Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Phenotype | Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M |
| Upregulated in class | FSHD2M |
| GeneSet | HALLMARK_PI3K_AKT_MTOR_SIGNALING |
| Enrichment Score (ES) | -0.3483678 |
| Normalized Enrichment Score (NES) | -1.3027841 |
| Nominal p-value | 0.066273935 |
| FDR q-value | 0.0930443 |
| FWER p-Value | 0.867 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PLCB1 | ENSG00000182621.18 | 147 | 3.498 | 0.0305 | No | ||
| 2 | CAB39L | ENSG00000102547.19 | 467 | 2.647 | 0.0487 | No | ||
| 3 | EGFR | ENSG00000146648.18 | 529 | 2.570 | 0.0721 | No | ||
| 4 | STAT2 | ENSG00000170581.14 | 1323 | 1.925 | 0.0723 | No | ||
| 5 | SQSTM1 | ENSG00000161011.20 | 1557 | 1.815 | 0.0845 | No | ||
| 6 | CAMK4 | ENSG00000152495.11 | 1728 | 1.744 | 0.0974 | No | ||
| 7 | GNA14 | ENSG00000156049.7 | 1907 | 1.665 | 0.1094 | No | ||
| 8 | MYD88 | ENSG00000172936.14 | 2301 | 1.535 | 0.1151 | No | ||
| 9 | NCK1 | ENSG00000158092.7 | 2423 | 1.498 | 0.1268 | No | ||
| 10 | VAV3 | ENSG00000134215.16 | 2801 | 1.377 | 0.1314 | No | ||
| 11 | RIPK1 | ENSG00000137275.14 | 2864 | 1.362 | 0.1432 | No | ||
| 12 | TNFRSF1A | ENSG00000067182.7 | 3407 | 1.243 | 0.1426 | No | ||
| 13 | MAP2K6 | ENSG00000108984.15 | 3826 | 1.160 | 0.1441 | No | ||
| 14 | ACACA | ENSG00000278540.5 | 4007 | 1.126 | 0.1508 | No | ||
| 15 | CDK4 | ENSG00000135446.17 | 4137 | 1.105 | 0.1585 | No | ||
| 16 | IRAK4 | ENSG00000198001.13 | 4188 | 1.096 | 0.1680 | No | ||
| 17 | DDIT3 | ENSG00000175197.12 | 4354 | 1.068 | 0.1745 | No | ||
| 18 | PIKFYVE | ENSG00000115020.17 | 4506 | 1.043 | 0.1811 | No | ||
| 19 | MKNK2 | ENSG00000099875.14 | 5890 | 0.854 | 0.1572 | No | ||
| 20 | CDKN1B | ENSG00000111276.11 | 6128 | 0.825 | 0.1597 | No | ||
| 21 | NGF | ENSG00000134259.3 | 6597 | 0.778 | 0.1563 | No | ||
| 22 | PRKAG1 | ENSG00000181929.13 | 6839 | 0.753 | 0.1580 | No | ||
| 23 | FGF17 | ENSG00000158815.11 | 7666 | 0.674 | 0.1454 | No | ||
| 24 | IL4 | ENSG00000113520.11 | 7818 | 0.662 | 0.1483 | No | ||
| 25 | AKT1S1 | ENSG00000204673.10 | 8702 | 0.591 | 0.1334 | No | ||
| 26 | RPS6KA3 | ENSG00000177189.14 | 8961 | 0.570 | 0.1330 | No | ||
| 27 | SMAD2 | ENSG00000175387.16 | 9648 | 0.526 | 0.1221 | No | ||
| 28 | ECSIT | ENSG00000130159.14 | 10673 | 0.467 | 0.1028 | No | ||
| 29 | PIK3R3 | ENSG00000117461.15 | 11004 | 0.444 | 0.0995 | No | ||
| 30 | RALB | ENSG00000144118.14 | 11252 | 0.430 | 0.0979 | No | ||
| 31 | MKNK1 | ENSG00000079277.21 | 11964 | 0.389 | 0.0851 | No | ||
| 32 | THEM4 | ENSG00000159445.13 | 12525 | 0.364 | 0.0756 | No | ||
