Details for gene set KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS[GSEA]

Table: GSEA Results Summary

Dataset	NOV0093_collapsed_to_symbols.NOV0093.cls #obese_versus_normal.NOV0093.cls #obese_versus_normal_repos
Phenotype	NOV0093.cls#obese_versus_normal_repos
Upregulated in class	1
GeneSet	KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS
Enrichment Score (ES)	0.5722842
Normalized Enrichment Score (NES)	2.1018004
Nominal p-value	0.0
FDR q-value	0.2311868
FWER p-Value	0.308

Fig 1: Enrichment plot: KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	FCGR2B	FCGR2B Entrez,  Source	Fc fragment of IgG, low affinity IIb, receptor (CD32)	8	0.466	0.0547	Yes
2	FCGR1A	FCGR1A Entrez,  Source	Fc fragment of IgG, high affinity Ia, receptor (CD64)	10	0.465	0.1096	Yes
3	NCF1	NCF1 Entrez,  Source	neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)	21	0.420	0.1587	Yes
4	VAV1	VAV1 Entrez,  Source	vav 1 oncogene	32	0.405	0.2062	Yes
5	FCGR2C	FCGR2C Entrez,  Source	Fc fragment of IgG, low affinity IIb, receptor for (CD32)	43	0.398	0.2527	Yes
6	WAS	WAS Entrez,  Source	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	71	0.381	0.2965	Yes
7	FCGR2A	FCGR2A Entrez,  Source	Fc fragment of IgG, low affinity IIa, receptor (CD32)	220	0.323	0.3277	Yes
8	DOCK2	DOCK2 Entrez,  Source	dedicator of cytokinesis 2	247	0.316	0.3638	Yes
9	HCK	HCK Entrez,  Source	hemopoietic cell kinase	300	0.306	0.3975	Yes
10	PIK3R5	PIK3R5 Entrez,  Source	phosphoinositide-3-kinase, regulatory subunit 5, p101	318	0.302	0.4324	Yes
11	PTPRC	PTPRC Entrez,  Source	protein tyrosine phosphatase, receptor type, C	719	0.250	0.4429	Yes
12	SCIN	SCIN Entrez,  Source	scinderin	808	0.242	0.4674	Yes
13	PIK3CG	PIK3CG Entrez,  Source	phosphoinositide-3-kinase, catalytic, gamma polypeptide	853	0.238	0.4935	Yes
14	RAC2	RAC2 Entrez,  Source	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	1005	0.228	0.5133	Yes
15	AMPH	AMPH Entrez,  Source	amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)	1296	0.211	0.5245	Yes
16	DNM1	DNM1 Entrez,  Source	dynamin 1	1443	0.202	0.5414	Yes
17	SYK	SYK Entrez,  Source	spleen tyrosine kinase	1640	0.194	0.5550	Yes
18	PRKCB			1749	0.190	0.5723	Yes
19	FCGR3A	FCGR3A Entrez,  Source	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	2299	0.169	0.5662	No
20	PIK3CD	PIK3CD Entrez,  Source	phosphoinositide-3-kinase, catalytic, delta polypeptide	3055	0.148	0.5478	No
21	ASAP2			3142	0.145	0.5609	No
22	WASF1	WASF1 Entrez,  Source	WAS protein family, member 1	3790	0.130	0.5455	No
23	PIP5K1B	PIP5K1B Entrez,  Source	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	4091	0.122	0.5457	No
24	PRKCA	PRKCA Entrez,  Source	protein kinase C, alpha	4153	0.121	0.5571	No
25	LYN	LYN Entrez,  Source	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	4186	0.120	0.5698	No
26	VAV3	VAV3 Entrez,  Source	vav 3 oncogene	5333	0.097	0.5268	No
