Details for gene set HALLMARK_TNFA_SIGNALING_VIA_NFKB[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2M
GeneSet	HALLMARK_TNFA_SIGNALING_VIA_NFKB
Enrichment Score (ES)	-0.29043508
Normalized Enrichment Score (NES)	-1.1663333
Nominal p-value	0.14054054
FDR q-value	0.2237661
FWER p-Value	0.999

Fig 1: Enrichment plot: HALLMARK_TNFA_SIGNALING_VIA_NFKB   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	PLPP3	ENSG00000162407.9			18	4.425	0.0186	No
2	CD44	ENSG00000026508.18			157	3.446	0.0302	No
3	IL6ST	ENSG00000134352.20			282	3.044	0.0404	No
4	ZFP36	ENSG00000128016.7			348	2.862	0.0512	No
5	STAT5A	ENSG00000126561.16			383	2.783	0.0624	No
6	LITAF	ENSG00000189067.12			390	2.767	0.0742	No
7	KLF4	ENSG00000136826.15			421	2.729	0.0852	No
8	IFIT2	ENSG00000119922.10			471	2.644	0.0954	No
9	ETS2	ENSG00000157557.13			695	2.368	0.1004	No
10	IFNGR2	ENSG00000159128.14			882	2.184	0.1055	No
11	SDC4	ENSG00000124145.6			886	2.182	0.1148	No
12	LDLR	ENSG00000130164.13			900	2.174	0.1238	No
13	TNFAIP8	ENSG00000145779.8			915	2.162	0.1328	No
14	CEBPD	ENSG00000221869.5			972	2.120	0.1406	No
15	MAFF	ENSG00000185022.12			1086	2.057	0.1468	No
16	DRAM1	ENSG00000136048.14			1107	2.046	0.1552	No
17	EGR2	ENSG00000122877.16			1207	1.986	0.1614	No
18	CEBPB	ENSG00000172216.6			1238	1.972	0.1692	No
19	IL15RA	ENSG00000134470.21			1434	1.873	0.1727	No
20	EGR3	ENSG00000179388.9			1551	1.818	0.1778	No
21	SQSTM1	ENSG00000161011.20			1557	1.815	0.1855	No
22	PNRC1	ENSG00000146278.11			1595	1.801	0.1924	No
23	DUSP5	ENSG00000138166.6			1674	1.764	0.1982	No
24	GEM	ENSG00000164949.8			1767	1.729	0.2035	No
25	IFIH1	ENSG00000115267.8			1866	1.683	0.2084	No
26	NR4A3	ENSG00000119508.18			1867	1.681	0.2156	No
27	CSF1	ENSG00000184371.14			2219	1.559	0.2142	No
28	NFKBIE	ENSG00000146232.16			2442	1.492	0.2154	No
29	FUT4	ENSG00000196371.3			2452	1.489	0.2216	No
30	MXD1	ENSG00000059728.11			2648	1.427	0.2232	No
31	PTX3	ENSG00000163661.4			2789	1.381	0.2259	No
32	PTGS2	ENSG00000073756.12			2837	1.370	0.2307	No
33	NFIL3	ENSG00000165030.4			2885	1.360	0.2354	No
34	NFAT5	ENSG00000102908.22			3058	1.319	0.2371	No
35	BMP2	ENSG00000125845.7			3203	1.288	0.2393	No
36	KLF6	ENSG00000067082.15			3324	1.262	0.2419	No
37	IER5	ENSG00000162783.11			3373	1.250	0.2462	No
38	IRF1	ENSG00000125347.14			3458	1.235	0.2495	No
39	ABCA1	ENSG00000165029.16			3576	1.212	0.2520	No
40	FOSL1	ENSG00000175592.9			4023	1.122	0.2465	No
41	NAMPT	ENSG00000105835.12			4118	1.109	0.2490	No
42	ICAM1	ENSG00000090339.9			4204	1.093	0.2518	No
43	TNC	ENSG00000041982.16			4396	1.062	0.2519	No
44	SGK1	ENSG00000118515.11			4450	1.052	0.2552	No
45	MARCKS	ENSG00000277443.3			4535	1.038	0.2577	No
46	TNFSF9	ENSG00000125657.5			4548	1.036	0.2618	No
47	DDX58	ENSG00000107201.10			4602	1.028	0.2650	No
48	CCND1	ENSG00000110092.3			4717	1.011	0.2667	No
49	SERPINB2	ENSG00000197632.9			4983	0.970	0.2647	No
50	IRS2	ENSG00000185950.9			5127	0.950	0.2655	No
51	PDE4B	ENSG00000184588.18			5193	0.941	0.2680	No
52	TRIB1	ENSG00000173334.4			5448	0.906	0.2660	No
53	CXCL6	ENSG00000124875.10			5459	0.905	0.2696	No
54	NFKB1	ENSG00000109320.13			6111	0.828	0.2580	No
55	TRIP10	ENSG00000125733.18			6133	0.825	0.2611	No
56	NR4A2	ENSG00000153234.14			6161	0.821	0.2640	No
57	EGR1	ENSG00000120738.8			6348	0.802	0.2631	No
58	TSC22D1	ENSG00000102804.15			6662	0.772	0.2591	No
59	TRAF1	ENSG00000056558.11			6707	0.767	0.2614	No
60	IL18	ENSG00000150782.12			6797	0.757	0.2626	No
61	TNIP2	ENSG00000168884.15			6811	0.756	0.2655	No
62	SPSB1	ENSG00000171621.14			6947	0.743	0.2656	No
63	ACKR3	ENSG00000144476.6			6973	0.741	0.2682	No
64	SLC2A6	ENSG00000160326.14			6999	0.739	0.2708	No
65	OLR1	ENSG00000173391.9			7038	0.734	0.2731	No
66	GCH1	ENSG00000131979.19			7161	0.723	0.2733	No
67	KYNU	ENSG00000115919.15			7285	0.711	0.2735	No
68	PHLDA1	ENSG00000139289.13			7327	0.707	0.2756	No
69	PHLDA2	ENSG00000181649.8			7373	0.703	0.2776	No
70	CCL2	ENSG00000108691.9			7391	0.701	0.2802	No
71	NFE2L2	ENSG00000116044.16			7678	0.674	0.2764	No
72	PTGER4	ENSG00000171522.6			7713	0.671	0.2785	No
73	CCNL1	ENSG00000163660.11			7737	0.669	0.2809	No
74	RELB	ENSG00000104856.14			7830	0.661	0.2816	No
75	SPHK1	ENSG00000176170.13			8512	0.605	0.2683	No
76	CD83	ENSG00000112149.10			8612	0.598	0.2686	No
77	IL23A	ENSG00000110944.9			8635	0.596	0.2706	No
78	SERPINB8	ENSG00000166401.15			8682	0.592	0.2721	No
79	CCL5	ENSG00000271503.6			8798	0.583	0.2719	No
80	CCL4	ENSG00000275302.2			9015	0.568	0.2693	No
81	TLR2	ENSG00000137462.8			9313	0.549	0.2648	No
82	FOS	ENSG00000170345.10			9664	0.525	0.2589	No
83	IL1A	ENSG00000115008.5			10008	0.511	0.2531	No
84	CFLAR	ENSG00000003402.20			10310	0.491	0.2482	No
85	NFKBIA	ENSG00000100906.10			10473	0.480	0.2465	No
86	PFKFB3	ENSG00000170525.21			10834	0.456	0.2401	No
87	F3	ENSG00000117525.14			11227	0.431	0.2328	No
88	SLC16A6	ENSG00000108932.12			11350	0.424	0.2318	No
89	TANK	ENSG00000136560.14			11874	0.395	0.2213	No
90	BIRC3	ENSG00000023445.14			12432	0.366	0.2099	No
91	TAP1	ENSG00000168394.11			14010	0.316	0.1745	No
92	BTG1	ENSG00000133639.5			14119	0.310	0.1733	No
93	PPP1R15A	ENSG00000087074.8			14858	0.289	0.1574	No
94	SAT1	ENSG00000130066.16			15520	0.274	0.1431	No
95	TGIF1	ENSG00000177426.20			16517	0.219	0.1209	No
96	CXCL1	ENSG00000163739.5			17045	0.196	0.1094	No
97	PLEK	ENSG00000115956.10			17299	0.183	0.1043	No
98	IL1B	ENSG00000125538.12			17487	0.172	0.1007	No
99	SLC2A3	ENSG00000059804.16			17679	0.164	0.0970	No
100	ZC3H12A	ENSG00000163874.11			17978	0.147	0.0907	No
101	CXCL11	ENSG00000169248.13			18808	0.107	0.0718	No
102	RELA	ENSG00000173039.19			18880	0.104	0.0706	No
103	CLCF1	ENSG00000175505.11			19316	0.082	0.0608	No
104	ID2	ENSG00000115738.10			19442	0.074	0.0582	No
105	SMAD3	ENSG00000166949.16			20527	0.020	0.0331	No
106	KDM6B	ENSG00000132510.10			21098	-0.010	0.0198	No
107	NINJ1	ENSG00000131669.10			21249	-0.019	0.0164	No
108	DENND5A	ENSG00000184014.8			21947	-0.054	0.0004	No
109	IL12B	ENSG00000113302.4			22283	-0.073	-0.0071	No
110	CCN1	ENSG00000142871.17			22390	-0.079	-0.0092	No
111	EIF1	ENSG00000173812.11			23077	-0.117	-0.0247	No
112	IL7R	ENSG00000168685.15			23218	-0.125	-0.0274	No
113	MCL1	ENSG00000143384.13			23256	-0.127	-0.0277	No
114	IER2	ENSG00000160888.7			23278	-0.128	-0.0277	No
115	ZBTB10	ENSG00000205189.12			23649	-0.149	-0.0357	No
116	CXCL2	ENSG00000081041.9			23850	-0.161	-0.0396	No
117	MAP3K8	ENSG00000107968.10			23988	-0.170	-0.0421	No
118	TIPARP	ENSG00000163659.13			24403	-0.193	-0.0509	No
119	RIPK2	ENSG00000104312.8			24469	-0.197	-0.0516	No
120	SOD2	ENSG00000112096.18			24563	-0.202	-0.0529	No
121	GFPT2	ENSG00000131459.13			25476	-0.226	-0.0731	No
122	ATF3	ENSG00000162772.17			25795	-0.246	-0.0795	No
123	FOSB	ENSG00000125740.14			25850	-0.250	-0.0797	No
124	CD69	ENSG00000110848.8			26251	-0.263	-0.0879	No
125	REL	ENSG00000162924.14			26525	-0.268	-0.0931	No
126	F2RL1	ENSG00000164251.5			28125	-0.319	-0.1290	No
127	BCL2A1	ENSG00000140379.8			29080	-0.352	-0.1497	No
128	BIRC2	ENSG00000110330.8			29123	-0.355	-0.1491	No
129	AREG	ENSG00000109321.11			29159	-0.357	-0.1484	No
130	CXCL10	ENSG00000169245.6			29765	-0.392	-0.1608	No
131	MAP2K3	ENSG00000034152.19			30173	-0.419	-0.1685	No
132	KLF9	ENSG00000119138.4			31322	-0.480	-0.1932	No
133	NFKB2	ENSG00000077150.20			32229	-0.529	-0.2120	No
134	CXCL3	ENSG00000163734.4			32436	-0.541	-0.2145	No
135	IER3	ENSG00000137331.12			33260	-0.602	-0.2311	No
136	BCL3	ENSG00000069399.15			33424	-0.615	-0.2322	No
137	SIK1	ENSG00000142178.9			33525	-0.623	-0.2319	No
138	SOCS3	ENSG00000184557.4			34239	-0.677	-0.2456	No
139	NR4A1	ENSG00000123358.20			34316	-0.685	-0.2444	No
140	JUNB	ENSG00000171223.6			34828	-0.728	-0.2532	No
141	MYC	ENSG00000136997.19			35251	-0.763	-0.2597	No
142	DUSP2	ENSG00000158050.5			35482	-0.785	-0.2617	No
143	JAG1	ENSG00000101384.12			35655	-0.804	-0.2622	No
144	BTG3	ENSG00000154640.14			36393	-0.887	-0.2756	No
145	PANX1	ENSG00000110218.9			37031	-0.971	-0.2863	Yes
146	JUN	ENSG00000177606.7			37141	-0.985	-0.2846	Yes
147	BTG2	ENSG00000159388.6			37157	-0.987	-0.2807	Yes
148	IL6	ENSG00000136244.12			37366	-1.015	-0.2811	Yes
149	TNFAIP6	ENSG00000123610.5			37407	-1.021	-0.2777	Yes
150	CDKN1A	ENSG00000124762.13			37465	-1.029	-0.2746	Yes
151	TNF	ENSG00000232810.4			37586	-1.048	-0.2729	Yes
152	YRDC	ENSG00000196449.4			37665	-1.061	-0.2701	Yes
153	CCL20	ENSG00000115009.13			37860	-1.093	-0.2700	Yes
