Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NOV0093_D0_fat_corrected_collapsed_to_symbols.NOV0093.cls #obese_versus_normal.NOV0093.cls #obese_versus_normal_repos |
| Phenotype | NOV0093.cls#obese_versus_normal_repos |
| Upregulated in class | 0 |
| GeneSet | MODULE_432 |
| Enrichment Score (ES) | -0.7344921 |
| Normalized Enrichment Score (NES) | -1.5298887 |
| Nominal p-value | 0.014084507 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.998 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 9994 | 0.032 | -0.1257 | No |
| 2 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 16189 | 0.016 | -0.2093 | No |
| 3 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 19111 | 0.011 | -0.2435 | No |
| 4 | SQLE | SQLE Entrez, Source | squalene epoxidase | 43050 | -0.005 | -0.6529 | No |
| 5 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 47732 | -0.013 | -0.7149 | Yes |
| 6 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 48776 | -0.015 | -0.7103 | Yes |
| 7 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 49242 | -0.016 | -0.6940 | Yes |
| 8 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 50022 | -0.018 | -0.6800 | Yes |
| 9 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 51134 | -0.021 | -0.6669 | Yes |
| 10 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 51186 | -0.021 | -0.6351 | Yes |
| 11 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 51770 | -0.023 | -0.6096 | Yes |
| 12 | CNBP | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 53086 | -0.029 | -0.5884 | Yes |
| 13 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 55813 | -0.052 | -0.5562 | Yes |
| 14 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 56176 | -0.058 | -0.4737 | Yes |
| 15 | HMGCS2 | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 57351 | -0.322 | -0.0000 | Yes |
