Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50719_832_collapsed_to_symbols.NS50719_832.cls #arhinia_versus_control.NS50719_832.cls #arhinia_versus_control_repos |
| Phenotype | NS50719_832.cls#arhinia_versus_control_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_TELOMERE_MAINTENANCE |
| Enrichment Score (ES) | -0.6775323 |
| Normalized Enrichment Score (NES) | -1.9285448 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.005947169 |
| FWER p-Value | 0.085 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 861 | 0.511 | -0.0110 | No |
| 2 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 1113 | 0.447 | 0.0067 | No |
| 3 | POLD4 | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 3282 | 0.156 | -0.1001 | No |
| 4 | WRAP53 | 3672 | 0.132 | -0.1120 | No | ||
| 5 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 4487 | 0.094 | -0.1497 | No |
| 6 | LIG1 | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 4548 | 0.091 | -0.1465 | No |
| 7 | POLE | POLE Entrez, Source | polymerase (DNA directed), epsilon | 4631 | 0.088 | -0.1448 | No |
| 8 | TINF2 | TINF2 Entrez, Source | TERF1 (TRF1)-interacting nuclear factor 2 | 4848 | 0.080 | -0.1509 | No |
| 9 | TERT | TERT Entrez, Source | telomerase reverse transcriptase | 4892 | 0.079 | -0.1477 | No |
| 10 | FEN1 | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 5097 | 0.073 | -0.1536 | No |
| 11 | DNA2 | 5554 | 0.062 | -0.1741 | No | ||
| 12 | POLE2 | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 6096 | 0.049 | -0.2000 | No |
| 13 | TERF2 | TERF2 Entrez, Source | telomeric repeat binding factor 2 | 6508 | 0.042 | -0.2194 | No |
| 14 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 6671 | 0.039 | -0.2255 | No |
| 15 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 7090 | 0.031 | -0.2461 | No |
| 16 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 8236 | 0.013 | -0.3074 | No |
| 17 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 8415 | 0.010 | -0.3163 | No |
| 18 | POLA1 | POLA1 Entrez, Source | polymerase (DNA directed), alpha 1 | 8954 | 0.003 | -0.3454 | No |
| 19 | RFC5 | RFC5 Entrez, Source | replication factor C (activator 1) 5, 36.5kDa | 9156 | -0.000 | -0.3563 | No |
| 20 | NHP2 | 9257 | -0.002 | -0.3616 | No | ||
| 21 | ACD | ACD Entrez, Source | adrenocortical dysplasia homolog (mouse) | 9473 | -0.005 | -0.3729 | No |
| 22 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 9555 | -0.006 | -0.3769 | No |
| 23 | RUVBL1 | RUVBL1 Entrez, Source | RuvB-like 1 (E. coli) | 9892 | -0.011 | -0.3943 | No |
| 24 | TERF1 | TERF1 Entrez, Source | telomeric repeat binding factor (NIMA-interacting) 1 | 10073 | -0.014 | -0.4032 | No |
| 25 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 10371 | -0.018 | -0.4180 | No |
| 26 | POLD2 | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 10605 | -0.022 | -0.4292 | No |
| 27 | POT1 | POT1 Entrez, Source | POT1 protection of telomeres 1 homolog (S. pombe) | 10982 | -0.029 | -0.4475 | No |
| 28 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 11068 | -0.031 | -0.4500 | No |
| 29 | RUVBL2 | RUVBL2 Entrez, Source | RuvB-like 2 (E. coli) | 11169 | -0.032 | -0.4532 | No |
| 30 | RFC3 | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 11588 | -0.040 | -0.4731 | No |
| 31 | RFC4 | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 11682 | -0.042 | -0.4752 | No |
| 32 | PRIM2 | 11836 | -0.045 | -0.4803 | No | ||
| 33 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 12544 | -0.062 | -0.5144 | No |
| 34 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 12747 | -0.068 | -0.5205 | No |
| 35 | DKC1 | DKC1 Entrez, Source | dyskeratosis congenita 1, dyskerin | 12819 | -0.070 | -0.5195 | No |
| 36 | RFC2 | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 13067 | -0.078 | -0.5275 | No |
| 37 | PRIM1 | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 13237 | -0.084 | -0.5308 | No |
| 38 | POLA2 | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 13504 | -0.093 | -0.5387 | No |
| 39 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 13513 | -0.093 | -0.5327 | No |
| 40 | TERF2IP | TERF2IP Entrez, Source | telomeric repeat binding factor 2, interacting protein | 14391 | -0.138 | -0.5706 | No |
| 41 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 15559 | -0.226 | -0.6182 | No |
| 42 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 16046 | -0.283 | -0.6248 | No |
| 43 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 16155 | -0.298 | -0.6097 | No |
| 44 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 16205 | -0.307 | -0.5909 | No |
| 45 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 17801 | -0.696 | -0.6287 | Yes |
| 46 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 17855 | -0.724 | -0.5809 | Yes |
| 47 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 17876 | -0.733 | -0.5306 | Yes |
| 48 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 18048 | -0.840 | -0.4810 | Yes |
| 49 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 18050 | -0.843 | -0.4220 | Yes |
| 50 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 18317 | -1.150 | -0.3558 | Yes |
| 51 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 18365 | -1.265 | -0.2697 | Yes |
| 52 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 18373 | -1.283 | -0.1802 | Yes |
| 53 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 18380 | -1.300 | -0.0894 | Yes |
| 54 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 18393 | -1.337 | 0.0037 | Yes |
