Details for gene set GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM[GSEA]

Table: GSEA Results Summary

Dataset	NS50832_collapsed_to_symbols.NS50832.cls #558AP2_versus_S78.NS50832.cls #558AP2_versus_S78_repos
Phenotype	NS50832.cls#558AP2_versus_S78_repos
Upregulated in class	1
GeneSet	GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM
Enrichment Score (ES)	0.57148993
Normalized Enrichment Score (NES)	1.89851
Nominal p-value	0.0
FDR q-value	0.054105885
FWER p-Value	0.284

Fig 1: Enrichment plot: GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	HAND1	HAND1 Entrez,  Source	heart and neural crest derivatives expressed 1	63	4.144	0.0663	Yes
2	SIX1	SIX1 Entrez,  Source	sine oculis homeobox homolog 1 (Drosophila)	113	3.493	0.1224	Yes
3	IRX1	IRX1 Entrez,  Source	iroquois homeobox protein 1	134	3.309	0.1768	Yes
4	GRHL3	GRHL3 Entrez,  Source	grainyhead-like 3 (Drosophila)	198	2.948	0.2230	Yes
5	ALX1			239	2.734	0.2668	Yes
6	TFAP2A	TFAP2A Entrez,  Source	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	264	2.598	0.3092	Yes
7	FGF8	FGF8 Entrez,  Source	fibroblast growth factor 8 (androgen-induced)	277	2.560	0.3514	Yes
8	WNT7B	WNT7B Entrez,  Source	wingless-type MMTV integration site family, member 7B	290	2.527	0.3931	Yes
9	GATA3	GATA3 Entrez,  Source	GATA binding protein 3	505	1.890	0.4144	Yes
10	IRX3	IRX3 Entrez,  Source	iroquois homeobox protein 3	515	1.867	0.4452	Yes
11	BMP4	BMP4 Entrez,  Source	bone morphogenetic protein 4	620	1.680	0.4683	Yes
12	T	T Entrez,  Source	T, brachyury homolog (mouse)	641	1.634	0.4947	Yes
13	TWIST1	TWIST1 Entrez,  Source	twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)	653	1.619	0.5213	Yes
14	GDNF	GDNF Entrez,  Source	glial cell derived neurotrophic factor	699	1.554	0.5451	Yes
15	HHEX	HHEX Entrez,  Source	homeobox, hematopoietically expressed	846	1.359	0.5608	Yes
16	GREM1	GREM1 Entrez,  Source	gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)	1577	0.822	0.5396	Yes
17	PTCH1	PTCH1 Entrez,  Source	patched homolog 1 (Drosophila)	1582	0.820	0.5531	Yes
18	PCDH8	PCDH8 Entrez,  Source	protocadherin 8	1853	0.708	0.5520	Yes
19	RET	RET Entrez,  Source	ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)	1919	0.680	0.5603	Yes
20	FZD1	FZD1 Entrez,  Source	frizzled homolog 1 (Drosophila)	1923	0.678	0.5715	Yes
21	IRX2	IRX2 Entrez,  Source	iroquois homeobox protein 2	2882	0.421	0.5326	No
22	TULP3	TULP3 Entrez,  Source	tubby like protein 3	3496	0.310	0.5084	No
23	NODAL	NODAL Entrez,  Source	nodal homolog (mouse)	3518	0.308	0.5126	No
24	IFT172	IFT172 Entrez,  Source	intraflagellar transport 172 homolog (Chlamydomonas)	4017	0.246	0.4928	No
25	SFRP2	SFRP2 Entrez,  Source	secreted frizzled-related protein 2	4747	0.188	0.4610	No
26	APAF1	APAF1 Entrez,  Source	apoptotic peptidase activating factor	5094	0.168	0.4472	No
