Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 1 |
| GeneSet | GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL |
| Enrichment Score (ES) | 0.5510735 |
| Normalized Enrichment Score (NES) | 1.6689416 |
| Nominal p-value | 0.0046838406 |
| FDR q-value | 0.9869995 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SCN4B | SCN4B Entrez, Source | sodium channel, voltage-gated, type IV, beta | 24 | 1.203 | 0.1009 | Yes |
| 2 | MAPK8IP2 | MAPK8IP2 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 2 | 217 | 0.732 | 0.1524 | Yes |
| 3 | HCN2 | HCN2 Entrez, Source | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | 284 | 0.679 | 0.2065 | Yes |
| 4 | SEZ6 | SEZ6 Entrez, Source | seizure related 6 homolog (mouse) | 323 | 0.652 | 0.2598 | Yes |
| 5 | HCN1 | HCN1 Entrez, Source | hyperpolarization activated cyclic nucleotide-gated potassium channel 1 | 413 | 0.592 | 0.3051 | Yes |
| 6 | SCN2B | SCN2B Entrez, Source | sodium channel, voltage-gated, type II, beta | 451 | 0.572 | 0.3516 | Yes |
| 7 | HCN3 | HCN3 Entrez, Source | hyperpolarization activated cyclic nucleotide-gated potassium channel 3 | 541 | 0.533 | 0.3920 | Yes |
| 8 | CX3CL1 | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 628 | 0.502 | 0.4299 | Yes |
| 9 | SCN1A | SCN1A Entrez, Source | sodium channel, voltage-gated, type I, alpha | 734 | 0.470 | 0.4640 | Yes |
| 10 | ADORA1 | ADORA1 Entrez, Source | adenosine A1 receptor | 1126 | 0.372 | 0.4739 | Yes |
| 11 | SLC17A7 | SLC17A7 Entrez, Source | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 | 1130 | 0.371 | 0.5052 | Yes |
| 12 | ADRB2 | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 1189 | 0.356 | 0.5323 | Yes |
| 13 | GRIN2C | GRIN2C Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2C | 1880 | 0.257 | 0.5159 | Yes |
| 14 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 2090 | 0.234 | 0.5242 | Yes |
| 15 | DGKI | DGKI Entrez, Source | diacylglycerol kinase, iota | 2190 | 0.225 | 0.5378 | Yes |
| 16 | NPAS4 | NPAS4 Entrez, Source | neuronal PAS domain protein 4 | 2428 | 0.202 | 0.5418 | Yes |
| 17 | CATSPER4 | CATSPER4 Entrez, Source | cation channel, sperm associated 4 | 2555 | 0.191 | 0.5511 | Yes |
| 18 | SCN3B | SCN3B Entrez, Source | sodium channel, voltage-gated, type III, beta | 3107 | 0.152 | 0.5335 | No |
| 19 | NLGN3 | NLGN3 Entrez, Source | neuroligin 3 | 3212 | 0.146 | 0.5401 | No |
| 20 | DRD4 | DRD4 Entrez, Source | dopamine receptor D4 | 4302 | 0.099 | 0.4882 | No |
| 21 | GRIK5 | GRIK5 Entrez, Source | glutamate receptor, ionotropic, kainate 5 | 4882 | 0.081 | 0.4631 | No |
| 22 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 4904 | 0.081 | 0.4687 | No |
| 23 | SLC29A1 | SLC29A1 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 1 | 5035 | 0.077 | 0.4681 | No |
| 24 | CDK5 | CDK5 Entrez, Source | cyclin-dependent kinase 5 | 6581 | 0.044 | 0.3863 | No |
| 25 | SCN9A | SCN9A Entrez, Source | sodium channel, voltage-gated, type IX, alpha | 7057 | 0.036 | 0.3631 | No |
| 26 | SCN2A | 7260 | 0.033 | 0.3547 | No | ||
| 27 | PKD2 | PKD2 Entrez, Source | polycystic kidney disease 2 (autosomal dominant) | 7646 | 0.027 | 0.3357 | No |
| 28 | SCN1B | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 10023 | -0.008 | 0.2047 | No |
| 29 | GABRB3 | GABRB3 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 10449 | -0.015 | 0.1825 | No |
| 30 | MECP2 | MECP2 Entrez, Source | methyl CpG binding protein 2 (Rett syndrome) | 10492 | -0.015 | 0.1815 | No |
| 31 | MEF2C | MEF2C Entrez, Source | MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) | 10663 | -0.018 | 0.1736 | No |
| 32 | CHRNA4 | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 10675 | -0.018 | 0.1746 | No |
| 33 | PPP3CA | PPP3CA Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) | 10812 | -0.021 | 0.1688 | No |
| 34 | SCN8A | SCN8A Entrez, Source | sodium channel, voltage gated, type VIII, alpha | 12573 | -0.058 | 0.0763 | No |
| 35 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 13014 | -0.073 | 0.0581 | No |
| 36 | GRIN1 | GRIN1 Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 13140 | -0.076 | 0.0576 | No |
| 37 | PPP1R9A | PPP1R9A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 9A | 13143 | -0.077 | 0.0640 | No |
| 38 | HCN4 | HCN4 Entrez, Source | hyperpolarization activated cyclic nucleotide-gated potassium channel 4 | 14378 | -0.136 | 0.0072 | No |
| 39 | RAB3GAP1 | RAB3GAP1 Entrez, Source | RAB3 GTPase activating protein subunit 1 (catalytic) | 14444 | -0.140 | 0.0155 | No |
| 40 | SCN11A | SCN11A Entrez, Source | sodium channel, voltage-gated, type XI, alpha | 16101 | -0.287 | -0.0518 | No |
| 41 | SCN4A | SCN4A Entrez, Source | sodium channel, voltage-gated, type IV, alpha | 16230 | -0.305 | -0.0330 | No |
| 42 | GRIK2 | GRIK2 Entrez, Source | glutamate receptor, ionotropic, kainate 2 | 16251 | -0.309 | -0.0079 | No |
| 43 | GRIN2A | GRIN2A Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 16584 | -0.362 | 0.0045 | No |
| 44 | GRID2 | GRID2 Entrez, Source | glutamate receptor, ionotropic, delta 2 | 17032 | -0.461 | 0.0189 | No |
| 45 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 17079 | -0.472 | 0.0565 | No |
