Details for gene set HALLMARK_IL2_STAT5_SIGNALING[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2
GeneSet	HALLMARK_IL2_STAT5_SIGNALING
Enrichment Score (ES)	0.3034224
Normalized Enrichment Score (NES)	1.3679502
Nominal p-value	0.008695652
FDR q-value	0.048372414
FWER p-Value	0.325

Fig 1: Enrichment plot: HALLMARK_IL2_STAT5_SIGNALING   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	MAP6	ENSG00000171533.11			71	3.921	0.0142	Yes
2	CD44	ENSG00000026508.18			157	3.446	0.0262	Yes
3	PLAGL1	ENSG00000118495.19			342	2.879	0.0336	Yes
4	BCL2	ENSG00000171791.13			349	2.862	0.0450	Yes
5	FLT3LG	ENSG00000090554.13			428	2.716	0.0542	Yes
6	PLIN2	ENSG00000147872.10			455	2.674	0.0644	Yes
7	P2RX4	ENSG00000135124.14			481	2.631	0.0745	Yes
8	AHR	ENSG00000106546.14			498	2.602	0.0846	Yes
9	BATF3	ENSG00000123685.9			617	2.449	0.0918	Yes
10	EMP1	ENSG00000134531.10			648	2.414	0.1009	Yes
11	GPX4	ENSG00000167468.17			652	2.411	0.1105	Yes
12	SLC39A8	ENSG00000138821.13			676	2.382	0.1197	Yes
13	RORA	ENSG00000069667.16			686	2.376	0.1291	Yes
14	SNX9	ENSG00000130340.16			793	2.266	0.1358	Yes
15	IFITM3	ENSG00000142089.16			861	2.207	0.1431	Yes
16	LRRC8C	ENSG00000171488.15			946	2.135	0.1498	Yes
17	CAPG	ENSG00000042493.16			994	2.108	0.1573	Yes
18	PRNP	ENSG00000171867.17			1012	2.101	0.1654	Yes
19	PLSCR1	ENSG00000188313.13			1031	2.090	0.1734	Yes
20	CISH	ENSG00000114737.15			1052	2.083	0.1814	Yes
21	MAFF	ENSG00000185022.12			1086	2.057	0.1889	Yes
22	ECM1	ENSG00000143369.15			1104	2.046	0.1968	Yes
23	NRP1	ENSG00000099250.18			1128	2.034	0.2045	Yes
24	CD81	ENSG00000110651.11			1137	2.025	0.2125	Yes
25	PRAF2	ENSG00000243279.4			1181	2.001	0.2196	Yes
26	ANXA4	ENSG00000196975.16			1230	1.975	0.2265	Yes
27	AHNAK	ENSG00000124942.14			1278	1.953	0.2333	Yes
28	COL6A1	ENSG00000142156.14			1639	1.786	0.2322	Yes
29	TWSG1	ENSG00000128791.12			1689	1.759	0.2381	Yes
30	FAH	ENSG00000103876.12			1782	1.725	0.2430	Yes
31	TNFRSF1B	ENSG00000028137.19			1790	1.722	0.2498	Yes
32	NT5E	ENSG00000135318.12			2035	1.617	0.2506	Yes
33	NDRG1	ENSG00000104419.14			2162	1.579	0.2541	Yes
34	CSF1	ENSG00000184371.14			2219	1.559	0.2591	Yes
35	GABARAPL1	ENSG00000139112.11			2353	1.520	0.2622	Yes
36	IL13	ENSG00000169194.9			2466	1.483	0.2656	Yes
37	SMPDL3A	ENSG00000172594.13			2582	1.447	0.2687	Yes
38	GSTO1	ENSG00000148834.13			2646	1.427	0.2730	Yes
39	MXD1	ENSG00000059728.11			2648	1.427	0.2788	Yes
40	IL1R2	ENSG00000115590.14			2747	1.394	0.2822	Yes
41	MUC1	ENSG00000185499.16			2826	1.372	0.2859	Yes
42	NFIL3	ENSG00000165030.4			2885	1.360	0.2900	Yes
43	IGF1R	ENSG00000140443.15			3111	1.309	0.2901	Yes
44	BMP2	ENSG00000125845.7			3203	1.288	0.2932	Yes
45	KLF6	ENSG00000067082.15			3324	1.262	0.2955	Yes
46	TNFSF10	ENSG00000121858.11			3755	1.173	0.2902	Yes
47	SWAP70	ENSG00000133789.15			3991	1.130	0.2893	Yes
48	GBP4	ENSG00000162654.9			4028	1.122	0.2930	Yes
49	PLPP1	ENSG00000067113.17			4224	1.088	0.2929	Yes
50	SOCS2	ENSG00000120833.14			4228	1.088	0.2972	Yes
51	ABCB1	ENSG00000085563.14			4477	1.048	0.2957	Yes
52	IFNGR1	ENSG00000027697.14			4559	1.035	0.2980	Yes
53	IKZF2	ENSG00000030419.16			4662	1.020	0.2997	Yes
54	GUCY1B1	ENSG00000061918.13			4682	1.017	0.3034	Yes
55	SELL	ENSG00000188404.10			4919	0.981	0.3019	No
56	RNH1	ENSG00000023191.17			5371	0.917	0.2951	No
57	NCOA3	ENSG00000124151.19			5512	0.899	0.2955	No
58	SHE	ENSG00000169291.10			5541	0.895	0.2984	No
59	SOCS1	ENSG00000185338.5			5891	0.854	0.2938	No
60	PENK	ENSG00000181195.11			5979	0.843	0.2952	No
61	WLS	ENSG00000116729.14			6310	0.806	0.2907	No
62	EEF1AKMT1	ENSG00000150456.11			6399	0.797	0.2919	No
63	IL2RB	ENSG00000100385.14			6472	0.790	0.2934	No
64	CTSZ	ENSG00000101160.14			6508	0.788	0.2958	No
65	TRAF1	ENSG00000056558.11			6707	0.767	0.2943	No
66	PHLDA1	ENSG00000139289.13			7327	0.707	0.2827	No
67	LRIG1	ENSG00000144749.13			7468	0.693	0.2823	No
68	SPRY4	ENSG00000187678.9			7662	0.675	0.2805	No
69	ITIH5	ENSG00000123243.15			7798	0.664	0.2801	No
70	F2RL2	ENSG00000164220.7			7910	0.654	0.2801	No
71	IKZF4	ENSG00000123411.15			8260	0.622	0.2745	No
72	CD83	ENSG00000112149.10			8612	0.598	0.2688	No
73	IRF4	ENSG00000137265.15			9062	0.567	0.2606	No
74	S100A1	ENSG00000160678.11			9481	0.539	0.2530	No
75	IL2RA	ENSG00000134460.17			9914	0.516	0.2451	No
76	FAM126B	ENSG00000155744.9			10078	0.505	0.2433	No
77	TNFRSF18	ENSG00000186891.14			10951	0.448	0.2248	No
78	MYO1E	ENSG00000157483.9			10969	0.447	0.2262	No
79	CKAP4	ENSG00000136026.14			11165	0.434	0.2234	No
80	SPRED2	ENSG00000198369.10			11240	0.431	0.2234	No
81	SYT11	ENSG00000132718.9			11247	0.431	0.2251	No
82	GPR65	ENSG00000140030.6			11401	0.420	0.2232	No
83	IL18R1	ENSG00000115604.10			11692	0.402	0.2181	No
84	EOMES	ENSG00000163508.13			13296	0.340	0.1821	No
85	TTC39B	ENSG00000155158.20			13360	0.336	0.1820	No
86	GATA1	ENSG00000102145.14			13468	0.329	0.1808	No
87	TGM2	ENSG00000198959.12			14132	0.309	0.1666	No
88	PTGER2	ENSG00000125384.7			14137	0.308	0.1678	No
89	BATF	ENSG00000156127.7			14541	0.308	0.1596	No
90	FGL2	ENSG00000127951.7			14791	0.292	0.1550	No
91	PTCH1	ENSG00000185920.15			15447	0.278	0.1409	No
92	SNX14	ENSG00000135317.13			15633	0.268	0.1377	No
93	APLP1	ENSG00000105290.12			16304	0.230	0.1230	No
94	PIM1	ENSG00000137193.14			16645	0.213	0.1159	No
95	ETFBKMT	ENSG00000139160.13			17288	0.184	0.1017	No
96	GALM	ENSG00000143891.17			17349	0.181	0.1010	No
97	ITGAE	ENSG00000083457.12			17609	0.168	0.0957	No
98	SLC2A3	ENSG00000059804.16			17679	0.164	0.0947	No
99	GLIPR2	ENSG00000122694.16			17940	0.149	0.0893	No
100	ENPP1	ENSG00000197594.13			18652	0.116	0.0732	No
101	ST3GAL4	ENSG00000110080.18			18992	0.098	0.0657	No
102	SPP1	ENSG00000118785.14			20575	0.018	0.0289	No
103	HK2	ENSG00000159399.9			21120	-0.012	0.0163	No
104	SERPINC1	ENSG00000117601.13			21552	-0.034	0.0064	No
105	DENND5A	ENSG00000184014.8			21947	-0.054	-0.0026	No
106	ALCAM	ENSG00000170017.12			21952	-0.054	-0.0025	No
107	SLC1A5	ENSG00000105281.12			23007	-0.112	-0.0266	No
108	UMPS	ENSG00000114491.14			23154	-0.122	-0.0295	No
109	RHOH	ENSG00000168421.13			23214	-0.125	-0.0303	No
110	DRC1	ENSG00000157856.12			23245	-0.126	-0.0305	No
111	ETV4	ENSG00000175832.13			23795	-0.157	-0.0427	No
112	TLR7	ENSG00000196664.5			23985	-0.170	-0.0464	No
113	MAP3K8	ENSG00000107968.10			23988	-0.170	-0.0458	No
114	POU2F1	ENSG00000143190.23			25927	-0.256	-0.0899	No
115	CCND3	ENSG00000112576.12			26472	-0.264	-0.1015	No
116	SLC29A2	ENSG00000174669.12			28514	-0.337	-0.1477	No
117	MAPKAPK2	ENSG00000162889.10			28673	-0.343	-0.1500	No
118	IRF8	ENSG00000140968.11			28903	-0.351	-0.1539	No
119	CD86	ENSG00000114013.16			29238	-0.360	-0.1602	No
120	TNFRSF8	ENSG00000120949.15			29278	-0.362	-0.1596	No
121	RABGAP1L	ENSG00000152061.23			29444	-0.371	-0.1620	No
122	CXCL10	ENSG00000169245.6			29765	-0.392	-0.1679	No
123	LTB	ENSG00000227507.2			30077	-0.411	-0.1734	No
124	BCL2L1	ENSG00000171552.13			30289	-0.428	-0.1766	No
125	SCN9A	ENSG00000169432.16			30394	-0.431	-0.1773	No
126	P4HA1	ENSG00000122884.12			30621	-0.444	-0.1808	No
127	AMACR	ENSG00000242110.8			31155	-0.472	-0.1913	No
128	COCH	ENSG00000100473.18			31549	-0.493	-0.1984	No
129	TNFRSF21	ENSG00000146072.6			31612	-0.495	-0.1979	No
130	SERPINB6	ENSG00000124570.20			32078	-0.519	-0.2066	No
131	XBP1	ENSG00000100219.16			32221	-0.529	-0.2078	No
132	DHRS3	ENSG00000162496.9			32706	-0.560	-0.2168	No
133	TNFSF11	ENSG00000120659.15			32990	-0.582	-0.2210	No
134	IRF6	ENSG00000117595.12			33101	-0.590	-0.2212	No
135	CYFIP1	ENSG00000273749.5			33425	-0.615	-0.2262	No
136	CDCP1	ENSG00000163814.8			33459	-0.618	-0.2245	No
137	IL1RL1	ENSG00000115602.17			33631	-0.632	-0.2259	No
138	DCPS	ENSG00000110063.10			33848	-0.649	-0.2283	No
139	HOPX	ENSG00000171476.22			33915	-0.655	-0.2272	No
140	CAPN3	ENSG00000092529.24			34141	-0.671	-0.2297	No
141	PNP	ENSG00000198805.11			34508	-0.703	-0.2354	No
142	MYC	ENSG00000136997.19			35251	-0.763	-0.2496	No
143	IL4R	ENSG00000077238.14			35619	-0.801	-0.2549	No
144	PUS1	ENSG00000177192.14			35670	-0.806	-0.2528	No
145	AGER	ENSG00000204305.14			35896	-0.830	-0.2547	No
146	ICOS	ENSG00000163600.12			36093	-0.855	-0.2558	No
147	PLEC	ENSG00000178209.15			36280	-0.875	-0.2566	No
148	RGS16	ENSG00000143333.7			36334	-0.882	-0.2543	No
149	IL10RA	ENSG00000110324.10			36391	-0.887	-0.2520	No
150	SELP	ENSG00000174175.17			36579	-0.910	-0.2527	No
151	CA2	ENSG00000104267.10			36626	-0.919	-0.2500	No
152	CD48	ENSG00000117091.10			37061	-0.976	-0.2562	No
153	PTRH2	ENSG00000141378.14			37226	-0.996	-0.2560	No
154	PTH1R	ENSG00000160801.14			37338	-1.011	-0.2544	No
155	IGF2R	ENSG00000197081.14			37384	-1.018	-0.2514	No
156	MYO1C	ENSG00000197879.17			37451	-1.026	-0.2488	No
157	FURIN	ENSG00000140564.12			37563	-1.044	-0.2471	No
158	CCR4	ENSG00000183813.7			38034	-1.123	-0.2535	No
159	AHCY	ENSG00000101444.13			38037	-1.123	-0.2490	No
160	PHTF2	ENSG00000006576.16			38256	-1.164	-0.2494	No
161	CST7	ENSG00000077984.6			38468	-1.200	-0.2495	No
162	RHOB	ENSG00000143878.10			38518	-1.210	-0.2457	No
163	NOP2	ENSG00000111641.11			38743	-1.252	-0.2458	No
164	BMPR2	ENSG00000204217.15			38845	-1.277	-0.2430	No
165	HUWE1	ENSG00000086758.16			38984	-1.305	-0.2410	No
166	SH3BGRL2	ENSG00000198478.8			39159	-1.344	-0.2396	No
167	UCK2	ENSG00000143179.16			40011	-1.551	-0.2531	No
168	BHLHE40	ENSG00000134107.5			40173	-1.593	-0.2504	No
169	SYNGR2	ENSG00000108639.7			40316	-1.632	-0.2471	No
170	CSF2	ENSG00000164400.6			40320	-1.633	-0.2406	No
171	GPR83	ENSG00000123901.9			40678	-1.743	-0.2419	No
172	TNFRSF4	ENSG00000186827.11			40786	-1.782	-0.2371	No
173	LCLAT1	ENSG00000172954.13			40851	-1.802	-0.2313	No
174	GADD45B	ENSG00000099860.9			40977	-1.852	-0.2267	No
175	CD79B	ENSG00000007312.12			41027	-1.877	-0.2203	No
176	ITGAV	ENSG00000138448.12			41100	-1.907	-0.2142	No
177	CDKN1C	ENSG00000129757.13			41169	-1.945	-0.2080	No
178	CCNE1	ENSG00000105173.14			41239	-1.974	-0.2016	No
179	RRAGD	ENSG00000025039.15			41478	-2.121	-0.1985	No
180	CDC42SE2	ENSG00000158985.13			41509	-2.135	-0.1906	No
181	NCS1	ENSG00000107130.10			41512	-2.136	-0.1820	No
182	CDC6	ENSG00000094804.12			41614	-2.200	-0.1754	No
183	ARL4A	ENSG00000122644.13			41707	-2.259	-0.1684	No
184	TNFRSF9	ENSG00000049249.8			41845	-2.364	-0.1621	No
185	CCND2	ENSG00000118971.8			41960	-2.462	-0.1548	No
186	PRKCH	ENSG00000027075.15			41980	-2.474	-0.1452	No
187	TIAM1	ENSG00000156299.13			42155	-2.641	-0.1385	No
188	PDCD2L	ENSG00000126249.8			42188	-2.682	-0.1284	No
189	CASP3	ENSG00000164305.19			42313	-2.869	-0.1197	No
190	NFKBIZ	ENSG00000144802.11			42390	-2.970	-0.1095	No
191	CTLA4	ENSG00000163599.17			42395	-2.974	-0.0975	No
192	HIPK2	ENSG00000064393.16			42572	-3.249	-0.0885	No
193	ODC1	ENSG00000115758.13			42710	-3.622	-0.0770	No
194	IL10	ENSG00000136634.7			42757	-3.743	-0.0629	No
195	LIF	ENSG00000128342.5			42847	-4.098	-0.0484	No
196	ADAM19	ENSG00000135074.15			42902	-4.288	-0.0323	No
197	ENO3	ENSG00000108515.17			42958	-4.537	-0.0152	No
198	ITGA6	ENSG00000091409.15			42992	-4.680	0.0030	No

Fig 2: HALLMARK_IL2_STAT5_SIGNALING   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_IL2_STAT5_SIGNALING: Random ES distribution   
Gene set null distribution of ES for HALLMARK_IL2_STAT5_SIGNALING