Details for gene set HALLMARK_UV_RESPONSE_DN[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2
GeneSet	HALLMARK_UV_RESPONSE_DN
Enrichment Score (ES)	0.42318705
Normalized Enrichment Score (NES)	1.8281183
Nominal p-value	0.0
FDR q-value	6.230769E-4
FWER p-Value	0.002

Fig 1: Enrichment plot: HALLMARK_UV_RESPONSE_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	FBLN5	ENSG00000140092.14			11	4.579	0.0247	Yes
2	PLPP3	ENSG00000162407.9			18	4.425	0.0486	Yes
3	PDGFRB	ENSG00000113721.14			106	3.655	0.0665	Yes
4	PRKCE	ENSG00000171132.14			128	3.568	0.0854	Yes
5	LPAR1	ENSG00000198121.13			173	3.367	0.1027	Yes
6	AMPH	ENSG00000078053.17			178	3.355	0.1209	Yes
7	RND3	ENSG00000115963.13			242	3.154	0.1366	Yes
8	DBP	ENSG00000105516.11			266	3.086	0.1529	Yes
9	KIT	ENSG00000157404.15			270	3.076	0.1695	Yes
10	PMP22	ENSG00000109099.15			310	2.946	0.1847	Yes
11	GRK5	ENSG00000198873.12			321	2.912	0.2003	Yes
12	ADGRL2	ENSG00000117114.19			339	2.881	0.2156	Yes
13	TGFBR3	ENSG00000069702.11			474	2.641	0.2268	Yes
14	MAGI2	ENSG00000187391.21			570	2.509	0.2383	Yes
15	ADD3	ENSG00000148700.15			598	2.472	0.2511	Yes
16	ATP2B4	ENSG00000058668.14			627	2.432	0.2637	Yes
17	NR3C1	ENSG00000113580.15			693	2.369	0.2751	Yes
18	RBPMS	ENSG00000157110.16			766	2.294	0.2859	Yes
19	PTGFR	ENSG00000122420.10			801	2.260	0.2974	Yes
20	NR1D2	ENSG00000174738.13			848	2.218	0.3084	Yes
21	LDLR	ENSG00000130164.13			900	2.174	0.3190	Yes
22	CACNA1A	ENSG00000141837.20			1085	2.059	0.3260	Yes
23	NRP1	ENSG00000099250.18			1128	2.034	0.3361	Yes
24	ANXA4	ENSG00000196975.16			1230	1.975	0.3445	Yes
25	INSIG1	ENSG00000186480.13			1265	1.957	0.3543	Yes
26	RXRA	ENSG00000186350.12			1332	1.918	0.3632	Yes
27	RASA2	ENSG00000155903.12			1460	1.860	0.3704	Yes
28	PTPRM	ENSG00000173482.16			1747	1.738	0.3732	Yes
29	IGFBP5	ENSG00000115461.5			1987	1.637	0.3766	Yes
30	TFPI	ENSG00000003436.16			2020	1.622	0.3846	Yes
31	PRKAR2B	ENSG00000005249.13			2294	1.537	0.3867	Yes
32	GJA1	ENSG00000152661.9			2383	1.509	0.3928	Yes
33	DDAH1	ENSG00000153904.20			2653	1.424	0.3943	Yes
34	CAV1	ENSG00000105974.12			2696	1.410	0.4010	Yes
35	TGFBR2	ENSG00000163513.18			2797	1.379	0.4062	Yes
36	PPARG	ENSG00000132170.21			2883	1.360	0.4116	Yes
37	IGF1R	ENSG00000140443.15			3111	1.309	0.4135	Yes
38	LTBP1	ENSG00000049323.16			3213	1.284	0.4181	Yes
39	SLC22A18	ENSG00000110628.15			3336	1.257	0.4221	Yes
40	SYNJ2	ENSG00000078269.15			3818	1.161	0.4172	Yes
41	ZMIZ1	ENSG00000108175.17			3844	1.156	0.4229	Yes
42	DAB2	ENSG00000153071.15			4095	1.112	0.4232	Yes
43	SNAI2	ENSG00000019549.13			4808	0.996	0.4120	No
44	EFEMP1	ENSG00000115380.20			5601	0.888	0.3984	No
45	MGMT	ENSG00000170430.10			5829	0.861	0.3978	No
46	MMP16	ENSG00000156103.16			5924	0.851	0.4003	No
