Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_corrected2_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 1 |
| GeneSet | GNF2_HPN |
| Enrichment Score (ES) | 0.5651021 |
| Normalized Enrichment Score (NES) | 1.4627788 |
| Nominal p-value | 0.004484305 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GSTM1 | GSTM1 Entrez, Source | glutathione S-transferase M1 | 0 | 5.000 | 0.1181 | Yes |
| 2 | F10 | F10 Entrez, Source | coagulation factor X | 14 | 3.683 | 0.2045 | Yes |
| 3 | CYP2C8 | CYP2C8 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 8 | 124 | 2.597 | 0.2603 | Yes |
| 4 | FTCD | FTCD Entrez, Source | formiminotransferase cyclodeaminase | 194 | 2.303 | 0.3112 | Yes |
| 5 | SLC22A7 | SLC22A7 Entrez, Source | solute carrier family 22 (organic anion transporter), member 7 | 247 | 2.157 | 0.3596 | Yes |
| 6 | HGFAC | HGFAC Entrez, Source | HGF activator | 636 | 1.618 | 0.3781 | Yes |
| 7 | SERPINF2 | SERPINF2 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 734 | 1.520 | 0.4091 | Yes |
| 8 | CYP2D6 | CYP2D6 Entrez, Source | cytochrome P450, family 2, subfamily D, polypeptide 6 | 1154 | 1.261 | 0.4177 | Yes |
| 9 | F12 | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 1211 | 1.232 | 0.4439 | Yes |
| 10 | ALDH1L1 | ALDH1L1 Entrez, Source | aldehyde dehydrogenase 1 family, member L1 | 1326 | 1.180 | 0.4660 | Yes |
| 11 | CES1 | CES1 Entrez, Source | carboxylesterase 1 (monocyte/macrophage serine esterase 1) | 1358 | 1.165 | 0.4920 | Yes |
| 12 | ABCC6 | ABCC6 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 6 | 2123 | 0.890 | 0.4743 | Yes |
| 13 | MASP2 | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 2176 | 0.875 | 0.4923 | Yes |
| 14 | CYP27A1 | CYP27A1 Entrez, Source | cytochrome P450, family 27, subfamily A, polypeptide 1 | 2191 | 0.871 | 0.5122 | Yes |
| 15 | MAT1A | MAT1A Entrez, Source | methionine adenosyltransferase I, alpha | 2414 | 0.812 | 0.5201 | Yes |
| 16 | SARDH | SARDH Entrez, Source | sarcosine dehydrogenase | 2433 | 0.807 | 0.5383 | Yes |
| 17 | AKR7A3 | AKR7A3 Entrez, Source | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | 2471 | 0.794 | 0.5551 | Yes |
| 18 | GSTM2 | GSTM2 Entrez, Source | glutathione S-transferase M2 (muscle) | 2685 | 0.733 | 0.5616 | Yes |
| 19 | HPN | HPN Entrez, Source | hepsin (transmembrane protease, serine 1) | 3059 | 0.642 | 0.5579 | Yes |
| 20 | LCAT | LCAT Entrez, Source | lecithin-cholesterol acyltransferase | 3414 | 0.571 | 0.5535 | Yes |
| 21 | HPX | HPX Entrez, Source | hemopexin | 3534 | 0.546 | 0.5603 | Yes |
| 22 | RDH16 | RDH16 Entrez, Source | retinol dehydrogenase 16 (all-trans) | 3940 | 0.469 | 0.5509 | Yes |
| 23 | ORM1 | ORM1 Entrez, Source | orosomucoid 1 | 4004 | 0.459 | 0.5585 | Yes |
| 24 | SLC38A3 | SLC38A3 Entrez, Source | solute carrier family 38, member 3 | 4136 | 0.442 | 0.5623 | Yes |
| 25 | TMPRSS6 | TMPRSS6 Entrez, Source | transmembrane protease, serine 6 | 4433 | 0.395 | 0.5567 | Yes |
| 26 | GNMT | GNMT Entrez, Source | glycine N-methyltransferase | 4607 | 0.372 | 0.5567 | Yes |
| 27 | CES2 | CES2 Entrez, Source | carboxylesterase 2 (intestine, liver) | 4635 | 0.369 | 0.5641 | Yes |
| 28 | ORM2 | ORM2 Entrez, Source | orosomucoid 2 | 4856 | 0.344 | 0.5610 | Yes |
| 29 | SLC25A10 | SLC25A10 Entrez, Source | solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 | 4933 | 0.336 | 0.5651 | Yes |
| 30 | HMGCL | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 5356 | 0.288 | 0.5505 | No |
| 31 | ZGPAT | ZGPAT Entrez, Source | zinc finger, CCCH-type with G patch domain | 6145 | 0.221 | 0.5158 | No |
| 32 | TST | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 6220 | 0.217 | 0.5172 | No |
| 33 | TMEM176B | TMEM176B Entrez, Source | transmembrane protein 176B | 6375 | 0.206 | 0.5142 | No |
| 34 | RARRES2 | RARRES2 Entrez, Source | retinoic acid receptor responder (tazarotene induced) 2 | 6824 | 0.176 | 0.4957 | No |
| 35 | SLC27A5 | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 7521 | 0.140 | 0.4637 | No |
| 36 | HAAO | HAAO Entrez, Source | 3-hydroxyanthranilate 3,4-dioxygenase | 8438 | 0.101 | 0.4197 | No |
| 37 | PIPOX | PIPOX Entrez, Source | pipecolic acid oxidase | 8519 | 0.097 | 0.4179 | No |
| 38 | HPD | HPD Entrez, Source | 4-hydroxyphenylpyruvate dioxygenase | 9001 | 0.080 | 0.3954 | No |
| 39 | ALDH4A1 | ALDH4A1 Entrez, Source | aldehyde dehydrogenase 4 family, member A1 | 9385 | 0.068 | 0.3776 | No |
| 40 | ANG | ANG Entrez, Source | angiogenin, ribonuclease, RNase A family, 5 | 9674 | 0.060 | 0.3644 | No |
| 41 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 9817 | 0.056 | 0.3586 | No |
| 42 | RBP4 | RBP4 Entrez, Source | retinol binding protein 4, plasma | 10749 | 0.030 | 0.3121 | No |
| 43 | PROC | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 10820 | 0.028 | 0.3092 | No |
| 44 | DCXR | DCXR Entrez, Source | dicarbonyl/L-xylulose reductase | 10959 | 0.024 | 0.3028 | No |
| 45 | ASL | ASL Entrez, Source | argininosuccinate lyase | 10960 | 0.024 | 0.3034 | No |
| 46 | QPRT | QPRT Entrez, Source | quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) | 11414 | 0.012 | 0.2807 | No |
| 47 | SHMT1 | SHMT1 Entrez, Source | serine hydroxymethyltransferase 1 (soluble) | 11541 | 0.009 | 0.2745 | No |
| 48 | PEMT | PEMT Entrez, Source | phosphatidylethanolamine N-methyltransferase | 11809 | 0.003 | 0.2611 | No |
| 49 | AHSG | AHSG Entrez, Source | alpha-2-HS-glycoprotein | 12336 | -0.010 | 0.2346 | No |
| 50 | PCK2 | PCK2 Entrez, Source | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 12523 | -0.015 | 0.2256 | No |
| 51 | KHK | KHK Entrez, Source | ketohexokinase (fructokinase) | 13559 | -0.041 | 0.1741 | No |
| 52 | FAH | FAH Entrez, Source | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 13672 | -0.044 | 0.1694 | No |
| 53 | ECHS1 | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 13852 | -0.049 | 0.1615 | No |
| 54 | C8G | C8G Entrez, Source | complement component 8, gamma polypeptide | 13968 | -0.052 | 0.1569 | No |
| 55 | TMEM176A | TMEM176A Entrez, Source | transmembrane protein 176A | 13989 | -0.053 | 0.1572 | No |
| 56 | GAMT | GAMT Entrez, Source | guanidinoacetate N-methyltransferase | 14448 | -0.067 | 0.1355 | No |
| 57 | ASS1 | ASS1 Entrez, Source | argininosuccinate synthetase 1 | 14849 | -0.080 | 0.1172 | No |
| 58 | GSTZ1 | GSTZ1 Entrez, Source | glutathione transferase zeta 1 (maleylacetoacetate isomerase) | 15200 | -0.095 | 0.1017 | No |
| 59 | APOC1 | APOC1 Entrez, Source | apolipoprotein C-I | 15349 | -0.101 | 0.0965 | No |
| 60 | PXMP2 | PXMP2 Entrez, Source | peroxisomal membrane protein 2, 22kDa | 16197 | -0.149 | 0.0571 | No |
| 61 | ADH6 | ADH6 Entrez, Source | alcohol dehydrogenase 6 (class V) | 17165 | -0.261 | 0.0143 | No |
| 62 | PON1 | PON1 Entrez, Source | paraoxonase 1 | 17294 | -0.282 | 0.0145 | No |
| 63 | CYP2B6 | CYP2B6 Entrez, Source | cytochrome P450, family 2, subfamily B, polypeptide 6 | 17321 | -0.288 | 0.0199 | No |
| 64 | VTN | VTN Entrez, Source | vitronectin | 17550 | -0.336 | 0.0163 | No |
| 65 | ACOX2 | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 17767 | -0.389 | 0.0146 | No |
| 66 | AMBP | AMBP Entrez, Source | alpha-1-microglobulin/bikunin precursor | 17865 | -0.416 | 0.0195 | No |
| 67 | HSD17B6 | HSD17B6 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 6 | 17954 | -0.441 | 0.0254 | No |
| 68 | PON3 | PON3 Entrez, Source | paraoxonase 3 | 18141 | -0.500 | 0.0278 | No |
| 69 | CYP2E1 | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 18430 | -0.615 | 0.0278 | No |
| 70 | ATF5 | ATF5 Entrez, Source | activating transcription factor 5 | 18484 | -0.636 | 0.0401 | No |
| 71 | C3 | C3 Entrez, Source | complement component 3 | 19281 | -1.122 | 0.0263 | No |
