MAPK14 | ENSG00000112062.10 | 10900 | 0.451 | -0.0966 | No | ||
| 26 | WRN | ENSG00000165392.10 | 11488 | 0.414 | -0.1080 | No | ||
| 27 | PRIM2 | ENSG00000146143.19 | 11511 | 0.413 | -0.1063 | No | ||
| 28 | AC027237.1 | ENSG00000259191.2 | 11882 | 0.394 | -0.1128 | No | ||
| 29 | PURA | ENSG00000185129.7 | 12106 | 0.382 | -0.1160 | No | ||
| 30 | PDS5B | ENSG00000083642.19 | 14594 | 0.304 | -0.1723 | No | ||
| 31 | DBF4 | ENSG00000006634.8 | 15252 | 0.287 | -0.1860 | No | ||
| 32 | ARID4A | ENSG00000032219.19 | 15318 | 0.284 | -0.1860 | No | ||
| 33 | TENT4A | ENSG00000112941.14 | 15724 | 0.264 | -0.1941 | No | ||
| 34 | POLE | ENSG00000177084.17 | 16492 | 0.220 | -0.2107 | No | ||
| 35 | SMC4 | ENSG00000113810.16 | 17164 | 0.189 | -0.2254 | No | ||
| 36 | CHMP1A | ENSG00000131165.15 | 17351 | 0.181 | -0.2287 | No | ||
| 37 | TNPO2 | ENSG00000105576.15 | 18945 | 0.101 | -0.2653 | No | ||
| 38 | KATNA1 | ENSG00000186625.14 | 19338 | 0.081 | -0.2740 | No | ||
| 39 | SMAD3 | ENSG00000166949.16 | 20527 | 0.020 | -0.3016 | No | ||
| 40 | CKS2 | ENSG00000123975.5 | 20736 | 0.010 | -0.3063 | No | ||
| 41 | CDKN3 | ENSG00000100526.20 | 21058 | -0.007 | -0.3138 | No | ||
| 42 | SLC38A1 | ENSG00000111371.16 | 21291 | -0.021 | -0.3191 | No | ||
| 43 | H2AFX | ENSG00000188486.3 | 21679 | -0.041 | -0.3279 | No | ||
| 44 | NUSAP1 | ENSG00000137804.14 | 22190 | -0.067 | -0.3394 | No | ||
| 45 | FBXO5 | ENSG00000112029.10 | 22909 | -0.108 | -0.3555 | No | ||
| 46 | PRPF4B | ENSG00000112739.17 | 23395 | -0.135 | -0.3661 | No | ||
| 47 | NOTCH2 | ENSG00000134250.20 | 23887 | -0.164 | -0.3767 | No | ||
| 48 | CTCF | ENSG00000102974.16 | 24088 | -0.177 | -0.3804 | No | ||
| 49 | CDC7 | ENSG00000097046.13 | 24231 | -0.184 | -0.3827 | No | ||
| 50 | ODF2 | ENSG00000136811.16 | 24827 | -0.219 | -0.3954 | No | ||
| 51 | NUP98 | ENSG00000110713.17 | 24843 | -0.220 | -0.3946 | No | ||
| 52 | ORC5 | ENSG00000164815.11 | 24869 | -0.222 | -0.3939 | No | ||
| 53 | DTYMK | ENSG00000168393.13 | 24871 | -0.222 | -0.3928 | No | ||
| 54 | BUB3 | ENSG00000154473.18 | 25548 | -0.230 | -0.4073 | No | ||
| 55 | HUS1 | ENSG00000136273.13 | 25889 | -0.253 | -0.4138 | No | ||
| 56 | CUL1 | ENSG00000055130.17 | 26496 | -0.266 | -0.4265 | No | ||
| 57 | KMT5A | ENSG00000183955.13 | 26588 | -0.273 | -0.4272 | No | ||
| 58 | ORC6 | ENSG00000091651.9 | 27104 | -0.281 | -0.4377 | No | ||
| 59 | EFNA5 | ENSG00000184349.13 | 27306 | -0.296 | -0.4408 | No | ||
| 60 | DDX39A | ENSG00000123136.15 | 27337 | -0.297 | -0.4399 | No | ||
| 61 | MCM6 | ENSG00000076003.5 | 28225 | -0.325 | -0.4588 | No | ||
| 62 | SAP30 | ENSG00000164105.4 | 28782 | -0.351 | -0.4699 | No | ||
| 63 | MT2A | ENSG00000125148.7 | 29124 | -0.355 | -0.4759 | No | ||
| 64 | SRSF10 | ENSG00000188529.15 | 29186 | -0.359 | -0.4754 | No | ||
| 65 | AURKA | ENSG00000087586.17 | 29575 | -0.379 | -0.4824 | No | ||
| 66 | MCM3 | ENSG00000112118.20 | 29614 | -0.382 | -0.4812 | No | ||
| 67 | ESPL1 | ENSG00000135476.11 | 29621 | -0.383 | -0.4793 | No | ||
| 68 | KIF11 | ENSG00000138160.6 | 29654 | -0.385 | -0.4780 | No | ||
| 69 | NDC80 | ENSG00000080986.13 | 29934 | -0.401 | -0.4823 | No | ||
| 70 | CENPA | ENSG00000115163.15 | 30030 | -0.409 | -0.4823 | No | ||
| 71 | CCNB2 | ENSG00000157456.8 | 30092 | -0.412 | -0.4815 | No | ||
| 72 | BIRC5 | ENSG00000089685.15 | 30216 | -0.422 | -0.4821 | No | ||
| 73 | H2AFZ | ENSG00000164032.12 | 30267 | -0.427 | -0.4810 | No | ||
| 74 | CDC25B | ENSG00000101224.17 | 30297 | -0.429 | -0.4794 | No | ||
| 75 | CHAF1A | ENSG00000167670.16 | 30437 | -0.434 | -0.4803 | No | ||
| 76 | PBK | ENSG00000168078.10 | 30547 | -0.437 | -0.4805 | No | ||
| 77 | CASP8AP2 | ENSG00000118412.12 | 30587 | -0.440 | -0.4790 | No | ||
| 78 | SUV39H1 | ENSG00000101945.16 | 30758 | -0.451 | -0.4805 | No | ||
| 79 | NEK2 | ENSG00000117650.13 | 30994 | -0.459 | -0.4836 | No | ||
| 80 | RBL1 | ENSG00000080839.12 | 31037 | -0.462 | -0.4820 | No | ||
| 81 | CDK1 | ENSG00000170312.16 | 31062 | -0.464 | -0.4801 | No | ||
| 82 | HNRNPU | ENSG00000153187.20 | 31095 | -0.467 | -0.4783 | No | ||
| 83 | ATRX | ENSG00000085224.22 | 31252 | -0.474 | -0.4794 | No | ||
| 84 | SMC2 | ENSG00000136824.19 | 31412 | -0.486 | -0.4805 | No | ||
| 85 | E2F3 | ENSG00000112242.15 | 31678 | -0.497 | -0.4840 | No | ||
| 86 | KIF20B | ENSG00000138182.14 | 31739 | -0.499 | -0.4827 | No | ||
| 87 | E2F2 | ENSG00000007968.7 | 31923 | -0.510 | -0.4843 | No | ||
| 88 | EWSR1 | ENSG00000182944.17 | 31981 | -0.512 | -0.4828 | No | ||
| 89 | CENPE | ENSG00000138778.12 | 32083 | -0.520 | -0.4824 | No | ||
| 90 | GINS2 | ENSG00000131153.9 | 32126 | -0.521 | -0.4806 | No | ||
| 91 | MAD2L1 | ENSG00000164109.14 | 32397 | -0.539 | -0.4840 | No | ||
| 92 | TACC3 | ENSG00000013810.19 | 32622 | -0.553 | -0.4862 | Yes | ||
| 93 | STIL | ENSG00000123473.15 | 32707 | -0.560 | -0.4852 | Yes | ||
| 94 | RACGAP1 | ENSG00000161800.13 | 32756 | -0.565 | -0.4832 | Yes | ||
| 95 | CDC27 | ENSG00000004897.12 | 32830 | -0.571 | -0.4819 | Yes | ||
