Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NOV0093_collapsed_to_symbols.NOV0093.cls #obese_versus_normal.NOV0093.cls #obese_versus_normal_repos |
| Phenotype | NOV0093.cls#obese_versus_normal_repos |
| Upregulated in class | 0 |
| GeneSet | MODULE_432 |
| Enrichment Score (ES) | -0.6568101 |
| Normalized Enrichment Score (NES) | -1.9941062 |
| Nominal p-value | 0.002057613 |
| FDR q-value | 0.3479265 |
| FWER p-Value | 0.535 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 7475 | 0.060 | -0.2998 | No |
| 2 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 7788 | 0.055 | -0.2651 | No |
| 3 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 9452 | 0.032 | -0.3150 | No |
| 4 | SQLE | SQLE Entrez, Source | squalene epoxidase | 10695 | 0.019 | -0.3566 | No |
| 5 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 17040 | -0.038 | -0.6225 | Yes |
| 6 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 17116 | -0.039 | -0.5909 | Yes |
| 7 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 17542 | -0.044 | -0.5710 | Yes |
| 8 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 18088 | -0.052 | -0.5497 | Yes |
| 9 | CNBP | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 18090 | -0.052 | -0.5026 | Yes |
| 10 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 18102 | -0.053 | -0.4558 | Yes |
| 11 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 18631 | -0.062 | -0.4248 | Yes |
| 12 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 18742 | -0.065 | -0.3716 | Yes |
| 13 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 20389 | -0.129 | -0.3333 | Yes |
| 14 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 20455 | -0.135 | -0.2152 | Yes |
| 15 | HMGCS2 | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 21090 | -0.275 | 0.0026 | Yes |
