Details for gene set HALLMARK_HEME_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2M
GeneSet	HALLMARK_HEME_METABOLISM
Enrichment Score (ES)	-0.26141134
Normalized Enrichment Score (NES)	-1.0483344
Nominal p-value	0.36481243
FDR q-value	0.37862027
FWER p-Value	1.0

Fig 1: Enrichment plot: HALLMARK_HEME_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	CLIC2	ENSG00000155962.13			4	4.773	0.0232	Yes
2	GYPE	ENSG00000197465.14			32	4.276	0.0435	Yes
3	CTSB	ENSG00000164733.21			145	3.504	0.0580	Yes
4	GYPC	ENSG00000136732.16			189	3.328	0.0733	Yes
5	TSPAN5	ENSG00000168785.8			230	3.209	0.0881	Yes
6	EPB41	ENSG00000159023.21			269	3.077	0.1022	Yes
7	NR3C1	ENSG00000113580.15			693	2.369	0.1040	Yes
8	ERMAP	ENSG00000164010.15			933	2.141	0.1089	Yes
9	LPIN2	ENSG00000101577.9			1243	1.970	0.1113	Yes
10	GCLC	ENSG00000001084.13			1297	1.942	0.1196	Yes
11	PRDX2	ENSG00000167815.12			1348	1.906	0.1277	Yes
12	SELENBP1	ENSG00000143416.21			1592	1.804	0.1309	Yes
13	BLVRB	ENSG00000090013.11			1648	1.782	0.1383	Yes
14	MGST3	ENSG00000143198.13			1903	1.667	0.1405	Yes
15	MARCH8	ENSG00000165406.16			1941	1.654	0.1478	Yes
16	SDCBP	ENSG00000137575.12			2234	1.554	0.1486	Yes
17	TFRC	ENSG00000072274.13			2501	1.475	0.1496	Yes
18	HEBP1	ENSG00000013583.10			2535	1.461	0.1559	Yes
19	BMP2K	ENSG00000138756.17			2593	1.444	0.1617	Yes
20	SLC22A4	ENSG00000197208.6			2636	1.430	0.1677	Yes
21	MXI1	ENSG00000119950.21			2783	1.382	0.1710	Yes
22	HTATIP2	ENSG00000109854.13			2815	1.375	0.1770	Yes
23	KLF3	ENSG00000109787.13			2827	1.371	0.1835	Yes
24	FN3K	ENSG00000167363.14			3116	1.307	0.1832	Yes
25	SNCA	ENSG00000145335.15			3307	1.267	0.1849	Yes
26	BNIP3L	ENSG00000104765.16			3379	1.249	0.1894	Yes
27	CTNS	ENSG00000040531.14			3394	1.246	0.1952	Yes
28	ADD2	ENSG00000075340.23			3448	1.237	0.2000	Yes
29	CCDC28A	ENSG00000024862.17			3646	1.195	0.2012	Yes
30	PDZK1IP1	ENSG00000162366.8			3726	1.178	0.2052	Yes
31	KHNYN	ENSG00000100441.10			3904	1.145	0.2066	Yes
32	FBXO7	ENSG00000100225.18			3910	1.144	0.2121	Yes
33	SLC10A3	ENSG00000126903.16			4001	1.127	0.2155	Yes
34	GDE1	ENSG00000006007.12			4008	1.125	0.2209	Yes
35	SLC6A9	ENSG00000196517.11			4044	1.120	0.2255	Yes
36	C3	ENSG00000125730.17			4292	1.078	0.2251	Yes
37	SLC30A1	ENSG00000170385.10			4302	1.076	0.2301	Yes
38	CPOX	ENSG00000080819.9			4313	1.075	0.2351	Yes
39	CROCCP2	ENSG00000215908.10			4393	1.062	0.2385	Yes
40	SLC25A38	ENSG00000144659.13			4425	1.057	0.2429	Yes
41	ARL2BP	ENSG00000102931.8			4525	1.041	0.2457	Yes
42	NUDT4	ENSG00000173598.14			4659	1.020	0.2476	Yes
43	LMO2	ENSG00000135363.12			4673	1.019	0.2523	Yes
44	CAST	ENSG00000153113.23			4896	0.984	0.2519	Yes
45	OPTN	ENSG00000123240.17			4961	0.974	0.2552	Yes
