Details for gene set HALLMARK_P53_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2M
GeneSet	HALLMARK_P53_PATHWAY
Enrichment Score (ES)	-0.29642415
Normalized Enrichment Score (NES)	-1.1995268
Nominal p-value	0.11227154
FDR q-value	0.19240734
FWER p-Value	0.994

Fig 1: Enrichment plot: HALLMARK_P53_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	TCN2	ENSG00000185339.9			137	3.537	0.0119	No
2	EPHX1	ENSG00000143819.12			223	3.237	0.0237	No
3	STOM	ENSG00000148175.13			238	3.179	0.0369	No
4	PERP	ENSG00000112378.12			350	2.857	0.0465	No
5	KLF4	ENSG00000136826.15			421	2.729	0.0565	No
6	MXD4	ENSG00000123933.17			489	2.618	0.0661	No
7	NUPR1	ENSG00000176046.8			666	2.393	0.0722	No
8	DDB2	ENSG00000134574.11			714	2.356	0.0812	No
9	CTSF	ENSG00000174080.11			899	2.175	0.0862	No
10	FAS	ENSG00000026103.22			911	2.164	0.0951	No
11	PITPNC1	ENSG00000154217.15			938	2.137	0.1036	No
12	XPC	ENSG00000154767.14			941	2.136	0.1127	No
13	CCNG1	ENSG00000113328.19			949	2.133	0.1216	No
14	PROCR	ENSG00000101000.6			990	2.109	0.1297	No
15	RALGDS	ENSG00000160271.16			1077	2.063	0.1365	No
16	DRAM1	ENSG00000136048.14			1107	2.046	0.1445	No
17	PIDD1	ENSG00000177595.18			1116	2.042	0.1530	No
18	CD81	ENSG00000110651.11			1137	2.025	0.1612	No
19	UPP1	ENSG00000183696.14			1170	2.007	0.1690	No
20	HIST3H2A	ENSG00000181218.5			1182	1.999	0.1773	No
21	ISCU	ENSG00000136003.15			1254	1.961	0.1840	No
22	RXRA	ENSG00000186350.12			1332	1.918	0.1904	No
23	S100A4	ENSG00000196154.12			1525	1.834	0.1937	No
24	TAX1BP3	ENSG00000213977.8			1926	1.659	0.1915	No
25	FDXR	ENSG00000161513.12			1927	1.658	0.1985	No
26	S100A10	ENSG00000197747.9			2097	1.600	0.2014	No
27	GM2A	ENSG00000196743.9			2138	1.587	0.2072	No
28	NDRG1	ENSG00000104419.14			2162	1.579	0.2134	No
29	STEAP3	ENSG00000115107.20			2299	1.536	0.2168	No
30	FUCA1	ENSG00000179163.11			2594	1.443	0.2161	No
31	MXD1	ENSG00000059728.11			2648	1.427	0.2210	No
32	RAP2B	ENSG00000181467.5			2763	1.389	0.2242	No
33	CASP1	ENSG00000137752.24			2840	1.369	0.2283	No
34	TSPYL2	ENSG00000184205.14			2867	1.362	0.2335	No
35	CLCA2	ENSG00000137975.8			3108	1.309	0.2335	No
36	BMP2	ENSG00000125845.7			3203	1.288	0.2368	No
37	IER5	ENSG00000162783.11			3373	1.250	0.2382	No
38	ZBTB16	ENSG00000109906.14			3519	1.222	0.2400	No
39	BAX	ENSG00000087088.20			3520	1.222	0.2452	No
40	INHBB	ENSG00000163083.6			3525	1.221	0.2503	No
41	H2AFJ	ENSG00000246705.4			3572	1.212	0.2544	No
42	PMM1	ENSG00000100417.12			3784	1.168	0.2545	No
43	DDIT3	ENSG00000175197.12			4354	1.068	0.2458	No
44	OSGIN1	ENSG00000140961.14			4397	1.062	0.2493	No
45	TNFSF9	ENSG00000125657.5			4548	1.036	0.2503	No
46	RAD9A	ENSG00000172613.8			4962	0.974	0.2448	No
47	RAB40C	ENSG00000197562.10			5141	0.949	0.2447	No
48	ADA	ENSG00000196839.13			5246	0.934	0.2462	No
