Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NS50832_collapsed_to_symbols.NS50832.cls #558AP2_versus_S78.NS50832.cls #558AP2_versus_S78_repos |
| Phenotype | NS50832.cls#558AP2_versus_S78_repos |
| Upregulated in class | 0 |
| GeneSet | SA_PTEN_PATHWAY |
| Enrichment Score (ES) | -0.7898776 |
| Normalized Enrichment Score (NES) | -1.6328793 |
| Nominal p-value | 0.0045871558 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PIK3CD | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 5231 | 0.159 | -0.2242 | No |
| 2 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 6688 | 0.096 | -0.2783 | No |
| 3 | ILK | ILK Entrez, Source | integrin-linked kinase | 6864 | 0.090 | -0.2724 | No |
| 4 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 7114 | 0.083 | -0.2711 | No |
| 5 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 7413 | 0.074 | -0.2735 | No |
| 6 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 7953 | 0.060 | -0.2898 | No |
| 7 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 9676 | 0.017 | -0.3692 | No |
| 8 | BPNT1 | BPNT1 Entrez, Source | 3'(2'), 5'-bisphosphate nucleotidase 1 | 10053 | 0.007 | -0.3860 | No |
| 9 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 11216 | -0.023 | -0.4377 | No |
| 10 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11777 | -0.040 | -0.4581 | No |
| 11 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 12022 | -0.048 | -0.4622 | No |
| 12 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 12419 | -0.061 | -0.4714 | No |
| 13 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 12590 | -0.067 | -0.4689 | No |
| 14 | RBL2 | RBL2 Entrez, Source | retinoblastoma-like 2 (p130) | 13750 | -0.119 | -0.5053 | No |
| 15 | SOS1 | SOS1 Entrez, Source | son of sevenless homolog 1 (Drosophila) | 13796 | -0.121 | -0.4883 | No |
| 16 | PTK2B | PTK2B Entrez, Source | PTK2B protein tyrosine kinase 2 beta | 15544 | -0.252 | -0.5318 | Yes |
| 17 | IPCEF1 | 20959 | -5.000 | 0.0015 | Yes |
