Figures in the main text - Figure 1: illustion * rationale of variance loci * existing tests (i.e., DLM) fail on binary * VLA fits a 2nd-order polynomial curve and test positive gradient * existing tests (i.e., DLM) is less efficient under pure GxE - Figure 2: Selected Simulation Results * display false positive rate (when GxE is null) * display net positive rate (when GxE is not null) * shows Gaussian, balance binary, and imbalanced binary. (do not show Poisson) - Figure 3: Manhatton and QQ Plots for whole genome putative GxE tests * 3a: on BMI * 3b: on T2D - Figure 4: enrichment analysis * 4a: internal (Putative GxE based on British Whites --> empirical GxE based on non-British Whites) * 4b: external (Putative GxE based on UKBB Whites --> empirical GxE based on PEGS participants) * 4c: functional (Putative GxE based on UKBB Whites --> variant functional labels by ANNOVAR) - Figure 5: GxE discovery around ABCB7