Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 1 |
| GeneSet | BOSCO_INTERFERON_INDUCED_ANTIVIRAL_MODULE |
| Enrichment Score (ES) | -0.79663104 |
| Normalized Enrichment Score (NES) | -1.8709937 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.022786E-4 |
| FWER p-Value | 0.003 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | AVPR2 | AVPR2 Entrez, Source | arginine vasopressin receptor 2 (nephrogenic diabetes insipidus) | 651 | 0.375 | -0.0150 | No |
| 2 | LAMP3 | LAMP3 Entrez, Source | lysosomal-associated membrane protein 3 | 1475 | 0.233 | -0.0405 | No |
| 3 | ITGA4 | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 1538 | 0.225 | -0.0368 | No |
| 4 | ST3GAL5 | ST3GAL5 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 2050 | 0.172 | -0.0519 | No |
| 5 | NCOA7 | NCOA7 Entrez, Source | nuclear receptor coactivator 7 | 2385 | 0.161 | -0.0605 | No |
| 6 | STAT2 | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 3441 | 0.099 | -0.0986 | No |
| 7 | GCH1 | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 3743 | 0.087 | -0.1079 | No |
| 8 | ZBP1 | ZBP1 Entrez, Source | Z-DNA binding protein 1 | 4016 | 0.085 | -0.1161 | No |
| 9 | SLAMF7 | SLAMF7 Entrez, Source | SLAM family member 7 | 5914 | 0.074 | -0.1875 | No |
| 10 | PTPN2 | PTPN2 Entrez, Source | protein tyrosine phosphatase, non-receptor type 2 | 8025 | 0.072 | -0.2672 | No |
| 11 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 8233 | 0.069 | -0.2734 | No |
| 12 | CDK1 | 8548 | 0.063 | -0.2838 | No | ||
| 13 | OAS3 | OAS3 Entrez, Source | 2'-5'-oligoadenylate synthetase 3, 100kDa | 9242 | 0.055 | -0.3091 | No |
| 14 | RIN2 | RIN2 Entrez, Source | Ras and Rab interactor 2 | 9797 | 0.046 | -0.3293 | No |
| 15 | CD80 | CD80 Entrez, Source | CD80 molecule | 9947 | 0.044 | -0.3339 | No |
| 16 | TDRD7 | TDRD7 Entrez, Source | tudor domain containing 7 | 10188 | 0.041 | -0.3421 | No |
| 17 | TNFSF10 | TNFSF10 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 10 | 10244 | 0.040 | -0.3431 | No |
| 18 | ARAP2 | 10312 | 0.039 | -0.3446 | No | ||
| 19 | UBE2Z | UBE2Z Entrez, Source | ubiquitin-conjugating enzyme E2Z (putative) | 11906 | 0.020 | -0.4057 | No |
| 20 | GBP7 | GBP7 Entrez, Source | guanylate binding protein 7 | 12165 | 0.017 | -0.4153 | No |
| 21 | NUB1 | NUB1 Entrez, Source | negative regulator of ubiquitin-like proteins 1 | 12297 | 0.015 | -0.4199 | No |
| 22 | PANK2 | PANK2 Entrez, Source | pantothenate kinase 2 (Hallervorden-Spatz syndrome) | 12321 | 0.015 | -0.4204 | No |
| 23 | PNPT1 | PNPT1 Entrez, Source | polyribonucleotide nucleotidyltransferase 1 | 12329 | 0.015 | -0.4203 | No |
| 24 | LAT | LAT Entrez, Source | linker for activation of T cells | 12333 | 0.015 | -0.4200 | No |
| 25 | PRAF2 | PRAF2 Entrez, Source | PRA1 domain family, member 2 | 12686 | 0.010 | -0.4333 | No |
| 26 | KPTN | KPTN Entrez, Source | kaptin (actin binding protein) | 15040 | -0.020 | -0.5239 | No |
| 27 | SDC3 | SDC3 Entrez, Source | syndecan 3 (N-syndecan) | 15642 | -0.028 | -0.5464 | No |
| 28 | FTSJD2 | 16599 | -0.041 | -0.5823 | No | ||
| 29 | GOLGA4 | GOLGA4 Entrez, Source | golgi autoantigen, golgin subfamily a, 4 | 18018 | -0.071 | -0.6352 | No |
| 30 | P2RY14 | P2RY14 Entrez, Source | purinergic receptor P2Y, G-protein coupled, 14 | 18088 | -0.073 | -0.6359 | No |