| 96 | MCM5 | ENSG00000100297.16 | 32907 | -0.577 | -0.4805 | Yes | ||
| 97 | KIF15 | ENSG00000163808.17 | 32992 | -0.583 | -0.4794 | Yes | ||
| 98 | HMMR | ENSG00000072571.20 | 33009 | -0.584 | -0.4766 | Yes | ||
| 99 | CENPF | ENSG00000117724.13 | 33145 | -0.594 | -0.4765 | Yes | ||
| 100 | RAD54L | ENSG00000085999.13 | 33338 | -0.609 | -0.4777 | Yes | ||
| 101 | KIF2C | ENSG00000142945.13 | 33404 | -0.613 | -0.4760 | Yes | ||
| 102 | BCL3 | ENSG00000069399.15 | 33424 | -0.615 | -0.4731 | Yes | ||
| 103 | TRAIP | ENSG00000183763.9 | 33438 | -0.616 | -0.4701 | Yes | ||
| 104 | PLK4 | ENSG00000142731.11 | 33445 | -0.616 | -0.4669 | Yes | ||
| 105 | TTK | ENSG00000112742.10 | 33483 | -0.619 | -0.4645 | Yes | ||
| 106 | DR1 | ENSG00000117505.13 | 33492 | -0.621 | -0.4613 | Yes | ||
| 107 | TOP2A | ENSG00000131747.15 | 33556 | -0.624 | -0.4594 | Yes | ||
| 108 | POLQ | ENSG00000051341.14 | 33575 | -0.627 | -0.4565 | Yes | ||
| 109 | TRA2B | ENSG00000136527.18 | 33612 | -0.630 | -0.4539 | Yes | ||
| 110 | PRC1 | ENSG00000198901.14 | 33700 | -0.638 | -0.4525 | Yes | ||
| 111 | EXO1 | ENSG00000174371.17 | 33779 | -0.643 | -0.4509 | Yes | ||
| 112 | KPNB1 | ENSG00000108424.10 | 33836 | -0.648 | -0.4487 | Yes | ||
| 113 | TMPO | ENSG00000120802.13 | 33875 | -0.652 | -0.4461 | Yes | ||
| 114 | TROAP | ENSG00000135451.13 | 33975 | -0.661 | -0.4448 | Yes | ||
| 115 | KIF22 | ENSG00000079616.12 | 34367 | -0.690 | -0.4502 | Yes | ||
| 116 | TPX2 | ENSG00000088325.16 | 34396 | -0.692 | -0.4472 | Yes | ||
| 117 | KIF4A | ENSG00000090889.12 | 34413 | -0.694 | -0.4438 | Yes | ||
| 118 | CUL4A | ENSG00000139842.15 | 34513 | -0.703 | -0.4423 | Yes | ||
| 119 | FANCC | ENSG00000158169.13 | 34975 | -0.739 | -0.4491 | Yes | ||
| 120 | UBE2C | ENSG00000175063.17 | 34985 | -0.740 | -0.4453 | Yes | ||
| 121 | SNRPD1 | ENSG00000167088.11 | 35042 | -0.745 | -0.4426 | Yes | ||
| 122 | PLK1 | ENSG00000166851.15 | 35046 | -0.745 | -0.4387 | Yes | ||
| 123 | E2F1 | ENSG00000101412.13 | 35122 | -0.753 | -0.4364 | Yes | ||
| 124 | BUB1 | ENSG00000169679.15 | 35145 | -0.755 | -0.4329 | Yes | ||
| 125 | MKI67 | ENSG00000148773.14 | 35148 | -0.755 | -0.4288 | Yes | ||
| 126 | MYC | ENSG00000136997.19 | 35251 | -0.763 | -0.4271 | Yes | ||
| 127 | NSD2 | ENSG00000109685.18 | 35335 | -0.771 | -0.4249 | Yes | ||
| 128 | CDC45 | ENSG00000093009.10 | 35359 | -0.774 | -0.4213 | Yes | ||
| 129 | CCNA2 | ENSG00000145386.10 | 35426 | -0.780 | -0.4186 | Yes | ||
| 130 | BRCA2 | ENSG00000139618.15 | 35470 | -0.784 | -0.4154 | Yes | ||
