Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_AMYLOIDS |
| Enrichment Score (ES) | -0.7707644 |
| Normalized Enrichment Score (NES) | -2.0409977 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0012831187 |
| FWER p-Value | 0.005 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 861 | 0.511 | -0.0194 | No |
| 2 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 1113 | 0.447 | -0.0091 | No |
| 3 | LTF | LTF Entrez, Source | lactotransferrin | 1783 | 0.313 | -0.0286 | No |
| 4 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 2297 | 0.248 | -0.0431 | No |
| 5 | HSPG2 | HSPG2 Entrez, Source | heparan sulfate proteoglycan 2 (perlecan) | 3474 | 0.144 | -0.0993 | No |
| 6 | CST3 | CST3 Entrez, Source | cystatin C (amyloid angiopathy and cerebral hemorrhage) | 3806 | 0.124 | -0.1106 | No |
| 7 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 4796 | 0.083 | -0.1598 | No |
| 8 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 7328 | 0.027 | -0.2958 | No |
| 9 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 7809 | 0.019 | -0.3208 | No |
| 10 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 8415 | 0.010 | -0.3531 | No |
| 11 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 8669 | 0.007 | -0.3664 | No |
| 12 | B2M | B2M Entrez, Source | beta-2-microglobulin | 9568 | -0.006 | -0.4149 | No |
| 13 | ITM2B | ITM2B Entrez, Source | integral membrane protein 2B | 10251 | -0.016 | -0.4510 | No |
| 14 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 10299 | -0.017 | -0.4526 | No |
| 15 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 10371 | -0.018 | -0.4555 | No |
| 16 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 10742 | -0.025 | -0.4743 | No |
| 17 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 11068 | -0.031 | -0.4903 | No |
| 18 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 12747 | -0.068 | -0.5777 | No |
| 19 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 13513 | -0.093 | -0.6142 | No |
| 20 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 15559 | -0.226 | -0.7131 | No |
| 21 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 16046 | -0.283 | -0.7243 | No |
| 22 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 16155 | -0.298 | -0.7142 | No |
| 23 | SEMG1 | SEMG1 Entrez, Source | semenogelin I | 16184 | -0.303 | -0.6995 | No |
| 24 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 16205 | -0.307 | -0.6842 | No |
| 25 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 17801 | -0.696 | -0.7335 | Yes |
| 26 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 17855 | -0.724 | -0.6976 | Yes |
| 27 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 17876 | -0.733 | -0.6594 | Yes |
| 28 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 18048 | -0.840 | -0.6237 | Yes |
| 29 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18050 | -0.843 | -0.5786 | Yes |
| 30 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 18150 | -0.927 | -0.5343 | Yes |
| 31 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 18238 | -1.036 | -0.4836 | Yes |
| 32 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 18317 | -1.150 | -0.4262 | Yes |
| 33 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18365 | -1.265 | -0.3610 | Yes |
| 34 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 18373 | -1.283 | -0.2926 | Yes |
| 35 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 18380 | -1.300 | -0.2233 | Yes |
| 36 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 18393 | -1.337 | -0.1524 | Yes |
| 37 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 18402 | -1.376 | -0.0791 | Yes |
| 38 | CALCA | CALCA Entrez, Source | calcitonin/calcitonin-related polypeptide, alpha | 18436 | -1.535 | 0.0014 | Yes |