46	NFE2	ENSG00000123405.14			5075	0.957	0.2572	Yes
47	MARCH2	ENSG00000099785.10			5348	0.920	0.2554	Yes
48	SLC11A2	ENSG00000110911.16			5394	0.914	0.2588	Yes
49	ALAD	ENSG00000148218.16			5811	0.863	0.2534	Yes
50	EZH1	ENSG00000108799.13			5913	0.852	0.2552	Yes
51	TENT5C	ENSG00000183508.5			6006	0.841	0.2571	Yes
52	ALDH6A1	ENSG00000119711.13			6141	0.824	0.2580	Yes
53	DCAF10	ENSG00000122741.16			6369	0.801	0.2567	Yes
54	CAT	ENSG00000121691.7			6441	0.793	0.2589	Yes
55	MKRN1	ENSG00000133606.11			7189	0.720	0.2450	No
56	ELL2	ENSG00000118985.16			7312	0.708	0.2456	No
57	BSG	ENSG00000172270.19			7390	0.702	0.2473	No
58	AC092338.1	ENSG00000260635.1			8233	0.626	0.2307	No
59	CIR1	ENSG00000138433.16			8369	0.614	0.2306	No
60	ACP5	ENSG00000102575.13			8414	0.611	0.2325	No
61	BACH1	ENSG00000156273.16			8462	0.609	0.2344	No
62	LRP10	ENSG00000197324.9			8845	0.580	0.2284	No
63	CLCN3	ENSG00000109572.14			8935	0.573	0.2291	No
64	MINPP1	ENSG00000107789.16			9626	0.528	0.2156	No
65	ADD1	ENSG00000087274.17			9672	0.524	0.2171	No
66	HBD	ENSG00000223609.11			9869	0.518	0.2151	No
67	SLC30A10	ENSG00000196660.10			10031	0.509	0.2138	No
68	EPOR	ENSG00000187266.14			10084	0.505	0.2151	No
69	GMPS	ENSG00000163655.16			10157	0.500	0.2158	No
70	UROD	ENSG00000126088.14			10165	0.499	0.2181	No
71	SPTA1	ENSG00000163554.15			10687	0.466	0.2083	No
72	GCLM	ENSG00000023909.10			10865	0.454	0.2064	No
73	KAT2B	ENSG00000114166.8			11450	0.417	0.1948	No
74	RBM5	ENSG00000003756.17			12098	0.382	0.1816	No
75	TRIM10	ENSG00000204613.11			12479	0.365	0.1745	No
76	AHSP	ENSG00000169877.10			12917	0.355	0.1661	No
77	TCEA1	ENSG00000187735.14			13164	0.348	0.1620	No
78	EIF2AK1	ENSG00000086232.13			13316	0.338	0.1602	No
79	GATA1	ENSG00000102145.14			13468	0.329	0.1583	No
80	HBZ	ENSG00000130656.6			13968	0.319	0.1482	No
81	SLC7A11	ENSG00000151012.13			14604	0.304	0.1349	No
82	RHD	ENSG00000187010.21			15309	0.284	0.1199	No
83	PPOX	ENSG00000143224.18			15962	0.252	0.1059	No
84	OSBP2	ENSG00000184792.16			16123	0.241	0.1034	No
85	LAMP2	ENSG00000005893.15			16244	0.233	0.1017	No
86	AC010618.1	ENSG00000243771.1			16257	0.232	0.1026	No
87	FTCD	ENSG00000160282.14			16348	0.228	0.1016	No
88	RHCE	ENSG00000188672.18			16530	0.218	0.0985	No
89	H1F0	ENSG00000189060.5			16934	0.200	0.0900	No
90	MPP1	ENSG00000130830.15			17182	0.189	0.0852	No
91	SYNJ1	ENSG00000159082.17			17592	0.169	0.0765	No
92	RAP1GAP	ENSG00000076864.19			18593	0.119	0.0538	No
93	ALAS2	ENSG00000158578.21			18756	0.109	0.0506	No
94	FOXO3	ENSG00000118689.15			18792	0.107	0.0503	No
95	VEZF1	ENSG00000136451.9			19236	0.087	0.0404	No
96	RNF19A	ENSG00000034677.13			19454	0.073	0.0357	No
97	HBQ1	ENSG00000086506.3			19660	0.063	0.0312	No
98	YPEL5	ENSG00000119801.13			19847	0.053	0.0271	No
99	KLF1	ENSG00000105610.5			19884	0.052	0.0265	No
100	GYPA	ENSG00000170180.22			19896	0.052	0.0265	No
101	FOXJ2	ENSG00000065970.9			20324	0.031	0.0167	No
102	UBAC1	ENSG00000130560.9			20405	0.026	0.0150	No
103	TSPO2	ENSG00000112212.12			20878	0.003	0.0040	No
104	TMEM9B	ENSG00000175348.11			20961	-0.002	0.0021	No
105	DCAF11	ENSG00000100897.17			21911	-0.052	-0.0197	No
106	PSMD9	ENSG00000110801.14			23060	-0.115	-0.0459	No
107	BLVRA	ENSG00000106605.11			23148	-0.121	-0.0473	No
108	NCOA4	ENSG00000266412.5			23289	-0.129	-0.0500	No
109	HTRA2	ENSG00000115317.11			23340	-0.132	-0.0505	No
110	MOCOS	ENSG00000075643.6			23752	-0.153	-0.0593	No
111	BTRC	ENSG00000166167.18			23772	-0.155	-0.0590	No
112	SLC4A1	ENSG00000004939.15			24200	-0.182	-0.0681	No
113	CA1	ENSG00000133742.13			24216	-0.183	-0.0675	No
114	HBB	ENSG00000244734.4			24918	-0.223	-0.0828	No
115	TAL1	ENSG00000162367.11			26111	-0.263	-0.1092	No
116	CCND3	ENSG00000112576.12			26472	-0.264	-0.1163	No
117	HDGF	ENSG00000143321.19			27965	-0.306	-0.1496	No
118	HIST1H4C	ENSG00000197061.4			28019	-0.310	-0.1493	No
119	KDM7A	ENSG00000006459.11			28688	-0.344	-0.1632	No
120	MARK3	ENSG00000075413.18			29506	-0.375	-0.1804	No
121	PIGQ	ENSG00000007541.16			29573	-0.379	-0.1801	No
122	XPO7	ENSG00000130227.17			29722	-0.388	-0.1816	No
123	MAP2K3	ENSG00000034152.19			30173	-0.419	-0.1901	No
124	ANK1	ENSG00000029534.20			30376	-0.430	-0.1927	No
125	ISCA1	ENSG00000135070.15			30563	-0.438	-0.1949	No
126	AGPAT4	ENSG00000026652.15			30798	-0.454	-0.1981	No
127	ARHGEF12	ENSG00000196914.9			30804	-0.455	-0.1960	No
128	DCUN1D1	ENSG00000043093.15			30997	-0.459	-0.1982	No
129	ASNS	ENSG00000070669.17			31521	-0.490	-0.2080	No
130	ACSL6	ENSG00000164398.14			31563	-0.493	-0.2065	No
131	E2F2	ENSG00000007968.7			31923	-0.510	-0.2124	No
132	DAAM1	ENSG00000100592.15			32163	-0.524	-0.2154	No
133	PPP2R5B	ENSG00000068971.14			32568	-0.549	-0.2221	No
134	TFDP2	ENSG00000114126.17			32749	-0.564	-0.2236	No
135	CDC27	ENSG00000004897.12			32830	-0.571	-0.2226	No
136	RANBP10	ENSG00000141084.11			33510	-0.622	-0.2354	No
137	NEK7	ENSG00000151414.15			33923	-0.656	-0.2418	No
138	SLC25A37	ENSG00000147454.14			33940	-0.657	-0.2390	No
139	FECH	ENSG00000066926.11			34584	-0.709	-0.2505	No
140	ENDOD1	ENSG00000149218.5			34830	-0.728	-0.2526	No
141	RAD23A	ENSG00000179262.10			34971	-0.739	-0.2523	No
142	UROS	ENSG00000188690.15			35105	-0.751	-0.2517	No
143	ABCB6	ENSG00000115657.14			35179	-0.758	-0.2497	No
144	RNF123	ENSG00000164068.16			35311	-0.769	-0.2490	No
145	USP15	ENSG00000135655.16			35611	-0.799	-0.2521	No
146	MFHAS1	ENSG00000147324.11			35628	-0.801	-0.2485	No
147	NARF	ENSG00000141562.18			35682	-0.807	-0.2458	No
148	GLRX5	ENSG00000182512.5			35728	-0.812	-0.2429	No
149	ACKR1	ENSG00000213088.12			36116	-0.859	-0.2477	No
150	ATG4A	ENSG00000101844.18			36413	-0.890	-0.2502	No
151	FBXO9	ENSG00000112146.16			36535	-0.904	-0.2486	No
152	CA2	ENSG00000104267.10			36626	-0.919	-0.2462	No
153	ALDH1L1	ENSG00000144908.13			36733	-0.933	-0.2441	No
154	SIDT2	ENSG00000149577.16			36802	-0.941	-0.2411	No
155	BTG2	ENSG00000159388.6			37157	-0.987	-0.2446	No
156	NNT	ENSG00000112992.18			37192	-0.991	-0.2405	No
157	GAPVD1	ENSG00000165219.22			37440	-1.025	-0.2412	No
158	TYR	ENSG00000077498.9			37961	-1.111	-0.2479	No
159	PICALM	ENSG00000073921.18			38541	-1.214	-0.2555	No
160	SLC6A8	ENSG00000130821.16			38709	-1.245	-0.2533	No
161	TRIM58	ENSG00000162722.9			38717	-1.246	-0.2473	No
162	TNRC6B	ENSG00000100354.21			38760	-1.256	-0.2422	No
163	HMBS	ENSG00000256269.10			39152	-1.342	-0.2447	No
164	RCL1	ENSG00000120158.12			39318	-1.381	-0.2418	No
165	SMOX	ENSG00000088826.18			39379	-1.393	-0.2364	No
166	XK	ENSG00000047597.7			39398	-1.399	-0.2300	No
167	KEL	ENSG00000197993.9			39481	-1.419	-0.2250	No
168	BPGM	ENSG00000172331.12			39501	-1.423	-0.2184	No
169	ADIPOR1	ENSG00000159346.13			39717	-1.471	-0.2163	No
170	TOP1	ENSG00000198900.6			39794	-1.490	-0.2107	No
171	NFE2L1	ENSG00000082641.16			40596	-1.716	-0.2210	No
172	FBXO34	ENSG00000178974.10			40650	-1.734	-0.2138	No
173	SEC14L1	ENSG00000129657.16			40915	-1.830	-0.2110	No
174	IGSF3	ENSG00000143061.17			40917	-1.831	-0.2020	No
175	ATP6V0A1	ENSG00000033627.16			41061	-1.892	-0.1961	No
176	TRAK2	ENSG00000115993.13			41261	-1.982	-0.1911	No
177	HAGH	ENSG00000063854.13			41390	-2.057	-0.1840	No
178	P4HA2	ENSG00000072682.18			41436	-2.093	-0.1748	No
179	TNS1	ENSG00000079308.19			41474	-2.116	-0.1653	No
180	PC	ENSG00000173599.15			41477	-2.119	-0.1550	No
181	SPTB	ENSG00000070182.21			41597	-2.192	-0.1471	No
182	MOSPD1	ENSG00000101928.13			41617	-2.202	-0.1367	No
183	DMTN	ENSG00000158856.18			41757	-2.295	-0.1288	No
184	SLC2A1	ENSG00000117394.23			41840	-2.358	-0.1191	No
185	MBOAT2	ENSG00000143797.12			41927	-2.430	-0.1093	No
186	TMCC2	ENSG00000133069.17			42177	-2.669	-0.1020	No
187	RIOK3	ENSG00000101782.15			42254	-2.773	-0.0902	No
188	BCAM	ENSG00000187244.11			42367	-2.933	-0.0785	No
189	ABCG2	ENSG00000118777.12			42413	-2.995	-0.0649	No
190	RBM38	ENSG00000132819.17			42571	-3.248	-0.0527	No
191	AQP3	ENSG00000165272.16			42764	-3.770	-0.0387	No
192	UCP2	ENSG00000175567.10			42987	-4.667	-0.0211	No
193	MYL4	ENSG00000198336.9			43070	-4.932	0.0011	No

Fig 2: HALLMARK_HEME_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_HEME_METABOLISM: Random ES distribution   
Gene set null distribution of ES for HALLMARK_HEME_METABOLISM