Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50832_collapsed_to_symbols.NS50832.cls #558AP2_versus_S78.NS50832.cls #558AP2_versus_S78_repos |
| Phenotype | NS50832.cls#558AP2_versus_S78_repos |
| Upregulated in class | 0 |
| GeneSet | REACTOME_MEIOSIS |
| Enrichment Score (ES) | -0.6176321 |
| Normalized Enrichment Score (NES) | -1.6224021 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HIST1H2BL | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 1112 | 1.110 | -0.0325 | No |
| 2 | HIST1H4D | HIST1H4D Entrez, Source | histone cluster 1, H4d | 1674 | 0.784 | -0.0447 | No |
| 3 | HIST1H4H | HIST1H4H Entrez, Source | histone cluster 1, H4h | 1800 | 0.733 | -0.0371 | No |
| 4 | HIST1H2BC | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 1804 | 0.731 | -0.0236 | No |
| 5 | HIST2H2AC | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 1857 | 0.707 | -0.0129 | No |
| 6 | HIST1H2AE | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 2062 | 0.630 | -0.0109 | No |
| 7 | RAD51C | RAD51C Entrez, Source | RAD51 homolog C (S. cerevisiae) | 2719 | 0.460 | -0.0337 | No |
| 8 | SYNE1 | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 2969 | 0.404 | -0.0381 | No |
| 9 | MSH4 | MSH4 Entrez, Source | mutS homolog 4 (E. coli) | 2988 | 0.400 | -0.0315 | No |
| 10 | HIST1H3J | HIST1H3J Entrez, Source | histone cluster 1, H3j | 3655 | 0.289 | -0.0580 | No |
| 11 | LMNA | LMNA Entrez, Source | lamin A/C | 3789 | 0.272 | -0.0592 | No |
| 12 | HSPA2 | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 3822 | 0.269 | -0.0558 | No |
| 13 | HIST1H3F | HIST1H3F Entrez, Source | histone cluster 1, H3f | 4421 | 0.211 | -0.0804 | No |
| 14 | LMNB1 | LMNB1 Entrez, Source | lamin B1 | 4810 | 0.185 | -0.0955 | No |
| 15 | REC8 | 4878 | 0.180 | -0.0954 | No | ||
| 16 | TEX15 | TEX15 Entrez, Source | testis expressed sequence 15 | 5817 | 0.130 | -0.1378 | No |
| 17 | TINF2 | TINF2 Entrez, Source | TERF1 (TRF1)-interacting nuclear factor 2 | 5840 | 0.129 | -0.1365 | No |
| 18 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 5970 | 0.123 | -0.1404 | No |
| 19 | H3F3A | H3F3A Entrez, Source | H3 histone, family 3A | 6169 | 0.115 | -0.1477 | No |
| 20 | STAG1 | STAG1 Entrez, Source | stromal antigen 1 | 6221 | 0.113 | -0.1480 | No |
| 21 | MSH5 | MSH5 Entrez, Source | mutS homolog 5 (E. coli) | 6227 | 0.113 | -0.1461 | No |
| 22 | H2AFX | H2AFX Entrez, Source | H2A histone family, member X | 6444 | 0.104 | -0.1545 | No |
| 23 | H2AFZ | H2AFZ Entrez, Source | H2A histone family, member Z | 7072 | 0.084 | -0.1830 | No |
| 24 | STAG3 | STAG3 Entrez, Source | stromal antigen 3 | 7217 | 0.080 | -0.1884 | No |
| 25 | TERF1 | TERF1 Entrez, Source | telomeric repeat binding factor (NIMA-interacting) 1 | 7904 | 0.061 | -0.2200 | No |
| 26 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 7911 | 0.061 | -0.2192 | No |
| 27 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 8296 | 0.051 | -0.2366 | No |
| 28 | RPA3 | RPA3 Entrez, Source | replication protein A3, 14kDa | 8342 | 0.050 | -0.2378 | No |
| 29 | TERF2 | TERF2 Entrez, Source | telomeric repeat binding factor 2 | 8438 | 0.047 | -0.2415 | No |
| 30 | ATR | ATR Entrez, Source | ataxia telangiectasia and Rad3 related | 8586 | 0.044 | -0.2477 | No |
| 31 | RPA1 | RPA1 Entrez, Source | replication protein A1, 70kDa | 8984 | 0.034 | -0.2660 | No |
| 32 | DMC1 | DMC1 Entrez, Source | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 9048 | 0.032 | -0.2684 | No |
| 33 | MND1 | MND1 Entrez, Source | meiotic nuclear divisions 1 homolog (S. cerevisiae) | 9063 | 0.032 | -0.2685 | No |
| 34 | H3F3B | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 9123 | 0.030 | -0.2708 | No |
| 35 | MLH1 | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 9162 | 0.029 | -0.2720 | No |
| 36 | SYNE2 | SYNE2 Entrez, Source | spectrin repeat containing, nuclear envelope 2 | 9210 | 0.028 | -0.2738 | No |
| 37 | DIDO1 | DIDO1 Entrez, Source | death inducer-obliterator 1 | 9634 | 0.018 | -0.2937 | No |
| 38 | UBE2I | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 9976 | 0.009 | -0.3098 | No |
| 39 | BLM | BLM Entrez, Source | Bloom syndrome | 10172 | 0.005 | -0.3190 | No |
| 40 | ACD | ACD Entrez, Source | adrenocortical dysplasia homolog (mouse) | 10964 | -0.016 | -0.3566 | No |
| 41 | ATM | ATM Entrez, Source | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 11786 | -0.040 | -0.3951 | No |
| 42 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 12620 | -0.068 | -0.4336 | No |
| 43 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 12701 | -0.072 | -0.4361 | No |
| 44 | RPA2 | RPA2 Entrez, Source | replication protein A2, 32kDa | 12818 | -0.077 | -0.4402 | No |
| 45 | RAD51 | RAD51 Entrez, Source | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 12951 | -0.083 | -0.4450 | No |
| 46 | HIST1H2BH | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 13000 | -0.085 | -0.4457 | No |
| 47 | TOP3A | TOP3A Entrez, Source | topoisomerase (DNA) III alpha | 13016 | -0.085 | -0.4449 | No |
| 48 | SUN2 | 13039 | -0.086 | -0.4443 | No | ||
| 49 | RAD21 | RAD21 Entrez, Source | RAD21 homolog (S. pombe) | 13197 | -0.093 | -0.4501 | No |
| 50 | HIST1H2BK | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 13205 | -0.093 | -0.4487 | No |
| 51 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 13573 | -0.110 | -0.4642 | No |
| 52 | STAG2 | STAG2 Entrez, Source | stromal antigen 2 | 13675 | -0.115 | -0.4669 | No |
| 53 | RBBP8 | RBBP8 Entrez, Source | retinoblastoma binding protein 8 | 13740 | -0.118 | -0.4677 | No |
| 54 | POT1 | POT1 Entrez, Source | POT1 protection of telomeres 1 homolog (S. pombe) | 14163 | -0.142 | -0.4853 | No |
| 55 | NBN | NBN Entrez, Source | nibrin | 14422 | -0.161 | -0.4946 | No |
| 56 | HIST1H2BE | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 14463 | -0.164 | -0.4935 | No |
| 57 | MLH3 | MLH3 Entrez, Source | mutL homolog 3 (E. coli) | 15359 | -0.236 | -0.5319 | No |
| 58 | TERF2IP | TERF2IP Entrez, Source | telomeric repeat binding factor 2, interacting protein | 15802 | -0.282 | -0.5478 | No |
| 59 | HIST1H3I | HIST1H3I Entrez, Source | histone cluster 1, H3i | 16000 | -0.305 | -0.5515 | No |
| 60 | HIST1H3A | HIST1H3A Entrez, Source | histone cluster 1, H3a | 16043 | -0.311 | -0.5477 | No |
| 61 | HIST2H2BE | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 16298 | -0.347 | -0.5534 | No |
| 62 | HIST1H2BG | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 16429 | -0.367 | -0.5528 | No |
| 63 | RAD50 | RAD50 Entrez, Source | RAD50 homolog (S. cerevisiae) | 16732 | -0.414 | -0.5595 | No |
| 64 | HIST1H2BF | HIST1H2BF Entrez, Source | histone cluster 1, H2bf | 17290 | -0.531 | -0.5763 | No |
| 65 | HIST1H3B | HIST1H3B Entrez, Source | histone cluster 1, H3b | 17776 | -0.654 | -0.5873 | No |
| 66 | HIST1H4E | HIST1H4E Entrez, Source | histone cluster 1, H4e | 17843 | -0.676 | -0.5778 | No |
| 67 | HIST1H2BD | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 18676 | -0.971 | -0.5995 | Yes |
| 68 | SMC1B | SMC1B Entrez, Source | structural maintenance of chromosomes 1B | 18794 | -1.017 | -0.5862 | Yes |
| 69 | HIST1H3H | HIST1H3H Entrez, Source | histone cluster 1, H3h | 19248 | -1.251 | -0.5845 | Yes |
| 70 | SYCP2 | SYCP2 Entrez, Source | synaptonemal complex protein 2 | 19341 | -1.300 | -0.5647 | Yes |
| 71 | FKBP6 | FKBP6 Entrez, Source | FK506 binding protein 6, 36kDa | 19390 | -1.339 | -0.5421 | Yes |
| 72 | HIST1H2AC | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 19503 | -1.417 | -0.5210 | Yes |
| 73 | HIST1H4I | HIST1H4I Entrez, Source | histone cluster 1, H4i | 19573 | -1.473 | -0.4969 | Yes |
| 74 | SYCP1 | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 20123 | -2.020 | -0.4855 | Yes |
| 75 | HIST1H3E | HIST1H3E Entrez, Source | histone cluster 1, H3e | 20289 | -2.284 | -0.4508 | Yes |
| 76 | HIST2H4A | HIST2H4A Entrez, Source | histone cluster 2, H4a | 20322 | -2.327 | -0.4090 | Yes |
| 77 | HIST4H4 | HIST4H4 Entrez, Source | histone cluster 4, H4 | 20390 | -2.440 | -0.3667 | Yes |
| 78 | HIST1H3G | HIST1H3G Entrez, Source | histone cluster 1, H3g | 20514 | -2.709 | -0.3221 | Yes |
| 79 | HIST1H3D | HIST1H3D Entrez, Source | histone cluster 1, H3d | 20594 | -2.926 | -0.2714 | Yes |
| 80 | HIST1H2BJ | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 20719 | -3.326 | -0.2153 | Yes |
| 81 | HIST1H2BO | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 20735 | -3.400 | -0.1527 | Yes |
| 82 | HIST1H2BN | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 20809 | -3.847 | -0.0845 | Yes |
| 83 | HIST3H2BB | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 20947 | -5.000 | 0.0021 | Yes |
