Details for gene set MACAEVA_PBMC_RESPONSE_TO

Table: GSEA Results Summary

Dataset	NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos
Phenotype	NS50719_832.cls#arhinia_versus_control_repos
Upregulated in class	1
GeneSet	MACAEVA_PBMC_RESPONSE_TO_IR
Enrichment Score (ES)	0.56477505
Normalized Enrichment Score (NES)	1.9362487
Nominal p-value	0.0
FDR q-value	0.11609014
FWER p-Value	0.306

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	FGD3	FGD3 Entrez, Source	FYVE, RhoGEF and PH domain containing 3	84	0.949	0.0510	Yes
2	CDKN1A	CDKN1A Entrez, Source	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	127	0.840	0.0980	Yes
3	POLH	POLH Entrez, Source	polymerase (DNA directed), eta	179	0.768	0.1402	Yes
4	CD70			216	0.737	0.1815	Yes
5	MAMDC4	MAMDC4 Entrez, Source	MAM domain containing 4	367	0.618	0.2094	Yes
6	EDA2R	EDA2R Entrez, Source	ectodysplasin A2 receptor	402	0.597	0.2426	Yes
7	FAS	FAS Entrez, Source	Fas (TNF receptor superfamily, member 6)	533	0.537	0.2668	Yes
8	ZMAT3	ZMAT3 Entrez, Source	zinc finger, matrin type 3	814	0.447	0.2775	Yes
9	ACTA2	ACTA2 Entrez, Source	actin, alpha 2, smooth muscle, aorta	853	0.437	0.3010	Yes
10	TP53INP1	TP53INP1 Entrez, Source	tumor protein p53 inducible nuclear protein 1	855	0.437	0.3266	Yes
11	SPATA18	SPATA18 Entrez, Source	spermatogenesis associated 18 homolog (rat)	897	0.425	0.3493	Yes
12	TRIM22	TRIM22 Entrez, Source	tripartite motif-containing 22	1028	0.394	0.3652	Yes
13	SESN1	SESN1 Entrez, Source	sestrin 1	1131	0.371	0.3813	Yes
14	PAPPA	PAPPA Entrez, Source	pregnancy-associated plasma protein A, pappalysin 1	1194	0.355	0.3987	Yes
15	TNFRSF10D	TNFRSF10D Entrez, Source	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	1506	0.303	0.3993	Yes
16	ZNF79	ZNF79 Entrez, Source	zinc finger protein 79	1766	0.269	0.4006	Yes
17	BBC3	BBC3 Entrez, Source	BCL2 binding component 3	1818	0.264	0.4133	Yes
18	RAP2B	RAP2B Entrez, Source	RAP2B, member of RAS oncogene family	1886	0.256	0.4246	Yes
19	IKBIP			1916	0.253	0.4378	Yes
20	RPS27L	RPS27L Entrez, Source	ribosomal protein S27-like	1934	0.251	0.4516	Yes
21	FDXR	FDXR Entrez, Source	ferredoxin reductase	1937	0.250	0.4661	Yes
22	TNFSF4	TNFSF4 Entrez, Source	tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)	2064	0.237	0.4731	Yes
23	DDB2	DDB2 Entrez, Source	damage-specific DNA binding protein 2, 48kDa	2079	0.235	0.4861	Yes
24	BAX	BAX Entrez, Source	BCL2-associated X protein	2084	0.235	0.4996	Yes
25	BRMS1L	BRMS1L Entrez, Source	breast cancer metastasis-suppressor 1-like	2085	0.235	0.5134	Yes
26	ACER2			2108	0.232	0.5258	Yes
27	TMEM68	TMEM68 Entrez, Source	transmembrane protein 68	2347	0.209	0.5249	Yes
28	DCP1B	DCP1B Entrez, Source	DCP1 decapping enzyme homolog B (S. cerevisiae)	2372	0.207	0.5357	Yes
29	SLC7A6	SLC7A6 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6	2531	0.193	0.5382	Yes
30	TNFRSF10B	TNFRSF10B Entrez, Source	tumor necrosis factor receptor superfamily, member 10b	2651	0.183	0.5424	Yes
31	XPC	XPC Entrez, Source	xeroderma pigmentosum, complementation group C	2729	0.178	0.5485	Yes
32	RETSAT	RETSAT Entrez, Source	retinol saturase (all-trans-retinol 13,14-reductase)	2880	0.166	0.5499	Yes
33	MDM2	MDM2 Entrez, Source	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)	2982	0.159	0.5537	Yes
34	RINL			3295	0.141	0.5446	Yes
35	PANK1	PANK1 Entrez, Source	pantothenate kinase 1	3344	0.139	0.5501	Yes
36	TRIAP1	TRIAP1 Entrez, Source	TP53 regulated inhibitor of apoptosis 1	3370	0.138	0.5568	Yes
37	E2F7	E2F7 Entrez, Source	E2F transcription factor 7	3574	0.127	0.5530	Yes
38	RRM2B	RRM2B Entrez, Source	ribonucleotide reductase M2 B (TP53 inducible)	3596	0.126	0.5593	Yes
39	PPM1D	PPM1D Entrez, Source	protein phosphatase 1D magnesium-dependent, delta isoform	3630	0.125	0.5648	Yes
40	PCNA	PCNA Entrez, Source	proliferating cell nuclear antigen	3939	0.112	0.5542	No
41	FBXO22	FBXO22 Entrez, Source	F-box protein 22	4007	0.109	0.5569	No
42	LIG1	LIG1 Entrez, Source	ligase I, DNA, ATP-dependent	4238	0.101	0.5501	No
43	AEN			4305	0.099	0.5522	No
44	PHPT1	PHPT1 Entrez, Source	phosphohistidine phosphatase 1	4375	0.097	0.5541	No
45	SOCS4	SOCS4 Entrez, Source	suppressor of cytokine signaling 4	4558	0.091	0.5493	No
46	EI24	EI24 Entrez, Source	etoposide induced 2.4 mRNA	4605	0.089	0.5520	No
47	CCNG1	CCNG1 Entrez, Source	cyclin G1	4643	0.088	0.5551	No
48	TRIM32	TRIM32 Entrez, Source	tripartite motif-containing 32	4774	0.085	0.5528	No
49	CMBL	CMBL Entrez, Source	carboxymethylenebutenolidase homolog (Pseudomonas)	4892	0.081	0.5511	No
50	TM7SF3	TM7SF3 Entrez, Source	transmembrane 7 superfamily member 3	5001	0.078	0.5497	No
51	CCDC90B			5079	0.076	0.5499	No
52	TMEM30A	TMEM30A Entrez, Source	transmembrane protein 30A	5420	0.068	0.5350	No
53	ISCU			5487	0.066	0.5352	No
54	HECTD3	HECTD3 Entrez, Source	HECT domain containing 3	5558	0.064	0.5351	No
55	DNER	DNER Entrez, Source	-	5747	0.061	0.5282	No
56	PCNP	PCNP Entrez, Source	PEST proteolytic signal containing nuclear protein	5765	0.060	0.5308	No
57	APOBEC3C	APOBEC3C Entrez, Source	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C	5767	0.060	0.5343	No
58	ASTN2	ASTN2 Entrez, Source	astrotactin 2	5936	0.057	0.5283	No
59	ASCC3	ASCC3 Entrez, Source	activating signal cointegrator 1 complex subunit 3	6221	0.051	0.5155	No
60	TMEM131	TMEM131 Entrez, Source	transmembrane protein 131	6296	0.050	0.5143	No
61	PTP4A1	PTP4A1 Entrez, Source	protein tyrosine phosphatase type IVA, member 1	6557	0.045	0.5025	No
62	AMZ2	AMZ2 Entrez, Source	-	6870	0.040	0.4875	No
63	NSD1	NSD1 Entrez, Source	nuclear receptor binding SET domain protein 1	7530	0.028	0.4526	No
64	APOBEC3H			8346	0.016	0.4084	No
65	MAP4K4	MAP4K4 Entrez, Source	mitogen-activated protein kinase kinase kinase kinase 4	8699	0.011	0.3895	No
66	CPSF3	CPSF3 Entrez, Source	cleavage and polyadenylation specific factor 3, 73kDa	9145	0.005	0.3650	No
67	GADD45A	GADD45A Entrez, Source	growth arrest and DNA-damage-inducible, alpha	10013	-0.008	0.3174	No
68	POLR2A	POLR2A Entrez, Source	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	10365	-0.014	0.2987	No
69	ARHGEF3	ARHGEF3 Entrez, Source	Rho guanine nucleotide exchange factor (GEF) 3	10587	-0.017	0.2874	No
70	BLOC1S2	BLOC1S2 Entrez, Source	biogenesis of lysosome-related organelles complex-1, subunit 2	11191	-0.028	0.2556	No
71	GLS2	GLS2 Entrez, Source	glutaminase 2 (liver, mitochondrial)	11380	-0.031	0.2470	No
72	CDS2	CDS2 Entrez, Source	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	11433	-0.032	0.2460	No
73	PTGER1	PTGER1 Entrez, Source	prostaglandin E receptor 1 (subtype EP1), 42kDa	11787	-0.039	0.2287	No
74	ITPR2	ITPR2 Entrez, Source	inositol 1,4,5-triphosphate receptor, type 2	11889	-0.042	0.2255	No
75	NSF	NSF Entrez, Source	N-ethylmaleimide-sensitive factor	12928	-0.070	0.1720	No
76	ANXA4	ANXA4 Entrez, Source	annexin A4	12952	-0.070	0.1748	No
77	PRKAB1	PRKAB1 Entrez, Source	protein kinase, AMP-activated, beta 1 non-catalytic subunit	13299	-0.082	0.1605	No
78	METTL7A	METTL7A Entrez, Source	methyltransferase like 7A	13516	-0.092	0.1538	No
79	REV3L	REV3L Entrez, Source	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	13586	-0.094	0.1555	No
80	ANKRA2	ANKRA2 Entrez, Source	ankyrin repeat, family A (RFXANK-like), 2	13666	-0.098	0.1569	No
81	PLK2	PLK2 Entrez, Source	polo-like kinase 2 (Drosophila)	14061	-0.118	0.1419	No
82	ZNF337	ZNF337 Entrez, Source	zinc finger protein 337	14142	-0.122	0.1447	No
83	DENND2D	DENND2D Entrez, Source	DENN/MADD domain containing 2D	17489	-0.613	-0.0051	No
84	HIST1H3E	HIST1H3E Entrez, Source	histone cluster 1, H3e	17595	-0.663	0.0280	No