Details for gene set BLUM_RESPONSE_TO_SALIRASIB_DN[GSEA]

Table: GSEA Results Summary

Dataset	NS50832_padj
Phenotype	NoPhenotypeAvailable
Upregulated in class	na_pos
GeneSet	BLUM_RESPONSE_TO_SALIRASIB_DN
Enrichment Score (ES)	0.31692836
Normalized Enrichment Score (NES)	6.774233
Nominal p-value	0.0
FDR q-value	0.0
FWER p-Value	0.0

Fig 1: Enrichment plot: BLUM_RESPONSE_TO_SALIRASIB_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

Table: GSEA details [plain text format]

	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	TMEM2			47	99.047	0.0012	Yes
2	VGF			48	98.362	0.0042	Yes
3	ENC1			91	69.229	0.0055	Yes
4	TUBB4B			131	57.538	0.0070	Yes
5	INCENP			157	50.373	0.0090	Yes
6	KPNA2			160	49.616	0.0119	Yes
7	NNAT			167	47.370	0.0147	Yes
8	TUBB3			179	43.838	0.0173	Yes
9	SDC1			189	42.210	0.0199	Yes
10	SRSF2			209	39.532	0.0222	Yes
11	TUBB			221	38.042	0.0247	Yes
12	DDX23			251	34.799	0.0266	Yes
13	PCNA			255	34.423	0.0295	Yes
14	RRM1			269	32.565	0.0319	Yes
15	DHX9			284	31.114	0.0344	Yes
16	PTMA			286	31.046	0.0373	Yes
17	MEST			314	28.357	0.0393	Yes
18	PDE4A			361	25.689	0.0405	Yes
19	UBE2N			368	25.440	0.0432	Yes
20	HMGB1			376	25.074	0.0460	Yes
21	LMNA			381	24.893	0.0488	Yes
22	GMNN			382	24.892	0.0518	Yes
23	MSH6			383	24.811	0.0548	Yes
24	NASP			421	23.205	0.0563	Yes
25	DUT			423	23.182	0.0593	Yes
26	TSPAN7			432	22.923	0.0619	Yes
27	NR4A2			450	22.126	0.0643	Yes
28	TRIP13			457	21.942	0.0670	Yes
29	FEN1			473	21.511	0.0694	Yes
30	HSPA2			480	21.303	0.0722	Yes
31	CPS1			505	20.455	0.0743	Yes
32	HMGB3			518	20.166	0.0768	Yes
33	TUBA1A			529	19.799	0.0794	Yes
34	CBX1			532	19.723	0.0823	Yes
35	SRRT			567	18.978	0.0840	Yes
36	CRABP2			576	18.712	0.0866	Yes
37	DDX39A			596	18.368	0.0889	Yes
38	MKI67			606	18.195	0.0915	Yes
39	CCNF			632	17.659	0.0936	Yes
40	KIF20A			649	17.335	0.0959	Yes
41	B4GALT5			671	16.885	0.0981	Yes
42	GALNT2			675	16.844	0.1010	Yes
43	CDK1			676	16.831	0.1040	Yes
44	GPSM2			689	16.522	0.1065	Yes
45	CARHSP1			698	16.292	0.1092	Yes
46	HNRNPR			762	15.243	0.1097	Yes
47	CHST12			777	15.040	0.1122	Yes
48	UBE2C			803	14.837	0.1142	Yes
49	RBM14			808	14.771	0.1170	Yes
50	LIG1			831	14.296	0.1192	Yes
51	POLE			841	14.121	0.1218	Yes
52	NDUFB3			878	13.682	0.1234	Yes
53	PFKFB3			905	13.335	0.1254	Yes
54	COL1A1			966	12.528	0.1261	Yes
55	KPNB1			995	12.236	0.1280	Yes
56	STMN1			1019	11.862	0.1301	Yes
57	NDUFA2			1051	11.590	0.1319	Yes
58	ATP5G3			1063	11.489	0.1344	Yes
59	CRIP2			1065	11.475	0.1374	Yes
60	FASN			1094	11.155	0.1393	Yes
61	LINC00094			1099	11.108	0.1421	Yes
62	RRM2			1235	10.035	0.1399	Yes
63	ISYNA1			1242	9.978	0.1426	Yes
64	DHX15			1302	9.631	0.1434	Yes
65	MAD2L1			1335	9.368	0.1451	Yes
66	HSP90AA1			1345	9.282	0.1478	Yes
67	F2R			1349	9.224	0.1506	Yes
68	NTHL1			1364	9.099	0.1531	Yes
69	CDC20			1367	9.068	0.1560	Yes
70	CCNA2			1369	9.062	0.1589	Yes
71	DGCR2			1385	8.956	0.1613	Yes
72	SKP2			1397	8.871	0.1639	Yes
73	RBX1			1452	8.585	0.1648	Yes
74	EBP			1467	8.488	0.1672	Yes
75	CBX3			1527	8.187	0.1680	Yes
76	VDAC3			1574	7.911	0.1692	Yes
77	SOX4			1692	7.315	0.1677	Yes
78	VAMP1			1711	7.211	0.1699	Yes
79	CENPF			1716	7.186	0.1728	Yes
80	DHFR			1721	7.167	0.1756	Yes
81	CD37			1756	7.032	0.1773	Yes
82	HDAC1			1775	6.955	0.1796	Yes
83	HNRNPA2B1			1777	6.941	0.1825	Yes
84	NPEPPS			1823	6.740	0.1838	Yes
85	PTTG1			1861	6.575	0.1853	Yes
86	NUSAP1			1985	6.109	0.1836	Yes
87	OAZ2			1988	6.095	0.1865	Yes
88	H2AFZ			2051	5.890	0.1871	Yes
89	SNRPF			2066	5.846	0.1895	Yes
90	ADCY9			2137	5.614	0.1898	Yes
91	TIMELESS			2233	5.311	0.1892	Yes
92	RECQL4			2253	5.246	0.1914	Yes
93	PAFAH1B3			2281	5.154	0.1934	Yes
94	TROAP			2326	5.024	0.1947	Yes
95	MID1			2382	4.889	0.1955	Yes
96	LPCAT3			2427	4.771	0.1968	Yes
97	ACLY			2430	4.768	0.1997	Yes
98	TWSG1			2508	4.615	0.1997	Yes
99	TYMS			2510	4.612	0.2027	Yes
100	TPI1			2516	4.596	0.2055	Yes
101	DHCR24			2520	4.587	0.2084	Yes
102	TTK			2547	4.538	0.2103	Yes
103	RAB40B			2554	4.525	0.2131	Yes
104	SNRPD1			2610	4.392	0.2140	Yes
105	FBXO5			2611	4.392	0.2169	Yes
106	POLA1			2699	4.178	0.2166	Yes
107	PARP1			2700	4.173	0.2196	Yes
108	PIAS3			2712	4.155	0.2221	Yes
109	TACC3			2729	4.128	0.2245	Yes
110	CDK2			2749	4.087	0.2268	Yes
111	PLK4			2763	4.052	0.2292	Yes
112	CSE1L			2773	4.034	0.2319	Yes
113	RBBP7			2813	3.942	0.2334	Yes
114	DPYSL3			2835	3.902	0.2355	Yes
115	SYNCRIP			2873	3.833	0.2371	Yes
116	SMC1A			2896	3.795	0.2392	Yes
117	MEIS2			2903	3.781	0.2420	Yes
118	PACSIN2			2913	3.771	0.2446	Yes
119	HNRNPM			2925	3.750	0.2472	Yes
120	PRDX3			2939	3.721	0.2497	Yes
121	GTF3C2			2967	3.665	0.2516	Yes
122	SRSF1			3027	3.569	0.2523	Yes
123	PLS3			3040	3.543	0.2549	Yes
124	AURKB			3047	3.532	0.2576	Yes
125	SEMA5A			3134	3.374	0.2573	Yes
126	CKS2			3140	3.368	0.2601	Yes
127	KIF23			3267	3.187	0.2582	Yes
128	TUBG1			3279	3.171	0.2608	Yes
129	LDHA			3339	3.076	0.2615	Yes
130	ATP5J2			3356	3.050	0.2639	Yes
131	ACACA			3408	2.975	0.2649	Yes
132	CKB			3479	2.888	0.2652	Yes
133	UPK1B			3518	2.836	0.2667	Yes
134	EXO1			3553	2.799	0.2684	Yes
135	POLD1			3589	2.757	0.2700	Yes
136	HMG20B			3665	2.690	0.2701	Yes
137	ANKH			3676	2.678	0.2727	Yes
138	SRSF6			3805	2.524	0.2708	Yes
139	CDKN3			3853	2.464	0.2719	Yes
140	RANBP1			3895	2.417	0.2734	Yes
141	GAMT			3905	2.403	0.2760	Yes
142	IRS1			3974	2.342	0.2764	Yes
143	ORC1			3993	2.323	0.2787	Yes
144	RGS4			4025	2.299	0.2804	Yes
145	PRSS23			4069	2.246	0.2818	Yes
146	POLE2			4225	2.079	0.2788	Yes
147	PLOD2			4236	2.069	0.2814	Yes
148	ABCD3			4265	2.049	0.2833	Yes
149	KIF11			4328	1.989	0.2839	Yes
150	TECR			4373	1.956	0.2852	Yes
151	SLC9A3R1			4392	1.934	0.2875	Yes
152	MCM3			4394	1.932	0.2904	Yes
153	EWSR1			4400	1.929	0.2932	Yes
154	PIK3R3			4491	1.856	0.2927	Yes
155	DNMT1			4553	1.809	0.2934	Yes
156	NARF			4591	1.780	0.2949	Yes
157	PDGFRB			4620	1.763	0.2969	Yes
158	CYB5A			4645	1.744	0.2989	Yes
159	MYBL2			4689	1.701	0.3002	Yes
160	DBR1			4878	1.559	0.2960	Yes
161	SEPT9			4900	1.546	0.2982	Yes
162	E2F1			4963	1.500	0.2988	Yes
163	YWHAQ			5008	1.472	0.3001	Yes
164	ENO1			5055	1.435	0.3013	Yes
165	PXMP2			5136	1.389	0.3012	Yes
166	PGAM1			5155	1.378	0.3035	Yes
167	SPAG5			5159	1.376	0.3063	Yes
168	CDKN2C			5164	1.373	0.3092	Yes
169	SLC25A10			5166	1.373	0.3121	Yes
170	APC			5170	1.370	0.3150	Yes
171	SRSF3			5380	1.246	0.3099	Yes
172	RPA1			5418	1.232	0.3115	Yes
173	NUP50			5435	1.218	0.3139	Yes
174	PRC1			5574	1.134	0.3115	Yes
175	RPA3			5617	1.112	0.3129	Yes
176	MCM2			5651	1.090	0.3146	Yes
177	SUV39H1			5737	1.047	0.3143	Yes
178	KIF2C			5965	0.944	0.3086	Yes
179	MRPL23			5971	0.941	0.3114	Yes
180	TOP2A			6015	0.925	0.3127	Yes
181	OPN3			6021	0.922	0.3155	Yes
182	ZBTB33			6259	0.836	0.3094	Yes
183	KIF22			6298	0.824	0.3109	Yes
184	TOPBP1			6362	0.804	0.3114	Yes
185	AURKA			6451	0.778	0.3110	Yes
186	CDC25A			6466	0.773	0.3135	Yes
187	FNTB			6473	0.771	0.3162	Yes
188	ZWINT			6636	0.714	0.3130	Yes
189	KIF20B			6665	0.703	0.3149	Yes
190	CHAF1B			6750	0.671	0.3147	Yes
191	FOXG1			6788	0.661	0.3162	Yes
192	FKBP3			6848	0.648	0.3169	Yes
193	TIA1			6944	0.618	0.3163	No
194	CHAF1A			7015	0.597	0.3165	No
195	NPAT			7168	0.557	0.3137	No
196	MTHFD1			7190	0.551	0.3159	No
197	NCAPG			7310	0.527	0.3143	No
198	GREM1			7513	0.483	0.3095	No
199	ITGB3BP			7565	0.472	0.3105	No
200	SOX11			7600	0.463	0.3122	No
201	ID1			7629	0.457	0.3141	No
202	ITGB1BP1			7825	0.424	0.3096	No
203	CDC45			7930	0.407	0.3085	No
204	CDC7			7975	0.398	0.3098	No
205	SLC39A8			8030	0.392	0.3107	No
206	GALNT1			8248	0.361	0.3054	No
207	BUB1B			8264	0.360	0.3078	No
208	FOS			8533	0.318	0.3005	No
209	CDK2AP1			8547	0.316	0.3029	No
210	LSM5			8837	0.280	0.2948	No
211	PRKDC			8863	0.276	0.2968	No
212	H2AFV			8893	0.272	0.2987	No
213	JUNB			8956	0.266	0.2993	No
214	IQGAP2			9427	0.214	0.2842	No
215	BUB1			9451	0.212	0.2863	No
216	HSPB1			9513	0.206	0.2869	No
217	MATN2			9599	0.197	0.2866	No
218	SRSF7			9632	0.194	0.2884	No
219	ARPP19			9980	0.165	0.2780	No
220	PTTG3P			10019	0.161	0.2795	No
221	TMPO			10190	0.146	0.2760	No
222	SRSF10			10436	0.129	0.2695	No
223	CASP8AP2			10770	0.105	0.2597	No
224	RNASEH2A			10861	0.099	0.2592	No
225	SMC2			10992	0.092	0.2572	No
226	RIPK4			10994	0.092	0.2602	No
227	GINS2			11008	0.091	0.2626	No
228	SNRPA1			11250	0.079	0.2564	No
229	DCK			11306	0.076	0.2572	No
230	FOSB			11735	0.053	0.2437	No
231	DEK			11769	0.052	0.2455	No
232	SMC4			11822	0.050	0.2464	No
233	CCND3			11901	0.047	0.2464	No
234	PTPN4			12695	0.015	0.2189	No
235	NFYB			12995	0.005	0.2104	No
236	DDR2			13243	-0.004	0.2038	No
237	VRK1			13468	-0.011	0.1982	No
238	MYCBP			13499	-0.013	0.2000	No
239	CDC6			14100	-0.035	0.1799	No
240	ZNF107			14117	-0.036	0.1823	No
241	MIPEP			14123	-0.037	0.1851	No
242	CHEK1			14125	-0.037	0.1880	No
243	MED14			14172	-0.039	0.1893	No
244	SHMT1			14554	-0.053	0.1776	No
245	PBK			14571	-0.053	0.1799	No
246	NUP107			14717	-0.058	0.1773	No
247	PSMC3IP			14896	-0.067	0.1735	No
248	PLK1			14929	-0.069	0.1752	No
249	CCNB2			15281	-0.089	0.1647	No
250	KIF4A			15726	-0.115	0.1506	No
251	CENPA			15771	-0.118	0.1519	No
252	CNN3			15898	-0.127	0.1500	No
253	ESPL1			15985	-0.133	0.1497	No
254	TLE2			16052	-0.137	0.1502	No
255	TK1			16232	-0.150	0.1463	No
256	MCM5			16318	-0.155	0.1460	No
257	TRA2B			16371	-0.158	0.1470	No
258	EZH2			16405	-0.162	0.1487	No
259	MOK			16452	-0.166	0.1499	No
260	USP1			16798	-0.199	0.1396	No
261	MCM6			17316	-0.251	0.1227	No
262	MCCC2			17702	-0.298	0.1108	No
263	STIL			17805	-0.310	0.1099	No
264	SFPQ			17819	-0.312	0.1124	No
265	SETMAR			17845	-0.316	0.1144	No
266	CDC25B			18075	-0.344	0.1086	No
267	CBFB			18248	-0.371	0.1049	No
268	RFC5			18274	-0.376	0.1070	No
269	HS3ST3A1			18678	-0.449	0.0944	No
270	MTF2			18836	-0.480	0.0914	No
271	UBE2E3			19122	-0.540	0.0834	No
272	CCNE2			19156	-0.546	0.0851	No
273	HMMR			19243	-0.565	0.0848	No
274	AKR1C1			19331	-0.586	0.0844	No
275	COCH			19581	-0.654	0.0778	No
276	RFC3			19734	-0.693	0.0750	No
277	CHN1			19806	-0.717	0.0752	No
278	NEK2			19991	-0.782	0.0711	No
279	SKAP1			20089	-0.806	0.0704	No
280	MYLK			21210	-1.315	0.0303	No
281	ANP32A			21219	-1.318	0.0329	No
282	SMARCE1			21275	-1.349	0.0338	No
283	SIM2			21805	-1.690	0.0164	No
284	PRPS1			21841	-1.720	0.0181	No
285	TOP2B			21868	-1.742	0.0200	No
286	RAD51			21972	-1.839	0.0191	No
287	LTBP3			22135	-1.976	0.0158	No
288	WWTR1			22417	-2.253	0.0080	No
289	CDC25C			22485	-2.318	0.0084	No
290	RAD51AP1			22588	-2.438	0.0075	No
291	FANCA			22636	-2.493	0.0086	No
292	H2AFY			22676	-2.545	0.0101	No
293	DTYMK			22733	-2.598	0.0109	No
294	ZNF443			22765	-2.647	0.0127	No
295	RGS2			22796	-2.685	0.0146	No
296	ORC6			23001	-2.945	0.0097	No
297	BARD1			23005	-2.948	0.0126	No
298	CCL2			23117	-3.111	0.0113	No
299	DBP			23195	-3.235	0.0113	No
300	TNS3			23204	-3.248	0.0140	No
301	BRCA1			23247	-3.326	0.0154	No
302	SRP9			23252	-3.333	0.0182	No
303	TFDP1			23324	-3.462	0.0184	No
304	PDCD2			23413	-3.639	0.0180	No
305	VAV3			23486	-3.765	0.0182	No
306	ID2			23493	-3.773	0.0210	No
307	HIRIP3			23549	-3.890	0.0219	No
308	RFC2			23687	-4.196	0.0196	No
309	TCF4			23715	-4.268	0.0215	No
310	POLA2			23782	-4.426	0.0220	No
311	KIF15			23792	-4.451	0.0246	No
312	HSPA14			23845	-4.582	0.0256	No
313	USP13			23912	-4.768	0.0260	No
314	RAB4A			23938	-4.849	0.0281	No
315	GUCY1B3			23960	-4.906	0.0302	No
316	TPX2			24022	-5.106	0.0309	No
317	RFX5			24066	-5.232	0.0322	No
318	ABCC6			24104	-5.311	0.0338	No
319	MAPRE2			24131	-5.384	0.0358	No
320	CYP1B1			24480	-6.654	0.0253	No
321	RFC4			24686	-7.592	0.0204	No
322	MSH2			24778	-8.121	0.0199	No
323	PRIM1			25339	-13.161	0.0014	No
324	SCG5			25378	-13.724	0.0029	No
325	SGPP1			25412	-14.126	0.0046	No
326	NRIP1			25426	-14.295	0.0071	No
327	HLTF			25501	-15.425	0.0072	No
328	NPTX1			25528	-15.889	0.0092	No
329	BFSP1			25659	-18.927	0.0072	No
330	SOX9			25701	-19.956	0.0086	No
331	TFE3			25759	-21.664	0.0094	No
332	NDC80			25811	-22.998	0.0104	No
333	FZD2			25914	-28.452	0.0095	No
334	SLC27A2			26152	-51.939	0.0033	No
335	NME4			26187	-59.746	0.0050	No

Fig 2: BLUM_RESPONSE_TO_SALIRASIB_DN: Random ES distribution   
Gene set null distribution of ES for BLUM_RESPONSE_TO_SALIRASIB_DN