Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_corrected2_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_MEIOTIC_RECOMBINATION |
| Enrichment Score (ES) | -0.69855535 |
| Normalized Enrichment Score (NES) | -2.2502913 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.0016781E-4 |
| FWER p-Value | 0.001 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MSH5 | MSH5 Entrez, Source | mutS homolog 5 (E. coli) | 42 | 3.125 | 0.0920 | No |
| 2 | HIST1H3J | HIST1H3J Entrez, Source | histone cluster 1, H3j | 3358 | 0.582 | -0.0584 | No |
| 3 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 4459 | 0.392 | -0.1023 | No |
| 4 | TEX15 | TEX15 Entrez, Source | testis expressed sequence 15 | 5384 | 0.285 | -0.1405 | No |
| 5 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 5438 | 0.280 | -0.1347 | No |
| 6 | MND1 | MND1 Entrez, Source | meiotic nuclear divisions 1 homolog (S. cerevisiae) | 5872 | 0.242 | -0.1493 | No |
| 7 | DMC1 | DMC1 Entrez, Source | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 6095 | 0.225 | -0.1538 | No |
| 8 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 6531 | 0.194 | -0.1700 | No |
| 9 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 6744 | 0.181 | -0.1753 | No |
| 10 | BLM | BLM Entrez, Source | Bloom syndrome | 9078 | 0.078 | -0.2911 | No |
| 11 | ATM | ATM Entrez, Source | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 9186 | 0.074 | -0.2942 | No |
| 12 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 10803 | 0.029 | -0.3752 | No |
| 13 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 11379 | 0.013 | -0.4039 | No |
| 14 | RAD50 | RAD50 Entrez, Source | RAD50 homolog (S. cerevisiae) | 11497 | 0.010 | -0.4095 | No |
| 15 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 11922 | 0.000 | -0.4310 | No |
| 16 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 12081 | -0.004 | -0.4389 | No |
| 17 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 12264 | -0.009 | -0.4478 | No |
| 18 | RAD51 | RAD51 Entrez, Source | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 12626 | -0.017 | -0.4656 | No |
| 19 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 12717 | -0.019 | -0.4696 | No |
| 20 | RBBP8 | RBBP8 Entrez, Source | retinoblastoma binding protein 8 | 12749 | -0.020 | -0.4705 | No |
| 21 | MLH1 | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 13200 | -0.031 | -0.4924 | No |
| 22 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 14329 | -0.063 | -0.5476 | No |
| 23 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 14561 | -0.071 | -0.5572 | No |
| 24 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 14710 | -0.076 | -0.5624 | No |
| 25 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 14965 | -0.085 | -0.5727 | No |
| 26 | NBN | NBN Entrez, Source | nibrin | 15406 | -0.103 | -0.5919 | No |
| 27 | TOP3A | TOP3A Entrez, Source | topoisomerase (DNA) III alpha | 15639 | -0.116 | -0.6001 | No |
| 28 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 15708 | -0.119 | -0.6000 | No |
| 29 | RAD51C | RAD51C Entrez, Source | RAD51 homolog C (S. cerevisiae) | 15904 | -0.130 | -0.6059 | No |
| 30 | MLH3 | MLH3 Entrez, Source | mutL homolog 3 (E. coli) | 16258 | -0.154 | -0.6191 | No |
| 31 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 16468 | -0.172 | -0.6246 | No |
| 32 | HIST1H2BF | HIST1H2BF Entrez, Source | histone cluster 1, H2bf | 17743 | -0.382 | -0.6776 | No |
| 33 | HIST1H3D | HIST1H3D Entrez, Source | histone cluster 1, H3d | 17891 | -0.423 | -0.6723 | No |
| 34 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 18411 | -0.608 | -0.6803 | Yes |
| 35 | HIST1H3C | HIST1H3C Entrez, Source | histone cluster 1, H3c | 18447 | -0.619 | -0.6634 | Yes |
| 36 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18496 | -0.643 | -0.6464 | Yes |
| 37 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18599 | -0.688 | -0.6309 | Yes |
| 38 | HIST1H3B | HIST1H3B Entrez, Source | histone cluster 1, H3b | 18676 | -0.729 | -0.6128 | Yes |
| 39 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 19052 | -0.943 | -0.6034 | Yes |
| 40 | HIST1H3A | HIST1H3A Entrez, Source | histone cluster 1, H3a | 19137 | -0.996 | -0.5776 | Yes |
| 41 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 19207 | -1.051 | -0.5494 | Yes |
| 42 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 19226 | -1.071 | -0.5181 | Yes |
| 43 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 19248 | -1.094 | -0.4862 | Yes |
| 44 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 19289 | -1.131 | -0.4541 | Yes |
| 45 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 19368 | -1.195 | -0.4221 | Yes |
| 46 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 19519 | -1.394 | -0.3877 | Yes |
| 47 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 19576 | -1.507 | -0.3452 | Yes |
| 48 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 19623 | -1.605 | -0.2992 | Yes |
| 49 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 19684 | -1.758 | -0.2493 | Yes |
| 50 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 19715 | -1.903 | -0.1935 | Yes |
| 51 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 19736 | -2.067 | -0.1322 | Yes |
| 52 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 19741 | -2.101 | -0.0692 | Yes |
| 53 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 19771 | -2.393 | 0.0014 | Yes |
