Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_MEIOTIC_RECOMBINATION |
| Enrichment Score (ES) | -0.7054072 |
| Normalized Enrichment Score (NES) | -1.9434149 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0060653607 |
| FWER p-Value | 0.069 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MSH5 | MSH5 Entrez, Source | mutS homolog 5 (E. coli) | 558 | 0.625 | 0.0040 | No |
| 2 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 861 | 0.511 | 0.0156 | No |
| 3 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 1113 | 0.447 | 0.0265 | No |
| 4 | RAD51C | RAD51C Entrez, Source | RAD51 homolog C (S. cerevisiae) | 2448 | 0.233 | -0.0332 | No |
| 5 | DMC1 | DMC1 Entrez, Source | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 3151 | 0.167 | -0.0622 | No |
| 6 | TEX15 | TEX15 Entrez, Source | testis expressed sequence 15 | 3604 | 0.136 | -0.0793 | No |
| 7 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 4796 | 0.083 | -0.1395 | No |
| 8 | MND1 | MND1 Entrez, Source | meiotic nuclear divisions 1 homolog (S. cerevisiae) | 5045 | 0.075 | -0.1488 | No |
| 9 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 5887 | 0.054 | -0.1915 | No |
| 10 | BLM | BLM Entrez, Source | Bloom syndrome | 7576 | 0.023 | -0.2819 | No |
| 11 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 8236 | 0.013 | -0.3170 | No |
| 12 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 8415 | 0.010 | -0.3261 | No |
| 13 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 8669 | 0.007 | -0.3395 | No |
| 14 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 8801 | 0.005 | -0.3464 | No |
| 15 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 9555 | -0.006 | -0.3869 | No |
| 16 | ATM | ATM Entrez, Source | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 9556 | -0.006 | -0.3866 | No |
| 17 | MLH1 | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 9613 | -0.007 | -0.3892 | No |
| 18 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 9873 | -0.011 | -0.4027 | No |
| 19 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 10371 | -0.018 | -0.4287 | No |
| 20 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 11068 | -0.031 | -0.4648 | No |
| 21 | RAD51 | RAD51 Entrez, Source | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 12083 | -0.051 | -0.5171 | No |
| 22 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 12544 | -0.062 | -0.5387 | No |
| 23 | RBBP8 | RBBP8 Entrez, Source | retinoblastoma binding protein 8 | 12681 | -0.066 | -0.5424 | No |
| 24 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 12747 | -0.068 | -0.5422 | No |
| 25 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 13122 | -0.079 | -0.5582 | No |
| 26 | TOP3A | TOP3A Entrez, Source | topoisomerase (DNA) III alpha | 13302 | -0.086 | -0.5632 | No |
| 27 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 13513 | -0.093 | -0.5695 | No |
| 28 | NBN | NBN Entrez, Source | nibrin | 14097 | -0.121 | -0.5945 | No |
| 29 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 15559 | -0.226 | -0.6615 | No |
| 30 | MLH3 | MLH3 Entrez, Source | mutL homolog 3 (E. coli) | 15805 | -0.253 | -0.6609 | No |
| 31 | RAD50 | RAD50 Entrez, Source | RAD50 homolog (S. cerevisiae) | 15980 | -0.273 | -0.6554 | No |
| 32 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 16046 | -0.283 | -0.6434 | No |
| 33 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 16155 | -0.298 | -0.6329 | No |
| 34 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 16205 | -0.307 | -0.6188 | No |
| 35 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 17801 | -0.696 | -0.6672 | Yes |
| 36 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 17855 | -0.724 | -0.6305 | Yes |
| 37 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 17876 | -0.733 | -0.5914 | Yes |
| 38 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 18048 | -0.840 | -0.5546 | Yes |
| 39 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18050 | -0.843 | -0.5085 | Yes |
| 40 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 18150 | -0.927 | -0.4630 | Yes |
| 41 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 18238 | -1.036 | -0.4109 | Yes |
| 42 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 18317 | -1.150 | -0.3521 | Yes |
| 43 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18365 | -1.265 | -0.2853 | Yes |
| 44 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 18373 | -1.283 | -0.2154 | Yes |
| 45 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 18380 | -1.300 | -0.1444 | Yes |
| 46 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 18393 | -1.337 | -0.0718 | Yes |
| 47 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 18402 | -1.376 | 0.0032 | Yes |