27	SPHK1	SPHK1 Entrez,  Source	sphingosine kinase 1	6531	0.075	0.4789	No
28	VAV2	VAV2 Entrez,  Source	vav 2 oncogene	6644	0.073	0.4823	No
29	MAP2K1	MAP2K1 Entrez,  Source	mitogen-activated protein kinase kinase 1	6827	0.070	0.4819	No
30	PIP5K1C	PIP5K1C Entrez,  Source	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	6988	0.068	0.4823	No
31	PLA2G4A	PLA2G4A Entrez,  Source	phospholipase A2, group IVA (cytosolic, calcium-dependent)	6995	0.068	0.4900	No
32	GAB2	GAB2 Entrez,  Source	GRB2-associated binding protein 2	7113	0.066	0.4922	No
33	LIMK1	LIMK1 Entrez,  Source	LIM domain kinase 1	8349	0.047	0.4391	No
34	INPP5D	INPP5D Entrez,  Source	inositol polyphosphate-5-phosphatase, 145kDa	8454	0.045	0.4395	No
35	VASP	VASP Entrez,  Source	vasodilator-stimulated phosphoprotein	8607	0.043	0.4374	No
36	ARPC1B	ARPC1B Entrez,  Source	actin related protein 2/3 complex, subunit 1B, 41kDa	9062	0.037	0.4201	No
37	MARCKS	MARCKS Entrez,  Source	myristoylated alanine-rich protein kinase C substrate	9140	0.036	0.4207	No
38	DNM1L	DNM1L Entrez,  Source	dynamin 1-like	9251	0.034	0.4196	No
39	ARPC5L	ARPC5L Entrez,  Source	actin related protein 2/3 complex, subunit 5-like	9286	0.034	0.4220	No
40	PIP5K1A	PIP5K1A Entrez,  Source	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	9372	0.033	0.4218	No
41	MARCKSL1	MARCKSL1 Entrez,  Source	MARCKS-like 1	9390	0.033	0.4249	No
42	LIMK2	LIMK2 Entrez,  Source	LIM domain kinase 2	9779	0.028	0.4098	No
43	PRKCE	PRKCE Entrez,  Source	protein kinase C, epsilon	10363	0.022	0.3847	No
44	PAK1	PAK1 Entrez,  Source	p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)	10439	0.022	0.3837	No
45	PLA2G4F	PLA2G4F Entrez,  Source	phospholipase A2, group IVF	10455	0.021	0.3855	No
46	PLD1	PLD1 Entrez,  Source	phospholipase D1, phosphatidylcholine-specific	10498	0.021	0.3860	No
47	CFL1	CFL1 Entrez,  Source	cofilin 1 (non-muscle)	10533	0.021	0.3868	No
48	MAPK1	MAPK1 Entrez,  Source	mitogen-activated protein kinase 1	10802	0.018	0.3762	No
49	SPHK2	SPHK2 Entrez,  Source	sphingosine kinase 2	10913	0.017	0.3730	No
50	PLCG2	PLCG2 Entrez,  Source	phospholipase C, gamma 2 (phosphatidylinositol-specific)	11182	0.015	0.3621	No
51	WASF2	WASF2 Entrez,  Source	WAS protein family, member 2	11299	0.014	0.3581	No
52	WASL	WASL Entrez,  Source	Wiskott-Aldrich syndrome-like	11454	0.012	0.3522	No
53	GSN	GSN Entrez,  Source	gelsolin (amyloidosis, Finnish type)	11592	0.011	0.3470	No
54	ARF6	ARF6 Entrez,  Source	ADP-ribosylation factor 6	11818	0.009	0.3373	No
55	ARPC5	ARPC5 Entrez,  Source	actin related protein 2/3 complex, subunit 5, 16kDa	12183	0.005	0.3207	No
56	CRK	CRK Entrez,  Source	v-crk sarcoma virus CT10 oncogene homolog (avian)	12220	0.005	0.3195	No
57	LAT	LAT Entrez,  Source	linker for activation of T cells	12332	0.004	0.3147	No
58	ASAP3			12440	0.003	0.3100	No
59	PIK3CA	PIK3CA Entrez,  Source	phosphoinositide-3-kinase, catalytic, alpha polypeptide	12460	0.003	0.3094	No
60	ASAP1			12461	0.003	0.3097	No
61	CRKL	CRKL Entrez,  Source	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	12693	0.001	0.2989	No
62	AKT1	AKT1 Entrez,  Source	v-akt murine thymoma viral oncogene homolog 1	12791	0.000	0.2943	No
63	MYO10	MYO10 Entrez,  Source	myosin X	12996	-0.002	0.2848	No
64	ARPC2	ARPC2 Entrez,  Source	actin related protein 2/3 complex, subunit 2, 34kDa	13085	-0.002	0.2809	No
65	DNM2	DNM2 Entrez,  Source	dynamin 2	13109	-0.003	0.2801	No
66	RAC1	RAC1 Entrez,  Source	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	13803	-0.009	0.2482	No
67	WASF3	WASF3 Entrez,  Source	WAS protein family, member 3	13902	-0.010	0.2447	No
68	PIKFYVE			13981	-0.010	0.2422	No
69	ARPC4	ARPC4 Entrez,  Source	actin related protein 2/3 complex, subunit 4, 20kDa	14052	-0.011	0.2402	No
70	PLD2	PLD2 Entrez,  Source	phospholipase D2	14206	-0.012	0.2344	No
71	PIK3R1	PIK3R1 Entrez,  Source	phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)	14429	-0.014	0.2255	No
72	PIK3R3	PIK3R3 Entrez,  Source	phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)	14529	-0.015	0.2225	No
73	PRKCD	PRKCD Entrez,  Source	protein kinase C, delta	14536	-0.015	0.2240	No
74	CDC42	CDC42 Entrez,  Source	cell division cycle 42 (GTP binding protein, 25kDa)	14598	-0.015	0.2229	No
75	ARPC3	ARPC3 Entrez,  Source	actin related protein 2/3 complex, subunit 3, 21kDa	15180	-0.020	0.1977	No
76	RAF1	RAF1 Entrez,  Source	v-raf-1 murine leukemia viral oncogene homolog 1	15362	-0.022	0.1917	No
77	PLCG1	PLCG1 Entrez,  Source	phospholipase C, gamma 1	15449	-0.023	0.1903	No
78	PIP4K2B			15712	-0.025	0.1808	No
79	CFL2	CFL2 Entrez,  Source	cofilin 2 (muscle)	15745	-0.025	0.1823	No
80	AKT2	AKT2 Entrez,  Source	v-akt murine thymoma viral oncogene homolog 2	15825	-0.026	0.1816	No
81	PLA2G6	PLA2G6 Entrez,  Source	phospholipase A2, group VI (cytosolic, calcium-independent)	15873	-0.027	0.1825	No
82	RPS6KB2	RPS6KB2 Entrez,  Source	ribosomal protein S6 kinase, 70kDa, polypeptide 2	16047	-0.028	0.1776	No
83	RPS6KB1	RPS6KB1 Entrez,  Source	ribosomal protein S6 kinase, 70kDa, polypeptide 1	16565	-0.033	0.1570	No
84	PIK3CB	PIK3CB Entrez,  Source	phosphoinositide-3-kinase, catalytic, beta polypeptide	17216	-0.040	0.1308	No
85	PLA2G4B	PLA2G4B Entrez,  Source	phospholipase A2, group IVB (cytosolic)	17666	-0.046	0.1150	No
86	MAPK3	MAPK3 Entrez,  Source	mitogen-activated protein kinase 3	18147	-0.053	0.0985	No
87	ARPC1A	ARPC1A Entrez,  Source	actin related protein 2/3 complex, subunit 1A, 41kDa	18615	-0.062	0.0836	No
88	AKT3	AKT3 Entrez,  Source	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	19056	-0.072	0.0713	No
89	DNM3	DNM3 Entrez,  Source	dynamin 3	21017	-0.236	0.0060	No

Fig 2: KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS: Random ES distribution   
Gene set null distribution of ES for KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS