Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 1 |
| GeneSet | CASTELLANO_NRAS_TARGETS_UP |
| Enrichment Score (ES) | -0.78211784 |
| Normalized Enrichment Score (NES) | -1.8050181 |
| Nominal p-value | 0.0 |
| FDR q-value | 8.4529765E-4 |
| FWER p-Value | 0.036 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 2057 | 0.171 | -0.0740 | No |
| 2 | CFH | CFH Entrez, Source | complement factor H | 2846 | 0.132 | -0.1002 | No |
| 3 | DLX5 | DLX5 Entrez, Source | distal-less homeobox 5 | 3053 | 0.118 | -0.1043 | No |
| 4 | PPP1R7 | PPP1R7 Entrez, Source | protein phosphatase 1, regulatory subunit 7 | 4147 | 0.080 | -0.1440 | No |
| 5 | CRIP2 | CRIP2 Entrez, Source | cysteine-rich protein 2 | 9143 | 0.056 | -0.3355 | No |
| 6 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 9303 | 0.054 | -0.3399 | No |
| 7 | CRABP2 | CRABP2 Entrez, Source | cellular retinoic acid binding protein 2 | 9473 | 0.051 | -0.3448 | No |
| 8 | EPHX1 | EPHX1 Entrez, Source | epoxide hydrolase 1, microsomal (xenobiotic) | 10542 | 0.036 | -0.3849 | No |
| 9 | GBP1 | GBP1 Entrez, Source | guanylate binding protein 1, interferon-inducible, 67kDa | 10631 | 0.035 | -0.3872 | No |
| 10 | MEST | MEST Entrez, Source | mesoderm specific transcript homolog (mouse) | 11195 | 0.028 | -0.4081 | No |
| 11 | VPS25 | VPS25 Entrez, Source | vacuolar protein sorting 25 homolog (S. cerevisiae) | 13373 | 0.002 | -0.4923 | No |
| 12 | BAX | BAX Entrez, Source | BCL2-associated X protein | 14125 | -0.007 | -0.5211 | No |
| 13 | CCNG1 | CCNG1 Entrez, Source | cyclin G1 | 14282 | -0.009 | -0.5268 | No |
| 14 | TUBB2A | TUBB2A Entrez, Source | tubulin, beta 2A | 14372 | -0.010 | -0.5300 | No |
| 15 | EXOC4 | EXOC4 Entrez, Source | exocyst complex component 4 | 15047 | -0.020 | -0.5554 | No |
| 16 | SDC1 | SDC1 Entrez, Source | syndecan 1 | 15441 | -0.025 | -0.5698 | No |
| 17 | B2M | B2M Entrez, Source | beta-2-microglobulin | 15539 | -0.027 | -0.5726 | No |
| 18 | ACADM | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 16523 | -0.039 | -0.6094 | No |
| 19 | FNDC3A | FNDC3A Entrez, Source | fibronectin type III domain containing 3A | 16623 | -0.041 | -0.6119 | No |
| 20 | YIF1A | YIF1A Entrez, Source | Yip1 interacting factor homolog A (S. cerevisiae) | 16645 | -0.042 | -0.6113 | No |
| 21 | PHLDA3 | PHLDA3 Entrez, Source | pleckstrin homology-like domain, family A, member 3 | 17161 | -0.051 | -0.6296 | No |
| 22 | ERCC5 | ERCC5 Entrez, Source | me)) | 17348 | -0.055 | -0.6350 | No |
| 23 | TMEM43 | TMEM43 Entrez, Source | transmembrane protein 43 | 17355 | -0.056 | -0.6334 | No |
| 24 | LEPREL4 | 18087 | -0.073 | -0.6593 | No | ||
| 25 | AK1 | AK1 Entrez, Source | adenylate kinase 1 | 19196 | -0.108 | -0.6987 | No |
| 26 | ITIH2 | ITIH2 Entrez, Source | inter-alpha (globulin) inhibitor H2 | 19207 | -0.108 | -0.6955 | No |
| 27 | SARDH | SARDH Entrez, Source | sarcosine dehydrogenase | 19298 | -0.111 | -0.6954 | No |
| 28 | TRIM11 | TRIM11 Entrez, Source | tripartite motif-containing 11 | 19718 | -0.128 | -0.7074 | No |
| 29 | IL1RN | IL1RN Entrez, Source | interleukin 1 receptor antagonist | 20208 | -0.150 | -0.7214 | No |
| 30 | MMP13 | MMP13 Entrez, Source | matrix metallopeptidase 13 (collagenase 3) | 20649 | -0.169 | -0.7329 | No |
| 31 | CLEC11A | CLEC11A Entrez, Source | C-type lectin domain family 11, member A | 21059 | -0.192 | -0.7425 | No |
| 32 | GJA1 | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 21221 | -0.203 | -0.7421 | No |
| 33 | LBP | LBP Entrez, Source | lipopolysaccharide binding protein | 22126 | -0.272 | -0.7682 | No |
| 34 | PQLC3 | PQLC3 Entrez, Source | PQ loop repeat containing 3 | 22486 | -0.307 | -0.7721 | Yes |
| 35 | LCN2 | LCN2 Entrez, Source | lipocalin 2 (oncogene 24p3) | 22540 | -0.313 | -0.7639 | Yes |
| 36 | CX3CL1 | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 22608 | -0.320 | -0.7561 | Yes |
| 37 | MGP | MGP Entrez, Source | matrix Gla protein | 22626 | -0.322 | -0.7462 | Yes |
| 38 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 23259 | -0.399 | -0.7577 | Yes |
| 39 | VNN1 | VNN1 Entrez, Source | vanin 1 | 23428 | -0.424 | -0.7503 | Yes |
| 40 | AIM1 | AIM1 Entrez, Source | absent in melanoma 1 | 23587 | -0.446 | -0.7419 | Yes |
| 41 | PLTP | PLTP Entrez, Source | phospholipid transfer protein | 24181 | -0.562 | -0.7465 | Yes |
| 42 | TAP1 | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 24212 | -0.568 | -0.7291 | Yes |
| 43 | PCBD2 | PCBD2 Entrez, Source | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | 24452 | -0.630 | -0.7178 | Yes |
| 44 | ANXA4 | ANXA4 Entrez, Source | annexin A4 | 24531 | -0.655 | -0.6995 | Yes |
| 45 | PTX3 | PTX3 Entrez, Source | pentraxin-related gene, rapidly induced by IL-1 beta | 24609 | -0.678 | -0.6803 | Yes |
| 46 | IL13RA1 | IL13RA1 Entrez, Source | interleukin 13 receptor, alpha 1 | 24629 | -0.684 | -0.6587 | Yes |
| 47 | PON3 | PON3 Entrez, Source | paraoxonase 3 | 24772 | -0.726 | -0.6406 | Yes |
| 48 | ENPEP | ENPEP Entrez, Source | glutamyl aminopeptidase (aminopeptidase A) | 24815 | -0.741 | -0.6180 | Yes |
| 49 | LSP1 | LSP1 Entrez, Source | lymphocyte-specific protein 1 | 24855 | -0.756 | -0.5949 | Yes |
| 50 | NPR3 | NPR3 Entrez, Source | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | 25508 | -1.203 | -0.5808 | Yes |
| 51 | IFI35 | IFI35 Entrez, Source | interferon-induced protein 35 | 25621 | -1.385 | -0.5400 | Yes |
| 52 | PERP | PERP Entrez, Source | PERP, TP53 apoptosis effector | 25638 | -1.418 | -0.4943 | Yes |
| 53 | ISG15 | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 25699 | -1.594 | -0.4446 | Yes |
| 54 | ADCY2 | ADCY2 Entrez, Source | adenylate cyclase 2 (brain) | 25721 | -1.663 | -0.3912 | Yes |
| 55 | PSMB8 | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 25743 | -1.742 | -0.3352 | Yes |
| 56 | IFIH1 | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 25804 | -2.052 | -0.2705 | Yes |
| 57 | PENK | PENK Entrez, Source | proenkephalin | 25813 | -2.096 | -0.2025 | Yes |
| 58 | USP18 | USP18 Entrez, Source | ubiquitin specific peptidase 18 | 25830 | -2.231 | -0.1303 | Yes |
| 59 | IFIT1 | IFIT1 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 1 | 25894 | -4.073 | 0.0002 | Yes |
