Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_corrected2_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_AMYLOIDS |
| Enrichment Score (ES) | -0.76980287 |
| Normalized Enrichment Score (NES) | -2.4164205 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 2101 | 0.896 | -0.0788 | No |
| 2 | HIST1H3J | HIST1H3J Entrez, Source | histone cluster 1, H3j | 3358 | 0.582 | -0.1245 | No |
| 3 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 4459 | 0.392 | -0.1682 | No |
| 4 | SEMG1 | SEMG1 Entrez, Source | semenogelin I | 4597 | 0.373 | -0.1637 | No |
| 5 | HSPG2 | HSPG2 Entrez, Source | heparan sulfate proteoglycan 2 (perlecan) | 4603 | 0.372 | -0.1525 | No |
| 6 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 5001 | 0.329 | -0.1625 | No |
| 7 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 5438 | 0.280 | -0.1759 | No |
| 8 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 6531 | 0.194 | -0.2252 | No |
| 9 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 6744 | 0.181 | -0.2304 | No |
| 10 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 7544 | 0.139 | -0.2666 | No |
| 11 | B2M | B2M Entrez, Source | beta-2-microglobulin | 7852 | 0.125 | -0.2783 | No |
| 12 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 8038 | 0.116 | -0.2841 | No |
| 13 | CST3 | CST3 Entrez, Source | cystatin C (amyloid angiopathy and cerebral hemorrhage) | 10111 | 0.048 | -0.3875 | No |
| 14 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 11379 | 0.013 | -0.4512 | No |
| 15 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 11798 | 0.003 | -0.4723 | No |
| 16 | ITM2B | ITM2B Entrez, Source | integral membrane protein 2B | 12408 | -0.012 | -0.5027 | No |
| 17 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 12717 | -0.019 | -0.5177 | No |
| 18 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 14561 | -0.071 | -0.6088 | No |
| 19 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 15708 | -0.119 | -0.6632 | No |
| 20 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 16468 | -0.172 | -0.6963 | No |
| 21 | HIST1H2BF | HIST1H2BF Entrez, Source | histone cluster 1, H2bf | 17743 | -0.382 | -0.7491 | No |
| 22 | HIST1H3D | HIST1H3D Entrez, Source | histone cluster 1, H3d | 17891 | -0.423 | -0.7435 | No |
| 23 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 18411 | -0.608 | -0.7511 | Yes |
| 24 | HIST1H3C | HIST1H3C Entrez, Source | histone cluster 1, H3c | 18447 | -0.619 | -0.7339 | Yes |
| 25 | LTF | LTF Entrez, Source | lactotransferrin | 18475 | -0.633 | -0.7158 | Yes |
| 26 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18496 | -0.643 | -0.6971 | Yes |
| 27 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18599 | -0.688 | -0.6811 | Yes |
| 28 | HIST1H3B | HIST1H3B Entrez, Source | histone cluster 1, H3b | 18676 | -0.729 | -0.6626 | Yes |
| 29 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 19052 | -0.943 | -0.6526 | Yes |
| 30 | HIST1H3A | HIST1H3A Entrez, Source | histone cluster 1, H3a | 19137 | -0.996 | -0.6262 | Yes |
| 31 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 19207 | -1.051 | -0.5974 | Yes |
| 32 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 19226 | -1.071 | -0.5654 | Yes |
| 33 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 19248 | -1.094 | -0.5329 | Yes |
| 34 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 19289 | -1.131 | -0.5001 | Yes |
| 35 | CALCA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 19354 | -1.184 | -0.4670 | Yes |
| 36 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 19368 | -1.195 | -0.4310 | Yes |
| 37 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 19519 | -1.394 | -0.3957 | Yes |
| 38 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 19576 | -1.507 | -0.3523 | Yes |
| 39 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 19623 | -1.605 | -0.3053 | Yes |
| 40 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 19684 | -1.758 | -0.2543 | Yes |
| 41 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 19715 | -1.903 | -0.1974 | Yes |
| 42 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 19736 | -2.067 | -0.1349 | Yes |
| 43 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 19741 | -2.101 | -0.0706 | Yes |
| 44 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 19771 | -2.393 | 0.0014 | Yes |
