Details for gene set HALLMARK_XENOBIOTIC_METABOLISM[GSEA]

Table: GSEA Results Summary

Dataset	Normalized.Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Phenotype	Phenotype.FSHD2.FSHD2M.cls#FSHD2_versus_FSHD2M
Upregulated in class	FSHD2
GeneSet	HALLMARK_XENOBIOTIC_METABOLISM
Enrichment Score (ES)	0.32085335
Normalized Enrichment Score (NES)	1.4470309
Nominal p-value	0.0
FDR q-value	0.024542201
FWER p-Value	0.17

Fig 1: Enrichment plot: HALLMARK_XENOBIOTIC_METABOLISM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	DESCRIPTION (from dataset)	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	FBLN1	ENSG00000077942.19			63	3.993	0.0182	Yes
2	MAN1A1	ENSG00000111885.7			111	3.635	0.0350	Yes
3	IGFBP4	ENSG00000141753.7			151	3.478	0.0512	Yes
4	CFB	ENSG00000243649.8			196	3.306	0.0665	Yes
5	EPHX1	ENSG00000143819.12			223	3.237	0.0818	Yes
6	ACOX2	ENSG00000168306.13			370	2.812	0.0922	Yes
7	CYP27A1	ENSG00000135929.9			400	2.753	0.1051	Yes
8	CYP2E1	ENSG00000130649.10			447	2.683	0.1172	Yes
9	IL1R1	ENSG00000115594.12			542	2.559	0.1277	Yes
10	ETS2	ENSG00000157557.13			695	2.368	0.1358	Yes
11	ADH1C	ENSG00000248144.6			760	2.300	0.1456	Yes
12	IDH1	ENSG00000138413.13			771	2.290	0.1567	Yes
13	FAS	ENSG00000026103.22			911	2.164	0.1641	Yes
14	CBR1	ENSG00000159228.13			964	2.124	0.1733	Yes
15	PGRMC1	ENSG00000101856.10			966	2.124	0.1837	Yes
16	PROS1	ENSG00000184500.15			997	2.107	0.1934	Yes
17	UPP1	ENSG00000183696.14			1170	2.007	0.1993	Yes
18	LPIN2	ENSG00000101577.9			1243	1.970	0.2073	Yes
19	GCLC	ENSG00000001084.13			1297	1.942	0.2156	Yes
20	BLVRB	ENSG00000090013.11			1648	1.782	0.2163	Yes
21	PAPSS2	ENSG00000198682.13			1705	1.753	0.2236	Yes
22	FAH	ENSG00000103876.12			1782	1.725	0.2303	Yes
23	TDO2	ENSG00000151790.9			1817	1.707	0.2379	Yes
24	AOX1	ENSG00000138356.14			1818	1.707	0.2463	Yes
25	ADH5	ENSG00000197894.11			1943	1.653	0.2516	Yes
26	ARG2	ENSG00000081181.8			2017	1.623	0.2579	Yes
27	CD36	ENSG00000135218.19			2200	1.566	0.2613	Yes
28	GABARAPL1	ENSG00000139112.11			2353	1.520	0.2653	Yes
29	CDO1	ENSG00000129596.5			2454	1.488	0.2703	Yes
30	CYB5A	ENSG00000166347.19			2498	1.475	0.2765	Yes
31	GSTO1	ENSG00000148834.13			2646	1.427	0.2801	Yes
32	ESR1	ENSG00000091831.23			2697	1.410	0.2859	Yes
33	TPST1	ENSG00000169902.15			2718	1.403	0.2924	Yes
34	PSMB10	ENSG00000205220.12			3086	1.313	0.2903	Yes
35	AKR1C3	ENSG00000196139.14			3123	1.306	0.2959	Yes
36	TNFRSF1A	ENSG00000067182.7			3407	1.243	0.2954	Yes
37	PMM1	ENSG00000100417.12			3784	1.168	0.2924	Yes
38	ELOVL5	ENSG00000012660.14			3930	1.140	0.2946	Yes
39	UGDH	ENSG00000109814.12			3997	1.129	0.2986	Yes
40	TMEM97	ENSG00000109084.14			3999	1.128	0.3042	Yes
41	GSTM4	ENSG00000168765.17			4156	1.103	0.3060	Yes
42	TMEM176B	ENSG00000106565.18			4334	1.071	0.3071	Yes
43	AKR1C2	ENSG00000151632.17			4394	1.062	0.3110	Yes
44	PTGES	ENSG00000148344.11			4412	1.060	0.3158	Yes
45	ALDH3A1	ENSG00000108602.18			4556	1.035	0.3176	Yes
46	ABHD6	ENSG00000163686.15			4791	0.999	0.3170	Yes
47	F10	ENSG00000126218.12			4837	0.991	0.3209	Yes
48	GNMT	ENSG00000124713.6			5314	0.925	0.3143	No
49	AQP9	ENSG00000103569.10			5524	0.897	0.3139	No
50	HSD11B1	ENSG00000117594.10			5743	0.870	0.3131	No
51	SPINT2	ENSG00000167642.13			5942	0.848	0.3126	No
52	ALDH2	ENSG00000111275.13			6098	0.829	0.3131	No
53	CYFIP2	ENSG00000055163.20			6274	0.808	0.3130	No
54	FMO1	ENSG00000010932.17			6346	0.803	0.3153	No
55	CAT	ENSG00000121691.7			6441	0.793	0.3170	No
56	CDA	ENSG00000158825.6			6850	0.752	0.3112	No
57	GCH1	ENSG00000131979.19			7161	0.723	0.3076	No
58	KYNU	ENSG00000115919.15			7285	0.711	0.3082	No
59	VTN	ENSG00000109072.14			7359	0.704	0.3100	No
60	PPARD	ENSG00000112033.14			7445	0.695	0.3114	No
61	DHPS	ENSG00000095059.16			8069	0.641	0.3000	No
62	DHRS1	ENSG00000157379.14			8225	0.627	0.2995	No
63	NQO1	ENSG00000181019.13			8253	0.622	0.3019	No
64	CSAD	ENSG00000139631.18			8622	0.597	0.2963	No
65	ABCC2	ENSG00000023839.12			8657	0.594	0.2984	No
66	ASL	ENSG00000126522.17			8797	0.583	0.2981	No
67	SLC6A6	ENSG00000131389.17			8830	0.581	0.3002	No
68	CROT	ENSG00000005469.11			9050	0.567	0.2979	No
69	HMOX1	ENSG00000100292.17			9579	0.532	0.2882	No
70	CES1	ENSG00000198848.12			10401	0.485	0.2715	No
71	ITIH1	ENSG00000055957.11			10626	0.470	0.2686	No
72	ALDH9A1	ENSG00000143149.12			11047	0.441	0.2609	No
73	RETSAT	ENSG00000042445.14			11072	0.439	0.2625	No
74	ARG1	ENSG00000118520.15			11189	0.433	0.2620	No
75	HACL1	ENSG00000131373.15			11215	0.432	0.2635	No
76	PLG	ENSG00000122194.18			11880	0.394	0.2500	No
77	ACSM1	ENSG00000166743.9			12084	0.383	0.2471	No
78	PDK4	ENSG00000004799.8			12237	0.375	0.2455	No
79	CYP1A2	ENSG00000140505.7			12281	0.375	0.2463	No
80	XDH	ENSG00000158125.10			13151	0.349	0.2278	No
81	MBL2	ENSG00000165471.6			13582	0.322	0.2193	No
82	CRP	ENSG00000132693.12			14159	0.308	0.2074	No
83	CCL25	ENSG00000131142.13			14628	0.303	0.1980	No
84	DDC	ENSG00000132437.18			14883	0.287	0.1935	No
85	PEMT	ENSG00000133027.18			15342	0.283	0.1842	No
86	CYP2S1	ENSG00000167600.14			15734	0.264	0.1764	No
87	NMT1	ENSG00000136448.12			16003	0.249	0.1714	No
88	PTGDS	ENSG00000107317.13			16585	0.215	0.1589	No
89	ENPEP	ENSG00000138792.10			16680	0.211	0.1578	No
90	VNN1	ENSG00000112299.8			16738	0.208	0.1575	No
91	MARCH6	ENSG00000145495.16			17002	0.198	0.1523	No
92	UPB1	ENSG00000100024.15			17322	0.182	0.1458	No
93	ANGPTL3	ENSG00000132855.5			17385	0.179	0.1452	No
94	HSD17B2	ENSG00000086696.11			17842	0.155	0.1354	No
95	TMBIM6	ENSG00000139644.13			17875	0.153	0.1354	No
96	RAP1GAP	ENSG00000076864.19			18593	0.119	0.1193	No
97	ACOX1	ENSG00000161533.12			18902	0.103	0.1126	No
98	SLC35D1	ENSG00000116704.8			19060	0.097	0.1094	No