47	NFKB1	ENSG00000109320.13			6111	0.828	0.4005	No
48	CDKN1B	ENSG00000111276.11			6128	0.825	0.4046	No
49	AL162171.1	ENSG00000258789.1			6323	0.804	0.4045	No
50	COL1A2	ENSG00000164692.17			6324	0.804	0.4088	No
51	DLC1	ENSG00000164741.15			6359	0.801	0.4124	No
52	SRI	ENSG00000075142.13			6706	0.767	0.4085	No
53	CITED2	ENSG00000164442.10			6826	0.755	0.4099	No
54	ABCC1	ENSG00000103222.19			6987	0.740	0.4102	No
55	FZD2	ENSG00000180340.7			7116	0.726	0.4112	No
56	COL3A1	ENSG00000168542.14			7229	0.715	0.4124	No
57	PRKCA	ENSG00000154229.12			8575	0.601	0.3844	No
58	KCNMA1	ENSG00000156113.23			9150	0.560	0.3741	No
59	WDR37	ENSG00000047056.16			9166	0.558	0.3768	No
60	ATP2C1	ENSG00000017260.19			9381	0.545	0.3748	No
61	MAP2K5	ENSG00000137764.20			9457	0.542	0.3760	No
62	ANXA2	ENSG00000182718.16			9909	0.516	0.3683	No
63	MGLL	ENSG00000074416.14			10076	0.505	0.3672	No
64	SPOP	ENSG00000121067.19			10334	0.489	0.3639	No
65	GCNT1	ENSG00000187210.14			10361	0.487	0.3659	No
66	BMPR1A	ENSG00000107779.13			10847	0.455	0.3571	No
67	MAPK14	ENSG00000112062.10			10900	0.451	0.3584	No
68	PIK3R3	ENSG00000117461.15			11004	0.444	0.3584	No
69	F3	ENSG00000117525.14			11227	0.431	0.3556	No
70	PHF3	ENSG00000118482.11			11370	0.423	0.3546	No
71	ATRN	ENSG00000088812.18			11931	0.391	0.3437	No
72	CDK13	ENSG00000065883.16			13312	0.339	0.3134	No
73	BDNF	ENSG00000176697.19			13340	0.337	0.3146	No
74	TENT4A	ENSG00000112941.14			15724	0.264	0.2606	No
75	BCKDHB	ENSG00000083123.15			16615	0.213	0.2410	No
76	ADORA2B	ENSG00000170425.3			17637	0.167	0.2182	No
77	ICA1	ENSG00000003147.19			17661	0.166	0.2186	No
78	RGS4	ENSG00000117152.13			18763	0.109	0.1935	No
79	SCN8A	ENSG00000196876.17			19100	0.095	0.1862	No
80	SCAF8	ENSG00000213079.9			19111	0.094	0.1865	No
81	PRDM2	ENSG00000116731.22			19858	0.053	0.1694	No
82	DMAC2L	ENSG00000125375.15			19947	0.050	0.1677	No
83	SMAD3	ENSG00000166949.16			20527	0.020	0.1543	No
84	MT1E	ENSG00000169715.15			21218	-0.017	0.1383	No
85	PEX14	ENSG00000142655.13			21793	-0.047	0.1252	No
86	CCN1	ENSG00000142871.17			22390	-0.079	0.1118	No
87	LAMC1	ENSG00000135862.6			22432	-0.081	0.1113	No
88	PTEN	ENSG00000171862.11			22605	-0.091	0.1078	No
89	ACVR2A	ENSG00000121989.15			22689	-0.096	0.1064	No
90	FYN	ENSG00000010810.17			22887	-0.107	0.1024	No
91	FHL2	ENSG00000115641.19			23221	-0.125	0.0953	No
92	MTA1	ENSG00000182979.18			23313	-0.130	0.0939	No
93	MAP1B	ENSG00000131711.15			23686	-0.151	0.0860	No
94	PIAS3	ENSG00000131788.16			23847	-0.161	0.0832	No
95	NOTCH2	ENSG00000134250.20			23887	-0.164	0.0832	No
96	NIPBL	ENSG00000164190.19			25971	-0.258	0.0361	No
97	AGGF1	ENSG00000164252.13			26526	-0.268	0.0247	No
98	AKT3	ENSG00000117020.18			27205	-0.288	0.0105	No
99	CDC42BPA	ENSG00000143776.18			30007	-0.408	-0.0525	No
100	ATRX	ENSG00000085224.22			31252	-0.474	-0.0788	No
101	ITGB3	ENSG00000259207.7			31330	-0.481	-0.0780	No
102	TOGARAM1	ENSG00000198718.13			32006	-0.514	-0.0909	No
103	KALRN	ENSG00000160145.15			32042	-0.517	-0.0889	No
104	COL1A1	ENSG00000108821.13			32343	-0.536	-0.0930	No
105	SDC2	ENSG00000169439.12			32389	-0.538	-0.0911	No
106	CDON	ENSG00000064309.14			32722	-0.562	-0.0958	No
107	NFIB	ENSG00000147862.17			33084	-0.589	-0.1010	No
108	SMAD7	ENSG00000101665.9			33630	-0.632	-0.1102	No
109	NEK7	ENSG00000151414.15			33923	-0.656	-0.1134	No
110	MYC	ENSG00000136997.19			35251	-0.763	-0.1402	No
111	IRS1	ENSG00000169047.5			35781	-0.816	-0.1480	No
112	COL5A2	ENSG00000204262.14			36764	-0.936	-0.1658	No
113	CELF2	ENSG00000048740.18			37582	-1.047	-0.1791	No
114	VAV2	ENSG00000160293.17			37686	-1.065	-0.1757	No
115	YTHDC1	ENSG00000083896.12			37689	-1.065	-0.1699	No
116	DYRK1A	ENSG00000157540.21			37834	-1.089	-0.1674	No
117	TJP1	ENSG00000104067.16			37865	-1.093	-0.1621	No
118	SERPINE1	ENSG00000106366.8			38403	-1.189	-0.1681	No
119	ERBB2	ENSG00000141736.13			38420	-1.191	-0.1620	No
120	APBB2	ENSG00000163697.17			38687	-1.240	-0.1615	No
121	MET	ENSG00000105976.15			39028	-1.316	-0.1622	No
122	SYNE1	ENSG00000131018.24			39062	-1.323	-0.1558	No
123	ATXN1	ENSG00000124788.18			39238	-1.362	-0.1524	No
124	SIPA1L1	ENSG00000197555.9			39570	-1.435	-0.1523	No
125	DUSP1	ENSG00000120129.6			40039	-1.558	-0.1547	No
126	BHLHE40	ENSG00000134107.5			40173	-1.593	-0.1491	No
127	ATP2B1	ENSG00000070961.15			40174	-1.593	-0.1405	No
128	DLG1	ENSG00000075711.21			40257	-1.615	-0.1336	No
129	PIK3CD	ENSG00000171608.16			40260	-1.616	-0.1248	No
130	COL11A1	ENSG00000060718.22			40275	-1.618	-0.1164	No
131	MRPS31	ENSG00000102738.8			40457	-1.673	-0.1115	No
132	SLC7A1	ENSG00000139514.13			40707	-1.750	-0.1077	No
133	ID1	ENSG00000125968.9			40796	-1.785	-0.1001	No
134	RUNX1	ENSG00000159216.18			40891	-1.819	-0.0924	No
135	ARHGEF9	ENSG00000131089.16			41120	-1.918	-0.0872	No
136	PLCB4	ENSG00000101333.16			41175	-1.947	-0.0779	No
137	VLDLR	ENSG00000147852.16			41219	-1.967	-0.0682	No
138	SFMBT1	ENSG00000163935.14			41651	-2.222	-0.0661	No
139	INPP4B	ENSG00000109452.12			41836	-2.357	-0.0576	No
140	MIOS	ENSG00000164654.16			42040	-2.520	-0.0486	No
141	SCHIP1	ENSG00000151967.18			42173	-2.665	-0.0371	No
142	HAS2	ENSG00000170961.7			42403	-2.985	-0.0262	No
143	PDLIM5	ENSG00000163110.15			42795	-3.879	-0.0142	No
144	CAP2	ENSG00000112186.12			42820	-3.986	0.0070	No

Fig 2: HALLMARK_UV_RESPONSE_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_UV_RESPONSE_DN: Random ES distribution   
Gene set null distribution of ES for HALLMARK_UV_RESPONSE_DN