154	EHD1	ENSG00000110047.18			37992	-1.116	-0.2682	Yes
155	BCL6	ENSG00000113916.18			38004	-1.118	-0.2637	Yes
156	ICOSLG	ENSG00000160223.17			38080	-1.131	-0.2605	Yes
157	DUSP4	ENSG00000120875.9			38141	-1.142	-0.2570	Yes
158	SERPINE1	ENSG00000106366.8			38403	-1.189	-0.2580	Yes
159	TUBB2A	ENSG00000137267.6			38477	-1.201	-0.2545	Yes
160	RHOB	ENSG00000143878.10			38518	-1.210	-0.2503	Yes
161	KLF10	ENSG00000155090.15			38597	-1.222	-0.2468	Yes
162	B4GALT5	ENSG00000158470.5			38852	-1.279	-0.2472	Yes
163	HES1	ENSG00000114315.4			39235	-1.362	-0.2503	Yes
164	CD80	ENSG00000121594.12			39254	-1.364	-0.2448	Yes
165	TNFAIP3	ENSG00000118503.15			39359	-1.390	-0.2413	Yes
166	PTPRE	ENSG00000132334.16			39641	-1.452	-0.2416	Yes
167	B4GALT1	ENSG00000086062.12			39786	-1.489	-0.2385	Yes
168	EDN1	ENSG00000078401.7			39917	-1.527	-0.2350	Yes
169	FJX1	ENSG00000179431.7			39971	-1.541	-0.2296	Yes
170	DUSP1	ENSG00000120129.6			40039	-1.558	-0.2245	Yes
171	FOSL2	ENSG00000075426.12			40066	-1.563	-0.2183	Yes
172	LAMB3	ENSG00000196878.15			40157	-1.589	-0.2136	Yes
173	SNN	ENSG00000184602.6			40170	-1.592	-0.2070	Yes
174	BHLHE40	ENSG00000134107.5			40173	-1.593	-0.2002	Yes
175	ATP2B1	ENSG00000070961.15			40174	-1.593	-0.1934	Yes
176	CSF2	ENSG00000164400.6			40320	-1.633	-0.1897	Yes
177	TNFAIP2	ENSG00000185215.9			40807	-1.787	-0.1934	Yes
178	VEGFA	ENSG00000112715.22			40824	-1.792	-0.1860	Yes
179	PMEPA1	ENSG00000124225.16			40906	-1.826	-0.1801	Yes
180	GADD45B	ENSG00000099860.9			40977	-1.852	-0.1737	Yes
181	GPR183	ENSG00000169508.7			41040	-1.884	-0.1671	Yes
182	RNF19B	ENSG00000116514.16			41114	-1.914	-0.1605	Yes
183	PLAUR	ENSG00000011422.12			41170	-1.945	-0.1535	Yes
184	GADD45A	ENSG00000116717.13			41218	-1.966	-0.1461	Yes
185	MSC	ENSG00000178860.8			41270	-1.987	-0.1387	Yes
186	CCRL2	ENSG00000121797.10			41412	-2.072	-0.1331	Yes
187	INHBA	ENSG00000122641.11			41421	-2.082	-0.1243	Yes
188	PLK2	ENSG00000145632.15			41483	-2.122	-0.1166	Yes
189	TNIP1	ENSG00000145901.15			41689	-2.242	-0.1118	Yes
190	TNFRSF9	ENSG00000049249.8			41845	-2.364	-0.1052	Yes
191	G0S2	ENSG00000123689.6			41996	-2.485	-0.0980	Yes
192	KLF2	ENSG00000127528.5			42396	-2.975	-0.0945	Yes
193	RCAN1	ENSG00000159200.18			42416	-3.008	-0.0820	Yes
194	DNAJB4	ENSG00000162616.9			42440	-3.045	-0.0695	Yes
195	PLAU	ENSG00000122861.16			42698	-3.591	-0.0600	Yes
196	PDLIM5	ENSG00000163110.15			42795	-3.879	-0.0456	Yes
197	HBEGF	ENSG00000113070.8			42836	-4.053	-0.0291	Yes
198	LIF	ENSG00000128342.5			42847	-4.098	-0.0117	Yes
199	EFNA1	ENSG00000169242.12			42868	-4.183	0.0058	Yes

Fig 2: HALLMARK_TNFA_SIGNALING_VIA_NFKB   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_TNFA_SIGNALING_VIA_NFKB: Random ES distribution   
Gene set null distribution of ES for HALLMARK_TNFA_SIGNALING_VIA_NFKB