Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_AMYLOIDS |
| Enrichment Score (ES) | -0.7157608 |
| Normalized Enrichment Score (NES) | -1.9334958 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.060881335 |
| FWER p-Value | 0.16 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 664 | 0.491 | -0.0044 | No |
| 2 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 914 | 0.421 | 0.0095 | No |
| 3 | LTF | LTF Entrez, Source | lactotransferrin | 1567 | 0.295 | -0.0072 | No |
| 4 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 2090 | 0.234 | -0.0207 | No |
| 5 | HSPG2 | HSPG2 Entrez, Source | heparan sulfate proteoglycan 2 (perlecan) | 3565 | 0.127 | -0.0939 | No |
| 6 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 3841 | 0.116 | -0.1015 | No |
| 7 | CST3 | CST3 Entrez, Source | cystatin C (amyloid angiopathy and cerebral hemorrhage) | 4198 | 0.103 | -0.1145 | No |
| 8 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 8010 | 0.021 | -0.3241 | No |
| 9 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 8075 | 0.020 | -0.3263 | No |
| 10 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 8163 | 0.019 | -0.3299 | No |
| 11 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 8170 | 0.019 | -0.3290 | No |
| 12 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 8507 | 0.014 | -0.3466 | No |
| 13 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 9219 | 0.004 | -0.3858 | No |
| 14 | ITM2B | ITM2B Entrez, Source | integral membrane protein 2B | 9941 | -0.006 | -0.4253 | No |
| 15 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 9986 | -0.007 | -0.4272 | No |
| 16 | B2M | B2M Entrez, Source | beta-2-microglobulin | 10018 | -0.008 | -0.4284 | No |
| 17 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 10656 | -0.018 | -0.4625 | No |
| 18 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 12125 | -0.047 | -0.5407 | No |
| 19 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 13597 | -0.094 | -0.6159 | No |
| 20 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 13611 | -0.095 | -0.6103 | No |
| 21 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 14163 | -0.124 | -0.6327 | No |
| 22 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 15373 | -0.209 | -0.6859 | No |
| 23 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 15812 | -0.254 | -0.6934 | No |
| 24 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 16216 | -0.303 | -0.6958 | Yes |
| 25 | SEMG1 | SEMG1 Entrez, Source | semenogelin I | 16249 | -0.309 | -0.6773 | Yes |
| 26 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 16754 | -0.396 | -0.6791 | Yes |
| 27 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 16826 | -0.413 | -0.6558 | Yes |
| 28 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 16932 | -0.436 | -0.6329 | Yes |
| 29 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 17595 | -0.663 | -0.6259 | Yes |
| 30 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 17773 | -0.774 | -0.5848 | Yes |
| 31 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 17882 | -0.890 | -0.5321 | Yes |
| 32 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 17884 | -0.892 | -0.4735 | Yes |
| 33 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 17977 | -1.021 | -0.4113 | Yes |
| 34 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18007 | -1.109 | -0.3399 | Yes |
| 35 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 18024 | -1.161 | -0.2644 | Yes |
| 36 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 18062 | -1.272 | -0.1827 | Yes |
| 37 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 18071 | -1.326 | -0.0958 | Yes |
| 38 | CALCA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 18084 | -1.478 | 0.0008 | Yes |