27	IFT122	IFT122 Entrez,  Source	intraflagellar transport 122 homolog (Chlamydomonas)	5255	0.158	0.4422	No
28	TRIM71	TRIM71 Entrez,  Source	tripartite motif-containing 71	5656	0.137	0.4253	No
29	NOG	NOG Entrez,  Source	noggin	5925	0.125	0.4146	No
30	KAT2A			5987	0.123	0.4137	No
31	JAG2	JAG2 Entrez,  Source	jagged 2	6098	0.118	0.4104	No
32	SEMA4C	SEMA4C Entrez,  Source	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	6273	0.111	0.4039	No
33	LAMA5	LAMA5 Entrez,  Source	laminin, alpha 5	6338	0.108	0.4027	No
34	GLI2	GLI2 Entrez,  Source	GLI-Kruppel family member GLI2	6412	0.105	0.4010	No
35	LRP6	LRP6 Entrez,  Source	low density lipoprotein receptor-related protein 6	6462	0.104	0.4003	No
36	CELSR1	CELSR1 Entrez,  Source	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	6486	0.103	0.4009	No
37	SUFU	SUFU Entrez,  Source	suppressor of fused homolog (Drosophila)	6496	0.102	0.4022	No
38	SKI	SKI Entrez,  Source	v-ski sarcoma viral oncogene homolog (avian)	6684	0.096	0.3949	No
39	SDC4	SDC4 Entrez,  Source	syndecan 4 (amphiglycan, ryudocan)	6725	0.095	0.3946	No
40	SCRIB	SCRIB Entrez,  Source	scribbled homolog (Drosophila)	6749	0.094	0.3950	No
41	KIF20B			6774	0.094	0.3954	No
42	DEAF1	DEAF1 Entrez,  Source	deformed epidermal autoregulatory factor 1 (Drosophila)	6779	0.093	0.3968	No
43	SEC24B	SEC24B Entrez,  Source	SEC24 related gene family, member B (S. cerevisiae)	6819	0.092	0.3965	No
44	SOX4	SOX4 Entrez,  Source	SRY (sex determining region Y)-box 4	6940	0.088	0.3922	No
45	PLXNB2	PLXNB2 Entrez,  Source	plexin B2	6964	0.087	0.3926	No
46	SHROOM3	SHROOM3 Entrez,  Source	shroom family member 3	7041	0.085	0.3903	No
47	TSC2	TSC2 Entrez,  Source	tuberous sclerosis 2	7292	0.078	0.3797	No
48	STK4	STK4 Entrez,  Source	serine/threonine kinase 4	7309	0.078	0.3802	No
49	KDM2B			7469	0.073	0.3738	No
50	PHACTR4	PHACTR4 Entrez,  Source	phosphatase and actin regulator 4	7555	0.070	0.3709	No
51	LHX2	LHX2 Entrez,  Source	LIM homeobox 2	7562	0.070	0.3718	No
52	MIB1	MIB1 Entrez,  Source	mindbomb homolog 1 (Drosophila)	7658	0.068	0.3684	No
53	COBL	COBL Entrez,  Source	cordon-bleu homolog (mouse)	8034	0.057	0.3514	No
54	TMED2	TMED2 Entrez,  Source	transmembrane emp24 domain trafficking protein 2	8061	0.057	0.3511	No
55	FUZ	FUZ Entrez,  Source	fuzzy homolog (Drosophila)	8211	0.053	0.3448	No
56	STK3	STK3 Entrez,  Source	serine/threonine kinase 3 (STE20 homolog, yeast)	8227	0.052	0.3450	No
57	IFT52	IFT52 Entrez,  Source	intraflagellar transport 52 homolog (Chlamydomonas)	8262	0.052	0.3442	No
58	GDF7	GDF7 Entrez,  Source	growth differentiation factor 7	8374	0.049	0.3397	No
59	ARID1A	ARID1A Entrez,  Source	AT rich interactive domain 1A (SWI- like)	8667	0.042	0.3264	No
60	TSC1	TSC1 Entrez,  Source	tuberous sclerosis 1	8697	0.042	0.3257	No
61	LUZP1	LUZP1 Entrez,  Source	leucine zipper protein 1	8698	0.042	0.3264	No
62	PFN1	PFN1 Entrez,  Source	profilin 1	8761	0.040	0.3241	No
63	FZD3	FZD3 Entrez,  Source	frizzled homolog 3 (Drosophila)	8890	0.036	0.3186	No
64	SALL4	SALL4 Entrez,  Source	sal-like 4 (Drosophila)	8987	0.034	0.3146	No
65	FGFR2	FGFR2 Entrez,  Source	ffer syndrome, Jackson-Weiss syndrome)	9005	0.033	0.3143	No
66	MTHFD1L	MTHFD1L Entrez,  Source	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	9034	0.033	0.3135	No
67	ARHGAP35			9152	0.030	0.3084	No
68	RPS7	RPS7 Entrez,  Source	ribosomal protein S7	9184	0.029	0.3074	No
69	DVL1	DVL1 Entrez,  Source	dishevelled, dsh homolog 1 (Drosophila)	9223	0.028	0.3060	No
70	DVL2	DVL2 Entrez,  Source	dishevelled, dsh homolog 2 (Drosophila)	9296	0.026	0.3030	No
71	VANGL2	VANGL2 Entrez,  Source	vang-like 2 (van gogh, Drosophila)	9402	0.023	0.2984	No
72	EPB41L5	EPB41L5 Entrez,  Source	erythrocyte membrane protein band 4.1 like 5	9515	0.021	0.2934	No
73	SOX11	SOX11 Entrez,  Source	SRY (sex determining region Y)-box 11	9608	0.019	0.2893	No
74	PRKACB	PRKACB Entrez,  Source	protein kinase, cAMP-dependent, catalytic, beta	9612	0.018	0.2894	No
75	MTHFD1	MTHFD1 Entrez,  Source	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	9669	0.017	0.2870	No
76	SFRP1	SFRP1 Entrez,  Source	secreted frizzled-related protein 1	9775	0.014	0.2822	No
77	PTK7	PTK7 Entrez,  Source	PTK7 protein tyrosine kinase 7	9831	0.013	0.2798	No
78	CTNNB1	CTNNB1 Entrez,  Source	catenin (cadherin-associated protein), beta 1, 88kDa	9928	0.011	0.2754	No
79	VASP	VASP Entrez,  Source	vasodilator-stimulated phosphoprotein	9932	0.011	0.2754	No
80	ALDH1A3	ALDH1A3 Entrez,  Source	aldehyde dehydrogenase 1 family, member A3	10051	0.007	0.2699	No
81	ST14	ST14 Entrez,  Source	suppression of tumorigenicity 14 (colon carcinoma)	10279	0.002	0.2590	No
82	SETD2	SETD2 Entrez,  Source	SET domain containing 2	10457	-0.002	0.2506	No
83	GRSF1	GRSF1 Entrez,  Source	G-rich RNA sequence binding factor 1	10853	-0.013	0.2319	No
84	RARG	RARG Entrez,  Source	retinoic acid receptor, gamma	10913	-0.015	0.2293	No
85	SPINT1	SPINT1 Entrez,  Source	serine peptidase inhibitor, Kunitz type 1	11139	-0.021	0.2189	No
86	IFT57	IFT57 Entrez,  Source	intraflagellar transport 57 homolog (Chlamydomonas)	11198	-0.023	0.2165	No
87	TRAF6	TRAF6 Entrez,  Source	TNF receptor-associated factor 6	11434	-0.029	0.2057	No
88	STIL	STIL Entrez,  Source	SCL/TAL1 interrupting locus	11469	-0.030	0.2046	No
89	TCTN1			11756	-0.039	0.1915	No
90	HIF1A	HIF1A Entrez,  Source	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11883	-0.043	0.1862	No
91	MKS1	MKS1 Entrez,  Source	Meckel syndrome, type 1	12212	-0.054	0.1714	No
92	BCL10	BCL10 Entrez,  Source	B-cell CLL/lymphoma 10	12551	-0.066	0.1563	No
93	DVL3	DVL3 Entrez,  Source	dishevelled, dsh homolog 3 (Drosophila)	12687	-0.071	0.1510	No
94	BBS4	BBS4 Entrez,  Source	Bardet-Biedl syndrome 4	12758	-0.074	0.1489	No
95	PRKACA	PRKACA Entrez,  Source	protein kinase, cAMP-dependent, catalytic, alpha	12805	-0.077	0.1480	No
96	CC2D2A			12876	-0.079	0.1459	No
97	OSR1	OSR1 Entrez,  Source	odd-skipped related 1 (Drosophila)	13164	-0.091	0.1337	No
98	RALA	RALA Entrez,  Source	v-ral simian leukemia viral oncogene homolog A (ras related)	13422	-0.103	0.1231	No
99	SOX8	SOX8 Entrez,  Source	SRY (sex determining region Y)-box 8	13649	-0.113	0.1142	No
100	GLMN	GLMN Entrez,  Source	glomulin, FKBP associated protein	13837	-0.123	0.1073	No
101	GRHL2	GRHL2 Entrez,  Source	grainyhead-like 2 (Drosophila)	13840	-0.124	0.1093	No
102	WNT5A	WNT5A Entrez,  Source	wingless-type MMTV integration site family, member 5A	14532	-0.168	0.0790	No
103	LMO4	LMO4 Entrez,  Source	LIM domain only 4	14794	-0.190	0.0696	No
104	MED12	MED12 Entrez,  Source	mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)	14973	-0.202	0.0645	No
105	RDH10	RDH10 Entrez,  Source	retinol dehydrogenase 10 (all-trans)	15101	-0.211	0.0619	No
106	KDM6A			15605	-0.259	0.0421	No
107	LIAS	LIAS Entrez,  Source	lipoic acid synthetase	15863	-0.289	0.0347	No
108	FZD6	FZD6 Entrez,  Source	frizzled homolog 6 (Drosophila)	16057	-0.313	0.0306	No
109	RARA	RARA Entrez,  Source	retinoic acid receptor, alpha	16221	-0.336	0.0285	No
110	ALDH1A2	ALDH1A2 Entrez,  Source	aldehyde dehydrogenase 1 family, member A2	16424	-0.366	0.0249	No
111	IPMK	IPMK Entrez,  Source	inositol polyphosphate multikinase	16586	-0.392	0.0237	No
112	ADM	ADM Entrez,  Source	adrenomedullin	16823	-0.430	0.0196	No
113	WNT4	WNT4 Entrez,  Source	wingless-type MMTV integration site family, member 4	16859	-0.435	0.0252	No
114	FZD2	FZD2 Entrez,  Source	frizzled homolog 2 (Drosophila)	16897	-0.441	0.0308	No
115	ZEB2			17166	-0.501	0.0263	No
116	DLC1	DLC1 Entrez,  Source	deleted in liver cancer 1	17169	-0.501	0.0346	No
117	HNF1B			17674	-0.626	0.0210	No
118	OVOL2	OVOL2 Entrez,  Source	ovo-like 2 (Drosophila)	17739	-0.646	0.0287	No
119	WNT16	WNT16 Entrez,  Source	wingless-type MMTV integration site family, member 16	17920	-0.699	0.0318	No
120	CTHRC1	CTHRC1 Entrez,  Source	collagen triple helix repeat containing 1	18048	-0.741	0.0381	No
121	SOX9	SOX9 Entrez,  Source	SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)	18063	-0.745	0.0499	No
122	PRICKLE1	PRICKLE1 Entrez,  Source	prickle homolog 1 (Drosophila)	18098	-0.755	0.0609	No
123	FOLR1	FOLR1 Entrez,  Source	folate receptor 1 (adult)	18852	-1.050	0.0423	No
124	TGFB1I1	TGFB1I1 Entrez,  Source	transforming growth factor beta 1 induced transcript 1	19684	-1.569	0.0288	No
125	VEGFC	VEGFC Entrez,  Source	vascular endothelial growth factor C	20126	-2.023	0.0415	No

Fig 2: GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet

Fig 3: GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM: Random ES distribution   
Gene set null distribution of ES for GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM