Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_corrected2_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_CHROMOSOME_MAINTENANCE |
| Enrichment Score (ES) | -0.60760707 |
| Normalized Enrichment Score (NES) | -2.1442459 |
| Nominal p-value | 0.0 |
| FDR q-value | 7.232865E-4 |
| FWER p-Value | 0.009 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SMC1B | SMC1B Entrez, Source | structural maintenance of chromosomes 1B | 854 | 1.434 | 0.0060 | No |
| 2 | POLD4 | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 2918 | 0.674 | -0.0755 | No |
| 3 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 4459 | 0.392 | -0.1402 | No |
| 4 | SYNE1 | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 5326 | 0.290 | -0.1742 | No |
| 5 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 5438 | 0.280 | -0.1702 | No |
| 6 | ATR | ATR Entrez, Source | ataxia telangiectasia and Rad3 related | 6036 | 0.229 | -0.1926 | No |
| 7 | TERT | TERT Entrez, Source | telomerase reverse transcriptase | 6178 | 0.219 | -0.1922 | No |
| 8 | POT1 | POT1 Entrez, Source | POT1 protection of telomeres 1 homolog (S. pombe) | 6311 | 0.210 | -0.1917 | No |
| 9 | SYCP1 | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 6392 | 0.205 | -0.1887 | No |
| 10 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 6531 | 0.194 | -0.1890 | No |
| 11 | CENPH | CENPH Entrez, Source | centromere protein H | 6631 | 0.188 | -0.1876 | No |
| 12 | STAG3 | STAG3 Entrez, Source | stromal antigen 3 | 6830 | 0.176 | -0.1916 | No |
| 13 | SUN2 | 6862 | 0.174 | -0.1872 | No | ||
| 14 | ITGB3BP | ITGB3BP Entrez, Source | integrin beta 3 binding protein (beta3-endonexin) | 7523 | 0.140 | -0.2159 | No |
| 15 | TINF2 | TINF2 Entrez, Source | TERF1 (TRF1)-interacting nuclear factor 2 | 7772 | 0.129 | -0.2240 | No |
| 16 | CENPA | CENPA Entrez, Source | centromere protein A | 8358 | 0.104 | -0.2501 | No |
| 17 | ACD | ACD Entrez, Source | adrenocortical dysplasia homolog (mouse) | 8620 | 0.094 | -0.2602 | No |
| 18 | TERF2IP | TERF2IP Entrez, Source | telomeric repeat binding factor 2, interacting protein | 8862 | 0.085 | -0.2695 | No |
| 19 | RFC5 | RFC5 Entrez, Source | replication factor C (activator 1) 5, 36.5kDa | 9101 | 0.077 | -0.2789 | No |
| 20 | RFC4 | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 9127 | 0.076 | -0.2776 | No |
| 21 | POLE | POLE Entrez, Source | polymerase (DNA directed), epsilon | 9572 | 0.063 | -0.2979 | No |
| 22 | CENPQ | CENPQ Entrez, Source | centromere protein Q | 9611 | 0.062 | -0.2977 | No |
| 23 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 9642 | 0.061 | -0.2971 | No |
| 24 | TERF2 | TERF2 Entrez, Source | telomeric repeat binding factor 2 | 9751 | 0.058 | -0.3006 | No |
| 25 | RAD21 | RAD21 Entrez, Source | RAD21 homolog (S. pombe) | 9827 | 0.056 | -0.3025 | No |
| 26 | PRIM1 | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 9848 | 0.055 | -0.3016 | No |
| 27 | DNA2 | 9917 | 0.053 | -0.3033 | No | ||
| 28 | POLE2 | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 10136 | 0.047 | -0.3127 | No |
| 29 | LIG1 | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 10917 | 0.025 | -0.3514 | No |
| 30 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 10961 | 0.024 | -0.3528 | No |
| 31 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 11023 | 0.022 | -0.3551 | No |
| 32 | SMARCA5 | SMARCA5 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 11153 | 0.019 | -0.3610 | No |
| 33 | RSF1 | RSF1 Entrez, Source | remodeling and spacing factor 1 | 11225 | 0.017 | -0.3640 | No |
| 34 | CENPK | CENPK Entrez, Source | centromere protein K | 11702 | 0.006 | -0.3880 | No |
| 35 | MIS18A | 11804 | 0.003 | -0.3930 | No | ||
| 36 | MIS18BP1 | 12002 | -0.002 | -0.4029 | No | ||
| 37 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 12081 | -0.004 | -0.4068 | No |
| 38 | SYNE2 | SYNE2 Entrez, Source | spectrin repeat containing, nuclear envelope 2 | 12099 | -0.005 | -0.4075 | No |
| 39 | UBE2I | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 12129 | -0.005 | -0.4087 | No |
| 40 | WRAP53 | 12197 | -0.007 | -0.4119 | No | ||
| 41 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 12264 | -0.009 | -0.4150 | No |
| 42 | RBBP4 | RBBP4 Entrez, Source | retinoblastoma binding protein 4 | 12266 | -0.009 | -0.4147 | No |
| 43 | RBBP4P1 | 12365 | -0.011 | -0.4193 | No | ||
| 44 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 12392 | -0.012 | -0.4202 | No |
| 45 | PRIM2 | 12592 | -0.016 | -0.4298 | No | ||
| 46 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 12703 | -0.019 | -0.4347 | No |
| 47 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 12717 | -0.019 | -0.4347 | No |
| 48 | RUVBL1 | RUVBL1 Entrez, Source | RuvB-like 1 (E. coli) | 12917 | -0.025 | -0.4439 | No |
| 49 | NPM1 | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 13028 | -0.027 | -0.4486 | No |
| 50 | TERF1 | TERF1 Entrez, Source | telomeric repeat binding factor (NIMA-interacting) 1 | 13443 | -0.038 | -0.4683 | No |
| 51 | HJURP | 13454 | -0.038 | -0.4675 | No | ||
| 52 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 13511 | -0.040 | -0.4689 | No |
| 53 | NHP2 | 13764 | -0.046 | -0.4801 | No | ||
| 54 | RUVBL2 | RUVBL2 Entrez, Source | RuvB-like 2 (E. coli) | 13894 | -0.050 | -0.4850 | No |
| 55 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 13902 | -0.050 | -0.4836 | No |
| 56 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 14235 | -0.061 | -0.4983 | No |
| 57 | POLA2 | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 14264 | -0.061 | -0.4977 | No |
| 58 | HSPA2 | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 14430 | -0.066 | -0.5038 | No |
| 59 | LMNB1 | LMNB1 Entrez, Source | lamin B1 | 14498 | -0.069 | -0.5048 | No |
| 60 | FEN1 | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 14558 | -0.070 | -0.5054 | No |
| 61 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 14561 | -0.071 | -0.5030 | No |
| 62 | DKC1 | DKC1 Entrez, Source | dyskeratosis congenita 1, dyskerin | 14592 | -0.071 | -0.5021 | No |
| 63 | CENPP | CENPP Entrez, Source | centromere protein P | 14654 | -0.073 | -0.5027 | No |
| 64 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 14710 | -0.076 | -0.5029 | No |
| 65 | RBBP7 | RBBP7 Entrez, Source | retinoblastoma binding protein 7 | 14742 | -0.077 | -0.5018 | No |
| 66 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 14965 | -0.085 | -0.5102 | No |
| 67 | STAG2 | STAG2 Entrez, Source | stromal antigen 2 | 14977 | -0.085 | -0.5078 | No |
| 68 | OIP5 | OIP5 Entrez, Source | Opa interacting protein 5 | 15273 | -0.097 | -0.5194 | No |
| 69 | POLA1 | POLA1 Entrez, Source | polymerase (DNA directed), alpha 1 | 15461 | -0.106 | -0.5253 | No |
| 70 | CENPN | CENPN Entrez, Source | centromere protein N | 15466 | -0.107 | -0.5218 | No |
| 71 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 15708 | -0.119 | -0.5300 | No |
| 72 | CENPO | CENPO Entrez, Source | centromere protein O | 15736 | -0.121 | -0.5272 | No |
| 73 | DIDO1 | DIDO1 Entrez, Source | death inducer-obliterator 1 | 16306 | -0.159 | -0.5506 | No |
| 74 | CENPI | CENPI Entrez, Source | centromere protein I | 16351 | -0.162 | -0.5472 | No |
| 75 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 16468 | -0.172 | -0.5472 | No |
| 76 | STAG1 | STAG1 Entrez, Source | stromal antigen 1 | 16988 | -0.238 | -0.5654 | No |
| 77 | LMNA | LMNA Entrez, Source | lamin A/C | 17009 | -0.240 | -0.5581 | No |
| 78 | REC8 | 17041 | -0.244 | -0.5513 | No | ||
| 79 | HIST1H2BF | HIST1H2BF Entrez, Source | histone cluster 1, H2bf | 17743 | -0.382 | -0.5738 | No |
| 80 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 18411 | -0.608 | -0.5867 | Yes |
| 81 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18496 | -0.643 | -0.5689 | Yes |
| 82 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18599 | -0.688 | -0.5504 | Yes |
| 83 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 19052 | -0.943 | -0.5409 | Yes |
| 84 | SYCP2 | SYCP2 Entrez, Source | synaptonemal complex protein 2 | 19214 | -1.062 | -0.5125 | Yes |
| 85 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 19226 | -1.071 | -0.4763 | Yes |
| 86 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 19248 | -1.094 | -0.4397 | Yes |
| 87 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 19289 | -1.131 | -0.4029 | Yes |
| 88 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 19368 | -1.195 | -0.3657 | Yes |
| 89 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 19576 | -1.507 | -0.3244 | Yes |
| 90 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 19623 | -1.605 | -0.2716 | Yes |
| 91 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 19684 | -1.758 | -0.2142 | Yes |
| 92 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 19715 | -1.903 | -0.1503 | Yes |
| 93 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 19741 | -2.101 | -0.0794 | Yes |
| 94 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 19771 | -2.393 | 0.0014 | Yes |
