Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS |
| Enrichment Score (ES) | -0.6068633 |
| Normalized Enrichment Score (NES) | -1.8491095 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.06721232 |
| FWER p-Value | 0.646 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SSTR3 | SSTR3 Entrez, Source | somatostatin receptor 3 | 1 | 1.744 | 0.0631 | No |
| 2 | TAC3 | TAC3 Entrez, Source | tachykinin 3 (neuromedin K, neurokinin beta) | 116 | 0.864 | 0.0880 | No |
| 3 | CX3CL1 | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 628 | 0.502 | 0.0778 | No |
| 4 | EDN3 | EDN3 Entrez, Source | endothelin 3 | 714 | 0.474 | 0.0903 | No |
| 5 | C3 | C3 Entrez, Source | complement component 3 | 766 | 0.463 | 0.1042 | No |
| 6 | NPBWR1 | NPBWR1 Entrez, Source | neuropeptides B/W receptor 1 | 1097 | 0.379 | 0.0996 | No |
| 7 | CXCR4 | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 1173 | 0.361 | 0.1085 | No |
| 8 | GALR3 | GALR3 Entrez, Source | galanin receptor 3 | 1723 | 0.275 | 0.0880 | No |
| 9 | PDYN | PDYN Entrez, Source | prodynorphin | 1778 | 0.267 | 0.0947 | No |
| 10 | OPRD1 | OPRD1 Entrez, Source | opioid receptor, delta 1 | 2558 | 0.191 | 0.0584 | No |
| 11 | NTSR1 | NTSR1 Entrez, Source | neurotensin receptor 1 (high affinity) | 2997 | 0.158 | 0.0399 | No |
| 12 | HEBP1 | HEBP1 Entrez, Source | heme binding protein 1 | 3623 | 0.125 | 0.0097 | No |
| 13 | PYY | PYY Entrez, Source | peptide YY | 3639 | 0.125 | 0.0134 | No |
| 14 | F2R | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 3690 | 0.122 | 0.0151 | No |
| 15 | CXCL16 | CXCL16 Entrez, Source | chemokine (C-X-C motif) ligand 16 | 4763 | 0.085 | -0.0413 | No |
| 16 | AVPR1A | AVPR1A Entrez, Source | arginine vasopressin receptor 1A | 5150 | 0.074 | -0.0600 | No |
| 17 | OXTR | OXTR Entrez, Source | oxytocin receptor | 5347 | 0.070 | -0.0684 | No |
| 18 | SSTR2 | SSTR2 Entrez, Source | somatostatin receptor 2 | 5667 | 0.062 | -0.0838 | No |
| 19 | MC1R | MC1R Entrez, Source | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 6244 | 0.050 | -0.1139 | No |
| 20 | EDNRB | EDNRB Entrez, Source | endothelin receptor type B | 8489 | 0.014 | -0.2379 | No |
| 21 | F2RL1 | F2RL1 Entrez, Source | coagulation factor II (thrombin) receptor-like 1 | 9620 | -0.002 | -0.3005 | No |
| 22 | PENK | PENK Entrez, Source | proenkephalin | 9966 | -0.007 | -0.3194 | No |
| 23 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 10656 | -0.018 | -0.3569 | No |
| 24 | NPW | NPW Entrez, Source | neuropeptide W | 10996 | -0.024 | -0.3749 | No |
| 25 | NMB | NMB Entrez, Source | neuromedin B | 11055 | -0.025 | -0.3772 | No |
| 26 | CXCL12 | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 12554 | -0.058 | -0.4582 | No |
| 27 | SSTR1 | SSTR1 Entrez, Source | somatostatin receptor 1 | 12849 | -0.067 | -0.4720 | No |
| 28 | CCR10 | CCR10 Entrez, Source | chemokine (C-C motif) receptor 10 | 13107 | -0.075 | -0.4836 | No |
| 29 | POMC | POMC Entrez, Source | proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) | 13739 | -0.101 | -0.5149 | No |
| 30 | C5 | C5 Entrez, Source | complement component 5 | 14095 | -0.120 | -0.5303 | No |
| 31 | NPY | NPY Entrez, Source | neuropeptide Y | 14616 | -0.150 | -0.5537 | No |
| 32 | CCKBR | CCKBR Entrez, Source | cholecystokinin B receptor | 14978 | -0.176 | -0.5673 | No |
| 33 | EDN1 | EDN1 Entrez, Source | endothelin 1 | 15301 | -0.202 | -0.5779 | No |
| 34 | NPY1R | NPY1R Entrez, Source | neuropeptide Y receptor Y1 | 15585 | -0.227 | -0.5854 | No |
| 35 | CXCR6 | CXCR6 Entrez, Source | chemokine (C-X-C motif) receptor 6 | 15870 | -0.260 | -0.5917 | No |
| 36 | OPRL1 | OPRL1 Entrez, Source | opiate receptor-like 1 | 15887 | -0.262 | -0.5831 | No |
| 37 | QRFPR | 16316 | -0.318 | -0.5954 | Yes | ||
| 38 | TACR1 | TACR1 Entrez, Source | tachykinin receptor 1 | 16339 | -0.321 | -0.5850 | Yes |
| 39 | RLN2 | RLN2 Entrez, Source | relaxin 2 | 16340 | -0.321 | -0.5733 | Yes |
| 40 | GRPR | GRPR Entrez, Source | gastrin-releasing peptide receptor | 16484 | -0.346 | -0.5687 | Yes |
| 41 | EDNRA | EDNRA Entrez, Source | endothelin receptor type A | 16521 | -0.350 | -0.5581 | Yes |
| 42 | KISS1R | KISS1R Entrez, Source | KISS1 receptor | 16587 | -0.363 | -0.5485 | Yes |
| 43 | PROKR1 | PROKR1 Entrez, Source | prokineticin receptor 1 | 16629 | -0.372 | -0.5373 | Yes |
| 44 | MCHR1 | MCHR1 Entrez, Source | melanin-concentrating hormone receptor 1 | 16666 | -0.379 | -0.5256 | Yes |
| 45 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 16710 | -0.388 | -0.5140 | Yes |
| 46 | PROKR2 | PROKR2 Entrez, Source | prokineticin receptor 2 | 16868 | -0.423 | -0.5074 | Yes |
| 47 | GALR2 | GALR2 Entrez, Source | galanin receptor 2 | 16943 | -0.440 | -0.4956 | Yes |
| 48 | CXCL6 | CXCL6 Entrez, Source | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 17015 | -0.455 | -0.4830 | Yes |
| 49 | TACR3 | TACR3 Entrez, Source | tachykinin receptor 3 | 17044 | -0.463 | -0.4678 | Yes |
| 50 | NMU | NMU Entrez, Source | neuromedin U | 17045 | -0.463 | -0.4511 | Yes |
| 51 | GAL | GAL Entrez, Source | galanin | 17080 | -0.472 | -0.4359 | Yes |
| 52 | OPRK1 | OPRK1 Entrez, Source | opioid receptor, kappa 1 | 17091 | -0.475 | -0.4193 | Yes |
| 53 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 17205 | -0.507 | -0.4072 | Yes |
| 54 | AVPR1B | AVPR1B Entrez, Source | arginine vasopressin receptor 1B | 17234 | -0.514 | -0.3902 | Yes |
| 55 | BDKRB2 | BDKRB2 Entrez, Source | bradykinin receptor B2 | 17240 | -0.516 | -0.3718 | Yes |
| 56 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 17285 | -0.531 | -0.3550 | Yes |
| 57 | CXCR2 | 17363 | -0.559 | -0.3390 | Yes | ||
| 58 | CXCL5 | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 17403 | -0.575 | -0.3204 | Yes |
| 59 | NMUR1 | NMUR1 Entrez, Source | neuromedin U receptor 1 | 17404 | -0.575 | -0.2996 | Yes |
| 60 | CCK | CCK Entrez, Source | cholecystokinin | 17451 | -0.595 | -0.2806 | Yes |
| 61 | NPFFR2 | NPFFR2 Entrez, Source | neuropeptide FF receptor 2 | 17809 | -0.809 | -0.2712 | Yes |
| 62 | GALR1 | GALR1 Entrez, Source | galanin receptor 1 | 17861 | -0.856 | -0.2430 | Yes |
| 63 | CXCL3 | CXCL3 Entrez, Source | chemokine (C-X-C motif) ligand 3 | 17881 | -0.889 | -0.2119 | Yes |
| 64 | NPY5R | NPY5R Entrez, Source | neuropeptide Y receptor Y5 | 17925 | -0.945 | -0.1801 | Yes |
| 65 | NTS | NTS Entrez, Source | neurotensin | 17929 | -0.947 | -0.1460 | Yes |
| 66 | TAC1 | TAC1 Entrez, Source | tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) | 17960 | -0.998 | -0.1116 | Yes |
| 67 | NPY2R | NPY2R Entrez, Source | neuropeptide Y receptor Y2 | 17986 | -1.044 | -0.0752 | Yes |
| 68 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 18003 | -1.099 | -0.0363 | Yes |
| 69 | CCL28 | CCL28 Entrez, Source | chemokine (C-C motif) ligand 28 | 18021 | -1.148 | 0.0043 | Yes |
