Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | HALLMARK_MYOGENESIS |
| Enrichment Score (ES) | -0.75920826 |
| Normalized Enrichment Score (NES) | -3.05664 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | COL6A3 | ENSG00000163359.15 | 371 | 2.812 | -0.0025 | No | ||
| 2 | SOD3 | ENSG00000109610.6 | 527 | 2.571 | -0.0005 | No | ||
| 3 | AEBP1 | ENSG00000106624.11 | 659 | 2.404 | 0.0018 | No | ||
| 4 | COL6A2 | ENSG00000142173.15 | 816 | 2.246 | 0.0031 | No | ||
| 5 | SORBS3 | ENSG00000120896.13 | 884 | 2.183 | 0.0063 | No | ||
| 6 | LPIN1 | ENSG00000134324.11 | 901 | 2.168 | 0.0107 | No | ||
| 7 | PRNP | ENSG00000171867.17 | 1012 | 2.101 | 0.0127 | No | ||
| 8 | SCD | ENSG00000099194.6 | 1288 | 1.946 | 0.0106 | No | ||
| 9 | EFS | ENSG00000100842.13 | 1632 | 1.789 | 0.0065 | No | ||
| 10 | GAA | ENSG00000171298.13 | 1658 | 1.772 | 0.0098 | No | ||
| 11 | CRAT | ENSG00000095321.17 | 1730 | 1.743 | 0.0120 | No | ||
| 12 | IGFBP3 | ENSG00000146674.15 | 1828 | 1.702 | 0.0134 | No | ||
| 13 | CFD | ENSG00000197766.8 | 1895 | 1.671 | 0.0156 | No | ||
| 14 | APOD | ENSG00000189058.9 | 1901 | 1.668 | 0.0191 | No | ||
| 15 | PTGIS | ENSG00000124212.6 | 2119 | 1.592 | 0.0175 | No | ||
| 16 | CD36 | ENSG00000135218.19 | 2200 | 1.566 | 0.0191 | No | ||
| 17 | CLU | ENSG00000120885.22 | 2415 | 1.500 | 0.0174 | No | ||
| 18 | BDKRB2 | ENSG00000168398.6 | 2584 | 1.447 | 0.0167 | No | ||
| 19 | DAPK2 | ENSG00000035664.11 | 2675 | 1.416 | 0.0177 | No | ||
| 20 | OCEL1 | ENSG00000099330.9 | 2846 | 1.367 | 0.0167 | No | ||
| 21 | FST | ENSG00000134363.12 | 3045 | 1.322 | 0.0150 | No | ||
| 22 | MYL7 | ENSG00000106631.8 | 3191 | 1.291 | 0.0144 | No | ||
| 23 | FDPS | ENSG00000160752.14 | 3502 | 1.225 | 0.0099 | No | ||
| 24 | ITGB5 | ENSG00000082781.12 | 4315 | 1.074 | -0.0067 | No | ||
| 25 | HDAC5 | ENSG00000108840.15 | 4413 | 1.060 | -0.0066 | No | ||
| 26 | FGF2 | ENSG00000138685.15 | 4734 | 1.009 | -0.0118 | No | ||
| 27 | AKT2 | ENSG00000105221.18 | 4775 | 1.001 | -0.0106 | No | ||
| 28 | IFRD1 | ENSG00000006652.14 | 6482 | 0.790 | -0.0486 | No | ||
| 29 | COL3A1 | ENSG00000168542.14 | 7229 | 0.715 | -0.0644 | No | ||
| 30 | GPX3 | ENSG00000211445.12 | 7962 | 0.650 | -0.0800 | No | ||
| 31 | NQO1 | ENSG00000181019.13 | 8253 | 0.622 | -0.0854 | No | ||
| 32 | SPHK1 | ENSG00000176170.13 | 8512 | 0.605 | -0.0901 | No | ||
| 33 | CTF1 | ENSG00000150281.6 | 10097 | 0.504 | -0.1259 | No | ||
| 34 | VIPR1 | ENSG00000114812.13 | 10122 | 0.502 | -0.1254 | No | ||
| 35 | MAPK12 | ENSG00000188130.14 | 12424 | 0.368 | -0.1782 | No | ||
| 36 | APP | ENSG00000142192.21 | 14143 | 0.308 | -0.2175 | No | ||
| 37 | GNAO1 | ENSG00000087258.15 | 14836 | 0.289 | -0.2330 | No | ||
| 38 | ITGB4 | ENSG00000132470.14 | 16947 | 0.199 | -0.2817 | No | ||
| 39 | COL15A1 | ENSG00000204291.11 | 18002 | 0.146 | -0.3060 | No | ||
| 40 | PPP1R3C | ENSG00000119938.9 | 18717 | 0.111 | -0.3224 | No | ||
| 41 | MYLK | ENSG00000065534.18 | 19434 | 0.074 | -0.3389 | No | ||
| 42 | MYH11 | ENSG00000133392.18 | 20718 | 0.012 | -0.3687 | No | ||
| 43 | APLNR | ENSG00000134817.10 | 21199 | -0.016 | -0.3799 | No | ||
| 44 | BAG1 | ENSG00000107262.23 | 21672 | -0.041 | -0.3908 | No | ||
| 45 | TSC2 | ENSG00000103197.18 | 22130 | -0.064 | -0.4013 | No | ||
| 46 | FKBP1B | ENSG00000119782.14 | 22563 | -0.088 | -0.4112 | No | ||
| 47 | LAMA2 | ENSG00000196569.12 | 22603 | -0.091 | -0.4119 | No | ||
| 48 | ADCY9 | ENSG00000162104.10 | 22643 | -0.093 | -0.4126 | No | ||
| 49 | PSEN2 | ENSG00000143801.17 | 23491 | -0.140 | -0.4320 | No | ||
| 50 | STC2 | ENSG00000113739.10 | 24147 | -0.179 | -0.4469 | No | ||
| 51 | PLXNB2 | ENSG00000196576.15 | 24250 | -0.185 | -0.4489 | No | ||
| 52 | COX7A1 | ENSG00000161281.11 | 25467 | -0.225 | -0.4767 | No | ||
| 53 | EPHB3 | ENSG00000182580.3 | 25781 | -0.245 | -0.4835 | No | ||
| 54 | AGRN | ENSG00000188157.15 | 25926 | -0.255 | -0.4862 | No | ||
| 55 | NOTCH1 | ENSG00000148400.12 | 27170 | -0.285 | -0.5146 | No | ||
| 56 | PICK1 | ENSG00000100151.16 | 29519 | -0.375 | -0.5685 | No | ||
| 57 | IGF1 | ENSG00000017427.16 | 30420 | -0.433 | -0.5885 | No | ||
| 58 | COL1A1 | ENSG00000108821.13 | 32343 | -0.536 | -0.6321 | No | ||
| 59 | PFKM | ENSG00000152556.17 | 32577 | -0.549 | -0.6363 | No | ||
| 60 | GSN | ENSG00000148180.19 | 32592 | -0.551 | -0.6354 | No | ||
| 61 | ATP6AP1 | ENSG00000071553.17 | 32612 | -0.553 | -0.6347 | No | ||
| 62 | SH2B1 | ENSG00000178188.14 | 32818 | -0.570 | -0.6382 | No | ||
| 63 | ADAM12 | ENSG00000148848.14 | 32976 | -0.582 | -0.6406 | No | ||
| 64 | SPDEF | ENSG00000124664.11 | 33896 | -0.654 | -0.6605 | No | ||
| 65 | GABARAPL2 | ENSG00000034713.8 | 34575 | -0.708 | -0.6748 | No | ||
| 66 | ST5 | ENSG00000166444.19 | 34996 | -0.741 | -0.6830 | No | ||
| 67 | EIF4A2 | ENSG00000156976.17 | 35058 | -0.747 | -0.6827 | No | ||
| 68 | NOS1 | ENSG00000089250.19 | 35284 | -0.766 | -0.6863 | No | ||
| 69 | NAV2 | ENSG00000166833.21 | 35863 | -0.826 | -0.6980 | No | ||
| 70 | ITGB1 | ENSG00000150093.19 | 36454 | -0.895 | -0.7097 | No | ||
| 71 | SPARC | ENSG00000113140.11 | 37052 | -0.974 | -0.7215 | No | ||
| 72 | FLII | ENSG00000177731.16 | 37140 | -0.985 | -0.7214 | No | ||
| 73 | MYO1C | ENSG00000197879.17 | 37451 | -1.026 | -0.7264 | No | ||
| 74 | CDKN1A | ENSG00000124762.13 | 37465 | -1.029 | -0.7244 | No | ||
| 75 | SPEG | ENSG00000072195.15 | 38065 | -1.128 | -0.7359 | No | ||
| 76 | TGFB1 | ENSG00000105329.10 | 38478 | -1.201 | -0.7428 | No | ||
| 77 | SLC6A8 | ENSG00000130821.16 | 38709 | -1.245 | -0.7455 | No | ||
| 78 | FOXO4 | ENSG00000184481.17 | 38977 | -1.304 | -0.7488 | No | ||
| 79 | RIT1 | ENSG00000143622.11 | 39080 | -1.326 | -0.7483 | No | ||
| 80 | ACTN3 | ENSG00000248746.6 | 39105 | -1.332 | -0.7459 | No | ||
| 81 | COL4A2 | ENSG00000134871.19 | 39460 | -1.413 | -0.7511 | No | ||
| 82 | MYL3 | ENSG00000160808.10 | 39809 | -1.495 | -0.7559 | Yes | ||
| 83 | ACHE | ENSG00000087085.15 | 39892 | -1.520 | -0.7545 | Yes | ||
| 84 | MYL1 | ENSG00000168530.16 | 39896 | -1.521 | -0.7512 | Yes | ||
| 85 | IGFBP7 | ENSG00000163453.11 | 39937 | -1.531 | -0.7488 | Yes | ||
| 86 | PTP4A3 | ENSG00000184489.11 | 39941 | -1.533 | -0.7455 | Yes | ||
| 87 | FABP3 | ENSG00000121769.8 | 40068 | -1.563 | -0.7450 | Yes | ||
| 88 | SPTAN1 | ENSG00000197694.16 | 40071 | -1.565 | -0.7417 | Yes | ||
| 89 | ANKRD2 | ENSG00000165887.11 | 40101 | -1.571 | -0.7389 | Yes | ||
| 90 | CAMK2B | ENSG00000058404.20 | 40117 | -1.578 | -0.7358 | Yes | ||
| 91 | FXYD1 | ENSG00000266964.5 | 40154 | -1.588 | -0.7331 | Yes | ||
| 92 | BHLHE40 | ENSG00000134107.5 | 40173 | -1.593 | -0.7301 | Yes | ||
| 93 | PVALB | ENSG00000100362.13 | 40268 | -1.617 | -0.7287 | Yes | ||
| 94 | SYNGR2 | ENSG00000108639.7 | 40316 | -1.632 | -0.7262 | Yes | ||
| 95 | ACSL1 | ENSG00000151726.14 | 40389 | -1.654 | -0.7243 | Yes | ||
| 96 | CACNA1H | ENSG00000196557.13 | 40414 | -1.660 | -0.7212 | Yes | ||
| 97 | PDE4DIP | ENSG00000178104.19 | 40589 | -1.714 | -0.7215 | Yes | ||
| 98 | WWTR1 | ENSG00000018408.14 | 40806 | -1.787 | -0.7226 | Yes | ||
| 99 | DTNA | ENSG00000134769.21 | 40940 | -1.838 | -0.7217 | Yes | ||
| 100 | TNNI2 | ENSG00000130598.16 | 40957 | -1.846 | -0.7180 | Yes | ||
| 101 | LARGE1 | ENSG00000133424.20 | 40958 | -1.846 | -0.7140 | Yes | ||
| 102 | GADD45B | ENSG00000099860.9 | 40977 | -1.852 | -0.7103 | Yes | ||
| 103 | CNN3 | ENSG00000117519.16 | 41024 | -1.876 | -0.7073 | Yes | ||
| 104 | SGCD | ENSG00000170624.13 | 41042 | -1.886 | -0.7035 | Yes | ||
| 105 | TPD52L1 | ENSG00000111907.21 | 41057 | -1.891 | -0.6997 | Yes | ||
| 106 | CKB | ENSG00000166165.13 | 41077 | -1.898 | -0.6960 | Yes | ||
| 107 | CDH13 | ENSG00000140945.17 | 41157 | -1.936 | -0.6936 | Yes | ||
| 108 | AGL | ENSG00000162688.17 | 41336 | -2.026 | -0.6933 | Yes | ||
| 109 | MYOM2 | ENSG00000036448.10 | 41422 | -2.083 | -0.6907 | Yes | ||
| 110 | PC | ENSG00000173599.15 | 41477 | -2.119 | -0.6873 | Yes | ||
| 111 | TPM3 | ENSG00000143549.21 | 41507 | -2.135 | -0.6833 | Yes | ||
| 112 | SVIL | ENSG00000197321.14 | 41525 | -2.146 | -0.6790 | Yes | ||
| 113 | MYH9 | ENSG00000100345.21 | 41599 | -2.193 | -0.6759 | Yes | ||
| 114 | MEF2D | ENSG00000116604.18 | 41682 | -2.239 | -0.6729 | Yes | ||
| 115 | RB1 | ENSG00000139687.15 | 41706 | -2.257 | -0.6685 | Yes | ||
| 116 | MYH2 | ENSG00000125414.19 | 41719 | -2.268 | -0.6638 | Yes | ||
| 117 | ATP2A1 | ENSG00000196296.13 | 41742 | -2.285 | -0.6593 | Yes | ||
| 118 | KIFC3 | ENSG00000140859.16 | 41907 | -2.412 | -0.6579 | Yes | ||
| 119 | PDLIM7 | ENSG00000196923.14 | 41948 | -2.453 | -0.6534 | Yes | ||
| 120 | TAGLN | ENSG00000149591.17 | 41950 | -2.456 | -0.6480 | Yes | ||
| 121 | MYH3 | ENSG00000109063.15 | 41957 | -2.460 | -0.6428 | Yes | ||
| 122 | KCNH2 | ENSG00000055118.15 | 41985 | -2.477 | -0.6380 | Yes | ||
| 123 | GJA5 | ENSG00000265107.3 | 42000 | -2.491 | -0.6329 | Yes | ||
| 124 | FHL1 | ENSG00000022267.19 | 42064 | -2.539 | -0.6288 | Yes | ||
| 125 | CASQ1 | ENSG00000143318.13 | 42074 | -2.550 | -0.6234 | Yes | ||
| 126 | SMTN | ENSG00000183963.18 | 42080 | -2.556 | -0.6179 | Yes | ||
| 127 | SCHIP1 | ENSG00000151967.18 | 42173 | -2.665 | -0.6142 | Yes | ||
| 128 | MEF2A | ENSG00000068305.17 | 42179 | -2.672 | -0.6085 | Yes | ||
| 129 | CKMT2 | ENSG00000131730.16 | 42214 | -2.727 | -0.6033 | Yes | ||
| 130 | SGCG | ENSG00000102683.7 | 42272 | -2.813 | -0.5984 | Yes | ||
| 131 | MYH4 | ENSG00000264424.1 | 42308 | -2.855 | -0.5930 | Yes | ||
| 132 | SIRT2 | ENSG00000068903.20 | 42338 | -2.901 | -0.5873 | Yes | ||
| 133 | AK1 | ENSG00000106992.19 | 42370 | -2.941 | -0.5816 | Yes | ||
| 134 | SSPN | ENSG00000123096.11 | 42412 | -2.994 | -0.5760 | Yes | ||
| 135 | HRC | ENSG00000130528.12 | 42419 | -3.013 | -0.5695 | Yes | ||
| 136 | TNNC2 | ENSG00000101470.10 | 42424 | -3.025 | -0.5630 | Yes | ||
| 137 | PKIA | ENSG00000171033.13 | 42432 | -3.033 | -0.5565 | Yes | ||
| 138 | ABLIM1 | ENSG00000099204.20 | 42494 | -3.116 | -0.5511 | Yes | ||
| 139 | CKM | ENSG00000104879.5 | 42498 | -3.122 | -0.5443 | Yes | ||
| 140 | MYH8 | ENSG00000133020.4 | 42537 | -3.185 | -0.5382 | Yes | ||
| 141 | HSPB2 | ENSG00000170276.6 | 42564 | -3.233 | -0.5317 | Yes | ||
| 142 | MYBPH | ENSG00000133055.9 | 42568 | -3.239 | -0.5247 | Yes | ||
| 143 | MYOZ1 | ENSG00000177791.12 | 42579 | -3.271 | -0.5178 | Yes | ||
| 144 | MYH1 | ENSG00000109061.10 | 42581 | -3.278 | -0.5106 | Yes | ||
| 145 | MB | ENSG00000198125.13 | 42593 | -3.322 | -0.5036 | Yes | ||
| 146 | CRYAB | ENSG00000109846.9 | 42605 | -3.348 | -0.4965 | Yes | ||
| 147 | SGCA | ENSG00000108823.16 | 42629 | -3.407 | -0.4896 | Yes | ||
| 148 | MYH7 | ENSG00000092054.13 | 42632 | -3.422 | -0.4821 | Yes | ||
| 149 | MYOM1 | ENSG00000101605.12 | 42653 | -3.464 | -0.4750 | Yes | ||
| 150 | BIN1 | ENSG00000136717.15 | 42680 | -3.529 | -0.4678 | Yes | ||
| 151 | ACTA1 | ENSG00000143632.14 | 42721 | -3.653 | -0.4608 | Yes | ||
| 152 | MAPRE3 | ENSG00000084764.12 | 42786 | -3.853 | -0.4538 | Yes | ||
| 153 | DMPK | ENSG00000104936.17 | 42797 | -3.886 | -0.4455 | Yes | ||
| 154 | TNNT3 | ENSG00000130595.19 | 42808 | -3.940 | -0.4371 | Yes | ||
| 155 | HSPB8 | ENSG00000152137.6 | 42810 | -3.949 | -0.4285 | Yes | ||
| 156 | CASQ2 | ENSG00000118729.11 | 42823 | -4.006 | -0.4200 | Yes | ||
| 157 | CHRNB1 | ENSG00000170175.11 | 42828 | -4.014 | -0.4113 | Yes | ||
| 158 | HBEGF | ENSG00000113070.8 | 42836 | -4.053 | -0.4026 | Yes | ||
| 159 | SLN | ENSG00000170290.4 | 42839 | -4.058 | -0.3937 | Yes | ||
| 160 | CSRP3 | ENSG00000129170.10 | 42851 | -4.110 | -0.3850 | Yes | ||
| 161 | TPM2 | ENSG00000198467.15 | 42854 | -4.136 | -0.3759 | Yes | ||
| 162 | LDB3 | ENSG00000122367.19 | 42857 | -4.146 | -0.3669 | Yes | ||
| 163 | SH3BGR | ENSG00000185437.13 | 42858 | -4.146 | -0.3578 | Yes | ||
| 164 | KLF5 | ENSG00000102554.14 | 42887 | -4.240 | -0.3492 | Yes | ||
| 165 | MRAS | ENSG00000158186.13 | 42893 | -4.264 | -0.3399 | Yes | ||
| 166 | PYGM | ENSG00000068976.14 | 42896 | -4.270 | -0.3306 | Yes | ||
| 167 | ITGA7 | ENSG00000135424.16 | 42920 | -4.354 | -0.3216 | Yes | ||
| 168 | ERBB3 | ENSG00000065361.15 | 42934 | -4.434 | -0.3122 | Yes | ||
| 169 | LSP1 | ENSG00000130592.15 | 42941 | -4.475 | -0.3025 | Yes | ||
| 170 | DMD | ENSG00000198947.15 | 42943 | -4.488 | -0.2927 | Yes | ||
| 171 | KCNH1 | ENSG00000143473.13 | 42946 | -4.500 | -0.2829 | Yes | ||
| 172 | ENO3 | ENSG00000108515.17 | 42958 | -4.537 | -0.2732 | Yes | ||
| 173 | PPFIA4 | ENSG00000143847.15 | 42964 | -4.552 | -0.2634 | Yes | ||
| 174 | ACTN2 | ENSG00000077522.13 | 42966 | -4.553 | -0.2534 | Yes | ||
| 175 | MYLPF | ENSG00000180209.12 | 42967 | -4.555 | -0.2434 | Yes | ||
| 176 | MYL6B | ENSG00000196465.10 | 42969 | -4.580 | -0.2334 | Yes | ||
| 177 | TEAD4 | ENSG00000197905.9 | 42981 | -4.634 | -0.2235 | Yes | ||
| 178 | NCAM1 | ENSG00000149294.16 | 43007 | -4.750 | -0.2137 | Yes | ||
| 179 | CAV3 | ENSG00000182533.6 | 43009 | -4.750 | -0.2033 | Yes | ||
| 180 | MYL2 | ENSG00000111245.15 | 43025 | -4.822 | -0.1931 | Yes | ||
| 181 | TCAP | ENSG00000173991.5 | 43026 | -4.827 | -0.1825 | Yes | ||
| 182 | REEP1 | ENSG00000068615.18 | 43050 | -4.889 | -0.1723 | Yes | ||
| 183 | MEF2C | ENSG00000081189.15 | 43051 | -4.889 | -0.1616 | Yes | ||
| 184 | SORBS1 | ENSG00000095637.22 | 43061 | -4.908 | -0.1510 | Yes | ||
| 185 | CHRNA1 | ENSG00000138435.16 | 43066 | -4.916 | -0.1403 | Yes | ||
| 186 | MYL4 | ENSG00000198336.9 | 43070 | -4.932 | -0.1296 | Yes | ||
| 187 | COX6A2 | ENSG00000156885.6 | 43073 | -4.938 | -0.1188 | Yes | ||
| 188 | RYR1 | ENSG00000196218.12 | 43074 | -4.942 | -0.1080 | Yes | ||
| 189 | CACNG1 | ENSG00000108878.5 | 43077 | -4.944 | -0.0972 | Yes | ||
| 190 | CHRNG | ENSG00000196811.13 | 43082 | -4.950 | -0.0864 | Yes | ||
| 191 | DES | ENSG00000175084.12 | 43086 | -4.954 | -0.0757 | Yes | ||
| 192 | TNNT1 | ENSG00000105048.17 | 43087 | -4.955 | -0.0648 | Yes | ||
| 193 | TNNT2 | ENSG00000118194.20 | 43098 | -4.967 | -0.0541 | Yes | ||
| 194 | TNNC1 | ENSG00000114854.8 | 43100 | -4.968 | -0.0433 | Yes | ||
| 195 | MYOG | ENSG00000122180.5 | 43106 | -4.972 | -0.0325 | Yes | ||
| 196 | ACTC1 | ENSG00000159251.8 | 43108 | -4.973 | -0.0216 | Yes | ||
| 197 | TNNI1 | ENSG00000159173.19 | 43109 | -4.974 | -0.0107 | Yes | ||
| 198 | MYF6 | ENSG00000111046.4 | 43117 | -4.979 | 0.0000 | Yes |