| 31 | MOV10 | MOV10 Entrez, Source | Mov10, Moloney leukemia virus 10, homolog (mouse) | 18149 | -0.075 | -0.6362 | No |
| 32 | TRAFD1 | TRAFD1 Entrez, Source | TRAF-type zinc finger domain containing 1 | 19019 | -0.101 | -0.6671 | No |
| 33 | SLC25A28 | SLC25A28 Entrez, Source | solute carrier family 25, member 28 | 19038 | -0.102 | -0.6650 | No |
| 34 | IFITM3 | IFITM3 Entrez, Source | interferon induced transmembrane protein 3 (1-8U) | 19157 | -0.106 | -0.6667 | No |
| 35 | NOD1 | 19353 | -0.114 | -0.6711 | No | ||
| 36 | APOL6 | APOL6 Entrez, Source | apolipoprotein L, 6 | 19838 | -0.133 | -0.6862 | No |
| 37 | TMEM176A | TMEM176A Entrez, Source | transmembrane protein 176A | 20523 | -0.164 | -0.7083 | No |
| 38 | PML | PML Entrez, Source | promyelocytic leukemia | 20690 | -0.171 | -0.7100 | No |
| 39 | CYP24A1 | CYP24A1 Entrez, Source | cytochrome P450, family 24, subfamily A, polypeptide 1 | 21438 | -0.218 | -0.7330 | No |
| 40 | MYO1G | MYO1G Entrez, Source | myosin IG | 21641 | -0.235 | -0.7344 | No |
| 41 | TTYH2 | TTYH2 Entrez, Source | tweety homolog 2 (Drosophila) | 21859 | -0.252 | -0.7360 | No |
| 42 | EIF2AK2 | EIF2AK2 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 2 | 21911 | -0.256 | -0.7310 | No |
| 43 | TNIP3 | TNIP3 Entrez, Source | TNFAIP3 interacting protein 3 | 23273 | -0.402 | -0.7728 | No |
| 44 | EPSTI1 | EPSTI1 Entrez, Source | epithelial stromal interaction 1 (breast) | 23538 | -0.439 | -0.7710 | No |
| 45 | PARP12 | PARP12 Entrez, Source | poly (ADP-ribose) polymerase family, member 12 | 23548 | -0.441 | -0.7594 | No |
| 46 | DHX58 | 24511 | -0.647 | -0.7790 | Yes | ||
| 47 | CD40 | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 24666 | -0.694 | -0.7661 | Yes |
| 48 | SLC39A8 | SLC39A8 Entrez, Source | solute carrier family 39 (zinc transporter), member 8 | 25055 | -0.851 | -0.7580 | Yes |
| 49 | TMEM106A | TMEM106A Entrez, Source | transmembrane protein 106A | 25228 | -0.946 | -0.7389 | Yes |
| 50 | CD274 | CD274 Entrez, Source | CD274 molecule | 25335 | -1.036 | -0.7148 | Yes |
| 51 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 25437 | -1.129 | -0.6880 | Yes |
| 52 | OAS2 | OAS2 Entrez, Source | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 25558 | -1.284 | -0.6577 | Yes |
| 53 | IFI35 | IFI35 Entrez, Source | interferon-induced protein 35 | 25621 | -1.385 | -0.6225 | Yes |
| 54 | GBP4 | GBP4 Entrez, Source | guanylate binding protein 4 | 25655 | -1.448 | -0.5844 | Yes |
| 55 | DDX60 | 25710 | -1.643 | -0.5418 | Yes | ||
| 56 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 25794 | -2.009 | -0.4903 | Yes |
| 57 | RSAD2 | RSAD2 Entrez, Source | radical S-adenosyl methionine domain containing 2 | 25795 | -2.013 | -0.4356 | Yes |
| 58 | IFIH1 | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 25804 | -2.052 | -0.3801 | Yes |
| 59 | XAF1 | 25822 | -2.156 | -0.3221 | Yes | ||
| 60 | IFI44 | IFI44 Entrez, Source | interferon-induced protein 44 | 25831 | -2.278 | -0.2604 | Yes |
| 61 | IFIT3 | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 25844 | -2.414 | -0.1952 | Yes |
| 62 | SAMD9L | SAMD9L Entrez, Source | sterile alpha motif domain containing 9-like | 25888 | -3.178 | -0.1104 | Yes |
| 63 | IFIT1 | IFIT1 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 1 | 25894 | -4.073 | 0.0002 | Yes |
