DatasetNOV0093_collapsed_to_symbols.NOV0093.cls
#obese_versus_normal.NOV0093.cls
#obese_versus_normal_repos
PhenotypeNOV0093.cls#obese_versus_normal_repos
Upregulated in class1
GeneSetGO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE
Enrichment Score (ES)0.5042612
Normalized Enrichment Score (NES)2.1891227
Nominal p-value0.0019880715
FDR q-value0.1756959
FWER p-Value0.155
Table: GSEA Results Summary



Fig 1: Enrichment plot: GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ITGAMITGAM
Entrez,  Source
integrin, alpha M (complement component 3 receptor 3 subunit)130.4420.0283Yes
2PIK3AP1PIK3AP1
Entrez,  Source
phosphoinositide-3-kinase adaptor protein 1250.4160.0549Yes
3BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase280.4120.0818Yes
4CD86CD86
Entrez,  Source
CD86 molecule410.3980.1073Yes
5NLRC4780.3760.1301Yes
6TLR6TLR6
Entrez,  Source
toll-like receptor 61040.3650.1528Yes
7CD209CD209
Entrez,  Source
CD209 molecule1100.3620.1762Yes
8TLR8TLR8
Entrez,  Source
toll-like receptor 81440.3460.1973Yes
9CLEC7ACLEC7A
Entrez,  Source
C-type lectin domain family 7, member A1710.3360.2180Yes
10MARCOMARCO
Entrez,  Source
macrophage receptor with collagenous structure2760.3090.2333Yes
11TLR7TLR7
Entrez,  Source
toll-like receptor 72920.3060.2526Yes
12HCKHCK
Entrez,  Source
hemopoietic cell kinase3000.3060.2723Yes
13LBPLBP
Entrez,  Source
lipopolysaccharide binding protein3910.2900.2870Yes
14FCER1GFCER1G
Entrez,  Source
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide4210.2860.3044Yes
15ITGB2ITGB2
Entrez,  Source
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)4330.2840.3224Yes
16HAVCR2HAVCR2
Entrez,  Source
hepatitis A virus cellular receptor 24630.2790.3393Yes
17NOD29480.2320.3314Yes
18FCN1FCN1
Entrez,  Source
ficolin (collagen/fibrinogen domain containing) 110060.2280.3436Yes
19CD180CD180
Entrez,  Source
CD180 molecule10120.2280.3582Yes
20IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon10830.2230.3694Yes
21SCARA3SCARA3
Entrez,  Source
scavenger receptor class A, member 311060.2220.3829Yes
22TLR10TLR10
Entrez,  Source
toll-like receptor 1011310.2200.3961Yes
23LGMNLGMN
Entrez,  Source
legumain13350.2090.4001Yes
24CARD9CARD9
Entrez,  Source
caspase recruitment domain family, member 915350.1990.4036Yes
25SYKSYK
Entrez,  Source
spleen tyrosine kinase16400.1940.4113Yes
26TLR2TLR2
Entrez,  Source
toll-like receptor 217780.1880.4171Yes
27BIRC3BIRC3
Entrez,  Source
baculoviral IAP repeat-containing 317810.1880.4292Yes
28CLEC4ECLEC4E
Entrez,  Source
C-type lectin domain family 4, member E18880.1840.4362Yes
29CARD11CARD11
Entrez,  Source
caspase recruitment domain family, member 1119070.1840.4474Yes
30TLR1TLR1
Entrez,  Source
toll-like receptor 119680.1810.4564Yes
31RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 221840.1730.4574Yes
32TNFAIP3TNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 322120.1720.4674Yes
33CD14CD14
Entrez,  Source
CD14 molecule22130.1720.4786Yes
34COLEC12COLEC12
Entrez,  Source
collectin sub-family member 1224040.1660.4804Yes
35TIRAPTIRAP
Entrez,  Source
toll-interleukin 1 receptor (TIR) domain containing adaptor protein25210.1630.4855Yes
36TLR5TLR5
Entrez,  Source
toll-like receptor 526060.1600.4920Yes
37LY96LY96
Entrez,  Source
lymphocyte antigen 9626800.1580.4988Yes
38PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 329340.1510.4967Yes
39TRIL31610.1450.4954Yes
40CTSSCTSS
Entrez,  Source
cathepsin S31740.1450.5043Yes
41ICAM3ICAM3
Entrez,  Source
intercellular adhesion molecule 334890.1370.4982No
42KLRK1KLRK1
Entrez,  Source
killer cell lectin-like receptor subfamily K, member 137930.1300.4923No
43ADAM8ADAM8
Entrez,  Source
ADAM metallopeptidase domain 840100.1240.4901No
44LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog41860.1200.4896No
45TRAF3TRAF3
Entrez,  Source
TNF receptor-associated factor 342110.1200.4963No
46RELBRELB
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)42440.1190.5025No
47PSMD7PSMD7
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)60540.0840.4217No
48PSMB10PSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 1062460.0800.4178No
49LGALS9LGALS9
Entrez,  Source
lectin, galactoside-binding, soluble, 9 (galectin 9)63790.0780.4166No
50S100A14S100A14
Entrez,  Source
S100 calcium binding protein A1464510.0770.4183No
51TLR3TLR3
Entrez,  Source
toll-like receptor 366280.0740.4147No
52UBE2V1UBE2V1
Entrez,  Source
ubiquitin-conjugating enzyme E2 variant 167510.0710.4135No
53AIM2AIM2
Entrez,  Source
absent in melanoma 269990.0680.4062No
54KRASKRAS
Entrez,  Source
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog71960.0640.4010No
55IRAK2IRAK2
Entrez,  Source
interleukin-1 receptor-associated kinase 272650.0630.4019No
56PSMC1PSMC1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 174760.0600.3958No
57PSME4PSME4
Entrez,  Source
proteasome (prosome, macropain) activator subunit 476840.0570.3897No
58PSMD1PSMD1
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 177140.0560.3920No
59UBE2D1UBE2D1
Entrez,  Source
ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)79600.0520.3837No
60PSMA2PSMA2
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 279770.0520.3863No
61CTSBCTSB
Entrez,  Source
cathepsin B81990.0490.3790No
62NRASNRAS
Entrez,  Source
neuroblastoma RAS viral (v-ras) oncogene homolog82600.0480.3793No
63FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES83630.0460.3774No
64NOD184800.0450.3748No
65MYD88MYD88
Entrez,  Source
myeloid differentiation primary response gene (88)85470.0440.3745No
66HSPD1HSPD1
Entrez,  Source
heat shock 60kDa protein 1 (chaperonin)85560.0440.3770No
67ITCHITCH
Entrez,  Source
itchy homolog E3 ubiquitin protein ligase (mouse)91610.0360.3505No
68CTSKCTSK
Entrez,  Source
cathepsin K (pycnodysostosis)92720.0340.3475No
69IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 193140.0340.3477No
70SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)94100.0330.3453No
71HSP90B1HSP90B1
Entrez,  Source
heat shock protein 90kDa beta (Grp94), member 194740.0320.3444No
72CNPY395310.0310.3437No
73IFI16IFI16
Entrez,  Source
interferon, gamma-inducible protein 1697190.0290.3367No
74PSMB7PSMB7
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 797710.0280.3361No
75TNIP1TNIP1
Entrez,  Source
TNFAIP3 interacting protein 1101970.0240.3174No
76PSMB5PSMB5
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 5102380.0240.3171No
77DMBT1DMBT1
Entrez,  Source
deleted in malignant brain tumors 1102840.0230.3164No
78PIK3R4PIK3R4
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 4, p150102980.0230.3173No
79PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta103120.0230.3182No
80PRKCEPRKCE
Entrez,  Source
protein kinase C, epsilon103630.0220.3172No
81PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)104390.0220.3151No
82TLR4TLR4
Entrez,  Source
toll-like receptor 4104880.0210.3142No
83BIRC2BIRC2
Entrez,  Source
baculoviral IAP repeat-containing 2105050.0210.3148No
84RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 3106040.0200.3114No
85PAK2PAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 2106400.0200.3110No
86MAP3K1MAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1106620.0190.3113No
87TAB2107930.0180.3062No
88UNC93B1UNC93B1
Entrez,  Source
unc-93 homolog B1 (C. elegans)108290.0180.3057No
89CASP8CASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase109270.0170.3022No
90PLCG2PLCG2
Entrez,  Source
phospholipase C, gamma 2 (phosphatidylinositol-specific)111820.0150.2911No
91MAPKAPK2MAPKAPK2
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 2113420.0130.2843No
92PSMD11PSMD11
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11113940.0130.2827No
93EP300EP300
Entrez,  Source
E1A binding protein p300114720.0120.2798No
94MB21D1116830.0100.2704No
95NFKB1NFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)119610.0070.2577No
96PSMB2PSMB2
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 2122460.0050.2444No
97TICAM1TICAM1
Entrez,  Source
toll-like receptor adaptor molecule 1123810.0030.2383No
98PSMD14PSMD14
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14124380.0030.2358No
99CYLDCYLD
Entrez,  Source
cylindromatosis (turban tumor syndrome)124420.0030.2359No
100PSMC2PSMC2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 2124960.0030.2335No
101MAVS125290.0020.2321No
102FBXW11FBXW11
Entrez,  Source
F-box and WD-40 domain protein 11125750.0020.2301No
103TBK1TBK1
Entrez,  Source
TANK-binding kinase 1125780.0020.2301No
104CREBBPCREBBP
Entrez,  Source
CREB binding protein (Rubinstein-Taybi syndrome)125880.0020.2298No
105TANKTANK
Entrez,  Source
TRAF family member-associated NFKB activator125910.0020.2298No
106PSMD10PSMD10
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10126350.0010.2279No
107UBCUBC
Entrez,  Source
ubiquitin C126660.0010.2265No
108PSME3PSME3
Entrez,  Source
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)127570.0000.2222No
109PSMD6PSMD6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6127760.0000.2214No
110PSMD12PSMD12
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1212816-0.0000.2195No
111TRIM5TRIM5
Entrez,  Source
tripartite motif-containing 512876-0.0010.2168No
112IFIH1IFIH1
Entrez,  Source
interferon induced with helicase C domain 112971-0.0010.2124No
113PYCARDPYCARD
Entrez,  Source
PYD and CARD domain containing13204-0.0030.2015No
114PSMA6PSMA6
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 613219-0.0040.2011No
115MALT1MALT1
Entrez,  Source
mucosa associated lymphoid tissue lymphoma translocation gene 113263-0.0040.1993No
116PSMD2PSMD2
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 213293-0.0040.1982No
117LSM14ALSM14A
Entrez,  Source
LSM14 homolog A (SCD6, S. cerevisiae)13375-0.0050.1946No
118TRAF6TRAF6
Entrez,  Source
TNF receptor-associated factor 613413-0.0050.1932No
119CUL1CUL1
Entrez,  Source
cullin 113641-0.0070.1829No
120CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase13754-0.0080.1781No
121PSMD5PSMD5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 513805-0.0090.1763No
122NFKBIANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha13819-0.0090.1762No
123PSMB3PSMB3
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 313827-0.0090.1765No
124PIK3C3PIK3C3
Entrez,  Source
phosphoinositide-3-kinase, class 313944-0.0100.1716No
125PSMC6PSMC6
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 614293-0.0130.1558No
126CD36CD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)14295-0.0130.1566No
127RFTN1RFTN1
Entrez,  Source
raftlin, lipid raft linker 114305-0.0130.1570No
128PSMD4PSMD4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 414364-0.0130.1552No
129UBE2D3UBE2D3
Entrez,  Source
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)14465-0.0140.1513No
130PRKCDPRKCD
Entrez,  Source
protein kinase C, delta14536-0.0150.1489No
131UBE2D2UBE2D2
Entrez,  Source
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)14677-0.0160.1433No
132IRF3IRF3
Entrez,  Source
interferon regulatory factor 314709-0.0160.1429No
133PSMA5PSMA5
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 514758-0.0170.1417No
134SIN3ASIN3A
Entrez,  Source
SIN3 homolog A, transcription regulator (yeast)14919-0.0180.1353No
135PSME2PSME2
Entrez,  Source
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)14955-0.0180.1348No
136UBA52UBA52
Entrez,  Source
ubiquitin A-52 residue ribosomal protein fusion product 115098-0.0200.1293No
137PSMD13PSMD13
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1315101-0.0200.1305No
138PSMB8PSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)15266-0.0210.1240No
139RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 115282-0.0210.1247No
140TAB115285-0.0210.1260No
141IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta15314-0.0220.1261No
142PSMC4PSMC4
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 415335-0.0220.1265No
143RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 115362-0.0220.1267No
144MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 715371-0.0220.1278No
145PSMA4PSMA4
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 415481-0.0230.1241No
146PSMB4PSMB4
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 415527-0.0230.1235No
147PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha15636-0.0240.1199No
148PSMC3PSMC3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 315766-0.0250.1154No
149TAB315818-0.0260.1147No
150IRF7IRF7
Entrez,  Source
interferon regulatory factor 715840-0.0260.1154No
151PSMD3PSMD3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 315893-0.0270.1147No
152UBBUBB
Entrez,  Source
ubiquitin B15940-0.0270.1143No
153PSMA3PSMA3
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 315947-0.0270.1157No
154PSMB1PSMB1
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 116242-0.0300.1037No
155UBE2NUBE2N
Entrez,  Source
ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)16312-0.0310.1024No
156TMEM173TMEM173
Entrez,  Source
transmembrane protein 17316386-0.0310.1010No
157PSMD8PSMD8
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 816395-0.0320.1027No
158PSMF1PSMF1
Entrez,  Source
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)16453-0.0320.1021No
159PSMA7PSMA7
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 716484-0.0320.1027No
160PSMB6PSMB6
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 616495-0.0320.1044No
161RPS27ARPS27A
Entrez,  Source
ribosomal protein S27a16508-0.0320.1059No
162RELARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)16661-0.0340.1009No
163BTRCBTRC
Entrez,  Source
beta-transducin repeat containing16693-0.0340.1017No
164HMGB1HMGB1
Entrez,  Source
high-mobility group box 117008-0.0380.0892No
165DDX58DDX58
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5817183-0.0400.0835No
166MAPKAPK3MAPKAPK3
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 317392-0.0420.0763No
167SKP117457-0.0430.0761No
168PSME1PSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)17553-0.0450.0745No
169IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 417589-0.0450.0757No
170PDPK1PDPK1
Entrez,  Source
3-phosphoinositide dependent protein kinase-117787-0.0480.0695No
171RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 517876-0.0490.0685No
172PSMC5PSMC5
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 517886-0.0490.0713No
173FFAR2FFAR2
Entrez,  Source
free fatty acid receptor 218328-0.0560.0539No
174PGLYRP2PGLYRP2
Entrez,  Source
peptidoglycan recognition protein 218583-0.0610.0458No
175TNIP2TNIP2
Entrez,  Source
TNFAIP3 interacting protein 218649-0.0630.0468No
176HRASHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog18923-0.0690.0383No
177ICAM2ICAM2
Entrez,  Source
intercellular adhesion molecule 219340-0.0810.0237No
178PSMA1PSMA1
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 119344-0.0810.0289No
179PSMB9PSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)19621-0.0910.0217No
180PSMD9PSMD9
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, non-ATPase, 919651-0.0920.0263No
181MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 620166-0.1160.0094No
182IKBKGIKBKG
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma20251-0.1200.0132No
183IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 320304-0.1240.0188No
184BCL10BCL10
Entrez,  Source
B-cell CLL/lymphoma 1020313-0.1240.0266No
185FADDFADD
Entrez,  Source
Fas (TNFRSF6)-associated via death domain20913-0.1990.0110No
Table: GSEA details [plain text format]



Fig 2: GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE: Random ES distribution   
Gene set null distribution of ES for GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE