Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_CHROMOSOME_MAINTENANCE |
| Enrichment Score (ES) | -0.6120056 |
| Normalized Enrichment Score (NES) | -1.8873218 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.015002263 |
| FWER p-Value | 0.245 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 861 | 0.511 | -0.0180 | No |
| 2 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 1113 | 0.447 | -0.0064 | No |
| 3 | RBBP4P1 | 1909 | 0.294 | -0.0330 | No | ||
| 4 | SYNE1 | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 2285 | 0.249 | -0.0394 | No |
| 5 | POLD4 | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 3282 | 0.156 | -0.0847 | No |
| 6 | WRAP53 | 3672 | 0.132 | -0.0985 | No | ||
| 7 | CENPI | CENPI Entrez, Source | centromere protein I | 4427 | 0.096 | -0.1341 | No |
| 8 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 4487 | 0.094 | -0.1320 | No |
| 9 | LIG1 | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 4548 | 0.091 | -0.1301 | No |
| 10 | POLE | POLE Entrez, Source | polymerase (DNA directed), epsilon | 4631 | 0.088 | -0.1296 | No |
| 11 | ATR | ATR Entrez, Source | ataxia telangiectasia and Rad3 related | 4742 | 0.084 | -0.1308 | No |
| 12 | TINF2 | TINF2 Entrez, Source | TERF1 (TRF1)-interacting nuclear factor 2 | 4848 | 0.080 | -0.1320 | No |
| 13 | TERT | TERT Entrez, Source | telomerase reverse transcriptase | 4892 | 0.079 | -0.1299 | No |
| 14 | FEN1 | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 5097 | 0.073 | -0.1368 | No |
| 15 | DNA2 | 5554 | 0.062 | -0.1582 | No | ||
| 16 | CENPN | CENPN Entrez, Source | centromere protein N | 5773 | 0.057 | -0.1669 | No |
| 17 | LMNB1 | LMNB1 Entrez, Source | lamin B1 | 5801 | 0.056 | -0.1652 | No |
| 18 | RBBP4 | RBBP4 Entrez, Source | retinoblastoma binding protein 4 | 5982 | 0.052 | -0.1720 | No |
| 19 | POLE2 | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 6096 | 0.049 | -0.1754 | No |
| 20 | ITGB3BP | ITGB3BP Entrez, Source | integrin beta 3 binding protein (beta3-endonexin) | 6501 | 0.042 | -0.1950 | No |
| 21 | TERF2 | TERF2 Entrez, Source | telomeric repeat binding factor 2 | 6508 | 0.042 | -0.1930 | No |
| 22 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 6671 | 0.039 | -0.1996 | No |
| 23 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 6987 | 0.033 | -0.2149 | No |
| 24 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 7090 | 0.031 | -0.2187 | No |
| 25 | SMC1B | SMC1B Entrez, Source | structural maintenance of chromosomes 1B | 7273 | 0.028 | -0.2271 | No |
| 26 | MIS18BP1 | 7344 | 0.027 | -0.2294 | No | ||
| 27 | CENPO | CENPO Entrez, Source | centromere protein O | 8167 | 0.014 | -0.2733 | No |
| 28 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 8236 | 0.013 | -0.2763 | No |
| 29 | CENPH | CENPH Entrez, Source | centromere protein H | 8385 | 0.010 | -0.2838 | No |
| 30 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 8415 | 0.010 | -0.2848 | No |
| 31 | SYNE2 | SYNE2 Entrez, Source | spectrin repeat containing, nuclear envelope 2 | 8880 | 0.004 | -0.3099 | No |
| 32 | POLA1 | POLA1 Entrez, Source | polymerase (DNA directed), alpha 1 | 8954 | 0.003 | -0.3137 | No |
| 33 | LMNA | LMNA Entrez, Source | lamin A/C | 8986 | 0.002 | -0.3152 | No |
| 34 | SMARCA5 | SMARCA5 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 9153 | -0.000 | -0.3242 | No |
| 35 | RFC5 | RFC5 Entrez, Source | replication factor C (activator 1) 5, 36.5kDa | 9156 | -0.000 | -0.3243 | No |
| 36 | HSPA2 | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 9198 | -0.001 | -0.3265 | No |
| 37 | NHP2 | 9257 | -0.002 | -0.3296 | No | ||
| 38 | ACD | ACD Entrez, Source | adrenocortical dysplasia homolog (mouse) | 9473 | -0.005 | -0.3410 | No |
| 39 | HJURP | 9474 | -0.005 | -0.3407 | No | ||
| 40 | REC8 | 9519 | -0.006 | -0.3428 | No | ||
| 41 | CENPQ | CENPQ Entrez, Source | centromere protein Q | 9534 | -0.006 | -0.3432 | No |
| 42 | UBE2I | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 9535 | -0.006 | -0.3429 | No |
| 43 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 9555 | -0.006 | -0.3436 | No |
| 44 | STAG3 | STAG3 Entrez, Source | stromal antigen 3 | 9620 | -0.007 | -0.3466 | No |
| 45 | RUVBL1 | RUVBL1 Entrez, Source | RuvB-like 1 (E. coli) | 9892 | -0.011 | -0.3608 | No |
| 46 | OIP5 | OIP5 Entrez, Source | Opa interacting protein 5 | 10058 | -0.013 | -0.3690 | No |
| 47 | TERF1 | TERF1 Entrez, Source | telomeric repeat binding factor (NIMA-interacting) 1 | 10073 | -0.014 | -0.3690 | No |
| 48 | RBBP7 | RBBP7 Entrez, Source | retinoblastoma binding protein 7 | 10101 | -0.014 | -0.3697 | No |
| 49 | NPM1 | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 10367 | -0.018 | -0.3831 | No |
| 50 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 10371 | -0.018 | -0.3822 | No |
| 51 | CENPP | CENPP Entrez, Source | centromere protein P | 10486 | -0.020 | -0.3873 | No |
| 52 | STAG1 | STAG1 Entrez, Source | stromal antigen 1 | 10553 | -0.021 | -0.3897 | No |
| 53 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 10605 | -0.022 | -0.3912 | No |
| 54 | SUN2 | 10626 | -0.022 | -0.3910 | No | ||
| 55 | MIS18A | 10713 | -0.024 | -0.3944 | No | ||
| 56 | POT1 | POT1 Entrez, Source | POT1 protection of telomeres 1 homolog (S. pombe) | 10982 | -0.029 | -0.4073 | No |
| 57 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 11068 | -0.031 | -0.4102 | No |
| 58 | RUVBL2 | RUVBL2 Entrez, Source | RuvB-like 2 (E. coli) | 11169 | -0.032 | -0.4138 | No |
| 59 | CENPA | CENPA Entrez, Source | centromere protein A | 11482 | -0.038 | -0.4287 | No |
| 60 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 11588 | -0.040 | -0.4321 | No |
| 61 | RFC4 | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 11682 | -0.042 | -0.4348 | No |
| 62 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 11712 | -0.043 | -0.4340 | No |
| 63 | RAD21 | RAD21 Entrez, Source | RAD21 homolog (S. pombe) | 11731 | -0.043 | -0.4325 | No |
| 64 | PRIM2 | 11836 | -0.045 | -0.4356 | No | ||
| 65 | RSF1 | RSF1 Entrez, Source | remodeling and spacing factor 1 | 11853 | -0.045 | -0.4339 | No |
| 66 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 12544 | -0.062 | -0.4680 | No |
| 67 | DIDO1 | DIDO1 Entrez, Source | death inducer-obliterator 1 | 12686 | -0.066 | -0.4719 | No |
| 68 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 12747 | -0.068 | -0.4713 | No |
| 69 | DKC1 | DKC1 Entrez, Source | dyskeratosis congenita 1, dyskerin | 12819 | -0.070 | -0.4712 | No |
| 70 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 13067 | -0.078 | -0.4803 | No |
| 71 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 13122 | -0.079 | -0.4787 | No |
| 72 | PRIM1 | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 13237 | -0.084 | -0.4802 | No |
| 73 | STAG2 | STAG2 Entrez, Source | stromal antigen 2 | 13485 | -0.092 | -0.4884 | No |
| 74 | POLA2 | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 13504 | -0.093 | -0.4842 | No |
| 75 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 13513 | -0.093 | -0.4794 | No |
| 76 | CENPK | CENPK Entrez, Source | centromere protein K | 13793 | -0.106 | -0.4885 | No |
| 77 | TERF2IP | TERF2IP Entrez, Source | telomeric repeat binding factor 2, interacting protein | 14391 | -0.138 | -0.5132 | No |
| 78 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 15559 | -0.226 | -0.5640 | No |
| 79 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 16046 | -0.283 | -0.5745 | No |
| 80 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 16155 | -0.298 | -0.5635 | No |
| 81 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 16205 | -0.307 | -0.5488 | No |
| 82 | SYCP1 | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 17367 | -0.539 | -0.5815 | Yes |
| 83 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 17801 | -0.696 | -0.5658 | Yes |
| 84 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 17855 | -0.724 | -0.5277 | Yes |
| 85 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 17876 | -0.733 | -0.4874 | Yes |
| 86 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 18048 | -0.840 | -0.4492 | Yes |
| 87 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18050 | -0.843 | -0.4016 | Yes |
| 88 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 18317 | -1.150 | -0.3510 | Yes |
| 89 | SYCP2 | SYCP2 Entrez, Source | synaptonemal complex protein 2 | 18321 | -1.158 | -0.2857 | Yes |
| 90 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18365 | -1.265 | -0.2166 | Yes |
| 91 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 18373 | -1.283 | -0.1444 | Yes |
| 92 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 18380 | -1.300 | -0.0712 | Yes |
| 93 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 18393 | -1.337 | 0.0037 | Yes |
