Details for gene set GO_G1_DNA_DAMAGE_CHECKPOINT[GSEA]

Table: GSEA Results Summary

Dataset	NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos
Phenotype	NS50719_832.cls#arhinia_versus_control_repos
Upregulated in class	1
GeneSet	GO_G1_DNA_DAMAGE_CHECKPOINT
Enrichment Score (ES)	0.52205116
Normalized Enrichment Score (NES)	1.6956049
Nominal p-value	0.002762431
FDR q-value	0.9237187
FWER p-Value	1.0

Fig 1: Enrichment plot: GO_G1_DNA_DAMAGE_CHECKPOINT   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	TP73	TP73 Entrez,  Source	tumor protein p73	70	0.995	0.1203	Yes
2	CDKN1A	CDKN1A Entrez,  Source	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	127	0.840	0.2219	Yes
3	BTG2	BTG2 Entrez,  Source	BTG family, member 2	300	0.668	0.2957	Yes
4	SFN	SFN Entrez,  Source	stratifin	327	0.649	0.3752	Yes
5	PLK3	PLK3 Entrez,  Source	polo-like kinase 3 (Drosophila)	926	0.419	0.3943	Yes
6	CRADD	CRADD Entrez,  Source	CASP2 and RIPK1 domain containing adaptor with death domain	954	0.411	0.4440	Yes
7	PLAGL1	PLAGL1 Entrez,  Source	pleiomorphic adenoma gene-like 1	1030	0.394	0.4891	Yes
8	RPS27L	RPS27L Entrez,  Source	ribosomal protein S27-like	1934	0.251	0.4703	Yes
9	ZNF385A			1978	0.246	0.4986	Yes
10	BAX	BAX Entrez,  Source	BCL2-associated X protein	2084	0.235	0.5221	Yes
11	MDM2	MDM2 Entrez,  Source	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)	2982	0.159	0.4922	No
12	TRIAP1	TRIAP1 Entrez,  Source	TP53 regulated inhibitor of apoptosis 1	3370	0.138	0.4879	No
13	FBXO31	FBXO31 Entrez,  Source	F-box protein 31	3492	0.130	0.4974	No
14	E2F7	E2F7 Entrez,  Source	E2F transcription factor 7	3574	0.127	0.5088	No
15	CASP2	CASP2 Entrez,  Source	caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)	3829	0.116	0.5092	No
16	PCNA	PCNA Entrez,  Source	proliferating cell nuclear antigen	3939	0.112	0.5171	No
17	GTSE1	GTSE1 Entrez,  Source	G-2 and S-phase expressed 1	4159	0.104	0.5179	No
18	CENPJ	CENPJ Entrez,  Source	centromere protein J	4535	0.091	0.5085	No
19	E2F4	E2F4 Entrez,  Source	E2F transcription factor 4, p107/p130-binding	4804	0.084	0.5041	No
20	RBM38	RBM38 Entrez,  Source	RNA binding motif protein 38	4831	0.083	0.5130	No
21	PML	PML Entrez,  Source	promyelocytic leukemia	5087	0.076	0.5083	No
22	CDK1			5369	0.069	0.5014	No
23	CDK2	CDK2 Entrez,  Source	cyclin-dependent kinase 2	5601	0.063	0.4965	No
24	CCNB1	CCNB1 Entrez,  Source	cyclin B1	5822	0.059	0.4916	No
25	E2F1	E2F1 Entrez,  Source	E2F transcription factor 1	6103	0.054	0.4828	No
26	GIGYF2			6467	0.046	0.4684	No
27	SOX4	SOX4 Entrez,  Source	SRY (sex determining region Y)-box 4	6474	0.046	0.4739	No
28	CNOT6	CNOT6 Entrez,  Source	CCR4-NOT transcription complex, subunit 6	6562	0.045	0.4746	No
29	CNOT8	CNOT8 Entrez,  Source	CCR4-NOT transcription complex, subunit 8	6711	0.042	0.4717	No
30	MDM4	MDM4 Entrez,  Source	Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)	6778	0.041	0.4731	No
31	PRMT1	PRMT1 Entrez,  Source	protein arginine methyltransferase 1	7303	0.032	0.4481	No
32	UBB	UBB Entrez,  Source	ubiquitin B	7813	0.024	0.4229	No
33	RFWD3	RFWD3 Entrez,  Source	ring finger and WD repeat domain 3	7945	0.022	0.4184	No
34	ARID3A	ARID3A Entrez,  Source	AT rich interactive domain 3A (BRIGHT- like)	8549	0.013	0.3866	No
35	CNOT2	CNOT2 Entrez,  Source	CCR4-NOT transcription complex, subunit 2	8652	0.012	0.3825	No
36	CARM1	CARM1 Entrez,  Source	coactivator-associated arginine methyltransferase 1	8662	0.012	0.3835	No
37	TNKS1BP1	TNKS1BP1 Entrez,  Source	tankyrase 1 binding protein 1, 182kDa	8669	0.012	0.3846	No
38	EP300	EP300 Entrez,  Source	E1A binding protein p300	8772	0.010	0.3802	No
39	TFDP2	TFDP2 Entrez,  Source	transcription factor Dp-2 (E2F dimerization partner 2)	8841	0.009	0.3776	No
40	CHEK2	CHEK2 Entrez,  Source	CHK2 checkpoint homolog (S. pombe)	8860	0.009	0.3777	No
41	PRKDC	PRKDC Entrez,  Source	protein kinase, DNA-activated, catalytic polypeptide	8898	0.009	0.3767	No
42	ATM	ATM Entrez,  Source	ataxia telangiectasia mutated (includes complementation groups A, C and D)	9415	0.001	0.3483	No
43	CNOT1	CNOT1 Entrez,  Source	CCR4-NOT transcription complex, subunit 1	9728	-0.003	0.3314	No
44	UBA52	UBA52 Entrez,  Source	ubiquitin A-52 residue ribosomal protein fusion product 1	9732	-0.003	0.3316	No
45	MUC1	MUC1 Entrez,  Source	mucin 1, cell surface associated	9779	-0.004	0.3295	No
46	CNOT3	CNOT3 Entrez,  Source	CCR4-NOT transcription complex, subunit 3	9807	-0.004	0.3285	No
47	CDKN1B	CDKN1B Entrez,  Source	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	9881	-0.006	0.3252	No
48	GADD45A	GADD45A Entrez,  Source	growth arrest and DNA-damage-inducible, alpha	10013	-0.008	0.3189	No
49	NPM1	NPM1 Entrez,  Source	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	10260	-0.012	0.3067	No
50	RPS27A	RPS27A Entrez,  Source	ribosomal protein S27a	10308	-0.013	0.3057	No
51	DGKZ	DGKZ Entrez,  Source	diacylglycerol kinase, zeta 104kDa	10322	-0.013	0.3065	No
52	CNOT7	CNOT7 Entrez,  Source	CCR4-NOT transcription complex, subunit 7	11247	-0.029	0.2589	No
53	CNOT10	CNOT10 Entrez,  Source	CCR4-NOT transcription complex, subunit 10	11331	-0.030	0.2580	No
54	UBC	UBC Entrez,  Source	ubiquitin C	11369	-0.031	0.2598	No
55	AURKA	AURKA Entrez,  Source	aurora kinase A	11631	-0.036	0.2499	No
56	CNOT4	CNOT4 Entrez,  Source	CCR4-NOT transcription complex, subunit 4	11813	-0.040	0.2448	No
57	RBL2	RBL2 Entrez,  Source	retinoblastoma-like 2 (p130)	11833	-0.040	0.2488	No
58	TFDP1	TFDP1 Entrez,  Source	transcription factor Dp-1	11894	-0.042	0.2506	No
59	PPP2R5C	PPP2R5C Entrez,  Source	protein phosphatase 2, regulatory subunit B (B56), gamma isoform	12123	-0.047	0.2439	No
60	WAC	WAC Entrez,  Source	WW domain containing adaptor with coiled-coil	12165	-0.048	0.2476	No
61	CCND1	CCND1 Entrez,  Source	cyclin D1	12190	-0.048	0.2523	No
62	TP53	TP53 Entrez,  Source	tumor protein p53 (Li-Fraumeni syndrome)	12574	-0.058	0.2383	No
63	RPA2	RPA2 Entrez,  Source	replication protein A2, 32kDa	12717	-0.063	0.2383	No
64	CDC25C	CDC25C Entrez,  Source	cell division cycle 25C	13024	-0.073	0.2304	No
65	CNOT6L	CNOT6L Entrez,  Source	CCR4-NOT transcription complex, subunit 6-like	13404	-0.087	0.2202	No
66	PLK2	PLK2 Entrez,  Source	polo-like kinase 2 (Drosophila)	14061	-0.118	0.1985	No
67	PCBP4	PCBP4 Entrez,  Source	poly(rC) binding protein 4	15313	-0.203	0.1545	No

Fig 2: GO_G1_DNA_DAMAGE_CHECKPOINT   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: GO_G1_DNA_DAMAGE_CHECKPOINT: Random ES distribution   
Gene set null distribution of ES for GO_G1_DNA_DAMAGE_CHECKPOINT