Details for gene set GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	NOV0093_collapsed_to_symbols.NOV0093.cls #obese_versus_normal.NOV0093.cls #obese_versus_normal_repos
Phenotype	NOV0093.cls#obese_versus_normal_repos
Upregulated in class	1
GeneSet	GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
Enrichment Score (ES)	0.61508244
Normalized Enrichment Score (NES)	2.2171855
Nominal p-value	0.0
FDR q-value	0.30794573
FWER p-Value	0.132

Fig 1: Enrichment plot: GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ITGAM	ITGAM Entrez,  Source	integrin, alpha M (complement component 3 receptor 3 subunit)	13	0.442	0.0515	Yes
2	PIK3AP1	PIK3AP1 Entrez,  Source	phosphoinositide-3-kinase adaptor protein 1	25	0.416	0.1001	Yes
3	BTK	BTK Entrez,  Source	Bruton agammaglobulinemia tyrosine kinase	28	0.412	0.1486	Yes
4	CD86	CD86 Entrez,  Source	CD86 molecule	41	0.398	0.1951	Yes
5	TLR6	TLR6 Entrez,  Source	toll-like receptor 6	104	0.365	0.2351	Yes
6	TLR8	TLR8 Entrez,  Source	toll-like receptor 8	144	0.346	0.2741	Yes
7	TLR7	TLR7 Entrez,  Source	toll-like receptor 7	292	0.306	0.3033	Yes
8	LBP	LBP Entrez,  Source	lipopolysaccharide binding protein	391	0.290	0.3330	Yes
9	ITGB2	ITGB2 Entrez,  Source	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	433	0.284	0.3646	Yes
10	HAVCR2	HAVCR2 Entrez,  Source	hepatitis A virus cellular receptor 2	463	0.279	0.3962	Yes
11	CD180	CD180 Entrez,  Source	CD180 molecule	1012	0.228	0.3970	Yes
12	IKBKE	IKBKE Entrez,  Source	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	1083	0.223	0.4200	Yes
13	SCARA3	SCARA3 Entrez,  Source	scavenger receptor class A, member 3	1106	0.222	0.4451	Yes
14	TLR10	TLR10 Entrez,  Source	toll-like receptor 10	1131	0.220	0.4699	Yes
15	LGMN	LGMN Entrez,  Source	legumain	1335	0.209	0.4849	Yes
16	TLR2	TLR2 Entrez,  Source	toll-like receptor 2	1778	0.188	0.4861	Yes
17	BIRC3	BIRC3 Entrez,  Source	baculoviral IAP repeat-containing 3	1781	0.188	0.5082	Yes
18	TLR1	TLR1 Entrez,  Source	toll-like receptor 1	1968	0.181	0.5207	Yes
19	RIPK2	RIPK2 Entrez,  Source	receptor-interacting serine-threonine kinase 2	2184	0.173	0.5309	Yes
20	CD14	CD14 Entrez,  Source	CD14 molecule	2213	0.172	0.5498	Yes
21	COLEC12	COLEC12 Entrez,  Source	collectin sub-family member 12	2404	0.166	0.5604	Yes
22	TIRAP	TIRAP Entrez,  Source	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	2521	0.163	0.5742	Yes
23	TLR5	TLR5 Entrez,  Source	toll-like receptor 5	2606	0.160	0.5891	Yes
24	LY96	LY96 Entrez,  Source	lymphocyte antigen 96	2680	0.158	0.6042	Yes
25	TRIL			3161	0.145	0.5986	Yes
26	CTSS	CTSS Entrez,  Source	cathepsin S	3174	0.145	0.6151	Yes
27	TRAF3	TRAF3 Entrez,  Source	TNF receptor-associated factor 3	4211	0.120	0.5800	No
28	LGALS9	LGALS9 Entrez,  Source	lectin, galactoside-binding, soluble, 9 (galectin 9)	6379	0.078	0.4864	No
29	S100A14	S100A14 Entrez,  Source	S100 calcium binding protein A14	6451	0.077	0.4921	No
30	TLR3	TLR3 Entrez,  Source	toll-like receptor 3	6628	0.074	0.4924	No
31	IRAK2	IRAK2 Entrez,  Source	interleukin-1 receptor-associated kinase 2	7265	0.063	0.4697	No
32	UBE2D1	UBE2D1 Entrez,  Source	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	7960	0.052	0.4429	No
33	CTSB	CTSB Entrez,  Source	cathepsin B	8199	0.049	0.4374	No
34	MYD88	MYD88 Entrez,  Source	myeloid differentiation primary response gene (88)	8547	0.044	0.4261	No
35	HSPD1	HSPD1 Entrez,  Source	heat shock 60kDa protein 1 (chaperonin)	8556	0.044	0.4308	No
36	CTSK	CTSK Entrez,  Source	cathepsin K (pycnodysostosis)	9272	0.034	0.4009	No
37	IRAK1	IRAK1 Entrez,  Source	interleukin-1 receptor-associated kinase 1	9314	0.034	0.4030	No
38	HSP90B1	HSP90B1 Entrez,  Source	heat shock protein 90kDa beta (Grp94), member 1	9474	0.032	0.3991	No
39	CNPY3			9531	0.031	0.4001	No
40	TNIP1	TNIP1 Entrez,  Source	TNFAIP3 interacting protein 1	10197	0.024	0.3714	No
41	PIK3R4	PIK3R4 Entrez,  Source	phosphoinositide-3-kinase, regulatory subunit 4, p150	10298	0.023	0.3694	No
42	PRKCE	PRKCE Entrez,  Source	protein kinase C, epsilon	10363	0.022	0.3689	No
43	TLR4	TLR4 Entrez,  Source	toll-like receptor 4	10488	0.021	0.3655	No
44	BIRC2	BIRC2 Entrez,  Source	baculoviral IAP repeat-containing 2	10505	0.021	0.3672	No
45	RPS6KA3	RPS6KA3 Entrez,  Source	ribosomal protein S6 kinase, 90kDa, polypeptide 3	10604	0.020	0.3649	No
46	MAP3K1	MAP3K1 Entrez,  Source	mitogen-activated protein kinase kinase kinase 1	10662	0.019	0.3645	No
47	TAB2			10793	0.018	0.3605	No
48	UNC93B1	UNC93B1 Entrez,  Source	unc-93 homolog B1 (C. elegans)	10829	0.018	0.3609	No
49	CASP8	CASP8 Entrez,  Source	caspase 8, apoptosis-related cysteine peptidase	10927	0.017	0.3583	No
50	MAPKAPK2	MAPKAPK2 Entrez,  Source	mitogen-activated protein kinase-activated protein kinase 2	11342	0.013	0.3402	No
51	TICAM1	TICAM1 Entrez,  Source	toll-like receptor adaptor molecule 1	12381	0.003	0.2913	No
52	TBK1	TBK1 Entrez,  Source	TANK-binding kinase 1	12578	0.002	0.2823	No
53	TANK	TANK Entrez,  Source	TRAF family member-associated NFKB activator	12591	0.002	0.2819	No
54	UBC	UBC Entrez,  Source	ubiquitin C	12666	0.001	0.2785	No
55	TRAF6	TRAF6 Entrez,  Source	TNF receptor-associated factor 6	13413	-0.005	0.2437	No
56	CHUK	CHUK Entrez,  Source	conserved helix-loop-helix ubiquitous kinase	13754	-0.008	0.2286	No
57	NFKBIA	NFKBIA Entrez,  Source	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	13819	-0.009	0.2266	No
58	PIK3C3	PIK3C3 Entrez,  Source	phosphoinositide-3-kinase, class 3	13944	-0.010	0.2219	No
59	CD36	CD36 Entrez,  Source	CD36 molecule (thrombospondin receptor)	14295	-0.013	0.2068	No
60	RFTN1	RFTN1 Entrez,  Source	raftlin, lipid raft linker 1	14305	-0.013	0.2079	No
61	UBE2D3	UBE2D3 Entrez,  Source	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	14465	-0.014	0.2020	No
62	UBE2D2	UBE2D2 Entrez,  Source	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	14677	-0.016	0.1939	No
63	IRF3	IRF3 Entrez,  Source	interferon regulatory factor 3	14709	-0.016	0.1943	No
64	UBA52	UBA52 Entrez,  Source	ubiquitin A-52 residue ribosomal protein fusion product 1	15098	-0.020	0.1782	No
65	RIPK1	RIPK1 Entrez,  Source	receptor (TNFRSF)-interacting serine-threonine kinase 1	15282	-0.021	0.1721	No
66	TAB1			15285	-0.021	0.1745	No
67	IKBKB	IKBKB Entrez,  Source	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	15314	-0.022	0.1757	No
68	MAP3K7	MAP3K7 Entrez,  Source	mitogen-activated protein kinase kinase kinase 7	15371	-0.022	0.1756	No
69	TAB3			15818	-0.026	0.1575	No
70	IRF7	IRF7 Entrez,  Source	interferon regulatory factor 7	15840	-0.026	0.1596	No
71	UBB	UBB Entrez,  Source	ubiquitin B	15940	-0.027	0.1581	No
72	RPS27A	RPS27A Entrez,  Source	ribosomal protein S27a	16508	-0.032	0.1350	No
73	MAPKAPK3	MAPKAPK3 Entrez,  Source	mitogen-activated protein kinase-activated protein kinase 3	17392	-0.042	0.0981	No
74	IRAK4	IRAK4 Entrez,  Source	interleukin-1 receptor-associated kinase 4	17589	-0.045	0.0941	No
75	TNIP2	TNIP2 Entrez,  Source	TNFAIP3 interacting protein 2	18649	-0.063	0.0513	No
76	IKBKG	IKBKG Entrez,  Source	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	20251	-0.120	-0.0105	No
77	IRAK3	IRAK3 Entrez,  Source	interleukin-1 receptor-associated kinase 3	20304	-0.124	0.0016	No
78	BCL10	BCL10 Entrez,  Source	B-cell CLL/lymphoma 10	20313	-0.124	0.0159	No
79	FADD	FADD Entrez,  Source	Fas (TNFRSF6)-associated via death domain	20913	-0.199	0.0110	No

Fig 2: GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY