Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | -0.4166899 |
| Normalized Enrichment Score (NES) | -1.6773655 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0027543982 |
| FWER p-Value | 0.032 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | DHCR24 | ENSG00000116133.13 | 91 | 3.768 | 0.0139 | No | ||
| 2 | STC1 | ENSG00000159167.12 | 146 | 3.499 | 0.0275 | No | ||
| 3 | FADS2 | ENSG00000134824.14 | 326 | 2.899 | 0.0356 | No | ||
| 4 | ADD3 | ENSG00000148700.15 | 598 | 2.472 | 0.0398 | No | ||
| 5 | NUPR1 | ENSG00000176046.8 | 666 | 2.393 | 0.0484 | No | ||
| 6 | FADS1 | ENSG00000149485.19 | 718 | 2.353 | 0.0572 | No | ||
| 7 | IDH1 | ENSG00000138413.13 | 771 | 2.290 | 0.0657 | No | ||
| 8 | SQLE | ENSG00000104549.12 | 823 | 2.241 | 0.0740 | No | ||
| 9 | CYP51A1 | ENSG00000001630.17 | 829 | 2.232 | 0.0833 | No | ||
| 10 | LDLR | ENSG00000130164.13 | 900 | 2.174 | 0.0909 | No | ||
| 11 | CCNG1 | ENSG00000113328.19 | 949 | 2.133 | 0.0989 | No | ||
| 12 | INSIG1 | ENSG00000186480.13 | 1265 | 1.957 | 0.0998 | No | ||
| 13 | SCD | ENSG00000099194.6 | 1288 | 1.946 | 0.1076 | No | ||
| 14 | GCLC | ENSG00000001084.13 | 1297 | 1.942 | 0.1156 | No | ||
| 15 | HMGCR | ENSG00000113161.16 | 1456 | 1.862 | 0.1199 | No | ||
| 16 | SQSTM1 | ENSG00000161011.20 | 1557 | 1.815 | 0.1252 | No | ||
| 17 | CD9 | ENSG00000010278.14 | 1562 | 1.814 | 0.1328 | No | ||
| 18 | G6PD | ENSG00000160211.19 | 1825 | 1.702 | 0.1340 | No | ||
| 19 | SERP1 | ENSG00000120742.11 | 1898 | 1.669 | 0.1394 | No | ||
| 20 | FDXR | ENSG00000161513.12 | 1927 | 1.658 | 0.1458 | No | ||
| 21 | IGFBP5 | ENSG00000115461.5 | 1987 | 1.637 | 0.1513 | No | ||
| 22 | TFRC | ENSG00000072274.13 | 2501 | 1.475 | 0.1456 | No | ||
| 23 | ERO1A | ENSG00000197930.13 | 2702 | 1.409 | 0.1469 | No | ||
| 24 | HMGCS1 | ENSG00000112972.15 | 2715 | 1.404 | 0.1526 | No | ||
| 25 | NFIL3 | ENSG00000165030.4 | 2885 | 1.360 | 0.1545 | No | ||
| 26 | PSMG1 | ENSG00000183527.12 | 3125 | 1.305 | 0.1544 | No | ||
| 27 | STARD4 | ENSG00000164211.13 | 3550 | 1.216 | 0.1497 | No | ||
| 28 | DHCR7 | ENSG00000172893.15 | 3663 | 1.193 | 0.1522 | No | ||
| 29 | ELOVL5 | ENSG00000012660.14 | 3930 | 1.140 | 0.1508 | No | ||
| 30 | TMEM97 | ENSG00000109084.14 | 3999 | 1.128 | 0.1540 | No | ||
| 31 | ACACA | ENSG00000278540.5 | 4007 | 1.126 | 0.1586 | No | ||
| 32 | NAMPT | ENSG00000105835.12 | 4118 | 1.109 | 0.1608 | No | ||
