| Dataset | SMCHD1_KO_collapsed_to_symbols.SMCHD1_KO.cls #del_versus_fl.SMCHD1_KO.cls #del_versus_fl_repos |
| Phenotype | SMCHD1_KO.cls#del_versus_fl_repos |
| Upregulated in class | 0 |
| GeneSet | GNF2_CCNA2 |
| Enrichment Score (ES) | 0.5309702 |
| Normalized Enrichment Score (NES) | 1.9159663 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.19251941 |
| FWER p-Value | 0.707 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ASF1B | ASF1B Entrez,  Source | ASF1 anti-silencing function 1 homolog B (S. cerevisiae) | 1459 | 0.234 | 0.0020 | Yes |
| 2 | TYMS | TYMS Entrez,  Source | thymidylate synthetase | 2505 | 0.150 | -0.0009 | Yes |
| 3 | RAD51AP1 | RAD51AP1 Entrez,  Source | RAD51 associated protein 1 | 2626 | 0.146 | 0.0310 | Yes |
| 4 | CKS1B | CKS1B Entrez,  Source | CDC28 protein kinase regulatory subunit 1B | 2942 | 0.125 | 0.0502 | Yes |
| 5 | NDC80 | 3031 | 0.120 | 0.0767 | Yes | ||
| 6 | TTK | TTK Entrez,  Source | TTK protein kinase | 3042 | 0.119 | 0.1061 | Yes |
| 7 | SHCBP1 | SHCBP1 Entrez,  Source | SHC SH2-domain binding protein 1 | 3202 | 0.110 | 0.1275 | Yes |
| 8 | PRIM1 | PRIM1 Entrez,  Source | primase, polypeptide 1, 49kDa | 3268 | 0.107 | 0.1517 | Yes |
| 9 | RFC4 | RFC4 Entrez,  Source | replication factor C (activator 1) 4, 37kDa | 3299 | 0.105 | 0.1768 | Yes |
| 10 | GMNN | GMNN Entrez,  Source | geminin, DNA replication inhibitor | 3370 | 0.102 | 0.1996 | Yes |
| 11 | NCAPG | NCAPG Entrez,  Source | non-SMC condensin I complex, subunit G | 3663 | 0.090 | 0.2109 | Yes |
| 12 | BIRC5 | BIRC5 Entrez,  Source | baculoviral IAP repeat-containing 5 (survivin) | 3691 | 0.090 | 0.2322 | Yes |
| 13 | SMC4 | SMC4 Entrez,  Source | structural maintenance of chromosomes 4 | 3717 | 0.088 | 0.2533 | Yes |
| 14 | AURKA | AURKA Entrez,  Source | aurora kinase A | 3750 | 0.087 | 0.2739 | Yes |
| 15 | CENPA | CENPA Entrez,  Source | centromere protein A | 4032 | 0.084 | 0.2840 | Yes |
| 16 | MCM6 | MCM6 Entrez,  Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 4276 | 0.076 | 0.2936 | Yes |
| 17 | CCNA2 | CCNA2 Entrez,  Source | cyclin A2 | 7999 | 0.073 | 0.1678 | Yes |
| 18 | E2F8 | E2F8 Entrez,  Source | E2F transcription factor 8 | 8004 | 0.073 | 0.1859 | Yes |
| 19 | UBE2C | UBE2C Entrez,  Source | ubiquitin-conjugating enzyme E2C | 8018 | 0.072 | 0.2036 | Yes |
| 20 | NUSAP1 | NUSAP1 Entrez,  Source | nucleolar and spindle associated protein 1 | 8179 | 0.071 | 0.2150 | Yes |
| 21 | TMPO | TMPO Entrez,  Source | thymopoietin | 8207 | 0.070 | 0.2314 | Yes |
| 22 | MELK | MELK Entrez,  Source | maternal embryonic leucine zipper kinase | 8236 | 0.069 | 0.2476 | Yes |
| 23 | DLGAP5 | 8319 | 0.068 | 0.2615 | Yes | ||
| 24 | SMC2 | SMC2 Entrez,  Source | structural maintenance of chromosomes 2 | 8352 | 0.067 | 0.2770 | Yes |
| 25 | CDCA8 | CDCA8 Entrez,  Source | cell division cycle associated 8 | 8511 | 0.064 | 0.2869 | Yes |
| 26 | CDK1 | 8548 | 0.063 | 0.3012 | Yes | ||
| 27 | TPX2 | TPX2 Entrez,  Source | TPX2, microtubule-associated, homolog (Xenopus laevis) | 8581 | 0.062 | 0.3155 | Yes |
| 28 | MCM4 | MCM4 Entrez,  Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 8582 | 0.062 | 0.3311 | Yes |
| 29 | EZH2 | EZH2 Entrez,  Source | enhancer of zeste homolog 2 (Drosophila) | 8626 | 0.061 | 0.3447 | Yes |
| 30 | PLK1 | PLK1 Entrez,  Source | polo-like kinase 1 (Drosophila) | 8688 | 0.060 | 0.3575 | Yes |
| 31 | KIF14 | KIF14 Entrez,  Source | kinesin family member 14 | 8695 | 0.060 | 0.3723 | Yes |
| 32 | KIF18B | 8919 | 0.060 | 0.3785 | Yes | ||
| 33 | RRM1 | RRM1 Entrez,  Source | ribonucleotide reductase M1 polypeptide | 9137 | 0.056 | 0.3841 | Yes |
| 34 | HMMR | HMMR Entrez,  Source | hyaluronan-mediated motility receptor (RHAMM) | 9173 | 0.055 | 0.3965 | Yes |
| 35 | RACGAP1 | RACGAP1 Entrez,  Source | Rac GTPase activating protein 1 | 9253 | 0.055 | 0.4071 | Yes |
| 36 | TOP2A | TOP2A Entrez,  Source | topoisomerase (DNA) II alpha 170kDa | 9270 | 0.054 | 0.4200 | Yes |
| 37 | CCNB2 | CCNB2 Entrez,  Source | cyclin B2 | 9453 | 0.051 | 0.4257 | Yes |
| 38 | CENPE | CENPE Entrez,  Source | centromere protein E, 312kDa | 9548 | 0.050 | 0.4345 | Yes |
| 39 | MCM3 | MCM3 Entrez,  Source | MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) | 9611 | 0.049 | 0.4443 | Yes |
| 40 | KIF11 | KIF11 Entrez,  Source | kinesin family member 11 | 9652 | 0.048 | 0.4549 | Yes |
| 41 | ASPM | ASPM Entrez,  Source | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 9711 | 0.047 | 0.4645 | Yes |
| 42 | AURKB | AURKB Entrez,  Source | aurora kinase B | 9747 | 0.047 | 0.4748 | Yes |
| 43 | FANCI | FANCI Entrez,  Source | Fanconi anemia, complementation group I | 9924 | 0.045 | 0.4792 | Yes |
| 44 | MCM7 | MCM7 Entrez,  Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 9993 | 0.044 | 0.4875 | Yes |
| 45 | HMGB2 | HMGB2 Entrez,  Source | high-mobility group box 2 | 10107 | 0.042 | 0.4936 | Yes |
| 46 | CDCA3 | CDCA3 Entrez,  Source | cell division cycle associated 3 | 10212 | 0.041 | 0.4997 | Yes |
| 47 | BUB1B | BUB1B Entrez,  Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 10437 | 0.037 | 0.5004 | Yes |
| 48 | KIF20A | KIF20A Entrez,  Source | kinesin family member 20A | 10604 | 0.035 | 0.5028 | Yes |
| 49 | MCM2 | MCM2 Entrez,  Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 10680 | 0.034 | 0.5085 | Yes |
| 50 | NCAPD2 | NCAPD2 Entrez,  Source | non-SMC condensin I complex, subunit D2 | 10892 | 0.032 | 0.5082 | Yes |
| 51 | PCNA | PCNA Entrez,  Source | proliferating cell nuclear antigen | 10939 | 0.031 | 0.5142 | Yes |
| 52 | CDC20 | CDC20 Entrez,  Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 10950 | 0.031 | 0.5215 | Yes |
| 53 | RFC3 | RFC3 Entrez,  Source | replication factor C (activator 1) 3, 38kDa | 11033 | 0.030 | 0.5258 | Yes |
| 54 | RRM2 | RRM2 Entrez,  Source | ribonucleotide reductase M2 polypeptide | 11196 | 0.028 | 0.5266 | Yes |
| 55 | HJURP | 11262 | 0.027 | 0.5310 | Yes | ||
| 56 | PRC1 | PRC1 Entrez,  Source | protein regulator of cytokinesis 1 | 11666 | 0.023 | 0.5211 | No |
| 57 | ESPL1 | ESPL1 Entrez,  Source | extra spindle poles like 1 (S. cerevisiae) | 11672 | 0.023 | 0.5265 | No |
| 58 | FOXM1 | FOXM1 Entrez,  Source | forkhead box M1 | 11822 | 0.021 | 0.5260 | No |
| 59 | CKS2 | CKS2 Entrez,  Source | CDC28 protein kinase regulatory subunit 2 | 12217 | 0.016 | 0.5148 | No |
| 60 | FEN1 | FEN1 Entrez,  Source | flap structure-specific endonuclease 1 | 12646 | 0.011 | 0.5009 | No |
| 61 | CENPF | CENPF Entrez,  Source | centromere protein F, 350/400ka (mitosin) | 13466 | 0.001 | 0.4694 | No |
| 62 | H2AFX | H2AFX Entrez,  Source | H2A histone family, member X | 14049 | -0.006 | 0.4484 | No |
| 63 | ZWINT | ZWINT Entrez,  Source | ZW10 interactor | 14235 | -0.008 | 0.4433 | No |
| 64 | GINS2 | GINS2 Entrez,  Source | GINS complex subunit 2 (Psf2 homolog) | 14397 | -0.011 | 0.4397 | No |
| 65 | MKI67 | MKI67 Entrez,  Source | antigen identified by monoclonal antibody Ki-67 | 15149 | -0.022 | 0.4161 | No |

