Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_corrected2_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | GO_DNA_PACKAGING |
| Enrichment Score (ES) | -0.5924825 |
| Normalized Enrichment Score (NES) | -2.2279885 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.9060203E-4 |
| FWER p-Value | 0.002 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ERN2 | ERN2 Entrez, Source | endoplasmic reticulum to nucleus signalling 2 | 2130 | 0.887 | -0.0880 | No |
| 2 | HIST1H1B | HIST1H1B Entrez, Source | histone cluster 1, H1b | 2395 | 0.818 | -0.0827 | No |
| 3 | HIST1H3J | HIST1H3J Entrez, Source | histone cluster 1, H3j | 3358 | 0.582 | -0.1183 | No |
| 4 | BAHCC1 | BAHCC1 Entrez, Source | BAH domain and coiled-coil containing 1 | 4000 | 0.459 | -0.1404 | No |
| 5 | H2AFY2 | H2AFY2 Entrez, Source | H2A histone family, member Y2 | 4202 | 0.430 | -0.1408 | No |
| 6 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 4459 | 0.392 | -0.1448 | No |
| 7 | H1F0 | H1F0 Entrez, Source | H1 histone family, member 0 | 4538 | 0.381 | -0.1401 | No |
| 8 | TSSK6 | TSSK6 Entrez, Source | testis-specific serine kinase 6 | 4985 | 0.330 | -0.1552 | No |
| 9 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 5438 | 0.280 | -0.1718 | No |
| 10 | PRM1 | PRM1 Entrez, Source | protamine 1 | 6111 | 0.224 | -0.2008 | No |
| 11 | SYCP1 | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 6392 | 0.205 | -0.2104 | No |
| 12 | CENPH | CENPH Entrez, Source | centromere protein H | 6631 | 0.188 | -0.2182 | No |
| 13 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 6744 | 0.181 | -0.2197 | No |
| 14 | AKAP8L | AKAP8L Entrez, Source | A kinase (PRKA) anchor protein 8-like | 6750 | 0.180 | -0.2158 | No |
| 15 | CENPT | CENPT Entrez, Source | centromere protein T | 6954 | 0.168 | -0.2223 | No |
| 16 | NAP1L3 | NAP1L3 Entrez, Source | nucleosome assembly protein 1-like 3 | 7008 | 0.165 | -0.2212 | No |
| 17 | PAPD7 | 7125 | 0.159 | -0.2235 | No | ||
| 18 | ASF1B | ASF1B Entrez, Source | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 7451 | 0.142 | -0.2368 | No |
| 19 | ITGB3BP | ITGB3BP Entrez, Source | integrin beta 3 binding protein (beta3-endonexin) | 7523 | 0.140 | -0.2372 | No |
| 20 | ASH1L | ASH1L Entrez, Source | ash1 (absent, small, or homeotic)-like (Drosophila) | 7660 | 0.133 | -0.2411 | No |
| 21 | CABIN1 | CABIN1 Entrez, Source | - | 7708 | 0.131 | -0.2404 | No |
| 22 | H1FX | H1FX Entrez, Source | H1 histone family, member X | 7773 | 0.129 | -0.2407 | No |
| 23 | NAP1L2 | NAP1L2 Entrez, Source | nucleosome assembly protein 1-like 2 | 8256 | 0.108 | -0.2628 | No |
| 24 | HMGB2 | HMGB2 Entrez, Source | high-mobility group box 2 | 8276 | 0.107 | -0.2613 | No |
| 25 | ATRX | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 8348 | 0.105 | -0.2625 | No |
| 26 | CENPA | CENPA Entrez, Source | centromere protein A | 8358 | 0.104 | -0.2606 | No |
| 27 | KAT6A | 8506 | 0.098 | -0.2658 | No | ||
| 28 | DFFB | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 8544 | 0.096 | -0.2655 | No |
| 29 | NAP1L5 | NAP1L5 Entrez, Source | nucleosome assembly protein 1-like 5 | 8596 | 0.094 | -0.2659 | No |
| 30 | UBN1 | UBN1 Entrez, Source | ubinuclein 1 | 8626 | 0.093 | -0.2653 | No |
| 31 | TSPYL5 | TSPYL5 Entrez, Source | TSPY-like 5 | 8700 | 0.091 | -0.2669 | No |
| 32 | HP1BP3 | HP1BP3 Entrez, Source | heterochromatin protein 1, binding protein 3 | 8766 | 0.088 | -0.2682 | No |
| 33 | HMGA2 | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 8863 | 0.085 | -0.2712 | No |
