Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NOV0093_collapsed_to_symbols.NOV0093.cls #obese_versus_normal.NOV0093.cls #obese_versus_normal_repos |
| Phenotype | NOV0093.cls#obese_versus_normal_repos |
| Upregulated in class | 1 |
| GeneSet | WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 |
| Enrichment Score (ES) | 0.5057975 |
| Normalized Enrichment Score (NES) | 2.0822513 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.18187484 |
| FWER p-Value | 0.354 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CCR1 | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 22 | 0.419 | 0.1508 | Yes |
| 2 | IL18 | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 94 | 0.368 | 0.2806 | Yes |
| 3 | CDH2 | CDH2 Entrez, Source | cadherin 2, type 1, N-cadherin (neuronal) | 227 | 0.321 | 0.3907 | Yes |
| 4 | CDC20 | CDC20 Entrez, Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 601 | 0.262 | 0.4681 | Yes |
| 5 | F2R | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 1773 | 0.188 | 0.4809 | Yes |
| 6 | CDC25A | CDC25A Entrez, Source | cell division cycle 25A | 3360 | 0.140 | 0.4564 | Yes |
| 7 | MYBL2 | MYBL2 Entrez, Source | v-myb myeloblastosis viral oncogene homolog (avian)-like 2 | 3383 | 0.139 | 0.5058 | Yes |
| 8 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 4959 | 0.104 | 0.4688 | No |
| 9 | DDR2 | DDR2 Entrez, Source | discoidin domain receptor family, member 2 | 6833 | 0.070 | 0.4055 | No |
| 10 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 7041 | 0.067 | 0.4200 | No |
| 11 | MARCKSL1 | MARCKSL1 Entrez, Source | MARCKS-like 1 | 9390 | 0.033 | 0.3206 | No |
| 12 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 9658 | 0.030 | 0.3187 | No |
| 13 | SYP | SYP Entrez, Source | synaptophysin | 10092 | 0.025 | 0.3072 | No |
| 14 | NFE2L1 | NFE2L1 Entrez, Source | nuclear factor (erythroid-derived 2)-like 1 | 10279 | 0.023 | 0.3068 | No |
| 15 | FGFR1 | FGFR1 Entrez, Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 10375 | 0.022 | 0.3103 | No |
| 16 | APC | APC Entrez, Source | adenomatosis polyposis coli | 10912 | 0.017 | 0.2911 | No |
| 17 | ARHGDIA | ARHGDIA Entrez, Source | Rho GDP dissociation inhibitor (GDI) alpha | 11781 | 0.009 | 0.2532 | No |
| 18 | NFRKB | NFRKB Entrez, Source | nuclear factor related to kappaB binding protein | 12210 | 0.005 | 0.2347 | No |
| 19 | FECH | FECH Entrez, Source | ferrochelatase (protoporphyria) | 12350 | 0.004 | 0.2295 | No |
| 20 | ITGA7 | ITGA7 Entrez, Source | integrin, alpha 7 | 12564 | 0.002 | 0.2201 | No |
| 21 | TANK | TANK Entrez, Source | TRAF family member-associated NFKB activator | 12591 | 0.002 | 0.2195 | No |
| 22 | PHB | PHB Entrez, Source | prohibitin | 12848 | -0.000 | 0.2075 | No |
| 23 | GNB1 | GNB1 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 12884 | -0.001 | 0.2061 | No |
| 24 | HINT1 | HINT1 Entrez, Source | histidine triad nucleotide binding protein 1 | 13594 | -0.007 | 0.1750 | No |
| 25 | UBE2A | UBE2A Entrez, Source | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 13714 | -0.008 | 0.1722 | No |
| 26 | TJP1 | TJP1 Entrez, Source | tight junction protein 1 (zona occludens 1) | 13857 | -0.009 | 0.1689 | No |
| 27 | TSC2 | TSC2 Entrez, Source | tuberous sclerosis 2 | 13990 | -0.010 | 0.1664 | No |
| 28 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 14073 | -0.011 | 0.1665 | No |
| 29 | CCNT1 | CCNT1 Entrez, Source | cyclin T1 | 15062 | -0.019 | 0.1266 | No |
| 30 | CSNK1G2 | CSNK1G2 Entrez, Source | casein kinase 1, gamma 2 | 15179 | -0.020 | 0.1285 | No |
| 31 | JUN | JUN Entrez, Source | jun oncogene | 16551 | -0.033 | 0.0754 | No |
| 32 | PAIP1 | PAIP1 Entrez, Source | poly(A) binding protein interacting protein 1 | 16974 | -0.037 | 0.0690 | No |
| 33 | GNB2 | GNB2 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 17377 | -0.042 | 0.0652 | No |
| 34 | GTF2B | GTF2B Entrez, Source | general transcription factor IIB | 17438 | -0.043 | 0.0779 | No |
| 35 | ELK1 | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 17714 | -0.047 | 0.0818 | No |
| 36 | CDK9 | CDK9 Entrez, Source | cyclin-dependent kinase 9 (CDC2-related kinase) | 18241 | -0.055 | 0.0767 | No |
| 37 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 19192 | -0.076 | 0.0593 | No |
| 38 | SPRY2 | SPRY2 Entrez, Source | sprouty homolog 2 (Drosophila) | 19633 | -0.091 | 0.0716 | No |