| 131 | AURKB | ENSG00000178999.13 | 35505 | -0.787 | -0.4120 | Yes | ||
| 132 | PAFAH1B1 | ENSG00000007168.13 | 35553 | -0.792 | -0.4088 | Yes | ||
| 133 | G3BP1 | ENSG00000145907.15 | 35567 | -0.794 | -0.4048 | Yes | ||
| 134 | HNRNPD | ENSG00000138668.19 | 35597 | -0.797 | -0.4012 | Yes | ||
| 135 | SYNCRIP | ENSG00000135316.18 | 35659 | -0.804 | -0.3983 | Yes | ||
| 136 | KNL1 | ENSG00000137812.19 | 35694 | -0.808 | -0.3948 | Yes | ||
| 137 | CUL3 | ENSG00000036257.13 | 35818 | -0.820 | -0.3932 | Yes | ||
| 138 | CDC20 | ENSG00000117399.14 | 35877 | -0.828 | -0.3901 | Yes | ||
| 139 | CBX1 | ENSG00000108468.15 | 36090 | -0.855 | -0.3905 | Yes | ||
| 140 | AMD1 | ENSG00000123505.17 | 36105 | -0.856 | -0.3862 | Yes | ||
| 141 | HMGN2 | ENSG00000198830.11 | 36316 | -0.879 | -0.3864 | Yes | ||
| 142 | LMNB1 | ENSG00000113368.12 | 36411 | -0.890 | -0.3838 | Yes | ||
| 143 | MYBL2 | ENSG00000101057.16 | 36500 | -0.900 | -0.3810 | Yes | ||
| 144 | SFPQ | ENSG00000116560.11 | 36704 | -0.930 | -0.3807 | Yes | ||
| 145 | CCNT1 | ENSG00000129315.11 | 36877 | -0.950 | -0.3796 | Yes | ||
| 146 | MCM2 | ENSG00000073111.14 | 36965 | -0.962 | -0.3765 | Yes | ||
| 147 | PTTG3P | ENSG00000213005.3 | 37117 | -0.982 | -0.3747 | Yes | ||
| 148 | INCENP | ENSG00000149503.13 | 37272 | -1.002 | -0.3729 | Yes | ||
| 149 | SRSF1 | ENSG00000136450.13 | 37367 | -1.015 | -0.3696 | Yes | ||
| 150 | MTF2 | ENSG00000143033.18 | 37441 | -1.025 | -0.3658 | Yes | ||
| 151 | RPA2 | ENSG00000117748.10 | 37640 | -1.058 | -0.3647 | Yes | ||
| 152 | SRSF2 | ENSG00000161547.16 | 37659 | -1.061 | -0.3595 | Yes | ||
| 153 | YTHDC1 | ENSG00000083896.12 | 37689 | -1.065 | -0.3544 | Yes | ||
| 154 | XPO1 | ENSG00000082898.17 | 37727 | -1.072 | -0.3495 | Yes | ||
| 155 | HIF1A | ENSG00000100644.17 | 37783 | -1.081 | -0.3450 | Yes | ||
| 156 | NCL | ENSG00000115053.16 | 38115 | -1.137 | -0.3466 | Yes | ||
| 157 | CCNF | ENSG00000162063.13 | 38199 | -1.153 | -0.3423 | Yes | ||
| 158 | BARD1 | ENSG00000138376.11 | 38347 | -1.179 | -0.3394 | Yes | ||
| 159 | TGFB1 | ENSG00000105329.10 | 38478 | -1.201 | -0.3360 | Yes | ||
| 160 | PTTG1 | ENSG00000164611.13 | 38713 | -1.246 | -0.3347 | Yes | ||
| 161 | CDC25A | ENSG00000164045.12 | 38736 | -1.251 | -0.3285 | Yes | ||
| 162 | GSPT1 | ENSG00000103342.13 | 38876 | -1.284 | -0.3248 | Yes | ||
| 163 | ILF3 | ENSG00000129351.17 | 38976 | -1.304 | -0.3201 | Yes | ||
| 164 | H2AFV | ENSG00000105968.18 | 39061 | -1.323 | -0.3150 | Yes | ||
| 165 | DKC1 | ENSG00000130826.18 | 39123 | -1.336 | -0.3092 | Yes | ||
| 166 | RASAL2 | ENSG00000075391.16 | 39225 | -1.357 | -0.3043 | Yes | ||
| 167 | TLE3 | ENSG00000140332.16 | 39363 | -1.390 | -0.3000 | Yes | ||
| 168 | LIG3 | ENSG00000005156.12 | 39540 | -1.429 | -0.2964 | Yes | ||
| 169 | CUL5 | ENSG00000166266.14 | 39600 | -1.441 | -0.2900 | Yes | ||
| 170 | TOP1 | ENSG00000198900.6 | 39794 | -1.490 | -0.2865 | Yes | ||
| 171 | SMARCC1 | ENSG00000173473.11 | 39851 | -1.506 | -0.2797 | Yes | ||
| 172 | NASP | ENSG00000132780.17 | 39879 | -1.517 | -0.2722 | Yes | ||
| 173 | UCK2 | ENSG00000143179.16 | 40011 | -1.551 | -0.2669 | Yes | ||
| 174 | RBM14 | ENSG00000239306.4 | 40128 | -1.581 | -0.2611 | Yes | ||
| 175 | RAD23B | ENSG00000119318.13 | 40214 | -1.603 | -0.2545 | Yes | ||
| 176 | RPS6KA5 | ENSG00000100784.12 | 40351 | -1.642 | -0.2488 | Yes | ||
| 177 | HSPA8 | ENSG00000109971.14 | 40417 | -1.661 | -0.2414 | Yes | ||
| 178 | SLC7A1 | ENSG00000139514.13 | 40707 | -1.750 | -0.2387 | Yes | ||
| 179 | EGF | ENSG00000138798.13 | 40769 | -1.774 | -0.2306 | Yes | ||
| 180 | SMC1A | ENSG00000072501.17 | 40902 | -1.825 | -0.2239 | Yes | ||
| 181 | POLA2 | ENSG00000014138.9 | 41096 | -1.906 | -0.2181 | Yes | ||
| 182 | ATF5 | ENSG00000169136.11 | 41134 | -1.925 | -0.2087 | Yes | ||
| 183 | NOLC1 | ENSG00000166197.16 | 41247 | -1.977 | -0.2006 | Yes | ||
| 184 | KPNA2 | ENSG00000182481.9 | 41262 | -1.982 | -0.1903 | Yes | ||
| 185 | UBE2S | ENSG00000108106.14 | 41441 | -2.097 | -0.1832 | Yes | ||
| 186 | MNAT1 | ENSG00000020426.11 | 41558 | -2.168 | -0.1742 | Yes | ||
| 187 | CDC6 | ENSG00000094804.12 | 41614 | -2.200 | -0.1637 | Yes | ||
| 188 | STMN1 | ENSG00000117632.23 | 41736 | -2.282 | -0.1542 | Yes | ||
| 189 | RAD21 | ENSG00000164754.14 | 41762 | -2.297 | -0.1425 | Yes | ||
| 190 | HMGB3 | ENSG00000029993.15 | 41778 | -2.309 | -0.1304 | Yes | ||
| 191 | SLC12A2 | ENSG00000064651.14 | 41802 | -2.330 | -0.1184 | Yes | ||
| 192 | PRMT5 | ENSG00000100462.16 | 41891 | -2.396 | -0.1076 | Yes | ||
| 193 | EZH2 | ENSG00000106462.10 | 41901 | -2.405 | -0.0949 | Yes | ||
| 194 | HOXC10 | ENSG00000180818.5 | 42575 | -3.255 | -0.0930 | Yes | ||
| 195 | SLC7A5 | ENSG00000103257.9 | 42645 | -3.449 | -0.0761 | Yes | ||
| 196 | ODC1 | ENSG00000115758.13 | 42710 | -3.622 | -0.0581 | Yes | ||
| 197 | KIF5B | ENSG00000170759.11 | 42759 | -3.747 | -0.0391 | Yes | ||
| 198 | JPT1 | ENSG00000189159.16 | 42914 | -4.335 | -0.0194 | Yes | ||
| 199 | DMD | ENSG00000198947.15 | 42943 | -4.488 | 0.0041 | Yes |