| 34 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 8879 | 0.084 | -0.2700 | No |
| 35 | SMYD3 | SMYD3 Entrez, Source | SET and MYND domain containing 3 | 8971 | 0.081 | -0.2728 | No |
| 36 | CHAF1B | CHAF1B Entrez, Source | chromatin assembly factor 1, subunit B (p60) | 9018 | 0.080 | -0.2733 | No |
| 37 | NCAPG2 | NCAPG2 Entrez, Source | non-SMC condensin II complex, subunit G2 | 9026 | 0.079 | -0.2718 | No |
| 38 | CENPL | CENPL Entrez, Source | centromere protein L | 9086 | 0.078 | -0.2730 | No |
| 39 | CDAN1 | CDAN1 Entrez, Source | congenital dyserythropoietic anemia, type I | 9170 | 0.075 | -0.2755 | No |
| 40 | TSPYL2 | TSPYL2 Entrez, Source | TSPY-like 2 | 9504 | 0.065 | -0.2910 | No |
| 41 | CENPQ | CENPQ Entrez, Source | centromere protein Q | 9611 | 0.062 | -0.2950 | No |
| 42 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 9667 | 0.060 | -0.2964 | No |
| 43 | NAP1L1 | NAP1L1 Entrez, Source | nucleosome assembly protein 1-like 1 | 9895 | 0.054 | -0.3067 | No |
| 44 | CDK1 | 10283 | 0.043 | -0.3254 | No | ||
| 45 | H2AFY | H2AFY Entrez, Source | H2A histone family, member Y | 10435 | 0.039 | -0.3322 | No |
| 46 | CENPV | 10656 | 0.033 | -0.3426 | No | ||
| 47 | TSPYL1 | TSPYL1 Entrez, Source | TSPY-like 1 | 10786 | 0.029 | -0.3485 | No |
| 48 | ANP32B | ANP32B Entrez, Source | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 10954 | 0.024 | -0.3565 | No |
| 49 | SRPK1 | SRPK1 Entrez, Source | SFRS protein kinase 1 | 10990 | 0.024 | -0.3577 | No |
| 50 | PHF13 | PHF13 Entrez, Source | PHD finger protein 13 | 11085 | 0.020 | -0.3620 | No |
| 51 | NCAPG | NCAPG Entrez, Source | non-SMC condensin I complex, subunit G | 11098 | 0.020 | -0.3622 | No |
| 52 | NCAPD2 | NCAPD2 Entrez, Source | non-SMC condensin I complex, subunit D2 | 11126 | 0.019 | -0.3631 | No |
| 53 | HMGB1 | HMGB1 Entrez, Source | high-mobility group box 1 | 11139 | 0.019 | -0.3633 | No |
| 54 | SMARCA5 | SMARCA5 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 11153 | 0.019 | -0.3635 | No |
| 55 | RSF1 | RSF1 Entrez, Source | remodeling and spacing factor 1 | 11225 | 0.017 | -0.3668 | No |
| 56 | NUSAP1 | NUSAP1 Entrez, Source | nucleolar and spindle associated protein 1 | 11274 | 0.015 | -0.3689 | No |
| 57 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 11379 | 0.013 | -0.3738 | No |
| 58 | CENPM | CENPM Entrez, Source | centromere protein M | 11413 | 0.012 | -0.3752 | No |
| 59 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11625 | 0.008 | -0.3858 | No |
| 60 | CENPK | CENPK Entrez, Source | centromere protein K | 11702 | 0.006 | -0.3895 | No |
| 61 | MIS18A | 11804 | 0.003 | -0.3946 | No | ||
| 62 | NASP | NASP Entrez, Source | nuclear autoantigenic sperm protein (histone-binding) | 11946 | -0.001 | -0.4018 | No |
| 63 | MIS18BP1 | 12002 | -0.002 | -0.4045 | No | ||
| 64 | BAHD1 | BAHD1 Entrez, Source | bromo adjacent homology domain containing 1 | 12049 | -0.003 | -0.4068 | No |
| 65 | SET | SET Entrez, Source | SET translocation (myeloid leukemia-associated) | 12072 | -0.004 | -0.4078 | No |
| 66 | SHPRH | SHPRH Entrez, Source | SNF2 histone linker PHD RING helicase | 12193 | -0.007 | -0.4137 | No |
| 67 | RBBP4 | RBBP4 Entrez, Source | retinoblastoma binding protein 4 | 12266 | -0.009 | -0.4172 | No |
| 68 | NCAPD3 | NCAPD3 Entrez, Source | non-SMC condensin II complex, subunit D3 | 12288 | -0.009 | -0.4181 | No |
| 69 | HAT1 | HAT1 Entrez, Source | histone acetyltransferase 1 | 12355 | -0.011 | -0.4212 | No |
| 70 | NAP1L4 | NAP1L4 Entrez, Source | nucleosome assembly protein 1-like 4 | 12425 | -0.012 | -0.4244 | No |
| 71 | SART3 | SART3 Entrez, Source | squamous cell carcinoma antigen recognised by T cells 3 | 12470 | -0.013 | -0.4263 | No |
| 72 | BRD2 | BRD2 Entrez, Source | bromodomain containing 2 | 12654 | -0.018 | -0.4352 | No |
| 73 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 12717 | -0.019 | -0.4379 | No |
| 74 | ACIN1 | ACIN1 Entrez, Source | apoptotic chromatin condensation inducer 1 | 12726 | -0.020 | -0.4379 | No |
| 75 | RUVBL1 | RUVBL1 Entrez, Source | RuvB-like 1 (E. coli) | 12917 | -0.025 | -0.4470 | No |
| 76 | AIFM1 | 12987 | -0.026 | -0.4499 | No | ||
| 77 | NPM1 | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 13028 | -0.027 | -0.4513 | No |
| 78 | NAA60 | 13121 | -0.029 | -0.4553 | No | ||
| 79 | NCAPH | NCAPH Entrez, Source | non-SMC condensin I complex, subunit H | 13168 | -0.030 | -0.4570 | No |
| 80 | HMGA1 | HMGA1 Entrez, Source | high mobility group AT-hook 1 | 13360 | -0.036 | -0.4659 | No |
| 81 | HJURP | 13454 | -0.038 | -0.4697 | No | ||
| 82 | CHAF1A | CHAF1A Entrez, Source | chromatin assembly factor 1, subunit A (p150) | 13575 | -0.041 | -0.4749 | No |
| 83 | TSPY26P | 13667 | -0.044 | -0.4785 | No | ||
| 84 | NAA10 | 13906 | -0.050 | -0.4894 | No | ||
| 85 | NCAPH2 | NCAPH2 Entrez, Source | non-SMC condensin II complex, subunit H2 | 13978 | -0.053 | -0.4918 | No |
| 86 | HELLS | HELLS Entrez, Source | helicase, lymphoid-specific | 14016 | -0.054 | -0.4925 | No |
| 87 | AKAP8 | AKAP8 Entrez, Source | A kinase (PRKA) anchor protein 8 | 14071 | -0.056 | -0.4940 | No |
| 88 | SPTY2D1 | SPTY2D1 Entrez, Source | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 14100 | -0.057 | -0.4941 | No |
| 89 | HIRA | HIRA Entrez, Source | HIR histone cell cycle regulation defective homolog A (S. cerevisiae) | 14412 | -0.066 | -0.5084 | No |
| 90 | DAXX | DAXX Entrez, Source | death-associated protein 6 | 14508 | -0.069 | -0.5117 | No |
| 91 | NOC2L | NOC2L Entrez, Source | nucleolar complex associated 2 homolog (S. cerevisiae) | 14563 | -0.071 | -0.5128 | No |
| 92 | CENPP | CENPP Entrez, Source | centromere protein P | 14654 | -0.073 | -0.5157 | No |
| 93 | RBBP7 | RBBP7 Entrez, Source | retinoblastoma binding protein 7 | 14742 | -0.077 | -0.5184 | No |
| 94 | CDCA5 | CDCA5 Entrez, Source | cell division cycle associated 5 | 14743 | -0.077 | -0.5166 | No |
| 95 | PSME4 | PSME4 Entrez, Source | proteasome (prosome, macropain) activator subunit 4 | 14864 | -0.081 | -0.5209 | No |
| 96 | CENPW | 15115 | -0.091 | -0.5315 | No | ||
| 97 | PAF1 | PAF1 Entrez, Source | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 15116 | -0.091 | -0.5294 | No |
| 98 | MCM2 | MCM2 Entrez, Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 15143 | -0.092 | -0.5286 | No |
| 99 | CHMP1A | 15220 | -0.095 | -0.5303 | No | ||
| 100 | OIP5 | OIP5 Entrez, Source | Opa interacting protein 5 | 15273 | -0.097 | -0.5307 | No |
| 101 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 15299 | -0.098 | -0.5298 | No |
| 102 | CTCF | CTCF Entrez, Source | CCCTC-binding factor (zinc finger protein) | 15449 | -0.106 | -0.5349 | No |
| 103 | CENPN | CENPN Entrez, Source | centromere protein N | 15466 | -0.107 | -0.5333 | No |
| 104 | ASF1A | ASF1A Entrez, Source | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) | 15531 | -0.110 | -0.5340 | No |
| 105 | KAT6B | 15658 | -0.117 | -0.5378 | No | ||
| 106 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 15708 | -0.119 | -0.5375 | No |
| 107 | CENPO | CENPO Entrez, Source | centromere protein O | 15736 | -0.121 | -0.5361 | No |
| 108 | SMC2 | SMC2 Entrez, Source | structural maintenance of chromosomes 2 | 15870 | -0.128 | -0.5399 | No |
| 109 | TSPYL4 | TSPYL4 Entrez, Source | TSPY-like 4 | 15912 | -0.130 | -0.5390 | No |
| 110 | CENPI | CENPI Entrez, Source | centromere protein I | 16351 | -0.162 | -0.5576 | No |
| 111 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 16468 | -0.172 | -0.5596 | No |
| 112 | HIST1H1E | HIST1H1E Entrez, Source | histone cluster 1, H1e | 16814 | -0.214 | -0.5722 | No |
| 113 | TTN | TTN Entrez, Source | titin | 16898 | -0.226 | -0.5713 | No |
| 114 | CHD5 | CHD5 Entrez, Source | chromodomain helicase DNA binding protein 5 | 16980 | -0.237 | -0.5700 | No |
| 115 | TNRC18 | TNRC18 Entrez, Source | trinucleotide repeat containing 18 | 17253 | -0.275 | -0.5775 | No |
| 116 | NAP1L6 | NAP1L6 Entrez, Source | nucleosome assembly protein 1-like 6 | 17493 | -0.327 | -0.5822 | Yes |
| 117 | SOX9 | SOX9 Entrez, Source | SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) | 17561 | -0.338 | -0.5778 | Yes |
| 118 | HIST1H2BF | HIST1H2BF Entrez, Source | histone cluster 1, H2bf | 17743 | -0.382 | -0.5783 | Yes |
| 119 | HIST1H3D | HIST1H3D Entrez, Source | histone cluster 1, H3d | 17891 | -0.423 | -0.5761 | Yes |
| 120 | HIST1H1D | HIST1H1D Entrez, Source | histone cluster 1, H1d | 17930 | -0.433 | -0.5681 | Yes |
| 121 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 18411 | -0.608 | -0.5786 | Yes |
| 122 | HIST1H3C | HIST1H3C Entrez, Source | histone cluster 1, H3c | 18447 | -0.619 | -0.5662 | Yes |
| 123 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18599 | -0.688 | -0.5581 | Yes |
| 124 | HIST1H3B | HIST1H3B Entrez, Source | histone cluster 1, H3b | 18676 | -0.729 | -0.5452 | Yes |
| 125 | HIST1H1C | HIST1H1C Entrez, Source | histone cluster 1, H1c | 18954 | -0.882 | -0.5391 | Yes |
| 126 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 19052 | -0.943 | -0.5225 | Yes |
| 127 | HIST1H3A | HIST1H3A Entrez, Source | histone cluster 1, H3a | 19137 | -0.996 | -0.5039 | Yes |
| 128 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 19207 | -1.051 | -0.4833 | Yes |
| 129 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 19226 | -1.071 | -0.4597 | Yes |
| 130 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 19248 | -1.094 | -0.4357 | Yes |
| 131 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 19368 | -1.195 | -0.4144 | Yes |
| 132 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 19519 | -1.394 | -0.3901 | Yes |
| 133 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 19576 | -1.507 | -0.3584 | Yes |
| 134 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 19623 | -1.605 | -0.3239 | Yes |
| 135 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 19684 | -1.758 | -0.2867 | Yes |
| 136 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 19715 | -1.903 | -0.2447 | Yes |
| 137 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 19720 | -1.970 | -0.1998 | Yes |
| 138 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 19736 | -2.067 | -0.1532 | Yes |
| 139 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 19741 | -2.101 | -0.1052 | Yes |
| 140 | IPO4 | IPO4 Entrez, Source | importin 4 | 19764 | -2.325 | -0.0531 | Yes |
| 141 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 19771 | -2.393 | 0.0014 | Yes |
