| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 0 |
| GeneSet | GNF2_BUB1B |
| Enrichment Score (ES) | 0.54122794 |
| Normalized Enrichment Score (NES) | 1.8582426 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.212942 |
| FWER p-Value | 0.883 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ASF1B | ASF1B Entrez,  Source | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 1459 | 0.234 | 0.0202 | Yes |
| 2 | GINS1 | GINS1 Entrez,  Source | GINS complex subunit 1 (Psf1 homolog) | 1800 | 0.195 | 0.0709 | Yes |
| 3 | TYMS | TYMS Entrez,  Source | thymidylate synthetase | 2505 | 0.150 | 0.0930 | Yes |
| 4 | NDC80 | 3031 | 0.120 | 0.1120 | Yes | ||
| 5 | TTK | TTK Entrez,  Source | TTK protein kinase | 3042 | 0.119 | 0.1506 | Yes |
| 6 | BUB1 | BUB1 Entrez,  Source | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) | 3261 | 0.107 | 0.1774 | Yes |
| 7 | GMNN | GMNN Entrez,  Source | geminin, DNA replication inhibitor | 3370 | 0.102 | 0.2067 | Yes |
| 8 | CEP55 | CEP55 Entrez,  Source | centrosomal protein 55kDa | 3514 | 0.097 | 0.2328 | Yes |
| 9 | HELLS | HELLS Entrez,  Source | helicase, lymphoid-specific | 3542 | 0.095 | 0.2629 | Yes |
| 10 | SMC4 | SMC4 Entrez,  Source | structural maintenance of chromosomes 4 | 3717 | 0.088 | 0.2852 | Yes |
| 11 | AURKA | AURKA Entrez,  Source | aurora kinase A | 3750 | 0.087 | 0.3125 | Yes |
| 12 | CCNA2 | CCNA2 Entrez,  Source | cyclin A2 | 7999 | 0.073 | 0.1722 | Yes |
| 13 | UBE2C | UBE2C Entrez,  Source | ubiquitin-conjugating enzyme E2C | 8018 | 0.072 | 0.1953 | Yes |
| 14 | MELK | MELK Entrez,  Source | maternal embryonic leucine zipper kinase | 8236 | 0.069 | 0.2096 | Yes |
| 15 | CDCA8 | CDCA8 Entrez,  Source | cell division cycle associated 8 | 8511 | 0.064 | 0.2200 | Yes |
| 16 | MCM4 | MCM4 Entrez,  Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 8582 | 0.062 | 0.2377 | Yes |
| 17 | PLK1 | PLK1 Entrez,  Source | polo-like kinase 1 (Drosophila) | 8688 | 0.060 | 0.2534 | Yes |
| 18 | KIF14 | KIF14 Entrez,  Source | kinesin family member 14 | 8695 | 0.060 | 0.2729 | Yes |
| 19 | CSE1L | CSE1L Entrez,  Source | CSE1 chromosome segregation 1-like (yeast) | 8948 | 0.059 | 0.2825 | Yes |
| 20 | LMNB1 | LMNB1 Entrez,  Source | lamin B1 | 8951 | 0.059 | 0.3017 | Yes |
| 21 | RRM1 | RRM1 Entrez,  Source | ribonucleotide reductase M1 polypeptide | 9137 | 0.056 | 0.3128 | Yes |
| 22 | HMMR | HMMR Entrez,  Source | hyaluronan-mediated motility receptor (RHAMM) | 9173 | 0.055 | 0.3295 | Yes |
| 23 | RACGAP1 | RACGAP1 Entrez,  Source | Rac GTPase activating protein 1 | 9253 | 0.055 | 0.3443 | Yes |
| 24 | TOP2A | TOP2A Entrez,  Source | topoisomerase (DNA) II alpha 170kDa | 9270 | 0.054 | 0.3615 | Yes |
| 25 | PAICS | PAICS Entrez,  Source | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 9343 | 0.053 | 0.3760 | Yes |
| 26 | CCNB2 | CCNB2 Entrez,  Source | cyclin B2 | 9453 | 0.051 | 0.3886 | Yes |
| 27 | MCM3 | MCM3 Entrez,  Source | MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) | 9611 | 0.049 | 0.3986 | Yes |
| 28 | KIF11 | KIF11 Entrez,  Source | kinesin family member 11 | 9652 | 0.048 | 0.4128 | Yes |
| 29 | ASPM | ASPM Entrez,  Source | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 9711 | 0.047 | 0.4261 | Yes |
| 30 | AURKB | AURKB Entrez,  Source | aurora kinase B | 9747 | 0.047 | 0.4402 | Yes |
| 31 | NASP | NASP Entrez,  Source | nuclear autoantigenic sperm protein (histone-binding) | 9757 | 0.047 | 0.4552 | Yes |
| 32 | FANCI | FANCI Entrez,  Source | Fanconi anemia, complementation group I | 9924 | 0.045 | 0.4634 | Yes |
| 33 | POLD1 | POLD1 Entrez,  Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 10086 | 0.042 | 0.4711 | Yes |
| 34 | TCP1 | TCP1 Entrez,  Source | t-complex 1 | 10156 | 0.041 | 0.4820 | Yes |
| 35 | BUB1B | BUB1B Entrez,  Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 10437 | 0.037 | 0.4834 | Yes |
| 36 | KIF20A | KIF20A Entrez,  Source | kinesin family member 20A | 10604 | 0.035 | 0.4885 | Yes |
| 37 | MCM2 | MCM2 Entrez,  Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 10680 | 0.034 | 0.4969 | Yes |
| 38 | NCAPD2 | NCAPD2 Entrez,  Source | non-SMC condensin I complex, subunit D2 | 10892 | 0.032 | 0.4991 | Yes |
| 39 | PCNA | PCNA Entrez,  Source | proliferating cell nuclear antigen | 10939 | 0.031 | 0.5075 | Yes |
| 40 | CDC20 | CDC20 Entrez,  Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 10950 | 0.031 | 0.5172 | Yes |
| 41 | PA2G4 | PA2G4 Entrez,  Source | proliferation-associated 2G4, 38kDa | 11100 | 0.029 | 0.5211 | Yes |
| 42 | RRM2 | RRM2 Entrez,  Source | ribonucleotide reductase M2 polypeptide | 11196 | 0.028 | 0.5266 | Yes |
| 43 | HJURP | 11262 | 0.027 | 0.5331 | Yes | ||
| 44 | MRPL39 | MRPL39 Entrez,  Source | mitochondrial ribosomal protein L39 | 11362 | 0.026 | 0.5379 | Yes |
| 45 | NUP205 | NUP205 Entrez,  Source | nucleoporin 205kDa | 11583 | 0.024 | 0.5372 | Yes |
| 46 | ESPL1 | ESPL1 Entrez,  Source | extra spindle poles like 1 (S. cerevisiae) | 11672 | 0.023 | 0.5412 | Yes |
| 47 | CENPM | CENPM Entrez,  Source | centromere protein M | 12220 | 0.016 | 0.5253 | No |
| 48 | SPAG5 | SPAG5 Entrez,  Source | sperm associated antigen 5 | 13814 | -0.003 | 0.4647 | No |
| 49 | ZWINT | ZWINT Entrez,  Source | ZW10 interactor | 14235 | -0.008 | 0.4512 | No |