| 33 | DDIT3 | ENSG00000175197.12 | 4354 | 1.068 | 0.1598 | No | ||
| 34 | GBE1 | ENSG00000114480.13 | 4933 | 0.978 | 0.1505 | No | ||
| 35 | GLA | ENSG00000102393.10 | 5414 | 0.912 | 0.1432 | No | ||
| 36 | EDEM1 | ENSG00000134109.11 | 5690 | 0.878 | 0.1405 | No | ||
| 37 | TM7SF2 | ENSG00000149809.15 | 6196 | 0.817 | 0.1322 | No | ||
| 38 | IFRD1 | ENSG00000006652.14 | 6482 | 0.790 | 0.1289 | No | ||
| 39 | SKAP2 | ENSG00000005020.13 | 6720 | 0.765 | 0.1266 | No | ||
| 40 | SRD5A1 | ENSG00000145545.12 | 7045 | 0.733 | 0.1222 | No | ||
| 41 | CTSC | ENSG00000109861.16 | 7476 | 0.693 | 0.1151 | No | ||
| 42 | GTF2H1 | ENSG00000110768.12 | 7513 | 0.689 | 0.1172 | No | ||
| 43 | SEC11A | ENSG00000140612.14 | 7669 | 0.674 | 0.1165 | No | ||
| 44 | SSR1 | ENSG00000124783.14 | 8536 | 0.603 | 0.0989 | No | ||
| 45 | TXNRD1 | ENSG00000198431.16 | 8574 | 0.601 | 0.1005 | No | ||
| 46 | SLC6A6 | ENSG00000131389.17 | 8830 | 0.581 | 0.0971 | No | ||
| 47 | UFM1 | ENSG00000120686.12 | 9387 | 0.545 | 0.0864 | No | ||
| 48 | EBP | ENSG00000147155.11 | 9521 | 0.536 | 0.0856 | No | ||
| 49 | GMPS | ENSG00000163655.16 | 10157 | 0.500 | 0.0729 | No | ||
| 50 | PIK3R3 | ENSG00000117461.15 | 11004 | 0.444 | 0.0551 | No | ||
| 51 | ADIPOR2 | ENSG00000006831.10 | 11292 | 0.427 | 0.0502 | No | ||
| 52 | TCEA1 | ENSG00000187735.14 | 13164 | 0.348 | 0.0081 | No | ||
| 53 | HSPD1 | ENSG00000144381.17 | 13323 | 0.338 | 0.0059 | No | ||
| 54 | PPIA | ENSG00000196262.14 | 13437 | 0.331 | 0.0046 | No | ||
| 55 | SLC7A11 | ENSG00000151012.13 | 14604 | 0.304 | -0.0212 | No | ||
| 56 | TBK1 | ENSG00000183735.10 | 14758 | 0.294 | -0.0236 | No | ||
| 57 | FGL2 | ENSG00000127951.7 | 14791 | 0.292 | -0.0231 | No | ||
| 58 | PPP1R15A | ENSG00000087074.8 | 14858 | 0.289 | -0.0234 | No | ||
| 59 | NMT1 | ENSG00000136448.12 | 16003 | 0.249 | -0.0490 | No | ||
| 60 | LTA4H | ENSG00000111144.10 | 17667 | 0.165 | -0.0870 | No | ||
| 61 | SLC2A3 | ENSG00000059804.16 | 17679 | 0.164 | -0.0866 | No | ||
| 62 | LGMN | ENSG00000100600.15 | 17960 | 0.148 | -0.0925 | No | ||
| 63 | QDPR | ENSG00000151552.12 | 18140 | 0.139 | -0.0961 | No | ||
| 64 | HSPE1 | ENSG00000115541.11 | 19716 | 0.059 | -0.1325 | No | ||
| 65 | IDI1 | ENSG00000067064.11 | 20014 | 0.048 | -0.1392 | No | ||
| 66 | SLC37A4 | ENSG00000137700.18 | 20042 | 0.046 | -0.1397 | No | ||