99	ABCC3	ENSG00000108846.16			19322	0.082	0.1037	No
100	DCXR	ENSG00000169738.8			19340	0.081	0.1037	No
101	ID2	ENSG00000115738.10			19442	0.074	0.1017	No
102	HRG	ENSG00000113905.4			20309	0.031	0.0817	No
103	CYP17A1	ENSG00000148795.7			20505	0.022	0.0773	No
104	TTPA	ENSG00000137561.5			20512	0.022	0.0773	No
105	NINJ1	ENSG00000131669.10			21249	-0.019	0.0602	No
106	SLC46A3	ENSG00000139508.14			21423	-0.028	0.0563	No
107	NPC1	ENSG00000141458.13			21917	-0.052	0.0451	No
108	GCKR	ENSG00000084734.9			22056	-0.060	0.0422	No
109	GSTT2	ENSG00000099984.11			22183	-0.067	0.0396	No
110	PGD	ENSG00000142657.21			22717	-0.097	0.0276	No
111	PTS	ENSG00000150787.8			22993	-0.112	0.0218	No
112	SLC1A5	ENSG00000105281.12			23007	-0.112	0.0220	No
113	SLC22A1	ENSG00000175003.15			23659	-0.150	0.0076	No
114	ACP1	ENSG00000143727.16			24087	-0.176	-0.0015	No
115	GAD1	ENSG00000128683.14			24512	-0.200	-0.0104	No
116	TKFC	ENSG00000149476.15			24576	-0.203	-0.0109	No
117	CNDP2	ENSG00000133313.15			24711	-0.213	-0.0129	No
118	ADH7	ENSG00000196344.11			25515	-0.228	-0.0305	No
119	DHRS7	ENSG00000100612.14			25569	-0.232	-0.0306	No
120	CYP4F2	ENSG00000186115.13			26235	-0.263	-0.0448	No
121	LCAT	ENSG00000213398.8			27533	-0.300	-0.0736	No
122	ENTPD5	ENSG00000187097.12			27944	-0.305	-0.0816	No
123	SHMT2	ENSG00000182199.11			28773	-0.350	-0.0992	No
124	F11	ENSG00000088926.13			28806	-0.351	-0.0982	No
125	IRF8	ENSG00000140968.11			28903	-0.351	-0.0987	No
126	GSTA3	ENSG00000174156.15			28928	-0.351	-0.0975	No
127	MT2A	ENSG00000125148.7			29124	-0.355	-0.1003	No
128	SERPINA6	ENSG00000170099.6			29135	-0.356	-0.0988	No
129	PTGR1	ENSG00000106853.20			29333	-0.365	-0.1016	No
130	SERTAD1	ENSG00000197019.5			29388	-0.369	-0.1010	No
131	NFS1	ENSG00000244005.13			29467	-0.372	-0.1010	No
132	TAT	ENSG00000198650.11			29511	-0.375	-0.1002	No
133	FMO3	ENSG00000007933.13			29589	-0.380	-0.1001	No
134	DDAH2	ENSG00000213722.9			29609	-0.382	-0.0987	No
135	MAOA	ENSG00000189221.9			29884	-0.397	-0.1031	No
136	HPRT1	ENSG00000165704.15			29958	-0.404	-0.1028	No
137	HNF4A	ENSG00000101076.16			30407	-0.432	-0.1111	No
138	IGF1	ENSG00000017427.16			30420	-0.433	-0.1093	No
139	CASP6	ENSG00000138794.10			30445	-0.435	-0.1077	No
140	CYP1A1	ENSG00000140465.14			31019	-0.461	-0.1188	No
141	CYP2C18	ENSG00000108242.13			31100	-0.467	-0.1183	No
142	PYCR1	ENSG00000183010.17			31170	-0.473	-0.1176	No
143	PTGES3	ENSG00000110958.16			31379	-0.484	-0.1201	No
144	JUP	ENSG00000173801.17			31855	-0.505	-0.1286	No
145	ETFDH	ENSG00000171503.12			32005	-0.514	-0.1296	No
146	COMT	ENSG00000093010.13			32046	-0.517	-0.1280	No
147	ITIH4	ENSG00000055955.17			32653	-0.556	-0.1394	No
148	POR	ENSG00000127948.16			32862	-0.573	-0.1414	No
149	BPHL	ENSG00000137274.13			32864	-0.573	-0.1386	No
150	ACP2	ENSG00000134575.12			32966	-0.580	-0.1381	No
151	ECH1	ENSG00000104823.9			33133	-0.593	-0.1390	No
152	LEAP2	ENSG00000164406.8			33850	-0.649	-0.1525	No
153	ARPP19	ENSG00000128989.10			34335	-0.686	-0.1604	No
154	GSS	ENSG00000100983.12			34700	-0.717	-0.1654	No
155	RBP4	ENSG00000138207.14			35047	-0.745	-0.1697	No
156	MCCC2	ENSG00000131844.16			35103	-0.751	-0.1673	No
157	SLC12A4	ENSG00000124067.17			35557	-0.793	-0.1740	No
158	CYP26A1	ENSG00000095596.12			35654	-0.804	-0.1723	No
159	ABCD2	ENSG00000173208.4			35860	-0.826	-0.1730	No
160	AP4B1	ENSG00000134262.13			35950	-0.838	-0.1709	No
161	CA2	ENSG00000104267.10			36626	-0.919	-0.1821	No
162	APOE	ENSG00000130203.10			37045	-0.973	-0.1871	No
163	ALAS1	ENSG00000023330.15			37768	-1.078	-0.1986	No
164	MPP2	ENSG00000108852.14			37902	-1.101	-0.1963	No
165	TYR	ENSG00000077498.9			37961	-1.111	-0.1921	No
166	AHCY	ENSG00000101444.13			38037	-1.123	-0.1884	No
167	SERPINE1	ENSG00000106366.8			38403	-1.189	-0.1910	No
168	ACO2	ENSG00000100412.16			38900	-1.290	-0.1962	No
169	PINK1	ENSG00000158828.8			39057	-1.322	-0.1933	No
170	SAR1B	ENSG00000152700.14			39095	-1.330	-0.1877	No
171	FBP1	ENSG00000165140.10			39215	-1.356	-0.1837	No
172	FETUB	ENSG00000090512.12			39276	-1.370	-0.1784	No
173	NDRG2	ENSG00000165795.23			39317	-1.381	-0.1725	No
174	SMOX	ENSG00000088826.18			39379	-1.393	-0.1671	No
175	GSR	ENSG00000104687.14			39972	-1.542	-0.1733	No
176	ACOX3	ENSG00000087008.16			40088	-1.568	-0.1682	No
177	GART	ENSG00000159131.17			40185	-1.595	-0.1626	No
178	IGFBP1	ENSG00000146678.10			40197	-1.599	-0.1550	No
179	SLC35B1	ENSG00000121073.15			40441	-1.670	-0.1525	No
180	KARS	ENSG00000065427.14			40450	-1.672	-0.1444	No
181	BCAR1	ENSG00000050820.17			40713	-1.751	-0.1419	No
182	MTHFD1	ENSG00000100714.17			40724	-1.755	-0.1335	No
183	LONP1	ENSG00000196365.12			41293	-2.000	-0.1369	No
184	GCNT2	ENSG00000111846.17			41340	-2.028	-0.1280	No
185	ATOH8	ENSG00000168874.13			41366	-2.042	-0.1185	No
186	PC	ENSG00000173599.15			41477	-2.119	-0.1106	No
187	TGFB2	ENSG00000092969.12			41517	-2.139	-0.1010	No
188	SLC6A12	ENSG00000111181.12			41546	-2.160	-0.0910	No
189	HGFAC	ENSG00000109758.8			41560	-2.169	-0.0806	No
190	HES6	ENSG00000144485.11			41860	-2.373	-0.0759	No
191	FABP1	ENSG00000163586.10			41951	-2.456	-0.0659	No
192	ATP2A2	ENSG00000174437.17			42170	-2.663	-0.0579	No
193	SSR3	ENSG00000114850.6			42212	-2.725	-0.0454	No
194	BCAT1	ENSG00000060982.15			42267	-2.792	-0.0329	No
195	EPHA2	ENSG00000142627.13			42591	-3.321	-0.0241	No
196	CYP2J2	ENSG00000134716.11			42672	-3.507	-0.0087	No
197	PDLIM5	ENSG00000163110.15			42795	-3.879	0.0075	No

Fig 2: HALLMARK_XENOBIOTIC_METABOLISM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: HALLMARK_XENOBIOTIC_METABOLISM: Random ES distribution   
Gene set null distribution of ES for HALLMARK_XENOBIOTIC_METABOLISM