| 33 | CLTC | ENSG00000141367.12 | 12768 | 0.357 | 0.0735 | No | ||
| 34 | TBK1 | ENSG00000183735.10 | 14758 | 0.294 | 0.0301 | No | ||
| 35 | LCK | ENSG00000182866.17 | 15496 | 0.275 | 0.0156 | No | ||
| 36 | ATF1 | ENSG00000123268.9 | 16147 | 0.240 | 0.0028 | No | ||
| 37 | RAC1 | ENSG00000136238.18 | 16886 | 0.203 | -0.0124 | No | ||
| 38 | YWHAB | ENSG00000166913.13 | 17880 | 0.152 | -0.0340 | No | ||
| 39 | NOD1 | ENSG00000106100.11 | 18220 | 0.134 | -0.0406 | No | ||
| 40 | FGF22 | ENSG00000070388.11 | 20221 | 0.037 | -0.0867 | No | ||
| 41 | TRAF2 | ENSG00000127191.18 | 21170 | -0.015 | -0.1086 | No | ||
| 42 | TSC2 | ENSG00000103197.18 | 22130 | -0.064 | -0.1303 | No | ||
| 43 | ARF1 | ENSG00000143761.16 | 22558 | -0.088 | -0.1393 | No | ||
| 44 | ARPC3 | ENSG00000111229.16 | 22592 | -0.090 | -0.1392 | No | ||
| 45 | PTEN | ENSG00000171862.11 | 22605 | -0.091 | -0.1386 | No | ||
| 46 | TRIB3 | ENSG00000101255.11 | 23059 | -0.115 | -0.1481 | No | ||
| 47 | MAPK10 | ENSG00000109339.23 | 23124 | -0.120 | -0.1484 | No | ||
| 48 | MAPK9 | ENSG00000050748.17 | 23302 | -0.130 | -0.1512 | No | ||
| 49 | SFN | ENSG00000175793.12 | 23845 | -0.161 | -0.1623 | No | ||
| 50 | CSNK2B | ENSG00000204435.13 | 24146 | -0.179 | -0.1675 | No | ||
| 51 | PRKCB | ENSG00000166501.14 | 25604 | -0.234 | -0.1991 | No | ||
| 52 | RPTOR | ENSG00000141564.15 | 25631 | -0.236 | -0.1975 | No | ||
| 53 | ARHGDIA | ENSG00000141522.12 | 26488 | -0.265 | -0.2148 | No | ||
| 54 | AP2M1 | ENSG00000161203.13 | 28129 | -0.319 | -0.2498 | No | ||
| 55 | FASLG | ENSG00000117560.8 | 28350 | -0.331 | -0.2517 | No | ||
| 56 | PLCG1 | ENSG00000124181.14 | 29500 | -0.374 | -0.2748 | No | ||
| 57 | MAP2K3 | ENSG00000034152.19 | 30173 | -0.419 | -0.2864 | No | ||
| 58 | CDK1 | ENSG00000170312.16 | 31062 | -0.464 | -0.3025 | No | ||
| 59 | PPP2R1B | ENSG00000137713.16 | 31743 | -0.499 | -0.3135 | No | ||
| 60 | GNGT1 | ENSG00000127928.13 | 32085 | -0.520 | -0.3164 | No | ||
| 61 | PAK4 | ENSG00000130669.17 | 32641 | -0.555 | -0.3239 | No | ||
| 62 | PDK1 | ENSG00000152256.13 | 32654 | -0.556 | -0.3188 | No | ||
| 63 | RAF1 | ENSG00000132155.11 | 32694 | -0.559 | -0.3143 | No | ||
| 64 | MAPKAP1 | ENSG00000119487.17 | 32978 | -0.582 | -0.3153 | No | ||
| 65 | RPS6KA1 | ENSG00000117676.14 | 33047 | -0.587 | -0.3112 | No | ||
| 66 | AKT1 | ENSG00000142208.16 | 33520 | -0.623 | -0.3161 | No | ||
| 67 | CXCR4 | ENSG00000121966.6 | 34272 | -0.681 | -0.3270 | No | ||
| 68 | EIF4E | ENSG00000151247.12 | 35069 | -0.748 | -0.3382 | No | ||
| 69 | E2F1 | ENSG00000101412.13 | 35122 | -0.753 | -0.3322 | No | ||
