Details for gene set GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	NOV0093_collapsed_to_symbols.NOV0093.cls #obese_versus_normal.NOV0093.cls #obese_versus_normal_repos
Phenotype	NOV0093.cls#obese_versus_normal_repos
Upregulated in class	1
GeneSet	GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY
Enrichment Score (ES)	0.6053908
Normalized Enrichment Score (NES)	2.1936953
Nominal p-value	0.0
FDR q-value	0.19764999
FWER p-Value	0.153

Fig 1: Enrichment plot: GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ITGAM	ITGAM Entrez,  Source	integrin, alpha M (complement component 3 receptor 3 subunit)	13	0.442	0.0424	Yes
2	PIK3AP1	PIK3AP1 Entrez,  Source	phosphoinositide-3-kinase adaptor protein 1	25	0.416	0.0823	Yes
3	BTK	BTK Entrez,  Source	Bruton agammaglobulinemia tyrosine kinase	28	0.412	0.1223	Yes
4	CD86	CD86 Entrez,  Source	CD86 molecule	41	0.398	0.1605	Yes
5	TLR6	TLR6 Entrez,  Source	toll-like receptor 6	104	0.365	0.1931	Yes
6	TLR8	TLR8 Entrez,  Source	toll-like receptor 8	144	0.346	0.2249	Yes
7	CLEC7A	CLEC7A Entrez,  Source	C-type lectin domain family 7, member A	171	0.336	0.2564	Yes
8	MARCO	MARCO Entrez,  Source	macrophage receptor with collagenous structure	276	0.309	0.2815	Yes
9	TLR7	TLR7 Entrez,  Source	toll-like receptor 7	292	0.306	0.3107	Yes
10	LBP	LBP Entrez,  Source	lipopolysaccharide binding protein	391	0.290	0.3343	Yes
11	ITGB2	ITGB2 Entrez,  Source	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	433	0.284	0.3600	Yes
12	HAVCR2	HAVCR2 Entrez,  Source	hepatitis A virus cellular receptor 2	463	0.279	0.3858	Yes
13	NOD2			948	0.232	0.3854	Yes
14	FCN1	FCN1 Entrez,  Source	ficolin (collagen/fibrinogen domain containing) 1	1006	0.228	0.4049	Yes
15	CD180	CD180 Entrez,  Source	CD180 molecule	1012	0.228	0.4268	Yes
16	IKBKE	IKBKE Entrez,  Source	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	1083	0.223	0.4451	Yes
17	SCARA3	SCARA3 Entrez,  Source	scavenger receptor class A, member 3	1106	0.222	0.4656	Yes
18	TLR10	TLR10 Entrez,  Source	toll-like receptor 10	1131	0.220	0.4859	Yes
19	LGMN	LGMN Entrez,  Source	legumain	1335	0.209	0.4965	Yes
20	TLR2	TLR2 Entrez,  Source	toll-like receptor 2	1778	0.188	0.4938	Yes
21	BIRC3	BIRC3 Entrez,  Source	baculoviral IAP repeat-containing 3	1781	0.188	0.5120	Yes
22	TLR1	TLR1 Entrez,  Source	toll-like receptor 1	1968	0.181	0.5208	Yes
23	RIPK2	RIPK2 Entrez,  Source	receptor-interacting serine-threonine kinase 2	2184	0.173	0.5274	Yes
24	TNFAIP3	TNFAIP3 Entrez,  Source	tumor necrosis factor, alpha-induced protein 3	2212	0.172	0.5428	Yes
25	CD14	CD14 Entrez,  Source	CD14 molecule	2213	0.172	0.5596	Yes
26	COLEC12	COLEC12 Entrez,  Source	collectin sub-family member 12	2404	0.166	0.5667	Yes
27	TIRAP	TIRAP Entrez,  Source	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	2521	0.163	0.5771	Yes
28	TLR5	TLR5 Entrez,  Source	toll-like receptor 5	2606	0.160	0.5887	Yes
29	LY96	LY96 Entrez,  Source	lymphocyte antigen 96	2680	0.158	0.6006	Yes
30	TRIL			3161	0.145	0.5919	Yes
31	CTSS	CTSS Entrez,  Source	cathepsin S	3174	0.145	0.6054	Yes
32	TRAF3	TRAF3 Entrez,  Source	TNF receptor-associated factor 3	4211	0.120	0.5678	No
33	LGALS9	LGALS9 Entrez,  Source	lectin, galactoside-binding, soluble, 9 (galectin 9)	6379	0.078	0.4724	No
34	S100A14	S100A14 Entrez,  Source	S100 calcium binding protein A14	6451	0.077	0.4766	No
35	TLR3	TLR3 Entrez,  Source	toll-like receptor 3	6628	0.074	0.4754	No
36	UBE2V1	UBE2V1 Entrez,  Source	ubiquitin-conjugating enzyme E2 variant 1	6751	0.071	0.4765	No
37	IRAK2	IRAK2 Entrez,  Source	interleukin-1 receptor-associated kinase 2	7265	0.063	0.4583	No
38	UBE2D1	UBE2D1 Entrez,  Source	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	7960	0.052	0.4304	No
39	CTSB	CTSB Entrez,  Source	cathepsin B	8199	0.049	0.4239	No
40	NOD1			8480	0.045	0.4149	No
41	MYD88	MYD88 Entrez,  Source	myeloid differentiation primary response gene (88)	8547	0.044	0.4160	No
42	HSPD1	HSPD1 Entrez,  Source	heat shock 60kDa protein 1 (chaperonin)	8556	0.044	0.4199	No
43	ITCH	ITCH Entrez,  Source	itchy homolog E3 ubiquitin protein ligase (mouse)	9161	0.036	0.3947	No
44	CTSK	CTSK Entrez,  Source	cathepsin K (pycnodysostosis)	9272	0.034	0.3928	No
45	IRAK1	IRAK1 Entrez,  Source	interleukin-1 receptor-associated kinase 1	9314	0.034	0.3941	No
46	HSP90B1	HSP90B1 Entrez,  Source	heat shock protein 90kDa beta (Grp94), member 1	9474	0.032	0.3896	No
47	CNPY3			9531	0.031	0.3900	No
48	TNIP1	TNIP1 Entrez,  Source	TNFAIP3 interacting protein 1	10197	0.024	0.3607	No
49	DMBT1	DMBT1 Entrez,  Source	deleted in malignant brain tumors 1	10284	0.023	0.3589	No
50	PIK3R4	PIK3R4 Entrez,  Source	phosphoinositide-3-kinase, regulatory subunit 4, p150	10298	0.023	0.3605	No
51	PRKCE	PRKCE Entrez,  Source	protein kinase C, epsilon	10363	0.022	0.3596	No
52	TLR4	TLR4 Entrez,  Source	toll-like receptor 4	10488	0.021	0.3557	No
53	BIRC2	BIRC2 Entrez,  Source	baculoviral IAP repeat-containing 2	10505	0.021	0.3570	No
54	RPS6KA3	RPS6KA3 Entrez,  Source	ribosomal protein S6 kinase, 90kDa, polypeptide 3	10604	0.020	0.3543	No
55	MAP3K1	MAP3K1 Entrez,  Source	mitogen-activated protein kinase kinase kinase 1	10662	0.019	0.3534	No
56	TAB2			10793	0.018	0.3490	No
57	UNC93B1	UNC93B1 Entrez,  Source	unc-93 homolog B1 (C. elegans)	10829	0.018	0.3491	No
58	CASP8	CASP8 Entrez,  Source	caspase 8, apoptosis-related cysteine peptidase	10927	0.017	0.3462	No
59	MAPKAPK2	MAPKAPK2 Entrez,  Source	mitogen-activated protein kinase-activated protein kinase 2	11342	0.013	0.3278	No
60	TICAM1	TICAM1 Entrez,  Source	toll-like receptor adaptor molecule 1	12381	0.003	0.2788	No
61	CYLD	CYLD Entrez,  Source	cylindromatosis (turban tumor syndrome)	12442	0.003	0.2762	No
62	MAVS			12529	0.002	0.2724	No
63	TBK1	TBK1 Entrez,  Source	TANK-binding kinase 1	12578	0.002	0.2703	No
64	TANK	TANK Entrez,  Source	TRAF family member-associated NFKB activator	12591	0.002	0.2699	No
65	UBC	UBC Entrez,  Source	ubiquitin C	12666	0.001	0.2664	No
66	TRIM5	TRIM5 Entrez,  Source	tripartite motif-containing 5	12876	-0.001	0.2566	No
67	IFIH1	IFIH1 Entrez,  Source	interferon induced with helicase C domain 1	12971	-0.001	0.2523	No
68	LSM14A	LSM14A Entrez,  Source	LSM14 homolog A (SCD6, S. cerevisiae)	13375	-0.005	0.2336	No
69	TRAF6	TRAF6 Entrez,  Source	TNF receptor-associated factor 6	13413	-0.005	0.2323	No
70	CHUK	CHUK Entrez,  Source	conserved helix-loop-helix ubiquitous kinase	13754	-0.008	0.2170	No
71	NFKBIA	NFKBIA Entrez,  Source	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	13819	-0.009	0.2148	No
72	PIK3C3	PIK3C3 Entrez,  Source	phosphoinositide-3-kinase, class 3	13944	-0.010	0.2099	No
73	CD36	CD36 Entrez,  Source	CD36 molecule (thrombospondin receptor)	14295	-0.013	0.1945	No
74	RFTN1	RFTN1 Entrez,  Source	raftlin, lipid raft linker 1	14305	-0.013	0.1954	No
75	UBE2D3	UBE2D3 Entrez,  Source	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	14465	-0.014	0.1892	No
76	UBE2D2	UBE2D2 Entrez,  Source	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	14677	-0.016	0.1807	No
77	IRF3	IRF3 Entrez,  Source	interferon regulatory factor 3	14709	-0.016	0.1808	No
78	UBA52	UBA52 Entrez,  Source	ubiquitin A-52 residue ribosomal protein fusion product 1	15098	-0.020	0.1643	No
79	RIPK1	RIPK1 Entrez,  Source	receptor (TNFRSF)-interacting serine-threonine kinase 1	15282	-0.021	0.1577	No
80	TAB1			15285	-0.021	0.1596	No
81	IKBKB	IKBKB Entrez,  Source	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	15314	-0.022	0.1604	No
82	MAP3K7	MAP3K7 Entrez,  Source	mitogen-activated protein kinase kinase kinase 7	15371	-0.022	0.1599	No
83	TAB3			15818	-0.026	0.1412	No
84	IRF7	IRF7 Entrez,  Source	interferon regulatory factor 7	15840	-0.026	0.1428	No
85	UBB	UBB Entrez,  Source	ubiquitin B	15940	-0.027	0.1407	No
86	UBE2N	UBE2N Entrez,  Source	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	16312	-0.031	0.1261	No
87	RPS27A	RPS27A Entrez,  Source	ribosomal protein S27a	16508	-0.032	0.1200	No
88	RELA	RELA Entrez,  Source	v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)	16661	-0.034	0.1161	No
89	DDX58	DDX58 Entrez,  Source	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	17183	-0.040	0.0952	No
90	MAPKAPK3	MAPKAPK3 Entrez,  Source	mitogen-activated protein kinase-activated protein kinase 3	17392	-0.042	0.0894	No
91	IRAK4	IRAK4 Entrez,  Source	interleukin-1 receptor-associated kinase 4	17589	-0.045	0.0845	No
92	FFAR2	FFAR2 Entrez,  Source	free fatty acid receptor 2	18328	-0.056	0.0549	No
93	PGLYRP2	PGLYRP2 Entrez,  Source	peptidoglycan recognition protein 2	18583	-0.061	0.0488	No
94	TNIP2	TNIP2 Entrez,  Source	TNFAIP3 interacting protein 2	18649	-0.063	0.0518	No
95	MAP2K6	MAP2K6 Entrez,  Source	mitogen-activated protein kinase kinase 6	20166	-0.116	-0.0089	No
96	IKBKG	IKBKG Entrez,  Source	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	20251	-0.120	-0.0012	No
97	IRAK3	IRAK3 Entrez,  Source	interleukin-1 receptor-associated kinase 3	20304	-0.124	0.0083	No
98	BCL10	BCL10 Entrez,  Source	B-cell CLL/lymphoma 10	20313	-0.124	0.0200	No
99	FADD	FADD Entrez,  Source	Fas (TNFRSF6)-associated via death domain	20913	-0.199	0.0110	No

Fig 2: GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY