Details for gene set PID_PI3KCI_PATHWAY[GSEA]

Table: GSEA Results Summary

Dataset	NOV0093_collapsed_to_symbols.NOV0093.cls #obese_versus_normal.NOV0093.cls #obese_versus_normal_repos
Phenotype	NOV0093.cls#obese_versus_normal_repos
Upregulated in class	1
GeneSet	PID_PI3KCI_PATHWAY
Enrichment Score (ES)	0.61357117
Normalized Enrichment Score (NES)	2.12354
Nominal p-value	0.0020325202
FDR q-value	0.20192112
FWER p-Value	0.27

Fig 1: Enrichment plot: PID_PI3KCI_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	BTK	BTK Entrez,  Source	Bruton agammaglobulinemia tyrosine kinase	28	0.412	0.0931	Yes
2	HCK	HCK Entrez,  Source	hemopoietic cell kinase	300	0.306	0.1503	Yes
3	PIK3R5	PIK3R5 Entrez,  Source	phosphoinositide-3-kinase, regulatory subunit 5, p101	318	0.302	0.2188	Yes
4	DAPP1	DAPP1 Entrez,  Source	dual adaptor of phosphotyrosine and 3-phosphoinositides	474	0.276	0.2748	Yes
5	BLNK	BLNK Entrez,  Source	B-cell linker	600	0.263	0.3290	Yes
6	PIK3R6			687	0.253	0.3829	Yes
7	PIK3CG	PIK3CG Entrez,  Source	phosphoinositide-3-kinase, catalytic, gamma polypeptide	853	0.238	0.4297	Yes
8	ITK	ITK Entrez,  Source	IL2-inducible T-cell kinase	965	0.231	0.4773	Yes
9	LCK	LCK Entrez,  Source	lymphocyte-specific protein tyrosine kinase	1096	0.222	0.5220	Yes
10	SYK	SYK Entrez,  Source	spleen tyrosine kinase	1640	0.194	0.5407	Yes
11	FGR	FGR Entrez,  Source	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	2034	0.178	0.5628	Yes
12	BLK	BLK Entrez,  Source	B lymphoid tyrosine kinase	2079	0.177	0.6012	Yes
13	PIK3CD	PIK3CD Entrez,  Source	phosphoinositide-3-kinase, catalytic, delta polypeptide	3055	0.148	0.5888	Yes
14	ADAP1			3226	0.143	0.6136	Yes
15	LYN	LYN Entrez,  Source	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	4186	0.120	0.5957	No
16	KRAS	KRAS Entrez,  Source	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	7196	0.064	0.4678	No
17	PLEKHA2	PLEKHA2 Entrez,  Source	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2	8198	0.049	0.4316	No
18	NRAS	NRAS Entrez,  Source	neuroblastoma RAS viral (v-ras) oncogene homolog	8260	0.048	0.4397	No
19	FYN	FYN Entrez,  Source	FYN oncogene related to SRC, FGR, YES	8363	0.046	0.4454	No
20	PLEKHA1	PLEKHA1 Entrez,  Source	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	8398	0.046	0.4544	No
21	INPP5D	INPP5D Entrez,  Source	inositol polyphosphate-5-phosphatase, 145kDa	8454	0.045	0.4621	No
22	HSP90AA1	HSP90AA1 Entrez,  Source	heat shock protein 90kDa alpha (cytosolic), class A member 1	8482	0.045	0.4711	No
23	CYTH1			9158	0.036	0.4473	No
24	SRC	SRC Entrez,  Source	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	9410	0.033	0.4428	No
25	ZAP70	ZAP70 Entrez,  Source	zeta-chain (TCR) associated protein kinase 70kDa	10085	0.025	0.4166	No
26	YES1	YES1 Entrez,  Source	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	11136	0.015	0.3703	No
27	CYTH3			11155	0.015	0.3729	No
28	PLCG2	PLCG2 Entrez,  Source	phospholipase C, gamma 2 (phosphatidylinositol-specific)	11182	0.015	0.3751	No
29	ARF6	ARF6 Entrez,  Source	ADP-ribosylation factor 6	11818	0.009	0.3469	No
30	INPPL1	INPPL1 Entrez,  Source	inositol polyphosphate phosphatase-like 1	11888	0.008	0.3455	No
31	CYTH2			11962	0.007	0.3437	No
32	LAT	LAT Entrez,  Source	linker for activation of T cells	12332	0.004	0.3271	No
33	PIK3CA	PIK3CA Entrez,  Source	phosphoinositide-3-kinase, catalytic, alpha polypeptide	12460	0.003	0.3217	No
34	FOXO3			12759	0.000	0.3076	No
35	RHOA	RHOA Entrez,  Source	ras homolog gene family, member A	13163	-0.003	0.2892	No
36	RAC1	RAC1 Entrez,  Source	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	13803	-0.009	0.2610	No
37	RAP1A	RAP1A Entrez,  Source	RAP1A, member of RAS oncogene family	14406	-0.014	0.2356	No
38	PIK3R1	PIK3R1 Entrez,  Source	phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)	14429	-0.014	0.2378	No
39	PIK3R3	PIK3R3 Entrez,  Source	phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)	14529	-0.015	0.2364	No
40	SGK1			14611	-0.015	0.2361	No
41	ARF1	ARF1 Entrez,  Source	ADP-ribosylation factor 1	14865	-0.018	0.2282	No
42	PLCG1	PLCG1 Entrez,  Source	phospholipase C, gamma 1	15449	-0.023	0.2057	No
43	ARF5	ARF5 Entrez,  Source	ADP-ribosylation factor 5	16001	-0.028	0.1859	No
44	ARAP3			16800	-0.036	0.1563	No
45	PIK3CB	PIK3CB Entrez,  Source	phosphoinositide-3-kinase, catalytic, beta polypeptide	17216	-0.040	0.1458	No
46	PDPK1	PDPK1 Entrez,  Source	3-phosphoinositide dependent protein kinase-1	17787	-0.048	0.1298	No
47	PTEN	PTEN Entrez,  Source	phosphatase and tensin homolog (mutated in multiple advanced cancers 1)	18451	-0.059	0.1118	No
48	HRAS	HRAS Entrez,  Source	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	18923	-0.069	0.1053	No

Fig 2: PID_PI3KCI_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: PID_PI3KCI_PATHWAY: Random ES distribution   
Gene set null distribution of ES for PID_PI3KCI_PATHWAY