Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 1 |
| GeneSet | BROWNE_INTERFERON_RESPONSIVE_GENES |
| Enrichment Score (ES) | -0.777579 |
| Normalized Enrichment Score (NES) | -1.8427527 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.4676876E-4 |
| FWER p-Value | 0.009 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | TRIM21 | TRIM21 Entrez, Source | tripartite motif-containing 21 | 618 | 0.389 | -0.0121 | No |
| 2 | IFI30 | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 1579 | 0.218 | -0.0426 | No |
| 3 | CXCL11 | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 2436 | 0.157 | -0.0710 | No |
| 4 | KIF5C | KIF5C Entrez, Source | kinesin family member 5C | 3321 | 0.104 | -0.1021 | No |
| 5 | GCH1 | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 3743 | 0.087 | -0.1157 | No |
| 6 | CCL8 | CCL8 Entrez, Source | chemokine (C-C motif) ligand 8 | 5906 | 0.074 | -0.1971 | No |
| 7 | RGL1 | RGL1 Entrez, Source | ral guanine nucleotide dissociation stimulator-like 1 | 8222 | 0.070 | -0.2846 | No |
| 8 | MELK | MELK Entrez, Source | maternal embryonic leucine zipper kinase | 8236 | 0.069 | -0.2830 | No |
| 9 | SP110 | SP110 Entrez, Source | SP110 nuclear body protein | 9080 | 0.057 | -0.3139 | No |
| 10 | TREX1 | TREX1 Entrez, Source | three prime repair exonuclease 1 | 9102 | 0.056 | -0.3130 | No |
| 11 | TDRD7 | TDRD7 Entrez, Source | tudor domain containing 7 | 10188 | 0.041 | -0.3537 | No |
| 12 | TNFSF10 | TNFSF10 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 10 | 10244 | 0.040 | -0.3546 | No |
| 13 | BAZ1A | BAZ1A Entrez, Source | bromodomain adjacent to zinc finger domain, 1A | 10599 | 0.035 | -0.3673 | No |
| 14 | GBP1 | GBP1 Entrez, Source | guanylate binding protein 1, interferon-inducible, 67kDa | 10631 | 0.035 | -0.3674 | No |
| 15 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 10821 | 0.033 | -0.3737 | No |
| 16 | SAMHD1 | SAMHD1 Entrez, Source | SAM domain and HD domain 1 | 12750 | 0.010 | -0.4480 | No |
| 17 | RABGAP1L | RABGAP1L Entrez, Source | RAB GTPase activating protein 1-like | 14069 | -0.006 | -0.4989 | No |
| 18 | TRIM14 | TRIM14 Entrez, Source | tripartite motif-containing 14 | 14280 | -0.009 | -0.5067 | No |
| 19 | TYMP | 14791 | -0.016 | -0.5260 | No | ||
| 20 | NMI | NMI Entrez, Source | N-myc (and STAT) interactor | 17473 | -0.058 | -0.6279 | No |
| 21 | CYTH1 | 17883 | -0.068 | -0.6417 | No | ||
| 22 | PDZD2 | PDZD2 Entrez, Source | PDZ domain containing 2 | 18040 | -0.072 | -0.6456 | No |
| 23 | RBCK1 | RBCK1 Entrez, Source | RanBP-type and C3HC4-type zinc finger containing 1 | 18471 | -0.084 | -0.6597 | No |
| 24 | GBP2 | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 18610 | -0.088 | -0.6623 | No |
| 25 | UBE2L6 | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 18633 | -0.089 | -0.6605 | No |
| 26 | PLSCR1 | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 19108 | -0.104 | -0.6757 | No |
| 27 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 19862 | -0.134 | -0.7007 | No |
| 28 | IDO1 | 20686 | -0.171 | -0.7274 | No | ||
| 29 | PML | PML Entrez, Source | promyelocytic leukemia | 20690 | -0.171 | -0.7223 | No |
| 30 | ZBTB20 | ZBTB20 Entrez, Source | zinc finger and BTB domain containing 20 | 20962 | -0.185 | -0.7272 | No |
| 31 | MYD88 | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 21196 | -0.201 | -0.7301 | No |
| 32 | IL15RA | IL15RA Entrez, Source | interleukin 15 receptor, alpha | 21510 | -0.224 | -0.7354 | No |
| 33 | EIF2AK2 | EIF2AK2 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 2 | 21911 | -0.256 | -0.7431 | No |
| 34 | GMPR | GMPR Entrez, Source | guanosine monophosphate reductase | 22516 | -0.310 | -0.7571 | No |
| 35 | IL15 | IL15 Entrez, Source | interleukin 15 | 22561 | -0.316 | -0.7492 | No |
| 36 | BST2 | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 22902 | -0.355 | -0.7516 | No |
| 37 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 23259 | -0.399 | -0.7533 | No |
| 38 | SP100 | SP100 Entrez, Source | SP100 nuclear antigen | 23888 | -0.500 | -0.7624 | Yes |
| 39 | CXCL10 | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 23939 | -0.510 | -0.7489 | Yes |
| 40 | TAP1 | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 24212 | -0.568 | -0.7422 | Yes |
| 41 | IFIT2 | IFIT2 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 2 | 24672 | -0.695 | -0.7388 | Yes |
| 42 | LMO2 | LMO2 Entrez, Source | LIM domain only 2 (rhombotin-like 1) | 24692 | -0.701 | -0.7183 | Yes |
| 43 | MX2 | MX2 Entrez, Source | myxovirus (influenza virus) resistance 2 (mouse) | 25230 | -0.948 | -0.7103 | Yes |
| 44 | TLR3 | TLR3 Entrez, Source | toll-like receptor 3 | 25298 | -1.003 | -0.6825 | Yes |
| 45 | STX11 | STX11 Entrez, Source | syntaxin 11 | 25320 | -1.024 | -0.6523 | Yes |
| 46 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 25437 | -1.129 | -0.6225 | Yes |
| 47 | OAS2 | OAS2 Entrez, Source | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 25558 | -1.284 | -0.5882 | Yes |
| 48 | IFI35 | IFI35 Entrez, Source | interferon-induced protein 35 | 25621 | -1.385 | -0.5486 | Yes |
| 49 | ISG15 | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 25699 | -1.594 | -0.5032 | Yes |
| 50 | PSMB8 | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 25743 | -1.742 | -0.4521 | Yes |
| 51 | PSMB9 | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 25769 | -1.855 | -0.3967 | Yes |
| 52 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 25794 | -2.009 | -0.3367 | Yes |
| 53 | RSAD2 | RSAD2 Entrez, Source | radical S-adenosyl methionine domain containing 2 | 25795 | -2.013 | -0.2757 | Yes |
| 54 | XAF1 | 25822 | -2.156 | -0.2113 | Yes | ||
| 55 | IFI44 | IFI44 Entrez, Source | interferon-induced protein 44 | 25831 | -2.278 | -0.1425 | Yes |
| 56 | CASP1 | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 25838 | -2.365 | -0.0709 | Yes |
| 57 | IFIT3 | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 25844 | -2.414 | 0.0021 | Yes |