| 70 | MAPK1 | ENSG00000100030.14 | 35160 | -0.756 | -0.3257 | No | ||
| 71 | GSK3B | ENSG00000082701.15 | 35603 | -0.798 | -0.3282 | No | ||
| 72 | DAPP1 | ENSG00000070190.13 | 36470 | -0.897 | -0.3397 | Yes | ||
| 73 | ADCY2 | ENSG00000078295.17 | 36714 | -0.931 | -0.3363 | Yes | ||
| 74 | CAB39 | ENSG00000135932.11 | 36789 | -0.939 | -0.3289 | Yes | ||
| 75 | ACTR2 | ENSG00000138071.13 | 36811 | -0.942 | -0.3203 | Yes | ||
| 76 | CDK2 | ENSG00000123374.11 | 37047 | -0.974 | -0.3163 | Yes | ||
| 77 | FGF6 | ENSG00000111241.2 | 37174 | -0.989 | -0.3097 | Yes | ||
| 78 | CDKN1A | ENSG00000124762.13 | 37465 | -1.029 | -0.3065 | Yes | ||
| 79 | UBE2D3 | ENSG00000109332.20 | 37718 | -1.070 | -0.3020 | Yes | ||
| 80 | CFL1 | ENSG00000172757.13 | 37946 | -1.108 | -0.2965 | Yes | ||
| 81 | PTPN11 | ENSG00000179295.17 | 37966 | -1.112 | -0.2862 | Yes | ||
| 82 | PRKAR2A | ENSG00000114302.16 | 38008 | -1.118 | -0.2763 | Yes | ||
| 83 | HRAS | ENSG00000174775.17 | 38198 | -1.153 | -0.2695 | Yes | ||
| 84 | DUSP3 | ENSG00000108861.9 | 38272 | -1.167 | -0.2599 | Yes | ||
| 85 | UBE2N | ENSG00000177889.10 | 38590 | -1.222 | -0.2555 | Yes | ||
| 86 | CALR | ENSG00000179218.13 | 38727 | -1.249 | -0.2465 | Yes | ||
| 87 | HSP90B1 | ENSG00000166598.15 | 38735 | -1.251 | -0.2346 | Yes | ||
| 88 | ACTR3 | ENSG00000115091.12 | 38850 | -1.278 | -0.2249 | Yes | ||
| 89 | PLA2G12A | ENSG00000123739.11 | 38857 | -1.280 | -0.2126 | Yes | ||
| 90 | RIT1 | ENSG00000143622.11 | 39080 | -1.326 | -0.2049 | Yes | ||
| 91 | PPP1CA | ENSG00000172531.15 | 39292 | -1.374 | -0.1965 | Yes | ||
| 92 | GRB2 | ENSG00000177885.15 | 39308 | -1.380 | -0.1835 | Yes | ||
| 93 | PIN1 | ENSG00000127445.13 | 39734 | -1.475 | -0.1791 | Yes | ||
| 94 | GRK2 | ENSG00000173020.11 | 39759 | -1.481 | -0.1653 | Yes | ||
| 95 | PFN1 | ENSG00000108518.7 | 40055 | -1.560 | -0.1571 | Yes | ||
| 96 | NFKBIB | ENSG00000104825.17 | 40150 | -1.587 | -0.1439 | Yes | ||
| 97 | MAP3K7 | ENSG00000135341.18 | 40323 | -1.633 | -0.1321 | Yes | ||
| 98 | MAPK8 | ENSG00000107643.16 | 40914 | -1.829 | -0.1281 | Yes | ||
| 99 | SLC2A1 | ENSG00000117394.23 | 41840 | -2.358 | -0.1268 | Yes | ||
| 100 | ITPR2 | ENSG00000123104.12 | 41853 | -2.368 | -0.1041 | Yes | ||
| 101 | IL2RG | ENSG00000147168.12 | 41862 | -2.374 | -0.0813 | Yes | ||
| 102 | PRKAA2 | ENSG00000162409.11 | 41921 | -2.424 | -0.0592 | Yes | ||
| 103 | TIAM1 | ENSG00000156299.13 | 42155 | -2.641 | -0.0390 | Yes | ||
| 104 | PITX2 | ENSG00000164093.17 | 42509 | -3.137 | -0.0169 | Yes | ||
| 105 | SLA | ENSG00000155926.14 | 42545 | -3.204 | 0.0133 | Yes |
