Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_corrected2_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_TELOMERE_MAINTENANCE |
| Enrichment Score (ES) | -0.74178123 |
| Normalized Enrichment Score (NES) | -2.353647 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | POLD4 | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 2918 | 0.674 | -0.1184 | No |
| 2 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 4459 | 0.392 | -0.1794 | No |
| 3 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 5438 | 0.280 | -0.2167 | No |
| 4 | TERT | TERT Entrez, Source | telomerase reverse transcriptase | 6178 | 0.219 | -0.2446 | No |
| 5 | POT1 | POT1 Entrez, Source | POT1 protection of telomeres 1 homolog (S. pombe) | 6311 | 0.210 | -0.2421 | No |
| 6 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 6531 | 0.194 | -0.2448 | No |
| 7 | TINF2 | TINF2 Entrez, Source | TERF1 (TRF1)-interacting nuclear factor 2 | 7772 | 0.129 | -0.3020 | No |
| 8 | ACD | ACD Entrez, Source | adrenocortical dysplasia homolog (mouse) | 8620 | 0.094 | -0.3408 | No |
| 9 | TERF2IP | TERF2IP Entrez, Source | telomeric repeat binding factor 2, interacting protein | 8862 | 0.085 | -0.3493 | No |
| 10 | RFC5 | RFC5 Entrez, Source | replication factor C (activator 1) 5, 36.5kDa | 9101 | 0.077 | -0.3580 | No |
| 11 | RFC4 | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 9127 | 0.076 | -0.3560 | No |
| 12 | POLE | POLE Entrez, Source | polymerase (DNA directed), epsilon | 9572 | 0.063 | -0.3757 | No |
| 13 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 9642 | 0.061 | -0.3765 | No |
| 14 | TERF2 | TERF2 Entrez, Source | telomeric repeat binding factor 2 | 9751 | 0.058 | -0.3795 | No |
| 15 | PRIM1 | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 9848 | 0.055 | -0.3819 | No |
| 16 | DNA2 | 9917 | 0.053 | -0.3831 | No | ||
| 17 | POLE2 | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 10136 | 0.047 | -0.3921 | No |
| 18 | LIG1 | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 10917 | 0.025 | -0.4305 | No |
| 19 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 10961 | 0.024 | -0.4316 | No |
| 20 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 12081 | -0.004 | -0.4881 | No |
| 21 | WRAP53 | 12197 | -0.007 | -0.4936 | No | ||
| 22 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 12264 | -0.009 | -0.4966 | No |
| 23 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 12392 | -0.012 | -0.5025 | No |
| 24 | PRIM2 | 12592 | -0.016 | -0.5119 | No | ||
| 25 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 12717 | -0.019 | -0.5173 | No |
| 26 | RUVBL1 | RUVBL1 Entrez, Source | RuvB-like 1 (E. coli) | 12917 | -0.025 | -0.5263 | No |
| 27 | TERF1 | TERF1 Entrez, Source | telomeric repeat binding factor (NIMA-interacting) 1 | 13443 | -0.038 | -0.5512 | No |
| 28 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 13511 | -0.040 | -0.5529 | No |
| 29 | NHP2 | 13764 | -0.046 | -0.5636 | No | ||
| 30 | RUVBL2 | RUVBL2 Entrez, Source | RuvB-like 2 (E. coli) | 13894 | -0.050 | -0.5680 | No |
| 31 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 13902 | -0.050 | -0.5661 | No |
| 32 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 14235 | -0.061 | -0.5803 | No |
| 33 | POLA2 | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 14264 | -0.061 | -0.5791 | No |
| 34 | FEN1 | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 14558 | -0.070 | -0.5908 | No |
| 35 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 14561 | -0.071 | -0.5879 | No |
| 36 | DKC1 | DKC1 Entrez, Source | dyskeratosis congenita 1, dyskerin | 14592 | -0.071 | -0.5863 | No |
| 37 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 14965 | -0.085 | -0.6014 | No |
| 38 | POLA1 | POLA1 Entrez, Source | polymerase (DNA directed), alpha 1 | 15461 | -0.106 | -0.6219 | No |
| 39 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 15708 | -0.119 | -0.6291 | No |
| 40 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 16468 | -0.172 | -0.6601 | No |
| 41 | HIST1H2BF | HIST1H2BF Entrez, Source | histone cluster 1, H2bf | 17743 | -0.382 | -0.7080 | No |
| 42 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 18411 | -0.608 | -0.7153 | Yes |
| 43 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18496 | -0.643 | -0.6916 | Yes |
| 44 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18599 | -0.688 | -0.6668 | Yes |
| 45 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 19052 | -0.943 | -0.6486 | Yes |
| 46 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 19226 | -1.071 | -0.6107 | Yes |
| 47 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 19248 | -1.094 | -0.5642 | Yes |
| 48 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 19289 | -1.131 | -0.5170 | Yes |
| 49 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 19368 | -1.195 | -0.4689 | Yes |
| 50 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 19576 | -1.507 | -0.4138 | Yes |
| 51 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 19623 | -1.605 | -0.3462 | Yes |
| 52 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 19684 | -1.758 | -0.2728 | Yes |
| 53 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 19715 | -1.903 | -0.1915 | Yes |
| 54 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 19741 | -2.101 | -0.1013 | Yes |
| 55 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 19771 | -2.393 | 0.0014 | Yes |
