Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_MEIOSIS |
| Enrichment Score (ES) | -0.66506 |
| Normalized Enrichment Score (NES) | -1.9342942 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0057128104 |
| FWER p-Value | 0.076 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MSH5 | MSH5 Entrez, Source | mutS homolog 5 (E. coli) | 558 | 0.625 | -0.0006 | No |
| 2 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 861 | 0.511 | 0.0073 | No |
| 3 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 1113 | 0.447 | 0.0149 | No |
| 4 | SYNE1 | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 2285 | 0.249 | -0.0369 | No |
| 5 | RAD51C | RAD51C Entrez, Source | RAD51 homolog C (S. cerevisiae) | 2448 | 0.233 | -0.0346 | No |
| 6 | DMC1 | DMC1 Entrez, Source | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 3151 | 0.167 | -0.0649 | No |
| 7 | TEX15 | TEX15 Entrez, Source | testis expressed sequence 15 | 3604 | 0.136 | -0.0830 | No |
| 8 | ATR | ATR Entrez, Source | ataxia telangiectasia and Rad3 related | 4742 | 0.084 | -0.1408 | No |
| 9 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 4796 | 0.083 | -0.1397 | No |
| 10 | TINF2 | TINF2 Entrez, Source | TERF1 (TRF1)-interacting nuclear factor 2 | 4848 | 0.080 | -0.1386 | No |
| 11 | MND1 | MND1 Entrez, Source | meiotic nuclear divisions 1 homolog (S. cerevisiae) | 5045 | 0.075 | -0.1458 | No |
| 12 | LMNB1 | LMNB1 Entrez, Source | lamin B1 | 5801 | 0.056 | -0.1841 | No |
| 13 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 5887 | 0.054 | -0.1862 | No |
| 14 | TERF2 | TERF2 Entrez, Source | telomeric repeat binding factor 2 | 6508 | 0.042 | -0.2179 | No |
| 15 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 6987 | 0.033 | -0.2423 | No |
| 16 | SMC1B | SMC1B Entrez, Source | structural maintenance of chromosomes 1B | 7273 | 0.028 | -0.2565 | No |
| 17 | BLM | BLM Entrez, Source | Bloom syndrome | 7576 | 0.023 | -0.2719 | No |
| 18 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 8236 | 0.013 | -0.3071 | No |
| 19 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 8415 | 0.010 | -0.3163 | No |
| 20 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 8669 | 0.007 | -0.3297 | No |
| 21 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 8801 | 0.005 | -0.3366 | No |
| 22 | SYNE2 | SYNE2 Entrez, Source | spectrin repeat containing, nuclear envelope 2 | 8880 | 0.004 | -0.3407 | No |
| 23 | LMNA | LMNA Entrez, Source | lamin A/C | 8986 | 0.002 | -0.3463 | No |
| 24 | HSPA2 | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 9198 | -0.001 | -0.3577 | No |
| 25 | ACD | ACD Entrez, Source | adrenocortical dysplasia homolog (mouse) | 9473 | -0.005 | -0.3724 | No |
| 26 | REC8 | 9519 | -0.006 | -0.3745 | No | ||
| 27 | UBE2I | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 9535 | -0.006 | -0.3751 | No |
| 28 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 9555 | -0.006 | -0.3758 | No |
| 29 | ATM | ATM Entrez, Source | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 9556 | -0.006 | -0.3755 | No |
| 30 | MLH1 | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 9613 | -0.007 | -0.3782 | No |
| 31 | STAG3 | STAG3 Entrez, Source | stromal antigen 3 | 9620 | -0.007 | -0.3782 | No |
| 32 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 9873 | -0.011 | -0.3914 | No |
| 33 | TERF1 | TERF1 Entrez, Source | telomeric repeat binding factor (NIMA-interacting) 1 | 10073 | -0.014 | -0.4016 | No |
| 34 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 10371 | -0.018 | -0.4169 | No |
| 35 | STAG1 | STAG1 Entrez, Source | stromal antigen 1 | 10553 | -0.021 | -0.4257 | No |
| 36 | SUN2 | 10626 | -0.022 | -0.4286 | No | ||
| 37 | POT1 | POT1 Entrez, Source | POT1 protection of telomeres 1 homolog (S. pombe) | 10982 | -0.029 | -0.4465 | No |
| 38 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 11068 | -0.031 | -0.4497 | No |
| 39 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 11712 | -0.043 | -0.4826 | No |
| 40 | RAD21 | RAD21 Entrez, Source | RAD21 homolog (S. pombe) | 11731 | -0.043 | -0.4815 | No |
| 41 | RAD51 | RAD51 Entrez, Source | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 12083 | -0.051 | -0.4982 | No |
| 42 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 12544 | -0.062 | -0.5203 | No |
| 43 | RBBP8 | RBBP8 Entrez, Source | retinoblastoma binding protein 8 | 12681 | -0.066 | -0.5245 | No |
| 44 | DIDO1 | DIDO1 Entrez, Source | death inducer-obliterator 1 | 12686 | -0.066 | -0.5215 | No |
| 45 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 12747 | -0.068 | -0.5216 | No |
| 46 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 13122 | -0.079 | -0.5381 | No |
| 47 | TOP3A | TOP3A Entrez, Source | topoisomerase (DNA) III alpha | 13302 | -0.086 | -0.5438 | No |
| 48 | STAG2 | STAG2 Entrez, Source | stromal antigen 2 | 13485 | -0.092 | -0.5493 | No |
| 49 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 13513 | -0.093 | -0.5464 | No |
| 50 | NBN | NBN Entrez, Source | nibrin | 14097 | -0.121 | -0.5723 | No |
| 51 | TERF2IP | TERF2IP Entrez, Source | telomeric repeat binding factor 2, interacting protein | 14391 | -0.138 | -0.5817 | No |
| 52 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 15559 | -0.226 | -0.6343 | No |
| 53 | MLH3 | MLH3 Entrez, Source | mutL homolog 3 (E. coli) | 15805 | -0.253 | -0.6356 | No |
| 54 | RAD50 | RAD50 Entrez, Source | RAD50 homolog (S. cerevisiae) | 15980 | -0.273 | -0.6321 | No |
| 55 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 16046 | -0.283 | -0.6222 | No |
| 56 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 16155 | -0.298 | -0.6139 | No |
| 57 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 16205 | -0.307 | -0.6019 | No |
| 58 | SYCP1 | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 17367 | -0.539 | -0.6394 | Yes |
| 59 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 17801 | -0.696 | -0.6298 | Yes |
| 60 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 17855 | -0.724 | -0.5983 | Yes |
| 61 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 17876 | -0.733 | -0.5645 | Yes |
| 62 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 18048 | -0.840 | -0.5338 | Yes |
| 63 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18050 | -0.843 | -0.4937 | Yes |
| 64 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 18150 | -0.927 | -0.4550 | Yes |
| 65 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 18238 | -1.036 | -0.4104 | Yes |
| 66 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 18317 | -1.150 | -0.3599 | Yes |
| 67 | SYCP2 | SYCP2 Entrez, Source | synaptonemal complex protein 2 | 18321 | -1.158 | -0.3049 | Yes |
| 68 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18365 | -1.265 | -0.2471 | Yes |
| 69 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 18373 | -1.283 | -0.1864 | Yes |
| 70 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 18380 | -1.300 | -0.1248 | Yes |
| 71 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 18393 | -1.337 | -0.0618 | Yes |
| 72 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 18402 | -1.376 | 0.0032 | Yes |
