Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NOV0093_collapsed_to_symbols.NOV0093.cls #obese_versus_normal.NOV0093.cls #obese_versus_normal_repos |
| Phenotype | NOV0093.cls#obese_versus_normal_repos |
| Upregulated in class | 1 |
| GeneSet | GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION |
| Enrichment Score (ES) | 0.5693022 |
| Normalized Enrichment Score (NES) | 2.1289155 |
| Nominal p-value | 0.001980198 |
| FDR q-value | 0.23005988 |
| FWER p-Value | 0.258 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LILRB1 | LILRB1 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 48 | 0.393 | 0.1162 | Yes |
| 2 | TLR8 | TLR8 Entrez, Source | toll-like receptor 8 | 144 | 0.346 | 0.2160 | Yes |
| 3 | TLR7 | TLR7 Entrez, Source | toll-like receptor 7 | 292 | 0.306 | 0.3015 | Yes |
| 4 | IRF5 | IRF5 Entrez, Source | interferon regulatory factor 5 | 482 | 0.275 | 0.3755 | Yes |
| 5 | TLR2 | TLR2 Entrez, Source | toll-like receptor 2 | 1778 | 0.188 | 0.3709 | Yes |
| 6 | POLR3B | POLR3B Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide B | 1826 | 0.186 | 0.4248 | Yes |
| 7 | RIPK2 | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 2184 | 0.173 | 0.4600 | Yes |
| 8 | TIRAP | TIRAP Entrez, Source | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 2521 | 0.163 | 0.4932 | Yes |
| 9 | REL | REL Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog (avian) | 2848 | 0.153 | 0.5241 | Yes |
| 10 | ZBTB20 | ZBTB20 Entrez, Source | zinc finger and BTB domain containing 20 | 3764 | 0.130 | 0.5201 | Yes |
| 11 | TRAF3 | TRAF3 Entrez, Source | TNF receptor-associated factor 3 | 4211 | 0.120 | 0.5350 | Yes |
| 12 | RELB | RELB Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian) | 4244 | 0.119 | 0.5693 | Yes |
| 13 | TRAIP | TRAIP Entrez, Source | TRAF interacting protein | 6389 | 0.078 | 0.4912 | No |
| 14 | TLR3 | TLR3 Entrez, Source | toll-like receptor 3 | 6628 | 0.074 | 0.5022 | No |
| 15 | POLR3D | POLR3D Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | 8096 | 0.050 | 0.4479 | No |
| 16 | NLRX1 | 9128 | 0.036 | 0.4099 | No | ||
| 17 | POLR3A | POLR3A Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa | 9188 | 0.035 | 0.4177 | No |
| 18 | TRIM38 | TRIM38 Entrez, Source | tripartite motif-containing 38 | 9748 | 0.029 | 0.3998 | No |
| 19 | IFNAR1 | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 10243 | 0.024 | 0.3835 | No |
| 20 | TLR4 | TLR4 Entrez, Source | toll-like receptor 4 | 10488 | 0.021 | 0.3783 | No |
| 21 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 11218 | 0.014 | 0.3481 | No |
| 22 | RNF216 | 11550 | 0.011 | 0.3357 | No | ||
| 23 | PPM1B | PPM1B Entrez, Source | protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform | 12137 | 0.006 | 0.3096 | No |
| 24 | TICAM1 | TICAM1 Entrez, Source | toll-like receptor adaptor molecule 1 | 12381 | 0.003 | 0.2991 | No |
| 25 | DDX3X | DDX3X Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | 12427 | 0.003 | 0.2979 | No |
| 26 | MAVS | 12529 | 0.002 | 0.2938 | No | ||
| 27 | TBK1 | TBK1 Entrez, Source | TANK-binding kinase 1 | 12578 | 0.002 | 0.2921 | No |
| 28 | IFIH1 | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 12971 | -0.001 | 0.2740 | No |
| 29 | PYCARD | PYCARD Entrez, Source | PYD and CARD domain containing | 13204 | -0.003 | 0.2640 | No |
| 30 | TRAF3IP1 | TRAF3IP1 Entrez, Source | TNF receptor-associated factor 3 interacting protein 1 | 13498 | -0.006 | 0.2519 | No |
| 31 | ZC3HAV1 | ZC3HAV1 Entrez, Source | zinc finger CCCH-type, antiviral 1 | 14396 | -0.014 | 0.2136 | No |
| 32 | RNF135 | RNF135 Entrez, Source | ring finger protein 135 | 14612 | -0.015 | 0.2080 | No |
| 33 | IRF3 | IRF3 Entrez, Source | interferon regulatory factor 3 | 14709 | -0.016 | 0.2084 | No |
| 34 | NMI | NMI Entrez, Source | N-myc (and STAT) interactor | 14783 | -0.017 | 0.2100 | No |
| 35 | POLR3C | POLR3C Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide C (62kD) | 15009 | -0.019 | 0.2050 | No |
| 36 | FLOT1 | FLOT1 Entrez, Source | flotillin 1 | 15663 | -0.025 | 0.1815 | No |
| 37 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 15840 | -0.026 | 0.1811 | No |
| 38 | POLR3G | POLR3G Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | 16794 | -0.036 | 0.1466 | No |
| 39 | HMGB1 | HMGB1 Entrez, Source | high-mobility group box 1 | 17008 | -0.038 | 0.1479 | No |
| 40 | DDX58 | DDX58 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 17183 | -0.040 | 0.1517 | No |
| 41 | POLR3F | POLR3F Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa | 18467 | -0.059 | 0.1086 | No |
| 42 | HMGB2 | HMGB2 Entrez, Source | high-mobility group box 2 | 18526 | -0.060 | 0.1241 | No |
