Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_RNA_POL_I_TRANSCRIPTION |
| Enrichment Score (ES) | -0.672966 |
| Normalized Enrichment Score (NES) | -1.9411463 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.077978924 |
| FWER p-Value | 0.138 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 664 | 0.491 | -0.0034 | No |
| 2 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 914 | 0.421 | 0.0113 | No |
| 3 | GTF2H4 | GTF2H4 Entrez, Source | general transcription factor IIH, polypeptide 4, 52kDa | 2687 | 0.181 | -0.0746 | No |
| 4 | GTF2H2 | GTF2H2 Entrez, Source | general transcription factor IIH, polypeptide 2, 44kDa | 2946 | 0.161 | -0.0779 | No |
| 5 | TAF1C | TAF1C Entrez, Source | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa | 3833 | 0.116 | -0.1191 | No |
| 6 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 3841 | 0.116 | -0.1117 | No |
| 7 | POLR2H | POLR2H Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide H | 4841 | 0.082 | -0.1614 | No |
| 8 | EHMT2 | EHMT2 Entrez, Source | euchromatic histone-lysine N-methyltransferase 2 | 5971 | 0.056 | -0.2202 | No |
| 9 | POLR1B | POLR1B Entrez, Source | polymerase (RNA) I polypeptide B, 128kDa | 6118 | 0.053 | -0.2246 | No |
| 10 | UBTF | UBTF Entrez, Source | upstream binding transcription factor, RNA polymerase I | 6205 | 0.051 | -0.2259 | No |
| 11 | ERCC3 | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 6246 | 0.050 | -0.2247 | No |
| 12 | CBX3 | CBX3 Entrez, Source | chromobox homolog 3 (HP1 gamma homolog, Drosophila) | 6525 | 0.045 | -0.2371 | No |
| 13 | POLR2K | POLR2K Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 6939 | 0.038 | -0.2573 | No |
| 14 | POLR1C | POLR1C Entrez, Source | polymerase (RNA) I polypeptide C, 30kDa | 7846 | 0.024 | -0.3059 | No |
| 15 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 8010 | 0.021 | -0.3135 | No |
| 16 | TAF1A | TAF1A Entrez, Source | TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa | 8078 | 0.020 | -0.3158 | No |
| 17 | POLR1D | POLR1D Entrez, Source | polymerase (RNA) I polypeptide D, 16kDa | 8455 | 0.015 | -0.3357 | No |
| 18 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 8507 | 0.014 | -0.3376 | No |
| 19 | MBD2 | MBD2 Entrez, Source | methyl-CpG binding domain protein 2 | 8694 | 0.011 | -0.3471 | No |
| 20 | POLR1A | POLR1A Entrez, Source | polymerase (RNA) I polypeptide A, 194kDa | 9052 | 0.006 | -0.3664 | No |
| 21 | ERCC2 | ERCC2 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) | 9119 | 0.005 | -0.3698 | No |
| 22 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 9219 | 0.004 | -0.3750 | No |
| 23 | RRN3 | RRN3 Entrez, Source | RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) | 9865 | -0.005 | -0.4104 | No |
| 24 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 9986 | -0.007 | -0.4166 | No |
| 25 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 10169 | -0.010 | -0.4259 | No |
| 26 | GTF2H1 | GTF2H1 Entrez, Source | general transcription factor IIH, polypeptide 1, 62kDa | 10201 | -0.011 | -0.4269 | No |
| 27 | CCNH | CCNH Entrez, Source | cyclin H | 11048 | -0.025 | -0.4721 | No |
| 28 | KAT2B | 11514 | -0.034 | -0.4956 | No | ||
| 29 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 12125 | -0.047 | -0.5262 | No |
| 30 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 13096 | -0.075 | -0.5749 | No |
| 31 | ERCC6 | ERCC6 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 6 | 13331 | -0.083 | -0.5822 | No |
| 32 | GTF2H3 | GTF2H3 Entrez, Source | general transcription factor IIH, polypeptide 3, 34kDa | 13396 | -0.086 | -0.5799 | No |
| 33 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 13597 | -0.094 | -0.5845 | No |
| 34 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 13611 | -0.095 | -0.5788 | No |
| 35 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 14163 | -0.124 | -0.6009 | No |
| 36 | MNAT1 | MNAT1 Entrez, Source | menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) | 14438 | -0.139 | -0.6066 | No |
| 37 | TAF1B | TAF1B Entrez, Source | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | 14516 | -0.144 | -0.6011 | No |
| 38 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 15373 | -0.209 | -0.6344 | No |
| 39 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 15812 | -0.254 | -0.6414 | No |
| 40 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 16216 | -0.303 | -0.6432 | No |
| 41 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 16754 | -0.396 | -0.6461 | Yes |
| 42 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 16826 | -0.413 | -0.6220 | Yes |
| 43 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 16932 | -0.436 | -0.5982 | Yes |
| 44 | GTF2H2B | 17549 | -0.646 | -0.5884 | Yes | ||
| 45 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 17595 | -0.663 | -0.5459 | Yes |
| 46 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 17773 | -0.774 | -0.5032 | Yes |
| 47 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 17882 | -0.890 | -0.4487 | Yes |
| 48 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 17884 | -0.892 | -0.3882 | Yes |
| 49 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 17977 | -1.021 | -0.3240 | Yes |
| 50 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18007 | -1.109 | -0.2503 | Yes |
| 51 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 18024 | -1.161 | -0.1723 | Yes |
| 52 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 18062 | -1.272 | -0.0880 | Yes |
| 53 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 18071 | -1.326 | 0.0016 | Yes |
