Details for gene set HALLMARK_KRAS_SIGNALING_UP[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2
GeneSet	HALLMARK_KRAS_SIGNALING_UP
Enrichment Score (ES)	0.2934013
Normalized Enrichment Score (NES)	1.3333234
Nominal p-value	0.012244898
FDR q-value	0.057013694
FWER p-Value	0.403

Fig 1: Enrichment plot: HALLMARK_KRAS_SIGNALING_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	GPNMB	ENSG00000136235.16			163	3.424	0.0107	Yes
2	GYPC	ENSG00000136732.16			189	3.328	0.0242	Yes
3	ADGRA2	ENSG00000020181.18			190	3.323	0.0382	Yes
4	CFB	ENSG00000243649.8			196	3.306	0.0521	Yes
5	ITGA2	ENSG00000164171.11			327	2.899	0.0613	Yes
6	KLF4	ENSG00000136826.15			421	2.729	0.0707	Yes
7	CTSS	ENSG00000163131.11			442	2.687	0.0816	Yes
8	CAB39L	ENSG00000102547.19			467	2.647	0.0922	Yes
9	AKAP12	ENSG00000131016.17			561	2.526	0.1007	Yes
10	LY96	ENSG00000154589.7			593	2.480	0.1105	Yes
11	EMP1	ENSG00000134531.10			648	2.414	0.1194	Yes
12	DNMBP	ENSG00000107554.17			772	2.289	0.1262	Yes
13	ETV1	ENSG00000006468.14			859	2.210	0.1336	Yes
14	SATB1	ENSG00000182568.17			963	2.125	0.1402	Yes
15	PSMB8	ENSG00000204264.11			1023	2.095	0.1476	Yes
16	GNG11	ENSG00000127920.6			1076	2.064	0.1551	Yes
17	NRP1	ENSG00000099250.18			1128	2.034	0.1626	Yes
18	PRRX1	ENSG00000116132.12			1144	2.020	0.1707	Yes
19	ACE	ENSG00000159640.16			1197	1.991	0.1780	Yes
20	EPB41L3	ENSG00000082397.17			1516	1.836	0.1783	Yes
21	DUSP6	ENSG00000139318.8			1611	1.795	0.1837	Yes
22	MAP7	ENSG00000135525.18			1773	1.727	0.1873	Yes
23	TNFRSF1B	ENSG00000028137.19			1790	1.722	0.1942	Yes
24	IGFBP3	ENSG00000146674.15			1828	1.702	0.2005	Yes
25	APOD	ENSG00000189058.9			1901	1.668	0.2059	Yes
26	TFPI	ENSG00000003436.16			2020	1.622	0.2100	Yes
27	SPON1	ENSG00000262655.4			2107	1.596	0.2147	Yes
28	TMEM100	ENSG00000166292.12			2391	1.508	0.2145	Yes
29	IL1RL2	ENSG00000115598.10			2396	1.506	0.2208	Yes
30	ALDH1A3	ENSG00000184254.17			2445	1.491	0.2260	Yes
31	FUCA1	ENSG00000179163.11			2594	1.443	0.2286	Yes
32	MALL	ENSG00000144063.3			2663	1.422	0.2330	Yes
33	ERO1A	ENSG00000197930.13			2702	1.409	0.2381	Yes
34	HOXD11	ENSG00000128713.14			2820	1.373	0.2412	Yes
35	PTGS2	ENSG00000073756.12			2837	1.370	0.2466	Yes
36	PRKG2	ENSG00000138669.9			2843	1.368	0.2523	Yes
37	CPE	ENSG00000109472.14			2910	1.353	0.2565	Yes
38	ALDH1A2	ENSG00000128918.15			3198	1.290	0.2552	Yes
39	BMP2	ENSG00000125845.7			3203	1.288	0.2606	Yes
40	TRIB2	ENSG00000071575.11			3254	1.277	0.2648	Yes
41	GUCY1A1	ENSG00000164116.16			3397	1.246	0.2668	Yes
42	MAFB	ENSG00000204103.4			3567	1.214	0.2680	Yes
43	IL33	ENSG00000137033.11			3995	1.130	0.2628	Yes
44	SLPI	ENSG00000124107.5			4026	1.122	0.2668	Yes
45	TMEM176B	ENSG00000106565.18			4334	1.071	0.2642	Yes
46	SNAP25	ENSG00000132639.12			4440	1.054	0.2662	Yes
47	ABCB1	ENSG00000085563.14			4477	1.048	0.2698	Yes
48	MMP10	ENSG00000166670.10			4529	1.040	0.2730	Yes
49	TMEM176A	ENSG00000002933.9			4536	1.038	0.2773	Yes
50	SEMA3B	ENSG00000012171.20			4765	1.004	0.2762	Yes
51	AKT2	ENSG00000105221.18			4775	1.001	0.2802	Yes
52	ITGBL1	ENSG00000198542.14			4835	0.992	0.2831	Yes
53	CDADC1	ENSG00000102543.14			4890	0.985	0.2860	Yes
54	FBXO4	ENSG00000151876.13			4926	0.980	0.2893	Yes
55	EREG	ENSG00000124882.4			4928	0.979	0.2934	Yes
56	PRDM1	ENSG00000057657.17			5413	0.912	0.2860	No
57	TRIB1	ENSG00000173334.4			5448	0.906	0.2890	No
58	SDCCAG8	ENSG00000054282.16			5716	0.874	0.2865	No
59	HSD11B1	ENSG00000117594.10			5743	0.870	0.2896	No
60	ZNF277	ENSG00000198839.10			6297	0.807	0.2801	No
61	NGF	ENSG00000134259.3			6597	0.778	0.2764	No
62	TRAF1	ENSG00000056558.11			6707	0.767	0.2771	No
63	ADAMDEC1	ENSG00000134028.14			6951	0.743	0.2746	No
64	DOCK2	ENSG00000134516.17			7056	0.733	0.2753	No
65	ANGPTL4	ENSG00000167772.12			7297	0.710	0.2727	No
66	MAP3K1	ENSG00000095015.6			7811	0.662	0.2635	No
67	RELN	ENSG00000189056.14			8324	0.618	0.2542	No
68	CFH	ENSG00000000971.15			8408	0.612	0.2549	No
69	TSPAN1	ENSG00000117472.10			8534	0.603	0.2545	No
70	IKZF1	ENSG00000185811.19			8664	0.594	0.2540	No
71	NAP1L2	ENSG00000186462.9			8937	0.572	0.2501	No
72	TLR8	ENSG00000101916.11			9048	0.567	0.2499	No
73	CROT	ENSG00000005469.11			9050	0.567	0.2523	No
74	CLEC4A	ENSG00000111729.14			9649	0.526	0.2406	No
75	LCP1	ENSG00000136167.14			9877	0.517	0.2375	No
76	MTMR10	ENSG00000166912.17			10014	0.511	0.2365	No
77	ARG1	ENSG00000118520.15			11189	0.433	0.2110	No
78	PCP4	ENSG00000183036.11			11202	0.433	0.2125	No
79	SCN1B	ENSG00000105711.12			12081	0.383	0.1937	No
80	BIRC3	ENSG00000023445.14			12432	0.366	0.1871	No
81	WNT7A	ENSG00000154764.6			12532	0.364	0.1863	No
82	ADGRL4	ENSG00000162618.15			13276	0.341	0.1704	No
83	ZNF639	ENSG00000121864.10			13545	0.324	0.1656	No
84	CFHR2	ENSG00000080910.13			13602	0.322	0.1656	No
85	PIGR	ENSG00000162896.6			14330	0.308	0.1500	No
86	PPBP	ENSG00000163736.4			14361	0.308	0.1506	No
87	PPP1R15A	ENSG00000087074.8			14858	0.289	0.1402	No
88	SPARCL1	ENSG00000152583.12			15335	0.283	0.1304	No
89	CBX8	ENSG00000141570.11			15355	0.282	0.1311	No
90	GALNT3	ENSG00000115339.14			15510	0.274	0.1287	No
91	PCSK1N	ENSG00000102109.9			15841	0.258	0.1221	No
92	SERPINA3	ENSG00000196136.17			16370	0.226	0.1107	No
93	EVI5	ENSG00000067208.14			16617	0.213	0.1059	No
94	ANKH	ENSG00000154122.14			16879	0.203	0.1007	No
95	MMD	ENSG00000108960.9			17383	0.179	0.0897	No
96	IL1B	ENSG00000125538.12			17487	0.172	0.0880	No
97	SCG5	ENSG00000166922.8			17518	0.171	0.0881	No
98	HDAC9	ENSG00000048052.21			18434	0.129	0.0673	No
99	CIDEA	ENSG00000176194.18			18690	0.113	0.0618	No
100	ID2	ENSG00000115738.10			19442	0.074	0.0446	No
101	PEG3	ENSG00000198300.14			19582	0.067	0.0417	No
102	TSPAN13	ENSG00000106537.8			20061	0.045	0.0307	No
103	SPP1	ENSG00000118785.14			20575	0.018	0.0189	No
104	MMP11	ENSG00000099953.10			20933	-0.001	0.0106	No
105	DCBLD2	ENSG00000057019.16			21563	-0.035	-0.0040	No
106	TOR1AIP2	ENSG00000169905.12			21857	-0.049	-0.0106	No
107	PTBP2	ENSG00000117569.18			22086	-0.062	-0.0156	No
108	ENG	ENSG00000106991.13			22533	-0.086	-0.0257	No
109	IL7R	ENSG00000168685.15			23218	-0.125	-0.0411	No
110	PECAM1	ENSG00000261371.6			23502	-0.141	-0.0471	No
111	ETV4	ENSG00000175832.13			23795	-0.157	-0.0532	No
112	TMEM158	ENSG00000249992.2			24073	-0.175	-0.0589	No
113	NR1H4	ENSG00000012504.15			24416	-0.194	-0.0661	No
114	SCG3	ENSG00000104112.9			24442	-0.195	-0.0658	No
115	NR0B2	ENSG00000131910.5			24529	-0.200	-0.0670	No
116	GFPT2	ENSG00000131459.13			25476	-0.226	-0.0881	No
117	SOX9	ENSG00000125398.8			25922	-0.255	-0.0973	No
118	HIST1H2BB	ENSG00000276410.3			26550	-0.270	-0.1108	No
119	MPZL2	ENSG00000149573.9			26944	-0.275	-0.1188	No
120	F2RL1	ENSG00000164251.5			28125	-0.319	-0.1450	No
121	CBL	ENSG00000110395.6			28190	-0.323	-0.1451	No
122	USH1C	ENSG00000006611.16			28668	-0.342	-0.1547	No
123	ATG10	ENSG00000152348.16			28738	-0.347	-0.1549	No
124	IRF8	ENSG00000140968.11			28903	-0.351	-0.1572	No
125	RABGAP1L	ENSG00000152061.23			29444	-0.371	-0.1682	No
126	BTBD3	ENSG00000132640.15			29483	-0.373	-0.1675	No
127	CXCL10	ENSG00000169245.6			29765	-0.392	-0.1724	No
128	PLEK2	ENSG00000100558.9			29774	-0.392	-0.1710	No
129	ADAM8	ENSG00000151651.16			30427	-0.433	-0.1843	No
130	CMKLR1	ENSG00000174600.14			30724	-0.448	-0.1893	No
131	MMP9	ENSG00000100985.7			31139	-0.471	-0.1970	No
132	EPHB2	ENSG00000133216.16			31281	-0.477	-0.1982	No
133	JUP	ENSG00000173801.17			31855	-0.505	-0.2095	No
134	GABRA3	ENSG00000011677.13			32898	-0.576	-0.2313	No
135	ETS1	ENSG00000134954.14			33090	-0.589	-0.2333	No
136	LAPTM5	ENSG00000162511.8			33566	-0.626	-0.2417	No
137	WDR33	ENSG00000136709.12			33590	-0.628	-0.2396	No
138	KIF5C	ENSG00000168280.17			33966	-0.659	-0.2455	No
139	RBM4	ENSG00000173933.20			34144	-0.671	-0.2468	No
140	CXCR4	ENSG00000121966.6			34272	-0.681	-0.2469	No
141	PTCD2	ENSG00000049883.15			34628	-0.713	-0.2521	No
142	ST6GAL1	ENSG00000073849.15			34834	-0.728	-0.2538	No
143	RBP4	ENSG00000138207.14			35047	-0.745	-0.2556	No
144	TPH1	ENSG00000129167.9			35258	-0.764	-0.2573	No
145	PRELID3B	ENSG00000101166.16			35547	-0.792	-0.2606	No
146	ANO1	ENSG00000131620.17			35662	-0.805	-0.2599	No
147	RGS16	ENSG00000143333.7			36334	-0.882	-0.2718	No
148	IL10RA	ENSG00000110324.10			36391	-0.887	-0.2694	No
149	SNAP91	ENSG00000065609.14			36474	-0.897	-0.2675	No
150	CA2	ENSG00000104267.10			36626	-0.919	-0.2671	No
151	YRDC	ENSG00000196449.4			37665	-1.061	-0.2868	No