| 67 | UNG | ENSG00000076248.10 | 20600 | 0.017 | -0.1526 | No | ||
| 68 | PPA1 | ENSG00000180817.12 | 20900 | 0.002 | -0.1595 | No | ||
| 69 | CFP | ENSG00000126759.13 | 21023 | -0.005 | -0.1623 | No | ||
| 70 | HK2 | ENSG00000159399.9 | 21120 | -0.012 | -0.1645 | No | ||
| 71 | PHGDH | ENSG00000092621.12 | 21545 | -0.034 | -0.1743 | No | ||
| 72 | SLC1A5 | ENSG00000105281.12 | 23007 | -0.112 | -0.2078 | No | ||
| 73 | TRIB3 | ENSG00000101255.11 | 23059 | -0.115 | -0.2085 | No | ||
| 74 | RPA1 | ENSG00000132383.12 | 23094 | -0.118 | -0.2088 | No | ||
| 75 | LDHA | ENSG00000134333.14 | 23158 | -0.122 | -0.2098 | No | ||
| 76 | RDH11 | ENSG00000072042.13 | 23910 | -0.166 | -0.2266 | No | ||
| 77 | RAB1A | ENSG00000138069.18 | 24156 | -0.180 | -0.2315 | No | ||
| 78 | DDX39A | ENSG00000123136.15 | 27337 | -0.297 | -0.3043 | No | ||
| 79 | YKT6 | ENSG00000106636.8 | 28177 | -0.321 | -0.3225 | No | ||
| 80 | POLR3G | ENSG00000113356.12 | 28531 | -0.338 | -0.3293 | No | ||
| 81 | SHMT2 | ENSG00000182199.11 | 28773 | -0.350 | -0.3334 | No | ||
| 82 | SERPINH1 | ENSG00000149257.14 | 29331 | -0.364 | -0.3449 | No | ||
| 83 | AURKA | ENSG00000087586.17 | 29575 | -0.379 | -0.3489 | No | ||
| 84 | IFI30 | ENSG00000216490.4 | 29746 | -0.390 | -0.3512 | No | ||
| 85 | HPRT1 | ENSG00000165704.15 | 29958 | -0.404 | -0.3544 | No | ||
| 86 | PSAT1 | ENSG00000135069.14 | 29985 | -0.406 | -0.3533 | No | ||
| 87 | ACLY | ENSG00000131473.17 | 30065 | -0.411 | -0.3534 | No | ||
| 88 | MAP2K3 | ENSG00000034152.19 | 30173 | -0.419 | -0.3541 | No | ||
| 89 | PITPNB | ENSG00000180957.18 | 30279 | -0.427 | -0.3548 | No | ||
| 90 | P4HA1 | ENSG00000122884.12 | 30621 | -0.444 | -0.3608 | No | ||
| 91 | PSME3 | ENSG00000131467.11 | 30737 | -0.449 | -0.3616 | No | ||
| 92 | CYB5B | ENSG00000103018.16 | 30781 | -0.453 | -0.3607 | No | ||
| 93 | FKBP2 | ENSG00000173486.13 | 30845 | -0.457 | -0.3602 | No | ||
| 94 | CTH | ENSG00000116761.12 | 31007 | -0.460 | -0.3620 | No | ||
| 95 | RRM2 | ENSG00000171848.15 | 31059 | -0.464 | -0.3612 | No | ||
| 96 | MTHFD2 | ENSG00000065911.12 | 31162 | -0.472 | -0.3616 | No | ||
| 97 | ASNS | ENSG00000070669.17 | 31521 | -0.490 | -0.3679 | No | ||
| 98 | PGM1 | ENSG00000079739.17 | 31611 | -0.495 | -0.3678 | No | ||
| 99 | PSMA3 | ENSG00000100567.13 | 31911 | -0.509 | -0.3726 | No | ||
| 100 | DHFR | ENSG00000228716.7 | 32019 | -0.515 | -0.3729 | No | ||
| 101 | XBP1 | ENSG00000100219.16 | 32221 | -0.529 | -0.3754 | No | ||
| 102 | NUP205 | ENSG00000155561.15 | 32543 | -0.546 | -0.3805 | No | ||
| 103 | PDK1 | ENSG00000152256.13 | 32654 | -0.556 | -0.3807 | No | ||
| 104 | PSMD13 | ENSG00000185627.18 | 33437 | -0.616 | -0.3963 | No | ||
| 105 | PSPH | ENSG00000146733.14 | 33526 | -0.623 | -0.3958 | No | ||
| 106 | EIF2S2 | ENSG00000125977.7 | 33567 | -0.626 | -0.3940 | No | ||
| 107 | CXCR4 | ENSG00000121966.6 | 34272 | -0.681 | -0.4075 | No | ||
| 108 | GPI | ENSG00000105220.17 | 34273 | -0.681 | -0.4047 | No | ||
| 109 | SC5D | ENSG00000109929.10 | 34365 | -0.689 | -0.4038 | No | ||
| 110 | PNP | ENSG00000198805.11 | 34508 | -0.703 | -0.4042 | No | ||
| 111 | AK4 | ENSG00000162433.15 | 35031 | -0.743 | -0.4132 | Yes | ||
| 112 | PLK1 | ENSG00000166851.15 | 35046 | -0.745 | -0.4103 | Yes | ||
| 113 | BUB1 | ENSG00000169679.15 | 35145 | -0.755 | -0.4094 | Yes | ||
| 114 | EPRS | ENSG00000136628.18 | 35243 | -0.763 | -0.4085 | Yes | ||
| 115 | ENO1 | ENSG00000074800.16 | 35286 | -0.766 | -0.4062 | Yes | ||
| 116 | GSK3B | ENSG00000082701.15 | 35603 | -0.798 | -0.4102 | Yes | ||
| 117 | USO1 | ENSG00000138768.14 | 35693 | -0.808 | -0.4088 | Yes | ||
| 118 | ARPC5L | ENSG00000136950.13 | 35702 | -0.809 | -0.4056 | Yes | ||
| 119 | MCM4 | ENSG00000104738.18 | 35969 | -0.840 | -0.4082 | Yes | ||
| 120 | CACYBP | ENSG00000116161.18 | 36335 | -0.882 | -0.4129 | Yes | ||
| 121 | DAPP1 | ENSG00000070190.13 | 36470 | -0.897 | -0.4123 | Yes | ||
| 122 | PSMC2 | ENSG00000161057.12 | 36487 | -0.899 | -0.4088 | Yes | ||
| 123 | COPS5 | ENSG00000121022.14 | 36709 | -0.931 | -0.4100 | Yes | ||
| 124 | PFKL | ENSG00000141959.17 | 36723 | -0.933 | -0.4064 | Yes | ||
| 125 | ACTR2 | ENSG00000138071.13 | 36811 | -0.942 | -0.4044 | Yes | ||
| 126 | MCM2 | ENSG00000073111.14 | 36965 | -0.962 | -0.4039 | Yes | ||
| 127 | TUBG1 | ENSG00000131462.8 | 36973 | -0.963 | -0.4000 | Yes | ||
| 128 | NFYC | ENSG00000066136.20 | 37025 | -0.969 | -0.3970 | Yes | ||
| 129 | BTG2 | ENSG00000159388.6 | 37157 | -0.987 | -0.3959 | Yes | ||
| 130 | WARS | ENSG00000140105.18 | 37336 | -1.011 | -0.3957 | Yes | ||
| 131 | TUBA4A | ENSG00000127824.14 | 37405 | -1.021 | -0.3930 | Yes | ||
| 132 | CDKN1A | ENSG00000124762.13 | 37465 | -1.029 | -0.3900 | Yes | ||
| 133 | EEF1E1 | ENSG00000124802.12 | 37626 | -1.054 | -0.3893 | Yes | ||
| 134 | UBE2D3 | ENSG00000109332.20 | 37718 | -1.070 | -0.3868 | Yes | ||
| 135 | RPN1 | ENSG00000163902.12 | 37998 | -1.117 | -0.3886 | Yes | ||
| 136 | M6PR | ENSG00000003056.8 | 38125 | -1.138 | -0.3867 | Yes | ||
| 137 | NUFIP1 | ENSG00000083635.8 | 38132 | -1.141 | -0.3820 | Yes | ||
| 138 | CCNF | ENSG00000162063.13 | 38199 | -1.153 | -0.3786 | Yes | ||
| 139 | PSMA4 | ENSG00000041357.16 | 38333 | -1.177 | -0.3768 | Yes | ||
| 140 | PDAP1 | ENSG00000106244.13 | 38373 | -1.183 | -0.3726 | Yes | ||
| 141 | ELOVL6 | ENSG00000170522.9 | 38394 | -1.186 | -0.3681 | Yes | ||
| 142 | HSPA9 | ENSG00000113013.15 | 38400 | -1.187 | -0.3631 | Yes | ||
| 143 | ACSL3 | ENSG00000123983.14 | 38432 | -1.195 | -0.3588 | Yes | ||
| 144 | PSMB5 | ENSG00000100804.19 | 38565 | -1.217 | -0.3567 | Yes | ||
| 145 | ALDOA | ENSG00000149925.20 | 38602 | -1.223 | -0.3524 | Yes | ||
| 146 | DDIT4 | ENSG00000168209.5 | 38633 | -1.230 | -0.3478 | Yes | ||
| 147 | CALR | ENSG00000179218.13 | 38727 | -1.249 | -0.3447 | Yes | ||
| 148 | SORD | ENSG00000140263.14 | 38729 | -1.249 | -0.3394 | Yes | ||
| 149 | HSP90B1 | ENSG00000166598.15 | 38735 | -1.251 | -0.3342 | Yes | ||
| 150 | CDC25A | ENSG00000164045.12 | 38736 | -1.251 | -0.3289 | Yes | ||
| 151 | ACTR3 | ENSG00000115091.12 | 38850 | -1.278 | -0.3261 | Yes | ||
| 152 | ETF1 | ENSG00000120705.13 | 39011 | -1.312 | -0.3243 | Yes | ||
| 153 | RIT1 | ENSG00000143622.11 | 39080 | -1.326 | -0.3203 | Yes | ||
| 154 | HMBS | ENSG00000256269.10 | 39152 | -1.342 | -0.3162 | Yes | ||
| 155 | HSPA4 | ENSG00000170606.15 | 39177 | -1.348 | -0.3110 | Yes | ||
| 156 | ME1 | ENSG00000065833.9 | 39319 | -1.382 | -0.3085 | Yes | ||
| 157 | GAPDH | ENSG00000111640.15 | 39341 | -1.385 | -0.3031 | Yes | ||
| 158 | SLC9A3R1 | ENSG00000109062.12 | 39524 | -1.426 | -0.3013 | Yes | ||
| 159 | RRP9 | ENSG00000114767.7 | 39550 | -1.431 | -0.2958 | Yes | ||
| 160 | GOT1 | ENSG00000120053.12 | 39598 | -1.441 | -0.2908 | Yes | ||
| 161 | TPI1 | ENSG00000111669.15 | 39620 | -1.447 | -0.2851 | Yes | ||
| 162 | IMMT | ENSG00000132305.20 | 39920 | -1.527 | -0.2856 | Yes | ||
| 163 | GSR | ENSG00000104687.14 | 39972 | -1.542 | -0.2802 | Yes | ||
| 164 | NFKBIB | ENSG00000104825.17 | 40150 | -1.587 | -0.2776 | Yes | ||
| 165 | PSMD12 | ENSG00000197170.10 | 40160 | -1.590 | -0.2711 | Yes | ||
| 166 | BHLHE40 | ENSG00000134107.5 | 40173 | -1.593 | -0.2646 | Yes | ||
| 167 | ATP5MC1 | ENSG00000159199.14 | 40212 | -1.603 | -0.2587 | Yes | ||
| 168 | ABCF2 | ENSG00000033050.9 | 40259 | -1.616 | -0.2529 | Yes | ||
| 169 | SLC1A4 | ENSG00000115902.11 | 40339 | -1.639 | -0.2478 | Yes | ||
| 170 | PSMC4 | ENSG00000013275.8 | 40405 | -1.659 | -0.2423 | Yes | ||
| 171 | TOMM40 | ENSG00000130204.13 | 40475 | -1.681 | -0.2367 | Yes | ||
| 172 | CANX | ENSG00000127022.15 | 40544 | -1.700 | -0.2311 | Yes | ||
| 173 | ATP6V1D | ENSG00000100554.12 | 40671 | -1.741 | -0.2267 | Yes | ||
| 174 | PSMD14 | ENSG00000115233.12 | 40751 | -1.767 | -0.2210 | Yes | ||
| 175 | PSMC6 | ENSG00000100519.12 | 40791 | -1.783 | -0.2143 | Yes | ||
| 176 | TES | ENSG00000135269.18 | 40832 | -1.795 | -0.2077 | Yes | ||
| 177 | GLRX | ENSG00000173221.14 | 41105 | -1.909 | -0.2059 | Yes | ||
| 178 | PGK1 | ENSG00000102144.15 | 41108 | -1.912 | -0.1978 | Yes | ||
| 179 | STIP1 | ENSG00000168439.16 | 41211 | -1.963 | -0.1919 | Yes | ||
| 180 | VLDLR | ENSG00000147852.16 | 41219 | -1.967 | -0.1837 | Yes | ||
| 181 | ITGB2 | ENSG00000160255.18 | 41252 | -1.979 | -0.1760 | Yes | ||
| 182 | UCHL5 | ENSG00000116750.13 | 41288 | -1.998 | -0.1684 | Yes | ||
| 183 | CCT6A | ENSG00000146731.11 | 41295 | -2.003 | -0.1600 | Yes | ||
| 184 | PNO1 | ENSG00000115946.8 | 41309 | -2.014 | -0.1518 | Yes | ||
| 185 | PRDX1 | ENSG00000117450.14 | 41463 | -2.108 | -0.1464 | Yes | ||
| 186 | GGA2 | ENSG00000103365.15 | 41653 | -2.222 | -0.1414 | Yes | ||
| 187 | HSPA5 | ENSG00000044574.8 | 41668 | -2.232 | -0.1322 | Yes | ||
| 188 | SLC2A1 | ENSG00000117394.23 | 41840 | -2.358 | -0.1262 | Yes | ||
| 189 | ATP2A2 | ENSG00000174437.17 | 42170 | -2.663 | -0.1225 | Yes | ||
| 190 | CORO1A | ENSG00000102879.15 | 42194 | -2.687 | -0.1117 | Yes | ||
| 191 | MTHFD2L | ENSG00000163738.18 | 42210 | -2.722 | -0.1005 | Yes | ||
| 192 | BCAT1 | ENSG00000060982.15 | 42267 | -2.792 | -0.0899 | Yes | ||
| 193 | SDF2L1 | ENSG00000128228.5 | 42369 | -2.940 | -0.0798 | Yes | ||
| 194 | PLOD2 | ENSG00000152952.12 | 42521 | -3.156 | -0.0699 | Yes | ||
| 195 | SLA | ENSG00000155926.14 | 42545 | -3.204 | -0.0569 | Yes | ||
| 196 | SLC7A5 | ENSG00000103257.9 | 42645 | -3.449 | -0.0446 | Yes | ||
| 197 | MLLT11 | ENSG00000213190.3 | 42859 | -4.148 | -0.0319 | Yes | ||
| 198 | SYTL2 | ENSG00000137501.17 | 42895 | -4.270 | -0.0146 | Yes | ||
| 199 | EGLN3 | ENSG00000129521.14 | 42986 | -4.666 | 0.0031 | Yes |
