Details for gene set HALLMARK_SPERMATOGENESIS[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2M
GeneSet	HALLMARK_SPERMATOGENESIS
Enrichment Score (ES)	-0.3064051
Normalized Enrichment Score (NES)	-1.1618804
Nominal p-value	0.17191978
FDR q-value	0.22195023
FWER p-Value	0.999

Fig 1: Enrichment plot: HALLMARK_SPERMATOGENESIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SPATA6	ENSG00000132122.12			583	2.490	0.0101	No
2	LPIN1	ENSG00000134324.11			901	2.168	0.0234	No
3	ACE	ENSG00000159640.16			1197	1.991	0.0355	No
4	CAMK4	ENSG00000152495.11			1728	1.744	0.0398	No
5	MAP7	ENSG00000135525.18			1773	1.727	0.0552	No
6	CLGN	ENSG00000153132.13			1844	1.694	0.0697	No
7	IL13RA2	ENSG00000123496.8			1860	1.686	0.0854	No
8	TULP2	ENSG00000104804.8			1887	1.673	0.1007	No
9	PSMG1	ENSG00000183527.12			3125	1.305	0.0844	No
10	STRBP	ENSG00000165209.19			4099	1.111	0.0723	No
11	GAPDHS	ENSG00000105679.9			4145	1.104	0.0818	No
12	PACRG	ENSG00000112530.11			4163	1.102	0.0919	No
13	PCSK4	ENSG00000115257.15			4183	1.097	0.1019	No
14	CCT6B	ENSG00000132141.14			4283	1.079	0.1098	No
15	CLVS1	ENSG00000177182.11			4333	1.071	0.1189	No
16	DCC	ENSG00000187323.12			4719	1.011	0.1196	No
17	BRAF	ENSG00000157764.13			5044	0.962	0.1212	No
18	ALOX15	ENSG00000161905.12			5389	0.915	0.1219	No
19	SHE	ENSG00000169291.10			5541	0.895	0.1269	No
20	MLLT10	ENSG00000078403.17			5615	0.886	0.1336	No
21	RPL39L	ENSG00000163923.10			6548	0.784	0.1194	No
22	PHF7	ENSG00000010318.21			6755	0.762	0.1219	No
23	TEKT2	ENSG00000092850.12			8753	0.587	0.0810	No
24	NPHP1	ENSG00000144061.12			8835	0.581	0.0847	No
25	ODF1	ENSG00000155087.4			9282	0.550	0.0795	No
26	TCP11	ENSG00000124678.18			9486	0.539	0.0799	No
27	HSPA4L	ENSG00000164070.12			9659	0.525	0.0809	No
28	HTR5A	ENSG00000157219.5			9731	0.522	0.0843	No
29	THEG	ENSG00000105549.11			10113	0.502	0.0802	No
30	CFTR	ENSG00000001626.15			10205	0.497	0.0828	No
31	GSTM3	ENSG00000134202.11			10640	0.469	0.0772	No
32	IDE	ENSG00000119912.17			11123	0.437	0.0701	No
33	IP6K1	ENSG00000176095.12			11289	0.427	0.0703	No
34	MEP1B	ENSG00000141434.12			11877	0.394	0.0604	No
35	HOXB1	ENSG00000120094.9			12695	0.362	0.0449	No
36	ADAD1	ENSG00000164113.11			12956	0.355	0.0422	No
37	SIRT1	ENSG00000096717.12			13057	0.350	0.0432	No
38	TNP2	ENSG00000178279.4			13695	0.322	0.0315	No
39	HBZ	ENSG00000130656.6			13968	0.319	0.0282	No
40	HSPA2	ENSG00000126803.9			14084	0.312	0.0285	No
41	PAPOLB	ENSG00000218823.2			14752	0.294	0.0158	No
42	DBF4	ENSG00000006634.8			15252	0.287	0.0069	No
43	DPEP3	ENSG00000141096.6			15807	0.259	-0.0035	No
44	ZC2HC1C	ENSG00000119703.14			15808	0.259	-0.0010	No
45	PCSK1N	ENSG00000102109.9			15841	0.258	0.0007	No
46	ADCYAP1	ENSG00000141433.13			15875	0.255	0.0023	No
47	ACRBP	ENSG00000111644.8			16659	0.212	-0.0139	No
48	AKAP4	ENSG00000147081.15			16962	0.199	-0.0190	No
49	SYCP1	ENSG00000198765.12			16967	0.199	-0.0172	No
50	SCG5	ENSG00000166922.8			17518	0.171	-0.0284	No
51	TOPBP1	ENSG00000163781.14			17659	0.166	-0.0300	No
52	POMC	ENSG00000115138.11			18442	0.128	-0.0470	No
53	PDHA2	ENSG00000163114.6			18676	0.114	-0.0513	No
54	ZC3H14	ENSG00000100722.20			19383	0.078	-0.0670	No
55	CDKN3	ENSG00000100526.20			21058	-0.007	-0.1059	No
56	LDHC	ENSG00000166796.12			21646	-0.039	-0.1192	No
57	PEBP1	ENSG00000089220.5			21858	-0.049	-0.1236	No
58	PGK2	ENSG00000170950.6			23644	-0.148	-0.1637	No
59	DDX4	ENSG00000152670.19			23851	-0.162	-0.1670	No
60	PHKG2	ENSG00000156873.16			24134	-0.178	-0.1718	No
61	SCG3	ENSG00000104112.9			24442	-0.195	-0.1771	No
62	GAD1	ENSG00000128683.14			24512	-0.200	-0.1768	No
63	TUBA3C	ENSG00000198033.12			25534	-0.229	-0.1984	No
64	STAM2	ENSG00000115145.10			26463	-0.263	-0.2175	No
65	HIST1H1T	ENSG00000187475.5			26503	-0.266	-0.2158	No
66	NPY5R	ENSG00000164129.12			27858	-0.302	-0.2444	No
67	OAZ3	ENSG00000143450.16			27980	-0.307	-0.2443	No
68	CNIH2	ENSG00000174871.11			28031	-0.312	-0.2425	No
69	GMCL1	ENSG00000087338.5			28068	-0.315	-0.2404	No
70	COIL	ENSG00000121058.5			28412	-0.331	-0.2452	No
71	TALDO1	ENSG00000177156.11			29360	-0.367	-0.2637	No
72	AURKA	ENSG00000087586.17			29575	-0.379	-0.2651	No
73	NAA11	ENSG00000156269.5			29622	-0.383	-0.2625	No
74	HSPA1L	ENSG00000204390.10			29684	-0.386	-0.2603	No
75	ACTL7B	ENSG00000148156.8			29728	-0.389	-0.2576	No
76	PIAS2	ENSG00000078043.16			29960	-0.404	-0.2591	No
77	CCNB2	ENSG00000157456.8			30092	-0.412	-0.2582	No
78	TSN	ENSG00000211460.12			30658	-0.447	-0.2671	No
79	RAD17	ENSG00000152942.19			30897	-0.457	-0.2683	No
80	NEK2	ENSG00000117650.13			30994	-0.459	-0.2662	No
81	CDK1	ENSG00000170312.16			31062	-0.464	-0.2633	No
82	ACRV1	ENSG00000134940.14			31378	-0.484	-0.2660	No
83	TKTL1	ENSG00000007350.17			31396	-0.485	-0.2618	No
84	YBX2	ENSG00000006047.13			32122	-0.521	-0.2737	No
85	NCAPH	ENSG00000121152.10			32746	-0.564	-0.2828	No
86	KIF2C	ENSG00000142945.13			33404	-0.613	-0.2923	No
87	TTK	ENSG00000112742.10			33483	-0.619	-0.2882	No
88	CHFR	ENSG00000072609.17			33637	-0.633	-0.2857	No
89	DMRT1	ENSG00000137090.12			34473	-0.700	-0.2985	No
90	CCNA1	ENSG00000133101.10			34815	-0.726	-0.2995	Yes
91	IFT88	ENSG00000032742.17			34817	-0.726	-0.2926	Yes
92	BUB1	ENSG00000169679.15			35145	-0.755	-0.2930	Yes
93	NOS1	ENSG00000089250.19			35284	-0.766	-0.2889	Yes
94	ART3	ENSG00000156219.16			35609	-0.799	-0.2889	Yes
95	CHRM4	ENSG00000180720.7			36039	-0.848	-0.2908	Yes
96	PGS1	ENSG00000087157.19			36080	-0.853	-0.2836	Yes
97	GSG1	ENSG00000111305.19			36418	-0.891	-0.2830	Yes
98	SNAP91	ENSG00000065609.14			36474	-0.897	-0.2757	Yes
99	CSNK2A2	ENSG00000070770.9			37104	-0.980	-0.2810	Yes
100	MTNR1A	ENSG00000168412.6			37459	-1.028	-0.2794	Yes
101	RFC4	ENSG00000163918.10			37809	-1.085	-0.2772	Yes
102	MAST2	ENSG00000086015.21			37831	-1.088	-0.2674	Yes
103	PRKAR2A	ENSG00000114302.16			38008	-1.118	-0.2608	Yes
104	GPR182	ENSG00000166856.3			38071	-1.129	-0.2515	Yes
105	NF2	ENSG00000186575.18			38185	-1.151	-0.2432	Yes
106	GFI1	ENSG00000162676.12			39640	-1.451	-0.2632	Yes
107	CLPB	ENSG00000162129.14			39658	-1.456	-0.2497	Yes
108	PARP2	ENSG00000129484.13			39746	-1.477	-0.2377	Yes
109	VDAC3	ENSG00000078668.14			39954	-1.536	-0.2279	Yes
110	TLE4	ENSG00000106829.19			39959	-1.538	-0.2133	Yes
111	JAM3	ENSG00000166086.13			40198	-1.599	-0.2036	Yes
112	MLF1	ENSG00000178053.19			40218	-1.604	-0.1888	Yes
113	DDX25	ENSG00000109832.14			40262	-1.616	-0.1744	Yes
114	SLC2A5	ENSG00000142583.18			40648	-1.734	-0.1669	Yes
115	IL12RB2	ENSG00000081985.11			40696	-1.747	-0.1513	Yes
116	ELOVL3	ENSG00000119915.5			40747	-1.765	-0.1357	Yes
117	NEFH	ENSG00000100285.10			40864	-1.808	-0.1212	Yes
118	MTOR	ENSG00000198793.13			40903	-1.825	-0.1047	Yes
119	AGFG1	ENSG00000173744.17			40935	-1.836	-0.0879	Yes
120	TNNI3	ENSG00000129991.13			41255	-1.980	-0.0765	Yes
121	ARL4A	ENSG00000122644.13			41707	-2.259	-0.0655	Yes
122	SLC12A2	ENSG00000064651.14			41802	-2.330	-0.0455	Yes
123	EZH2	ENSG00000106462.10			41901	-2.405	-0.0249	Yes
124	GRM8	ENSG00000179603.17			42082	-2.558	-0.0047	Yes
125	DMC1	ENSG00000100206.10			42429	-3.029	0.0160	Yes

Fig 2: HALLMARK_SPERMATOGENESIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_SPERMATOGENESIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_SPERMATOGENESIS