152	ETV5	ENSG00000244405.8			37843	-1.090	-0.2863	No
153	CCL20	ENSG00000115009.13			37860	-1.093	-0.2821	No
154	AVL9	ENSG00000105778.19			38275	-1.167	-0.2868	No
155	MYCN	ENSG00000134323.12			38301	-1.172	-0.2824	No
156	LAT2	ENSG00000086730.17			38342	-1.178	-0.2784	No
157	SPRY2	ENSG00000136158.12			38459	-1.199	-0.2760	No
158	PLVAP	ENSG00000130300.9			38855	-1.279	-0.2798	No
159	CD37	ENSG00000104894.12			38942	-1.297	-0.2763	No
160	NIN	ENSG00000100503.23			38999	-1.310	-0.2721	No
161	HKDC1	ENSG00000156510.13			39104	-1.332	-0.2689	No
162	CCSER2	ENSG00000107771.17			39170	-1.346	-0.2647	No
163	STRN	ENSG00000115808.12			39197	-1.352	-0.2596	No
164	MAP4K1	ENSG00000104814.13			39205	-1.355	-0.2540	No
165	PDCD1LG2	ENSG00000197646.8			39306	-1.379	-0.2505	No
166	TNFAIP3	ENSG00000118503.15			39359	-1.390	-0.2459	No
167	BPGM	ENSG00000172331.12			39501	-1.423	-0.2431	No
168	ADAM17	ENSG00000151694.14			39944	-1.533	-0.2469	No
169	FGF9	ENSG00000102678.7			40051	-1.560	-0.2428	No
170	CSF2	ENSG00000164400.6			40320	-1.633	-0.2422	No
171	GPRC5B	ENSG00000167191.12			40394	-1.657	-0.2369	No
172	IGF2	ENSG00000167244.21			40765	-1.773	-0.2380	No
173	AMMECR1	ENSG00000101935.10			40781	-1.779	-0.2308	No
174	BTC	ENSG00000174808.12			40898	-1.823	-0.2258	No
175	GADD45G	ENSG00000130222.11			40980	-1.854	-0.2199	No
176	CBR4	ENSG00000145439.12			41059	-1.892	-0.2137	No
177	GLRX	ENSG00000173221.14			41105	-1.909	-0.2067	No
178	PLAUR	ENSG00000011422.12			41170	-1.945	-0.1999	No
179	USP12	ENSG00000152484.14			41186	-1.952	-0.1920	No
180	ITGB2	ENSG00000160255.18			41252	-1.979	-0.1852	No
181	VWA5A	ENSG00000110002.16			41384	-2.054	-0.1795	No
182	INHBA	ENSG00000122641.11			41421	-2.082	-0.1716	No
183	TSPAN7	ENSG00000156298.12			41547	-2.161	-0.1654	No
184	PLAT	ENSG00000104368.18			41640	-2.216	-0.1581	No
185	KCNN4	ENSG00000104783.14			41760	-2.297	-0.1512	No
186	IL2RG	ENSG00000147168.12			41862	-2.374	-0.1435	No
187	FLT4	ENSG00000037280.16			41958	-2.460	-0.1353	No
188	CCND2	ENSG00000118971.8			41960	-2.462	-0.1249	No
189	G0S2	ENSG00000123689.6			41996	-2.485	-0.1152	No
190	C3AR1	ENSG00000171860.5			42263	-2.787	-0.1097	No
191	FCER1G	ENSG00000158869.11			42299	-2.847	-0.0984	No
192	PTPRR	ENSG00000153233.13			42612	-3.370	-0.0915	No
193	PLAU	ENSG00000122861.16			42698	-3.591	-0.0783	No
194	ANXA10	ENSG00000109511.12			42740	-3.706	-0.0635	No
195	F13A1	ENSG00000124491.15			42818	-3.981	-0.0485	No
196	HBEGF	ENSG00000113070.8			42836	-4.053	-0.0318	No
197	LIF	ENSG00000128342.5			42847	-4.098	-0.0147	No
198	TNNT2	ENSG00000118194.20			43098	-4.967	0.0005	No

Fig 2: HALLMARK_KRAS_SIGNALING_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_KRAS_SIGNALING_UP: Random ES distribution   
Gene set null distribution of ES for HALLMARK_KRAS_SIGNALING_UP