49	ABAT	ENSG00000183044.12			5596	0.888	0.2419	No
50	ABHD4	ENSG00000100439.10			5880	0.855	0.2389	No
51	MKNK2	ENSG00000099875.14			5890	0.854	0.2424	No
52	SOCS1	ENSG00000185338.5			5891	0.854	0.2460	No
53	RPS12	ENSG00000112306.8			6184	0.819	0.2427	No
54	CYFIP2	ENSG00000055163.20			6274	0.808	0.2441	No
55	ZFP36L1	ENSG00000185650.9			6301	0.807	0.2469	No
56	ST14	ENSG00000149418.11			6638	0.774	0.2424	No
57	TSC22D1	ENSG00000102804.15			6662	0.772	0.2451	No
58	IP6K2	ENSG00000068745.15			6674	0.770	0.2482	No
59	ERCC5	ENSG00000134899.21			6886	0.749	0.2464	No
60	DEF6	ENSG00000023892.11			6922	0.745	0.2488	No
61	EPS8L2	ENSG00000177106.16			7225	0.716	0.2448	No
62	F2R	ENSG00000181104.7			7392	0.701	0.2439	No
63	PPM1D	ENSG00000170836.11			7867	0.658	0.2357	No
64	RACK1	ENSG00000204628.12			8353	0.615	0.2270	No
65	ZMAT3	ENSG00000172667.11			8498	0.606	0.2262	No
66	SPHK1	ENSG00000176170.13			8512	0.605	0.2285	No
67	SESN1	ENSG00000080546.13			8841	0.580	0.2234	No
68	PCNA	ENSG00000132646.11			8869	0.578	0.2252	No
69	HDAC3	ENSG00000171720.10			9283	0.550	0.2179	No
70	HMOX1	ENSG00000100292.17			9579	0.532	0.2133	No
71	HSPA4L	ENSG00000164070.12			9659	0.525	0.2137	No
72	SP1	ENSG00000185591.10			9660	0.525	0.2159	No
73	FOS	ENSG00000170345.10			9664	0.525	0.2181	No
74	IL1A	ENSG00000115008.5			10008	0.511	0.2123	No
75	SEC61A1	ENSG00000058262.10			10170	0.499	0.2107	No
76	ANKRA2	ENSG00000164331.10			10417	0.484	0.2070	No
77	ACVR1B	ENSG00000135503.13			10636	0.469	0.2039	No
78	CDKN2AIP	ENSG00000168564.6			10642	0.469	0.2058	No
79	CGRRF1	ENSG00000100532.12			10804	0.459	0.2040	No
80	TP53	ENSG00000141510.17			10940	0.449	0.2028	No
81	RETSAT	ENSG00000042445.14			11072	0.439	0.2016	No
82	BAIAP2	ENSG00000175866.15			11334	0.425	0.1973	No
83	MDM2	ENSG00000135679.25			11340	0.425	0.1990	No
84	GLS2	ENSG00000135423.13			11435	0.418	0.1986	No
85	EI24	ENSG00000149547.15			11484	0.415	0.1993	No
86	RPL36	ENSG00000130255.13			11640	0.405	0.1974	No
87	PLK3	ENSG00000173846.13			12765	0.357	0.1727	No
88	SDC1	ENSG00000115884.11			13286	0.340	0.1620	No
89	TAP1	ENSG00000168394.11			14010	0.316	0.1465	No
90	BTG1	ENSG00000133639.5			14119	0.310	0.1453	No
91	APP	ENSG00000142192.21			14143	0.308	0.1461	No
92	SLC7A11	ENSG00000151012.13			14604	0.304	0.1367	No
93	PPP1R15A	ENSG00000087074.8			14858	0.289	0.1320	No
94	VDR	ENSG00000111424.11			15378	0.281	0.1211	No
95	SAT1	ENSG00000130066.16			15520	0.274	0.1190	No
96	TM4SF1	ENSG00000169908.12			15820	0.259	0.1132	No
97	SERTAD3	ENSG00000167565.13			15995	0.249	0.1102	No
98	PRKAB1	ENSG00000111725.11			16157	0.239	0.1074	No
99	RPS27L	ENSG00000185088.14			16368	0.226	0.1035	No
100	ITGB4	ENSG00000132470.14			16947	0.199	0.0909	No
101	TP63	ENSG00000073282.13			17214	0.187	0.0855	No
102	PVT1	ENSG00000249859.11			17359	0.180	0.0829	No
103	CTSD	ENSG00000117984.14			18089	0.141	0.0665	No
104	IRAK1	ENSG00000184216.14			18454	0.127	0.0586	No
105	FOXO3	ENSG00000118689.15			18792	0.107	0.0512	No
106	RPL18	ENSG00000063177.13			18965	0.100	0.0476	No
107	SLC35D1	ENSG00000116704.8			19060	0.097	0.0458	No
108	AEN	ENSG00000181026.15			19254	0.085	0.0417	No
109	WWP1	ENSG00000123124.14			19271	0.085	0.0417	No
110	DCXR	ENSG00000169738.8			19340	0.081	0.0405	No
111	DGKA	ENSG00000065357.20			19536	0.070	0.0362	No
112	SERPINB5	ENSG00000206075.14			20115	0.042	0.0229	No
113	PRMT2	ENSG00000160310.18			20180	0.039	0.0216	No
114	CDKN2A	ENSG00000147889.17			20700	0.012	0.0096	No
115	NINJ1	ENSG00000131669.10			21249	-0.019	-0.0031	No
116	CDKN2B	ENSG00000147883.12			21714	-0.043	-0.0138	No
117	CCNK	ENSG00000090061.17			21883	-0.050	-0.0175	No
118	TRIB3	ENSG00000101255.11			23059	-0.115	-0.0443	No
119	FAM162A	ENSG00000114023.15			23550	-0.144	-0.0551	No
120	SFN	ENSG00000175793.12			23845	-0.161	-0.0613	No
121	PLXNB2	ENSG00000196576.15			24250	-0.185	-0.0699	No
122	CEBPA	ENSG00000245848.3			24410	-0.194	-0.0728	No
123	TM7SF3	ENSG00000064115.11			25563	-0.231	-0.0987	No
124	ATF3	ENSG00000162772.17			25795	-0.246	-0.1030	No
125	CCND3	ENSG00000112576.12			26472	-0.264	-0.1176	No
126	MAPKAPK3	ENSG00000114738.11			26615	-0.275	-0.1198	No
127	NOTCH1	ENSG00000148400.12			27170	-0.285	-0.1314	No
128	FBXW7	ENSG00000109670.16			28573	-0.341	-0.1627	No
129	IFI30	ENSG00000216490.4			29746	-0.390	-0.1883	No
130	POLH	ENSG00000170734.11			29886	-0.397	-0.1898	No
131	WRAP73	ENSG00000116213.16			30221	-0.423	-0.1958	No
132	KRT17	ENSG00000128422.17			30229	-0.423	-0.1942	No
133	TGFA	ENSG00000163235.16			31003	-0.459	-0.2102	No
134	POM121	ENSG00000196313.11			31048	-0.463	-0.2093	No
135	FGF13	ENSG00000129682.16			31976	-0.511	-0.2287	No
136	GPX2	ENSG00000176153.12			32232	-0.530	-0.2324	No
137	NOL8	ENSG00000198000.12			32290	-0.533	-0.2314	No
138	COQ8A	ENSG00000163050.17			32883	-0.574	-0.2428	No
139	ABCC5	ENSG00000114770.17			33064	-0.588	-0.2445	No
140	IER3	ENSG00000137331.12			33260	-0.602	-0.2465	No
141	RRP8	ENSG00000132275.11			33682	-0.637	-0.2535	No
142	TRIAP1	ENSG00000170855.4			34255	-0.679	-0.2640	No
143	ZNF365	ENSG00000138311.17			34585	-0.709	-0.2686	No
144	PTPN14	ENSG00000152104.12			35000	-0.741	-0.2751	No
145	HEXIM1	ENSG00000186834.3			35633	-0.802	-0.2864	No
146	BAK1	ENSG00000030110.13			35677	-0.806	-0.2840	No
147	ELP1	ENSG00000070061.15			36021	-0.846	-0.2884	No
148	LDHB	ENSG00000111716.13			36169	-0.865	-0.2881	No
149	RGS16	ENSG00000143333.7			36334	-0.882	-0.2882	No
150	TXNIP	ENSG00000265972.6			36595	-0.913	-0.2903	No
151	TPRKB	ENSG00000144034.15			36819	-0.944	-0.2915	No
152	TCHH	ENSG00000159450.12			37011	-0.967	-0.2918	Yes
153	RHBDF2	ENSG00000129667.12			37066	-0.976	-0.2889	Yes
154	JUN	ENSG00000177606.7			37141	-0.985	-0.2865	Yes
155	BTG2	ENSG00000159388.6			37157	-0.987	-0.2826	Yes
156	TOB1	ENSG00000141232.5			37303	-1.007	-0.2817	Yes
157	CDKN1A	ENSG00000124762.13			37465	-1.029	-0.2810	Yes
158	HINT1	ENSG00000169567.12			38126	-1.139	-0.2916	Yes
159	NUDT15	ENSG00000136159.4			38149	-1.144	-0.2872	Yes
160	CCP110	ENSG00000103540.16			38174	-1.148	-0.2829	Yes
161	HRAS	ENSG00000174775.17			38198	-1.153	-0.2785	Yes
162	CSRNP2	ENSG00000110925.7			38375	-1.184	-0.2775	Yes
163	SLC3A2	ENSG00000168003.16			38429	-1.193	-0.2737	Yes
164	APAF1	ENSG00000120868.13			38448	-1.197	-0.2690	Yes
165	TGFB1	ENSG00000105329.10			38478	-1.201	-0.2646	Yes
166	DDIT4	ENSG00000168209.5			38633	-1.230	-0.2629	Yes
167	PHLDA3	ENSG00000174307.7			38764	-1.258	-0.2606	Yes
168	PTPRE	ENSG00000132334.16			39641	-1.452	-0.2748	Yes
169	LRMP	ENSG00000118308.15			39651	-1.454	-0.2688	Yes
170	ALOX15B	ENSG00000179593.16			39887	-1.519	-0.2678	Yes
171	NHLH2	ENSG00000177551.5			39931	-1.530	-0.2623	Yes
172	RCHY1	ENSG00000163743.13			40078	-1.566	-0.2590	Yes
173	DNTTIP2	ENSG00000067334.14			40148	-1.586	-0.2539	Yes
174	RAD51C	ENSG00000108384.15			40548	-1.701	-0.2559	Yes
175	TRAFD1	ENSG00000135148.12			41030	-1.879	-0.2591	Yes
176	TPD52L1	ENSG00000111907.21			41057	-1.891	-0.2516	Yes
177	RNF19B	ENSG00000116514.16			41114	-1.914	-0.2448	Yes
178	CDH13	ENSG00000140945.17			41157	-1.936	-0.2375	Yes
179	GADD45A	ENSG00000116717.13			41218	-1.966	-0.2305	Yes
180	SLC19A2	ENSG00000117479.15			41343	-2.029	-0.2248	Yes
181	VWA5A	ENSG00000110002.16			41384	-2.054	-0.2169	Yes
182	PLK2	ENSG00000145632.15			41483	-2.122	-0.2102	Yes
183	HIST1H1C	ENSG00000187837.3			41503	-2.131	-0.2015	Yes
184	RB1	ENSG00000139687.15			41706	-2.257	-0.1966	Yes
185	BLCAP	ENSG00000166619.15			41924	-2.426	-0.1913	Yes
186	CCND2	ENSG00000118971.8			41960	-2.462	-0.1817	Yes
187	TRAF4	ENSG00000076604.15			42035	-2.515	-0.1727	Yes
188	RRAD	ENSG00000166592.12			42226	-2.740	-0.1654	Yes
189	AK1	ENSG00000106992.19			42370	-2.941	-0.1562	Yes
190	KIF13B	ENSG00000197892.13			42477	-3.100	-0.1455	Yes
191	EPHA2	ENSG00000142627.13			42591	-3.321	-0.1339	Yes
192	CD82	ENSG00000085117.12			42768	-3.776	-0.1219	Yes
193	HBEGF	ENSG00000113070.8			42836	-4.053	-0.1062	Yes
194	LIF	ENSG00000128342.5			42847	-4.098	-0.0890	Yes
195	PDGFA	ENSG00000197461.13			42876	-4.206	-0.0717	Yes
196	JAG2	ENSG00000184916.9			42906	-4.304	-0.0540	Yes
197	VAMP8	ENSG00000118640.11			42924	-4.365	-0.0358	Yes
198	CDK5R1	ENSG00000176749.9			42942	-4.486	-0.0171	Yes
199	TNNI1	ENSG00000159173.19			43109	-4.974	0.0002	Yes

Fig 2: HALLMARK_P53_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_P53_PATHWAY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_P53_PATHWAY