Xiaoran – This is just to follow up the conversation. These are notes on one of the top candidates for T2D: ABCB7 Related pathways - a) Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, b) Metabolism ABCB7 Gene - ATP Binding Cassette Subfamily B Member 7 Also involved in multidrug resistance ABC proteins transport various molecules across extra- and intra-cellular membranes. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. ABCB7 is an ATP-dependent mitochondrial transporter implicated in Fe–S cluster assembly. Disrupted circadian core-clock oscillations in Type 2 Diabetes are linked to altered rhythmic mitochondrial metabolism Roles of Fe–S proteins: from cofactor synthesis to iron homeostasis to protein synthesis . These defects can then result in cancer, neurologic dysfunction or type 2 diabetes. The absence of ABCB7 impairs the maturation of cytosolic iron -- sulfur proteins and induces iron accumulation in mitochondria. Knockdown of ABCB7 in HEK293T cells also caused mitochondrial iron accumulation , and activation of SOD enzymes . Regulation of mitochondrial iron homeostasis by sideroflexin 2 Human Iron−Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis knockdown of ABCB7 in HeLa cells resulted in an iron-deficient phenotype with mitochondrial iron accumulation - Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes Certain pigments in printer ink dyes contain iron pigments based on ferro and ferric cyanides, such as potash blue or soda blue pigments. Printer inks could also contain cadmium. https://www.pffc-online.com/magazine/782-paper-brief-chemistry-lesson Iron and iron-regulatory proteins and cadmium alter ABCB7 expression - https://med.causaly.com/search?public=e5064b4c-d65f-4aa9-bfd8-3507e62dce82 https://med.causaly.com/search?public=45642b61-11ec-4268-8b3f-3cd82f5682f3 ABCB7 is associated with fatty liver disease. T2D is a major risk factor for fatty liver disease and could have common pathways https://med.causaly.com/search?public=c7abb0f6-46aa-4556-a472-897dc06bec95 Prevalence and predictors of non-alcoholic fatty liver disease as defined by the fatty liver index in a type 2 diabetes population