Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_corrected2_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_MEIOSIS |
| Enrichment Score (ES) | -0.6187683 |
| Normalized Enrichment Score (NES) | -2.1290288 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0010732281 |
| FWER p-Value | 0.014 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MSH5 | MSH5 Entrez, Source | mutS homolog 5 (E. coli) | 42 | 3.125 | 0.0789 | No |
| 2 | SMC1B | SMC1B Entrez, Source | structural maintenance of chromosomes 1B | 854 | 1.434 | 0.0749 | No |
| 3 | HIST1H3J | HIST1H3J Entrez, Source | histone cluster 1, H3j | 3358 | 0.582 | -0.0369 | No |
| 4 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 4459 | 0.392 | -0.0826 | No |
| 5 | SYNE1 | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 5326 | 0.290 | -0.1190 | No |
| 6 | TEX15 | TEX15 Entrez, Source | testis expressed sequence 15 | 5384 | 0.285 | -0.1145 | No |
| 7 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 5438 | 0.280 | -0.1099 | No |
| 8 | MND1 | MND1 Entrez, Source | meiotic nuclear divisions 1 homolog (S. cerevisiae) | 5872 | 0.242 | -0.1256 | No |
| 9 | ATR | ATR Entrez, Source | ataxia telangiectasia and Rad3 related | 6036 | 0.229 | -0.1279 | No |
| 10 | DMC1 | DMC1 Entrez, Source | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 6095 | 0.225 | -0.1250 | No |
| 11 | POT1 | POT1 Entrez, Source | POT1 protection of telomeres 1 homolog (S. pombe) | 6311 | 0.210 | -0.1304 | No |
| 12 | SYCP1 | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 6392 | 0.205 | -0.1292 | No |
| 13 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 6531 | 0.194 | -0.1312 | No |
| 14 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 6744 | 0.181 | -0.1372 | No |
| 15 | STAG3 | STAG3 Entrez, Source | stromal antigen 3 | 6830 | 0.176 | -0.1370 | No |
| 16 | SUN2 | 6862 | 0.174 | -0.1340 | No | ||
| 17 | TINF2 | TINF2 Entrez, Source | TERF1 (TRF1)-interacting nuclear factor 2 | 7772 | 0.129 | -0.1768 | No |
| 18 | ACD | ACD Entrez, Source | adrenocortical dysplasia homolog (mouse) | 8620 | 0.094 | -0.2173 | No |
| 19 | TERF2IP | TERF2IP Entrez, Source | telomeric repeat binding factor 2, interacting protein | 8862 | 0.085 | -0.2273 | No |
| 20 | BLM | BLM Entrez, Source | Bloom syndrome | 9078 | 0.078 | -0.2362 | No |
| 21 | ATM | ATM Entrez, Source | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 9186 | 0.074 | -0.2397 | No |
| 22 | TERF2 | TERF2 Entrez, Source | telomeric repeat binding factor 2 | 9751 | 0.058 | -0.2668 | No |
| 23 | RAD21 | RAD21 Entrez, Source | RAD21 homolog (S. pombe) | 9827 | 0.056 | -0.2692 | No |
| 24 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 10803 | 0.029 | -0.3179 | No |
| 25 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 11023 | 0.022 | -0.3284 | No |
| 26 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 11379 | 0.013 | -0.3461 | No |
| 27 | RAD50 | RAD50 Entrez, Source | RAD50 homolog (S. cerevisiae) | 11497 | 0.010 | -0.3517 | No |
| 28 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 11922 | 0.000 | -0.3732 | No |
| 29 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 12081 | -0.004 | -0.3811 | No |
| 30 | SYNE2 | SYNE2 Entrez, Source | spectrin repeat containing, nuclear envelope 2 | 12099 | -0.005 | -0.3819 | No |
| 31 | UBE2I | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 12129 | -0.005 | -0.3832 | No |
| 32 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 12264 | -0.009 | -0.3898 | No |
| 33 | RAD51 | RAD51 Entrez, Source | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 12626 | -0.017 | -0.4076 | No |
| 34 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 12703 | -0.019 | -0.4110 | No |
| 35 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 12717 | -0.019 | -0.4111 | No |
| 36 | RBBP8 | RBBP8 Entrez, Source | retinoblastoma binding protein 8 | 12749 | -0.020 | -0.4122 | No |
| 37 | MLH1 | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 13200 | -0.031 | -0.4342 | No |
| 38 | TERF1 | TERF1 Entrez, Source | telomeric repeat binding factor (NIMA-interacting) 1 | 13443 | -0.038 | -0.4455 | No |
| 39 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 14329 | -0.063 | -0.4887 | No |
| 40 | HSPA2 | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 14430 | -0.066 | -0.4921 | No |
| 41 | LMNB1 | LMNB1 Entrez, Source | lamin B1 | 14498 | -0.069 | -0.4937 | No |
| 42 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 14561 | -0.071 | -0.4950 | No |
| 43 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 14710 | -0.076 | -0.5006 | No |
| 44 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 14965 | -0.085 | -0.5112 | No |
| 45 | STAG2 | STAG2 Entrez, Source | stromal antigen 2 | 14977 | -0.085 | -0.5096 | No |
| 46 | NBN | NBN Entrez, Source | nibrin | 15406 | -0.103 | -0.5286 | No |
| 47 | TOP3A | TOP3A Entrez, Source | topoisomerase (DNA) III alpha | 15639 | -0.116 | -0.5374 | No |
| 48 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 15708 | -0.119 | -0.5377 | No |
| 49 | RAD51C | RAD51C Entrez, Source | RAD51 homolog C (S. cerevisiae) | 15904 | -0.130 | -0.5442 | No |
| 50 | MLH3 | MLH3 Entrez, Source | mutL homolog 3 (E. coli) | 16258 | -0.154 | -0.5581 | No |
| 51 | DIDO1 | DIDO1 Entrez, Source | death inducer-obliterator 1 | 16306 | -0.159 | -0.5564 | No |
| 52 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 16468 | -0.172 | -0.5601 | No |
| 53 | STAG1 | STAG1 Entrez, Source | stromal antigen 1 | 16988 | -0.238 | -0.5803 | No |
| 54 | LMNA | LMNA Entrez, Source | lamin A/C | 17009 | -0.240 | -0.5751 | No |
| 55 | REC8 | 17041 | -0.244 | -0.5703 | No | ||
| 56 | HIST1H2BF | HIST1H2BF Entrez, Source | histone cluster 1, H2bf | 17743 | -0.382 | -0.5960 | No |
| 57 | HIST1H3D | HIST1H3D Entrez, Source | histone cluster 1, H3d | 17891 | -0.423 | -0.5925 | No |
| 58 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 18411 | -0.608 | -0.6030 | Yes |
| 59 | HIST1H3C | HIST1H3C Entrez, Source | histone cluster 1, H3c | 18447 | -0.619 | -0.5888 | Yes |
| 60 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18496 | -0.643 | -0.5745 | Yes |
| 61 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18599 | -0.688 | -0.5619 | Yes |
| 62 | HIST1H3B | HIST1H3B Entrez, Source | histone cluster 1, H3b | 18676 | -0.729 | -0.5468 | Yes |
| 63 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 19052 | -0.943 | -0.5414 | Yes |
| 64 | HIST1H3A | HIST1H3A Entrez, Source | histone cluster 1, H3a | 19137 | -0.996 | -0.5199 | Yes |
| 65 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 19207 | -1.051 | -0.4961 | Yes |
| 66 | SYCP2 | SYCP2 Entrez, Source | synaptonemal complex protein 2 | 19214 | -1.062 | -0.4689 | Yes |
| 67 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 19226 | -1.071 | -0.4417 | Yes |
| 68 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 19248 | -1.094 | -0.4144 | Yes |
| 69 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 19289 | -1.131 | -0.3871 | Yes |
| 70 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 19368 | -1.195 | -0.3601 | Yes |
| 71 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 19519 | -1.394 | -0.3316 | Yes |
| 72 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 19576 | -1.507 | -0.2954 | Yes |
| 73 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 19623 | -1.605 | -0.2561 | Yes |
| 74 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 19684 | -1.758 | -0.2136 | Yes |
| 75 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 19715 | -1.903 | -0.1659 | Yes |
| 76 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 19736 | -2.067 | -0.1133 | Yes |
| 77 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 19741 | -2.101 | -0.0591 | Yes |
| 78 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 19771 | -2.393 | 0.0014 | Yes |
